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Christian Landles · SciRah

Researcher profile · Semantic Scholar

Christian Landles

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Christian Landles — researcher profile on SciRah

h-index: 24
Works: 54
Citations: 4,403

Most-cited papers

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
M. Björkqvist, E. Wild, J. Thiele, A. Silvestroni +18 more
2008Journal of Experimental Medicine678 citations Open access
Semantic Scholar
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
Kirupa Sathasivam, Andreas Neueder, T. A. Gipson, Christian Landles +9 more
2013Proceedings of the National Academy of Sciences of the United States of America517 citations Open access
Semantic Scholar
Huntingtin and the molecular pathogenesis of Huntington's disease
Christian Landles, Gillian P. Bates
2004EMBO Reports516 citations Open access
Semantic Scholar
Natural Selection of Human Embryos: Impaired Decidualization of Endometrium Disables Embryo-Maternal Interactions and Causes Recurrent Pregnancy Loss
M. Salker, G. Teklenburg, M. Molokhia, S. Lavery +14 more
2010PLoS ONE400 citations Open access
Semantic Scholar
Natural Selection of Human Embryos: Decidualizing Endometrial Stromal Cells Serve as Sensors of Embryo Quality upon Implantation
G. Teklenburg, M. Salker, M. Molokhia, S. Lavery +14 more
2010PLoS ONE329 citations Open access
Semantic Scholar
Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease*
Christian Landles, Kirupa Sathasivam, A. Weiss, B. Woodman +10 more
2010Journal of Biological Chemistry326 citations Open access
Semantic Scholar
The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients
Andreas Neueder, Christian Landles, R. Ghosh, David S. Howland +4 more
2017Scientific Reports222 citations Open access
Semantic Scholar
Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure
M. Salker, M. Christian, J. Steel, J. Nautiyal +13 more
2011Nature Medicine188 citations
Semantic Scholar
The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes.
B. Woodman, Rachel Butler, Christian Landles, M. Lupton +5 more
2007Brain Research Bulletin174 citations
Semantic Scholar
HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration
Michal Mielcarek, Christian Landles, A. Weiss, A. Bradaia +17 more
2013PLoS Biology167 citations Open access
Semantic Scholar
Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression.
A. Weiss, U. Träger, E. Wild, Stephan Grueninger +12 more
2012Journal of Clinical Investigation140 citations Open access
Semantic Scholar
Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.
C. Benn, Christian Landles, He Li, Andrew D. Strand +11 more
2005Human Molecular Genetics128 citations
Semantic Scholar
Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation.
A. Zourlidou, T. Gidalevitz, M. Kristiansen, Christian Landles +7 more
2007Human Molecular Genetics98 citations Open access
Semantic Scholar
The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development.
Christian Landles, Sara Chalk, J. Steel, I. Rosewell +3 more
2003Molecular Endocrinology62 citations
Semantic Scholar
A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease
Sarah G. Aldous, Edward J Smith, Christian Landles, Georgina F. Osborne +11 more
2023bioRxiv49 citations Open access
Semantic Scholar
Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington’S Disease Model
Christian Landles, Rebecca E Milton, Nadira Ali, R. Flomen +13 more
2020Brain Communications48 citations Open access
Semantic Scholar
Phenotype onset in Huntington’s disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene
Nicholas R. Franich, M. Hickey, Chunni Zhu, Georgina F. Osborne +11 more
2019Journal of Neuroscience Research46 citations Open access
Semantic Scholar
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
R. N. Hegde, A. Chiki, Lara Petricca, Paola Martufi +12 more
2020EMBO Journal40 citations Open access
Semantic Scholar
Alternative processing of human HTT mRNA with implications for Huntington’s disease therapeutics
Sandra Fienko, Christian Landles, Kirupa Sathasivam, Sean J McAteer +10 more
2022Brain : a journal of neurology38 citations Open access
Semantic Scholar
Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches
Edward J. Smith, Kirupa Sathasivam, Christian Landles, Georgina F. Osborne +10 more
2023Brain Communications33 citations Open access
Semantic Scholar
HDAC4 Does Not Act as a Protein Deacetylase in the Postnatal Murine Brain In Vivo
Michal Mielcarek, T. Seredenina, M. Stokes, Georgina F. Osborne +7 more
2013PLoS ONE32 citations Open access
Semantic Scholar
Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms
Christian Landles, Rebecca E Milton, Alexandre Jean, Stuart J McLarnon +7 more
2021Brain Communications27 citations Open access
Semantic Scholar
Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice
D. Bryant, Christian Landles, A. Papadopoulou, Agnesska C. Benjamin +4 more
2017Scientific Reports25 citations Open access
Semantic Scholar
Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models
Marina Sogorb-González, Christian Landles, N. Caron, A. Stam +7 more
2024Brain : a journal of neurology24 citations Open access
Semantic Scholar
Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington’s disease
Christian Landles, A. Weiss, Sophie A. Franklin, David S. Howland +1 more
2012PLOS Currents23 citations Open access
Semantic Scholar
Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays
Christian Landles, Georgina F. Osborne, Jemima Phillips, María Cañibano-Pico +6 more
2024Brain Communications20 citations Open access
Semantic Scholar
Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease
Ya Zhou, Thomas R. Peskett, Christian Landles, J. B. Warner +7 more
2021Acta Neuropathologica Communications15 citations Open access
Semantic Scholar
Lowering the HTT1a transcript as an effective therapy for Huntington’s disease
A. Papadopoulou, J. Alterman, Christian Landles, Edward J Smith +17 more
2025bioRxiv10 citations Open access
Semantic Scholar
Selective targeting of mutant huntingtin intron 1 improves rescue provided by antisense oligonucleotides in Huntington's disease mice.
Robert M. Bragg, Christian Landles, Edward J Smith, Georgina F. Osborne +4 more
2026Science Translational Medicine6 citations
Semantic Scholar
Cas9 Nickase-Mediated Contraction of CAG/CTG Repeats in Vivo is Accompanied by Improvements in Huntington’s Disease Pathology
A. Murillo, M. Alpaugh, Ruban Peter-Durairaj, Emma L. Randall +21 more
2025bioRxiv6 citations Open access
Semantic Scholar
Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington’s disease pathogenesis in mice
Jillian Belgrad, Ashley Summers, Christian Landles, Jonathan R. Greene +22 more
2025bioRxiv4 citations Open access
Semantic Scholar
A021 Early detection of exon 1 Huntingtin aggregation in zQ175 brains by molecular and histological approaches
Edward J Smith, Kirupa Sathasivam, Christian Landles, Georgina F. Osborne +2 more
2024A: Pathogenic mechanisms4 citations Open access
Semantic Scholar
The HTT1a protein initiates HTT aggregation in a knock-in mouse model of Huntington’s disease
A. Papadopoulou, Christian Landles, Edward J Smith, Marie K Bondulich +15 more
2026Brain : a journal of neurology3 citations Open access
Semantic Scholar
Selective targeting of mutant huntingtin intron-1 improves rescue provided by antisense oligonucleotides
Robert M. Bragg, Christian Landles, Edward J Smith, Georgina F. Osborne +3 more
2025bioRxiv3 citations Open access
Semantic Scholar
I006 Lowering htt1a with sirnas has more impact on early molecular and histological phenotypes than lowering full-length htt
A. Papadopoulou, Christian Landles, Edward J Smith, Dan O’Reilly +12 more
2024Infotech@Aerospace Conference2 citations Open access
Semantic Scholar
TBK1 regulates autophagic clearance of soluble mutant huntingtin and inhibits aggregation/toxicity in different models of Huntington’s disease
R. N. Hegde, A. Chiki, Lara Petricca, Paola Martufi +11 more
2019bioRxiv2 citations Open access
Semantic Scholar
Blocking somatic repeat expansion and lowering huntingtin by RNAi synergize to attenuate Huntington's disease pathogenesis in mice.
Jillian Belgrad, Ashley Summers, Christian Landles, Jonathan R. Greene +23 more
2026Science Translational Medicine1 citations
Semantic Scholar
Mutant HTT protein decreases with CAG repeat expansion: implications for therapeutics and bioassays
Christian Landles, Georgina F. Osborne, Jemima Phillips, Maria Canibano Pico +5 more
2024bioRxiv1 citations Open access
Semantic Scholar
B03 Analysis of a Huntington’s disease knock-in mouse model designed to prevent the generation of the exon 1 HTT protein
Aikaterini-Smaragdi Papadopulou, Christian Landles, Edward Smith, Marie K Bondulich +5 more
2022Formal Specification and Development in B1 citations
Semantic Scholar
P3‐377: A novel pathogenic pathway of immune activation detectable before cinical onset in Huntington's disease
E. Wild, M. Björkqvist, J. Thiele, A. Silvestroni +15 more
20081 citations
Semantic Scholar
Molecular features of a Huntington's disease knock-in minipig
A. Kolesnikova, Kirupa Sathasivam, S. K. Tusi, Christian Landles +17 more
2026Disease Models & Mechanisms0 citations Open access
Semantic Scholar
Cas9 nickase-mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington's disease mouse model.
A. Murillo, M. Alpaugh, Ruban Peter-Durairaj, Emma L. Randall +21 more
2026Science Translational Medicine0 citations
Semantic Scholar
Development and validation of highly selective monoclonal antibodies for the detection of huntingtin neoepitopes
A. Missineo, L. Tomei, Nadine Alaimo, Paola Martufi +14 more
2026bioRxiv0 citations Open access
Semantic Scholar
Enhancing the detection of HTT1a with neoepitope antibodies in mouse models of Huntington’s disease
Georgina F. Osborne, Edward J Smith, Kirupa Sathasivam, Zi-Xin Kang +5 more
2026bioRxiv0 citations Open access
Semantic Scholar
Human-specific sequence features in HTT exon 1 promote toxic misprocessing via splicing factor SRSF7
Camilla Maffezzini, R. Iennaco, Andrea Scolz, Simone Maestri +13 more
2026Nature Communications0 citations Open access
Semantic Scholar
A015 Mutant Huntingtin protein levels decrease with CAG repeat expansion: implications for therapeutics and bioassays
Christian Landles, Georgina F. Osborne, Jemima Phillips, Maria Canibano Pico +4 more
2024A: Pathogenic mechanisms0 citations Open access
Semantic Scholar
B005 Characterisation of mouse embryonic fibroblast models of Huntington’s disease and their application as screening tools for therapeutic agents
Casandra Gomez-Paredes, Kirupa Sathasivam, A. Papadopoulou, Sandra Fienko +6 more
2024Formal Specification and Development in B0 citations Open access
Semantic Scholar
A002 A CAG repeat threshold for therapeutics targeting somatic instability in mouse models of Huntington’s disease
Sarah G. Aldous, Edward J Smith, Christian Landles, Georgina F. Osborne +12 more
2024A: Pathogenic mechanisms0 citations Open access
Semantic Scholar
A11 The temporal and spatial appearance of HTT aggregation in the brains of zQ175 mice
Edward J. Smith, Kirupa Sathasivam, Christian Landles, Georgina F. Osborne +2 more
2022A: Pathogenic mechanisms0 citations
Semantic Scholar
D03 Novel bioassays to detect soluble and aggregated isoforms of the huntingtin protein on three technology platforms
Christian Landles, Georgina F. Osborne, Rebecca E Milton, Alexandre Jean +4 more
2022I D0 citations
Semantic Scholar

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Georgina F. Osborne×29
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Kirupa Sathasivam×17
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Jemima Phillips

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Jonathan R. Greene×9

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María Cañibano-Pico×8

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C. Benn — researcher profile on SciRah

Marie K Bondulich×7

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Casandra Gomez-Paredes×7

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Casandra Gomez-Paredes — researcher profile on SciRah