Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

David S. Howland · SciRah

Researcher profile · Semantic Scholar

David S. Howland

Share profile

David S. Howland — researcher profile on SciRah

h-index: 31
Works: 67
Citations: 5,473

Most-cited papers

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
David S. Howland, Jian Liu, Yijin She, Beth Goad +9 more
2002Proceedings of the National Academy of Sciences of the United States of America850 citations Open access
Semantic Scholar
Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.
Bernadette H. LaMonte, K. Wallace, Beth A. Holloway, Spencer S. Shelly +5 more
2002Neuron580 citations Open access
Semantic Scholar
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
Kirupa Sathasivam, Andreas Neueder, T. A. Gipson, Christian Landles +9 more
2013Proceedings of the National Academy of Sciences of the United States of America517 citations Open access
Semantic Scholar
Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175
L. Menalled, A. Kudwa, Sam Miller, Jon Fitzpatrick +16 more
2012PLoS ONE435 citations Open access
Semantic Scholar
Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice
P. Langfelder, J. P. Cantle, Doxa Chatzopoulou, Nan Wang +18 more
2016Nature Neuroscience365 citations Open access
Semantic Scholar
Systematic behavioral evaluation of Huntington’s disease transgenic and knock-in mouse models
L. Menalled, Bassem F. El-Khodor, Monica Patry, M. Suárez-Fariñas +14 more
2009Neurobiology of Disease342 citations Open access
Semantic Scholar
Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease
T. Heikkinen, K. Lehtimäki, N. Vartiainen, Jukka T. Puoliväli +12 more
2012PLoS ONE242 citations Open access
Semantic Scholar
The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients
Andreas Neueder, Christian Landles, R. Ghosh, David S. Howland +4 more
2017Scientific Reports222 citations Open access
Semantic Scholar
Impaired Spinal Cord Glutamate Transport Capacity and Reduced Sensitivity to Riluzole in a Transgenic Superoxide Dismutase Mutant Rat Model of Amyotrophic Lateral Sclerosis
J. Dunlop, H. Beal McIlvain, Yijin She, David S. Howland
2003Journal of Neuroscience130 citations Open access
Semantic Scholar
A Transgenic Minipig Model of Huntington's Disease
M. Baxa, M. Hruska-Plochan, Š. Juhás, P. Vodička +20 more
2013Journal of Huntington's Disease116 citations
Semantic Scholar
Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis.
E. Holzbaur, David S. Howland, Nicholas Weber, K. Wallace +15 more
2006Neurobiology of Disease103 citations Open access
Semantic Scholar
A Novel BACHD Transgenic Rat Exhibits Characteristic Neuropathological Features of Huntington Disease
L. Yu-Taeger, E. Petrasch‐Parwez, A. Osmand, A. Redensek +10 more
2012Journal of Neuroscience101 citations Open access
Semantic Scholar
Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease
E. Pfister, N. Dinardo, Erica Mondo, F. Borel +20 more
2017Human Gene Therapy80 citations Open access
Semantic Scholar
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
V. Uribe, Bibiana K. Y. Wong, R. Graham, Corey L. Cusack +17 more
2012Human Molecular Genetics80 citations Open access
Semantic Scholar
Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington’s Disease
Huei-Bin Wang, Dawn H. Loh, Daniel S. Whittaker, T. Cutler +2 more
2018eNeuro79 citations Open access
Semantic Scholar
Pharmacokinetics of memantine in rats and mice
M. Beconi, David S. Howland, Larry C. Park, K. Lyons +4 more
2011PLOS Currents77 citations Open access
Semantic Scholar
Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out
Jacob M. Loupe, R. M. Pinto, Kyung-Hee Kim, T. Gillis +12 more
2020Human Molecular Genetics74 citations Open access
Semantic Scholar
Comprehensive Behavioral Testing in the R6/2 Mouse Model of Huntington's Disease Shows No Benefit from CoQ10 or Minocycline
L. Menalled, Monica Patry, Natalie H. Ragland, Phillip A. S. Lowden +9 more
2010PLoS ONE71 citations Open access
Semantic Scholar
Genetic Knock-Down of Hdac3 Does Not Modify Disease-Related Phenotypes in a Mouse Model of Huntington's Disease
L. Moumné, Ken Campbell, David S. Howland, Y. Ouyang +1 more
2012PLoS ONE64 citations Open access
Semantic Scholar
Brain Region Specific Actions of RGS4 Oppose Morphine Reward and Dependence but Promote Analgesia
V. Zachariou, W. Renthal, R. Ring, Z. Rahman +9 more
2009Biological Psychiatry64 citations Open access
Semantic Scholar
Caspase-6 activity in a BACHD mouse modulates steady state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment
J. Gafni, T. Papanikolaou, Francesco Degiacomo, Jennifer Holcomb +14 more
2012Journal of Neuroscience51 citations Open access
Semantic Scholar
Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice
Vadim Alexandrov, D. Brunner, L. Menalled, A. Kudwa +21 more
2016Nature Biotechnology49 citations
Semantic Scholar
MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice
P. Langfelder, Fuying Gao, Nan Wang, David S. Howland +7 more
2018PLoS ONE48 citations Open access
Semantic Scholar
Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease
S. Oakeshott, Fuat Balcı, I. Filippov, Carol A. Murphy +10 more
2011PLOS Currents47 citations Open access
Semantic Scholar
Phenotype onset in Huntington’s disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene
Nicholas R. Franich, M. Hickey, Chunni Zhu, Georgina F. Osborne +11 more
2019Journal of Neuroscience Research46 citations Open access
Semantic Scholar
Inflammatory mediators and growth factors in the spinal cord of G93A SOD1 rats
Yiheng Xie, P. Weydt, David S. Howland, M. Kliot +1 more
2004NeuroReport44 citations
Semantic Scholar
High resolution time‐course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock‐in mice across multiple genetic backgrounds
S. Ament, Jocelynn R. Pearl, Andrea Grindeland, Jason St. Claire +19 more
2017Human Molecular Genetics40 citations Open access
Semantic Scholar
High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease
Fuat Balcı, S. Oakeshott, J. L. Shamy, B. El-Khodor +10 more
2013PLOS Currents40 citations Open access
Semantic Scholar
Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington's Disease
L. Menalled, A. Kudwa, S. Oakeshott, A. Farrar +25 more
2014PLoS ONE38 citations Open access
Semantic Scholar
Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD
Paul C. P. Curtin, A. Farrar, S. Oakeshott, Jane C Sutphen +8 more
2016Frontiers in Behavioral Neuroscience35 citations Open access
Semantic Scholar
Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington’s Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits
A. Kudwa, L. Menalled, S. Oakeshott, Carol A. Murphy +9 more
2013PLOS Currents31 citations Open access
Semantic Scholar
Mutations causing Lopes-Maciel-Rodan Syndrome are huntingtin hypomorphs.
Roy Jung, Ye-Jin Lee, D. Barker, Kevin Correia +16 more
2021Human Molecular Genetics30 citations Open access
Semantic Scholar
Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway
Sevasti Gaspari, I. Purushothaman, Valeria Cogliani, F. Sakloth +6 more
2018Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
Semantic Scholar
Mind the gap: Models in multiple species needed for therapeutic development in Huntington's disease
David S. Howland, I. Muñoz-Sanjuán
2014Movement Disorders29 citations Open access
Semantic Scholar
Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington’s disease mice
Marie K Bondulich, Nelly Jolinon, Georgina F. Osborne, Edward J. Smith +25 more
2017Scientific Reports28 citations Open access
Semantic Scholar
Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms
Christian Landles, Rebecca E Milton, Alexandre Jean, Stuart J McLarnon +7 more
2021Brain Communications27 citations Open access
Semantic Scholar
A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington’s disease
S. Oakeshott, Russell G. Port, Jane Cummins-Sutphen, Jason D. Berger +6 more
2012PLOS Currents27 citations Open access
Semantic Scholar
Large Animal Models of Huntington’s Disease: What We Have Learned and Where We Need to Go Next
David S. Howland, Z. Ellederová, N. Aronin, Deborah Fernau +6 more
2020Journal of Huntington's Disease26 citations Open access
Semantic Scholar
Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars
Monika Mačáková, B. Bohuslavova, Petra Vochozková, A. Pavlok +22 more
2016Neurodegenerative Diseases24 citations
Semantic Scholar
Deficits in a Simple Visual Go/No-go Discrimination Task in Two Mouse Models of Huntington’s Disease
S. Oakeshott, A. Farrar, Russell G. Port, Jane Cummins-Sutphen +5 more
2013PLOS Currents23 citations Open access
Semantic Scholar
Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington’s disease
Christian Landles, A. Weiss, Sophie A. Franklin, David S. Howland +1 more
2012PLOS Currents23 citations Open access
Semantic Scholar
Cognitive Deficits in Transgenic and Knock-in HTT Mice Parallel those in Huntington's Disease
A. Farrar, Carol A. Murphy, Neil E. Paterson, S. Oakeshott +8 more
2014Journal of Huntington's Disease22 citations
Semantic Scholar
Extensive Expression Analysis of Htt Transcripts in Brain Regions from the zQ175 HD Mouse Model Using a QuantiGene Multiplex Assay
A. Papadopoulou, Casandra Gomez-Paredes, Michael A. Mason, Bridget A Taxy +2 more
2019Scientific Reports17 citations Open access
Semantic Scholar
Disruption of ShcA signaling halts cell proliferation--characterization of ShcC residues that influence signaling pathways using yeast.
J. Heinrich, S. Kwak, David S. Howland, Jin Chen +7 more
2006Cellular Signalling17 citations
Semantic Scholar
Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model
Deanna M. Marchionini, Jeh-Ping Liu, A. Ambesi-Impiombato, Kimberly Kerker +22 more
2022bioRxiv15 citations Open access
Semantic Scholar
Ablation of central nervous system progenitor cells in transgenic rats using bacterial nitroreductase system
S. Kwak, Jessica E. Malberg, David S. Howland, K. Cheng +4 more
2007Journal of Neuroscience Research15 citations
Semantic Scholar
Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs
J. Křížová, Hana Štufková, M. Rodinová, Monika Mačáková +9 more
2017Neurodegenerative Diseases13 citations
Semantic Scholar
Huntingtin lowering reduces somatic instability at CAG-expanded loci
S. Coffey, M. Andrew, H. Ging, Joseph Hamilton +19 more
2020bioRxiv9 citations Open access
Semantic Scholar
A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington's disease.
S. Oakeshott, Russell G. Port, Jane Cummins-Sutphen, Jason D. Berger +6 more
2012PLOS Currents8 citations Open access
Semantic Scholar
Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation
Robert M. Bragg, S. Coffey, J. P. Cantle, Shikai Hu +10 more
2023Life Science Alliance7 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

Seung Kwak×14
Invite
Seung Kwak — researcher profile on SciRah
D. Brunner×13
Invite
D. Brunner — researcher profile on SciRah
S. Ramboz×12
Invite
S. Ramboz — researcher profile on SciRah
G. Bates×10
Invite
G. Bates — researcher profile on SciRah

×10

Invite

L. Menalled — researcher profile on SciRah

S. Oakeshott×10

Invite

S. Oakeshott — researcher profile on SciRah

Larry C. Park×10

Invite

Larry C. Park — researcher profile on SciRah

I. Muñoz-Sanjuán×6

Invite

I. Muñoz-Sanjuán — researcher profile on SciRah

Russell G. Port×6

Invite

Russell G. Port — researcher profile on SciRah

Christian Landles×5

Invite

Christian Landles — researcher profile on SciRah

Invite

A. Kudwa — researcher profile on SciRah

Judy Watson-Johnson×5

Invite

Judy Watson-Johnson — researcher profile on SciRah