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C. Benn · SciRah

Researcher profile · Semantic Scholar

C. Benn

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C. Benn — researcher profile on SciRah

h-index: 25
Works: 44
Citations: 3,226

Most-cited papers

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
M. Björkqvist, E. Wild, J. Thiele, A. Silvestroni +18 more
2008Journal of Experimental Medicine678 citations Open access
Semantic Scholar
Physiology of Hyperuricemia and Urate-Lowering Treatments
C. Benn, P. Dua, R. Gurrell, P. Loudon +3 more
2018Frontiers in Medicine285 citations Open access
Semantic Scholar
Molecular and functional variation in iPSC-derived sensory neurons
J. Schwartzentruber, Stefanie Foskolou, H. Kilpinen, Julia Rodrigues +16 more
2017Nature Genetics221 citations Open access
Semantic Scholar
Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models.
G. Sadri-Vakili, Bérengère Bouzou, C. Benn, Mee‐Ohk Kim +9 more
2007Human Molecular Genetics214 citations
Semantic Scholar
Huntingtin modulates transcription, occupies gene promoters in vivo and binds directly to DNA in a polyglutamine-dependent manner
C. Benn, Ting-Ting Sun, G. Sadri-Vakili, Karen N. McFarland +5 more
2008Journal of Neuroscience209 citations Open access
Semantic Scholar
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
D. Barsyte-Lovejoy, Feng-Ling Li, M. Oudhoff, J. Tatlock +29 more
2014Proceedings of the National Academy of Sciences of the United States of America171 citations Open access
Semantic Scholar
SAHA Decreases HDAC 2 and 4 Levels In Vivo and Improves Molecular Phenotypes in the R6/2 Mouse Model of Huntington's Disease
Michal Mielcarek, C. Benn, Sophie A. Franklin, Donna L. Smith +3 more
2011PLoS ONE164 citations Open access
Semantic Scholar
Characterizing Human Stem Cell–derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research
G. Young, Alex Gutteridge, Heather de Fox, Anna L. Wilbrey +10 more
2014Molecular Therapy138 citations Open access
Semantic Scholar
Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.
C. Benn, Christian Landles, He Li, Andrew D. Strand +11 more
2005Human Molecular Genetics128 citations
Semantic Scholar
Sp1 Is Up-regulated in Cellular and Transgenic Models of Huntington Disease, and Its Reduction Is Neuroprotective*
Z. Qiu, F. Norflus, Bhupinder Singh, Mary K Swindell +9 more
2006Journal of Biological Chemistry117 citations Open access
Semantic Scholar
Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease.
Alice S. Chen-Plotkin, G. Sadri-Vakili, G. Yohrling, Melissa W. Braveman +8 more
2006Neurobiology of Disease113 citations Open access
Semantic Scholar
Forebrain Adenosine A2A Receptors Contribute to l-3,4-Dihydroxyphenylalanine-Induced Dyskinesia in Hemiparkinsonian Mice
Danqing Xiao, E. Bastia, Yuehang Xu, C. Benn +4 more
2006Journal of Neuroscience99 citations Open access
Semantic Scholar
Genetic Knock-Down of HDAC7 Does Not Ameliorate Disease Pathogenesis in the R6/2 Mouse Model of Huntington's Disease
C. Benn, Rachel Butler, Lydia Mariner, J. Nixon +4 more
2009PLoS ONE70 citations Open access
Semantic Scholar
Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis
Prasanna Kandel, F. Semerci, Rachana Mishra, William T. Choi +19 more
2022Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
Semantic Scholar
Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease
C. Benn, H. Fox, G. Bates
2008Molecular Neurodegeneration57 citations Open access
Semantic Scholar
Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease.
C. Benn, E. Slow, Laurie A. Farrell, R. Graham +3 more
2007Neuroscience57 citations Open access
Semantic Scholar
A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development
M. Nahorski, L. Al-Gazali, J. Hertecant, D. Owen +9 more
2015Brain : a journal of neurology51 citations Open access
Semantic Scholar
A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease
Sarah G. Aldous, Edward J Smith, Christian Landles, Georgina F. Osborne +11 more
2023bioRxiv49 citations Open access
Semantic Scholar
Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington’S Disease Model
Christian Landles, Rebecca E Milton, Nadira Ali, R. Flomen +13 more
2020Brain Communications48 citations Open access
Semantic Scholar
Clinically Precedented Protein Kinases: Rationale for Their Use in Neurodegenerative Disease
C. Benn, L. Dawson
2020Frontiers in Aging Neuroscience47 citations Open access
Semantic Scholar
Mechanisms of distribution of mouse β-galactosidase in the adult GM1-gangliosidosis brain
M. Broekman, Laryssa A. Tierney, C. Benn, P. Chawla +2 more
2009Gene Therapy36 citations Open access
Semantic Scholar
Environmental Enrichment Reduces Neuronal Intranuclear Inclusion Load But Has No Effect on Messenger RNA Expression in a Mouse Model of Huntington Disease
C. Benn, R. Luthi-Carter, Alexandre Kuhn, G. Sadri-Vakili +9 more
2010Journal of Neuropathology and Experimental Neurology35 citations Open access
Semantic Scholar
Drugging DNA Damage Repair Pathways for Trinucleotide Repeat Expansion Diseases
C. Benn, K. Gibson, David S Reynolds
2020Journal of Huntington's Disease30 citations Open access
Semantic Scholar
The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington’s disease
John S. Bett, C. Benn, K. Ryu, R. Kopito +1 more
2008Journal of Cellular and Molecular Medicine26 citations Open access
Semantic Scholar
Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice
D. Bryant, Christian Landles, A. Papadopoulou, Agnesska C. Benjamin +4 more
2017Scientific Reports25 citations Open access
Semantic Scholar
Tackling gaps in developing life-changing treatments for dementia
R. Mauricio, C. Benn, John B. Davis, G. Dawson +25 more
2019Alzheimer's & Dementia23 citations Open access
Semantic Scholar
Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter
Parul Choudhary, E. Armstrong, C. C. Jorgensen, Mary A. Piotrowski +8 more
2017Frontiers in Molecular Neuroscience16 citations Open access
Semantic Scholar
Targeting the cAMP and Transforming Growth Factor‐β Pathway Increases Proliferation to Promote Re‐Epithelialization of Human Stem Cell‐Derived Retinal Pigment Epithelium
Parul Choudhary, Alex Gutteridge, Emma Impey, R. Storer +4 more
2016Stem Cells Translational Medicine16 citations Open access
Semantic Scholar
A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells
Parul Choudhary, Benjamin T. Dodsworth, B. Sidders, Alex Gutteridge +4 more
2015PLoS ONE15 citations Open access
Semantic Scholar
Neurotransmitter receptor analysis in transgenic mouse models.
C. Benn, Laurie A. Farrell, J. Cha
2004Methods in molecular biology13 citations
Semantic Scholar
The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout
R. I. Storer, R. M. Owen, A. Pike, C. Benn +10 more
20167 citations
Semantic Scholar
The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of gout
A. Pike, R. I. Storer, R. M. Owen, E. Armstrong +9 more
20166 citations
Semantic Scholar
Oleic acid triggers hippocampal neurogenesis by binding to TLX/NR2E1
Prasanna Kandel, F. Semerci, A. Bajić, Dodge Baluya +18 more
2020bioRxiv5 citations Open access
Semantic Scholar
The polyglutamine diseases
Gillian P. Bates, C. Benn
20023 citations
Semantic Scholar
P3‐377: A novel pathogenic pathway of immune activation detectable before cinical onset in Huntington's disease
E. Wild, M. Björkqvist, J. Thiele, A. Silvestroni +15 more
20081 citations
Semantic Scholar
A002 A CAG repeat threshold for therapeutics targeting somatic instability in mouse models of Huntington’s disease
Sarah G. Aldous, Edward J Smith, Christian Landles, Georgina F. Osborne +12 more
2024A: Pathogenic mechanisms0 citations Open access
Semantic Scholar
Tackling gaps in developing life-changing treatments for dementia
C. Benn, John Davis, G. Dawson, L. Dawson +21 more
20190 citations
Semantic Scholar
Publisher Correction: Molecular and functional variation in iPSC-derived sensory neurons
J. Schwartzentruber, Stefanie Foskolou, H. Kilpinen, Julia Rodrigues +16 more
2019Nature Genetics0 citations Open access
Semantic Scholar
Tackling gaps in developing life-changing treatments for dementia
C. Benn, John Davis, G. Dawson, L. Dawson +21 more
20190 citations
Semantic Scholar
FOXM1 binds to promoters of proliferation associated genes.
Parul Choudhary, Benjamin T. Dodsworth, B. Sidders, Alex Gutteridge +4 more
20150 citations Open access
Semantic Scholar
The use of quantitative real-time PCR to characterise transcriptional dysregulation in mouse models of Huntington's disease
H. Fox, C. Benn, G. Bates
20080 citations
Semantic Scholar
Genetic knock-down of HDAC 4 improves motor impairment in the R6/2 mouse model of Huntington's disease
Michal Mielcarek, C. Benn, Rachel Butler, J. Robertson +4 more
20080 citations
Semantic Scholar
ForebrainAdenosineA 2A ReceptorsContributeto L-3,4- Dihydroxyphenylalanine-InducedDyskinesiain HemiparkinsonianMice
C. Benn
20060 citations
Semantic Scholar
The molecular basis of Huntington's disease and polyglutamine disorders
C. Benn, David G. Hay, E. Hockly, R. Gonitel +7 more
20000 citations
Semantic Scholar

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