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A. Chiki · SciRah

Researcher profile · Semantic Scholar

A. Chiki

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A. Chiki — researcher profile on SciRah

h-index: 18
Works: 34
Citations: 1,255

Most-cited papers

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
A. Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco +9 more
2020Nature Communications148 citations Open access
Semantic Scholar
Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.
Ritwik Burai, N. Ait-Bouziad, A. Chiki, H. Lashuel
2015Journal of the American Chemical Society143 citations Open access
Semantic Scholar
Nanoscale studies link amyloid maturity with polyglutamine diseases onset
F. Ruggeri, S. Vieweg, U. Cendrowska, G. Longo +3 more
2016Scientific Reports142 citations Open access
Semantic Scholar
N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
Sean M. Deguire, F. Ruggeri, Mohamed Fares, A. Chiki +3 more
2018Journal of Biological Chemistry71 citations Open access
Semantic Scholar
A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α‐synuclein research
Senthil T. Kumar, S. Donzelli, A. Chiki, Muhammed Muazzam Kamil Syed +1 more
2019bioRxiv67 citations Open access
Semantic Scholar
Deep Learning-Assisted Single-Molecule Detection of Protein Post-translational Modifications with a Biological Nanopore
Chan Cao, P. Magalhães, Lucien F. Krapp, J. F. Bada Juarez +5 more
2023bioRxiv66 citations Open access
Semantic Scholar
Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.
A. Chiki, Sean M. Deguire, F. Ruggeri, D. Sanfelice +8 more
2017Angewandte Chemie65 citations Open access
Semantic Scholar
Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
Cristina Cariulo, Lucia Azzollini, Margherita Verani, Paola Martufi +13 more
2017Proceedings of the National Academy of Sciences of the United States of America62 citations Open access
Semantic Scholar
Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM
U. Cendrowska, P. J. Silva, N. Ait-Bouziad, Marie Müller +11 more
2019Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity
H. Lashuel, Anne-Laure Mahul-Mellier, S. Novello, R. N. Hegde +13 more
2022npj Parkinson's Disease55 citations Open access
Semantic Scholar
Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology.
Johannes Burtscher, J. Copin, João Rodrigues, Senthil T. Kumar +4 more
2019Neurobiology of Aging49 citations Open access
Semantic Scholar
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
N. Ait-Bouziad, A. Chiki, Galina Limorenko, Shifeng Xiao +2 more
2020Journal of Biological Chemistry43 citations Open access
Semantic Scholar
The making of a Lewy body: the role of α-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions
Anne-Laure Mahul-Mellier, Firat Altay, Johannes Burtscher, N. Maharjan +17 more
2018bioRxiv43 citations Open access
Semantic Scholar
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
R. N. Hegde, A. Chiki, Lara Petricca, Paola Martufi +12 more
2020EMBO Journal40 citations Open access
Semantic Scholar
Exploring the role of post‐translational modifications in regulating α‐synuclein interactions by studying the effects of phosphorylation on nanobody binding
Farah El-Turk, E. De Genst, Tim Guilliams, Bruno Fauvet +7 more
2018Protein Science33 citations Open access
Semantic Scholar
The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1
S. Vieweg, Anne-Laure Mahul-Mellier, F. Ruggeri, Nathan Riguet +5 more
2021bioRxiv31 citations Open access
Semantic Scholar
Structural Basis of Huntingtin Fibril Polymorphism Revealed by Cryogenic Electron Microscopy of Exon 1 HTT Fibrils.
Sergey Nazarov, A. Chiki, Driss Boudeffa, H. Lashuel
2022Journal of the American Chemical Society29 citations Open access
Semantic Scholar
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
F. Herrmann, Manuela Hessmann, Sabine Schaertl, Karola Berg-Rosseburg +25 more
2021Scientific Reports28 citations Open access
Semantic Scholar
Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation
Anne-Laure Mahul-Mellier, M. Altay, N. Maharjan, N. Ait-Bouziad +21 more
2025npj Parkinson's Disease17 citations Open access
Semantic Scholar
Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
A. Reif, A. Chiki, Jonathan Ricci, H. Lashuel
2018Journal of Visualized Experiments15 citations Open access
Semantic Scholar
Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases
A. Chiki, Jonathan Ricci, R. N. Hegde, L. Abriata +3 more
2020ChemBioChem12 citations Open access
Semantic Scholar
Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation
A. Chiki, Zhidian Zhang, K. Rajasekhar, L. Abriata +5 more
2021bioRxiv10 citations Open access
Semantic Scholar
Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo
S. Donzelli, Sinead OSullivan, Anne-Laure Mahul-Mellier, A. Ulusoy +9 more
2023bioRxiv6 citations Open access
Semantic Scholar
Towards deciphering the Nt17 code: How the sequence and conformation of the first 17 amino acids in Huntingtin regulate the aggregation, cellular properties and neurotoxicity of mutant Httex1
S. Vieweg, Anne-Laure Mahul-Mellier, F. Ruggeri, Nathan Riguet +6 more
20216 citations
Semantic Scholar
Site-specific phosphorylation of Huntingtin exon 1 recombinant proteins enabled by the discovery of novel kinases
A. Chiki, Jonathan Ricci, R. N. Hegde, L. Abriata +2 more
2020bioRxiv6 citations Open access
Semantic Scholar
The structural basis of huntingtin (Htt) fibril polymorphism, revealed by cryo-EM of exon 1 Htt fibrils
Sergey Nazarov, A. Chiki, Driss Boudeffa, H. Lashuel
2021bioRxiv4 citations Open access
Semantic Scholar
Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies
H. Lashuel, Anne-Laure Mahul-Mellier, S. Novello, R. N. Hegde +13 more
2022bioRxiv3 citations Open access
Semantic Scholar
Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity
A. Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco +9 more
2019bioRxiv3 citations Open access
Semantic Scholar
TBK1 regulates autophagic clearance of soluble mutant huntingtin and inhibits aggregation/toxicity in different models of Huntington’s disease
R. N. Hegde, A. Chiki, Lara Petricca, Paola Martufi +11 more
2019bioRxiv2 citations Open access
Semantic Scholar
Dissecting the differential role of C-terminal truncations in the regulation of aSyn pathology formation and the biogenesis of Lewy bodies
Anne-Laure Mahul-Mellier, M. Altay, N. Maharjan, N. Ait-Bouziad +20 more
2024bioRxiv1 citations
Semantic Scholar
Chronic corticosterone enhancement aggravates alpha-synuclein brain spreading pathology and substantia nigra neurodegeneration in mice
Johannes Burtscher, J. Copin, João Rodrigues, S. Thangaraj +4 more
2018bioRxiv1 citations Open access
Semantic Scholar
The role of PTM crosstalks in Httex1 structure, aggregation and membrane interaction
Zhidian Zhang, A. Chiki, Charlotte Gehin, Rajasekhar Kolla +6 more
2022Biophysical Journal0 citations Open access
Semantic Scholar
N-terminal phosphorylation of Huntingtin: A molecular switch for regulating Htt aggregation, helical conformation, internalization and nuclear targeting
Sean M. Deguire, F. Ruggeri, Mohamed Fares, A. Chiki +3 more
2018bioRxiv0 citations Open access
Semantic Scholar
One-pot Semisynthesis Of Exon1 Of The Mutant Huntingtin Protein: An Important Advance Towards Elucidating The Molecular And Structural Determinants Of Huntingtin's Aggregation And Toxicity
A. Chiki, Ritwik Burai, S. Vieweg, Sean M. Deguire +1 more
20140 citations
Semantic Scholar

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