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C. Canman · SciRah

Researcher profile · Semantic Scholar

C. Canman

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C. Canman — researcher profile on SciRah

h-index: 41
Works: 67
Citations: 12K

Most-cited papers

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
C. Canman, D. Lim, Karlene A. Cimprich, Y. Taya +5 more
1998Science2,197 citations
Semantic Scholar
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
W. El-Deiry, J. Harper, P. M. O'Connor, V. Velculescu +6 more
1994Cancer Research2,134 citations
Semantic Scholar
DNA damage induces phosphorylation of the amino terminus of p53.
J. Siliciano, C. Canman, Y. Taya, K. Sakaguchi +2 more
1997Genes & Development907 citations Open access
Semantic Scholar
Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members*
S. T. Kim, D. Lim, C. Canman, M. Kastan
1999Journal of Biological Chemistry864 citations Open access
Semantic Scholar
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
R. Baskaran, L. Wood, L. L. Whitaker, C. Canman +7 more
1997Nature558 citations
Semantic Scholar
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.
Joon-Young Ahn, J. Schwarz, H. Piwnica-Worms, C. Canman
2000Cancer Research444 citations
Semantic Scholar
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
C. Canman, T. Gilmer, S. Coutts, M. Kastan
1995Genes & Development424 citations Open access
Semantic Scholar
P53, cell cycle control and apoptosis: Implications for cancer
M. Kastan, C. Canman, Christopher J. Leonard
1995Cancer Metastasis Review336 citations
Semantic Scholar
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair
M. Morgan, L. Parsels, Li-Li Zhao, Joshua D Parsels +11 more
2010Cancer Research298 citations Open access
Semantic Scholar
The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.
C. Canman, A. Wolff, Chaw-Yuan Chen, A. Fornace +1 more
1994Cancer Research277 citations
Semantic Scholar
PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer
John R. Prensner, Wei Chen, M. Iyer, Q. Cao +18 more
2014Cancer Research259 citations Open access
Semantic Scholar
Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated Domain*
Joon-Young Ahn, Xianghong Li, H. Davis, C. Canman
2002Journal of Biological Chemistry203 citations Open access
Semantic Scholar
The role of ATM in DNA damage responses and cancer
C. Canman, D. Lim
1998Oncogene177 citations
Semantic Scholar
ATM binds to β-adaptin in cytoplasmic vesicles
D. Lim, D. Kirsch, C. Canman, Jin-Hyun Ahn +5 more
1998173 citations Open access
Semantic Scholar
Three paths to stress relief
C. Canman, M. Kastan
1996Nature172 citations
Semantic Scholar
REV1 and polymerase ζ facilitate homologous recombination repair
Shilpy Sharma, J. K. Hicks, Colleen L. Chute, J. Brennan +3 more
2011Nucleic Acids Research142 citations Open access
Semantic Scholar
Gemcitabine sensitization by Chk1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells
L. Parsels, M. Morgan, Daria M. Tanska, Joshua D Parsels +7 more
2009Molecular Cancer Therapeutics140 citations Open access
Semantic Scholar
Differential Roles for DNA Polymerases Eta, Zeta, and REV1 in Lesion Bypass of Intrastrand versus Interstrand DNA Cross-Links
J. K. Hicks, Colleen L. Chute, M. Paulsen, Ryan L. Ragland +4 more
2009Molecular and Cellular Biology133 citations Open access
Semantic Scholar
Reversal of apoptosis by the leukaemia-associated E2A–HLF chimaeric transcription factor
T. Inaba, T. Inukai, Takao Yoshihara, H. Seyschab +5 more
1996Nature129 citations
Semantic Scholar
Loss of atm radiosensitizes multiple p53 null tissues.
C. Westphal, Katherine P Hoyes, C. Canman, Xin Huang +3 more
1998Cancer Research98 citations
Semantic Scholar
A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin*
A. Inoue, S. Kikuchi, A. Hishiki, Youming Shao +6 more
2014Journal of Biological Chemistry94 citations Open access
Semantic Scholar
Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity.
C. Canman, Hsin-Yi Tang, Daniel P. Normolle, T. Lawrence +1 more
1992Proceedings of the National Academy of Sciences of the United States of America94 citations Open access
Semantic Scholar
DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis.
C. Canman, Chaw-Yuan Chen, M.-H. Lee, M. Kastan
1994Cold Spring Harbor Symposia on Quantitative Biology91 citations
Semantic Scholar
Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase.
C. Canman, E. Radany, L. Parsels, M. Davis +2 more
1994Cancer Research90 citations
Semantic Scholar
Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate.
C. Canman, T. Lawrence, D. Shewach, Hsin-Yi Tang +1 more
1993Cancer Research88 citations
Semantic Scholar
Role of p53 in apoptosis.
C. Canman, M. Kastan
1997Advances in Pharmacology86 citations Open access
Semantic Scholar
Induction of apoptosis by tumor suppressor genes and oncogenes.
C. Canman, Michael B. Kastan
1995Seminars in Cancer Biology78 citations Open access
Semantic Scholar
Replication checkpoint: preventing mitotic catastrophe.
C. Canman
2001Current Biology77 citations Open access
Semantic Scholar
The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability
Shilpy Sharma, Corey M. Helchowski, C. Canman
2012Mutation research75 citations Open access
Semantic Scholar
ATM binds to beta-adaptin in cytoplasmic vesicles.
D. Lim, D. Kirsch, C. Canman, J. Ahn +5 more
1998Proceedings of the National Academy of Sciences of the United States of America73 citations
Semantic Scholar
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
J. Lee, Bo Xu, Chang-Hun Lee, Jun-Young Ahn +6 more
2003Molecular Cancer Research70 citations
Semantic Scholar
The role of p53 in cell-cycle control and apoptosis: implications for cancer.
Carly J. Leonard, C. Canman, M. Kastan
1995Important advances in oncology69 citations
Semantic Scholar
ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells
Li-Dong Wang, Huibin Yang, P. Palmbos, Gina M. Ney +15 more
2014Cancer Research64 citations Open access
Semantic Scholar
Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin
O. Ziv, A. Zeisel, Nataly Mirlas-Neisberg, Umakanta Swain +11 more
2014Nature Communications58 citations Open access
Semantic Scholar
Multiple signaling pathways involving ATM.
Michael B. Kastan, Dae-Sik Lim, Seong-Tae Kim, Bo Xu +1 more
2000Cold Spring Harbor Symposia on Quantitative Biology56 citations
Semantic Scholar
REV1 and DNA polymerase zeta in DNA interstrand crosslink repair
Shilpy Sharma, C. Canman
2012Environmental and Molecular Mutagenesis53 citations Open access
Semantic Scholar
BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade
Fen Tian, Shilpy Sharma, Jian-Qiu Zou, Shiaw-Yih Lin +7 more
2013Proceedings of the National Academy of Sciences of the United States of America51 citations Open access
Semantic Scholar
Signal transduction. Three paths to stress relief.
C. Canman, M. Kastan
1996Nature50 citations
Semantic Scholar
Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells
Su M. Metcalfe, C. Canman, J. Milner, R. Morris +2 more
1997Oncogene47 citations
Semantic Scholar
Psoralen-Induced DNA Interstrand Cross-Links Block Transcription and Induce p53 in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner
Frederick A. Derheimer, J. K. Hicks, M. Paulsen, C. Canman +1 more
2009Molecular Pharmacology44 citations Open access
Semantic Scholar
Checkpoint mediators: relaying signals from DNA strand breaks.
C. Canman
2003Current Biology44 citations Open access
Semantic Scholar
DNA Polymerase (cid:1) Is a Major Determinant of Resistance to Platinum-Based Chemotherapeutic Agents □ S
Shilpy Sharma, N. A. Shah, Ariell M Joiner, Kate Roberts +1 more
201241 citations Open access
Semantic Scholar
Combinatorial efficacy of olaparib with radiation and ATR inhibitor requires PARP1 protein in homologous recombination proficient pancreatic cancer
L. Parsels, Carl G. Engelke, Joshua D Parsels, S. Flanagan +6 more
2020Molecular Cancer Therapeutics34 citations Open access
Semantic Scholar
Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation.
Renu Garg, Shannon Callens, D. Lim, C. Canman +2 more
2004Molecular Cancer Research34 citations
Semantic Scholar
Replication Stress: an Achilles’ heel of glioma cancer stem-like cells
M. Morgan, C. Canman
2018Cancer Research33 citations Open access
Semantic Scholar
Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis
C. Canman, M. Kastan
1998Oncogene28 citations Open access
Semantic Scholar
A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci
Corey M. Helchowski, L. Skow, Katelyn H Roberts, Colleen L. Chute +1 more
2013Cell Cycle26 citations Open access
Semantic Scholar
Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.
Mukesh K. Nyati, Felix Y. Feng, D. Maheshwari, S. Varambally +10 more
2006Cancer Research26 citations Open access
Semantic Scholar
DNA Polymerase zeta is a major determinant of resistance to platinum-based chemotherapeutic agents
Shilpy Sharma, N. A. Shah, Ariell M Joiner, Kate Roberts +1 more
17 citations
Semantic Scholar
Dependence of etoposide-induced cytotoxicity and topoisomerase II-mediated DNA strand breakage on the intracellular ionic environment.
T. Lawrence, C. Canman, J. Maybaum, M. Davis
1989Cancer Research16 citations
Semantic Scholar

Frequent co-authors

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M. Kastan×18
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M. Kastan — researcher profile on SciRah
D. Lim×7
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D. Lim — researcher profile on SciRah
J. Maybaum×6
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J. Maybaum — researcher profile on SciRah
M. Davis×5
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M. Davis — researcher profile on SciRah

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T. Lawrence — researcher profile on SciRah

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M. Morgan — researcher profile on SciRah

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L. Parsels — researcher profile on SciRah

Shilpy Sharma×4

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Shilpy Sharma — researcher profile on SciRah

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J. K. Hicks — researcher profile on SciRah

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T. Lawrence — researcher profile on SciRah

Joon-Young Ahn×3

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Joon-Young Ahn — researcher profile on SciRah

Joshua D Parsels×3

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Joshua D Parsels — researcher profile on SciRah