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A. Fornace · SciRah

Researcher profile · Semantic Scholar

A. Fornace

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A. Fornace — researcher profile on SciRah

h-index: 103
Works: 461
Citations: 41K

Most-cited papers

Metabolomic Applications in Radiation Biodosimetry: Exploring Radiation Effects Through Small Molecules
E. Pannkuk, A. Fornace, E. Laiakis
2017International Journal of Radiation Biology107 citations Open access
Semantic Scholar
Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs
Heng-Hong Li, Ren-Xiang Chen, D. Hyduke, Andrew Williams +6 more
2017Proceedings of the National Academy of Sciences of the United States of America89 citations Open access
Semantic Scholar
Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine
Santosh Kumar, S. Suman, A. Fornace, Kamal Datta
2018Proceedings of the National Academy of Sciences of the United States of America73 citations Open access
Semantic Scholar
Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency
J. Jacobs, Lin Lin, M. Goudarzi, Paul M. Ruegger +5 more
2017Gut microbes51 citations Open access
Semantic Scholar
Lipidomic Signatures of Nonhuman Primates with Radiation-Induced Hematopoietic Syndrome
E. Pannkuk, E. Laiakis, V. Singh, A. Fornace
2017Scientific Reports50 citations Open access
Semantic Scholar
Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice
Santosh Kumar, S. Suman, A. Fornace, Kamal Datta
2019Aging49 citations Open access
Semantic Scholar
Application of the adverse outcome pathway framework to genotoxic modes of action
J. Sasaki, Ashley Allemang, S. Bryce, L. Custer +19 more
2019Environmental and Molecular Mutagenesis49 citations
Semantic Scholar
Galactic cosmic ray simulation at the NASA space radiation laboratory - Progress, challenges and recommendations on mixed-field effects.
J. Huff, F. Poignant, S. Rahmanian, N. Khan +12 more
2022Life sciences and space research48 citations Open access
Semantic Scholar
GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis.
Arslon Humayun, A. Fornace
2022Advances in Experimental Medicine and Biology48 citations
Semantic Scholar
Serum lipidomic analysis from mixed neutron/X-ray radiation fields reveals a hyperlipidemic and pro-inflammatory phenotype
E. Laiakis, Mònica Pujol Canadell, V. Grilj, A. Harken +5 more
2019Scientific Reports45 citations Open access
Semantic Scholar
Scaling Human Cancer Risks from Low LET to High LET when Dose-Effect Relationships are Complex
I. Shuryak, A. Fornace, Kamal Datta, S. Suman +3 more
2017Radiation Research42 citations Open access
Semantic Scholar
TGx-DDI, a Transcriptomic Biomarker for Genotoxicity Hazard Assessment of Pharmaceuticals and Environmental Chemicals
Heng-Hong Li, C. Yauk, Ren-Xiang Chen, D. Hyduke +6 more
2019Frontiers in Big Data41 citations Open access
Semantic Scholar
Gas Chromatography/Mass Spectrometry Metabolomics of Urine and Serum from Nonhuman Primates Exposed to Ionizing Radiation: Impacts on the Tricarboxylic Acid Cycle and Protein Metabolism
E. Pannkuk, E. Laiakis, S. Authier, Karen Wong +1 more
2017Journal of Proteome Research41 citations Open access
Semantic Scholar
A metabolomic serum signature from nonhuman primates treated with a radiation countermeasure, gamma-tocotrienol, and exposed to ionizing radiation
E. Pannkuk, E. Laiakis, A. Fornace, O. Fatanmi +1 more
2018Health Physics37 citations Open access
Semantic Scholar
Assessment of the performance of the TGx‐DDI biomarker to detect DNA damage‐inducing agents using quantitative RT‐PCR in TK6 cells
E. Cho, Julie K. Buick, Andrew Williams, Ren-Xiang Chen +5 more
2018Environmental and Molecular Mutagenesis37 citations Open access
Semantic Scholar
High-LET-Radiation-Induced Persistent DNA Damage Response Signaling and Gastrointestinal Cancer Development
Kamendra Kumar, Santosh Kumar, Kamal Datta, A. Fornace +1 more
2023Current Oncology36 citations Open access
Semantic Scholar
A Serum Small Molecule Biosignature of Radiation Exposure from Total Body Irradiated Patients
E. Laiakis, E. Pannkuk, S. Chauthe, Yi-Wen Wang +5 more
2017Journal of Proteome Research36 citations Open access
Semantic Scholar
Liquid Chromatography-Mass Spectrometry-Based Metabolomics of Nonhuman Primates after 4 Gy Total Body Radiation Exposure: Global Effects and Targeted Panels.
E. Pannkuk, E. Laiakis, Kirandeep Gill, Shreyans K. Jain +8 more
2019Journal of Proteome Research35 citations Open access
Semantic Scholar
Nonhuman Primates with Acute Radiation Syndrome: Results from a Global Serum Metabolomics Study after 7.2 Gy Total-Body Irradiation
E. Pannkuk, E. Laiakis, Melissa Garcia, A. Fornace +1 more
2018Radiation Research31 citations Open access
Semantic Scholar
Metabolic Dysregulation after Neutron Exposures Expected from an Improvised Nuclear Device
E. Laiakis, Yi-Wen Wang, Erik F. Young, A. Harken +5 more
2017Radiation Research29 citations Open access
Semantic Scholar
Temporal Effects on Radiation Responses in Nonhuman Primates: Identification of Biofluid Small Molecule Signatures by Gas Chromatography–Mass Spectrometry Metabolomics
E. Pannkuk, E. Laiakis, Michael Girgis, Sarah E. Dowd +8 more
2019bioRxiv28 citations Open access
Semantic Scholar
Prior irradiation results in elevated programmed cell death protein 1 (PD-1) in T cells
De-Guan Li, Ren-Xiang Chen, Yi-Wen Wang, A. Fornace +1 more
2018International Journal of Radiation Biology27 citations
Semantic Scholar
Arsenite and cadmium promote the development of mammary tumors
Shailaja D. Divekar, Heng-Hong Li, Daniela A. Parodi, T. Ghafouri +6 more
2019Carcinogenesis26 citations Open access
Semantic Scholar
Implications of genotypic differences in the generation of a urinary metabolomics radiation signature
E. Laiakis, E. Pannkuk, M. E. Diaz-Rubio, Yi-Wen Wang +4 more
2016Mutation research26 citations Open access
Semantic Scholar
8-OxodG: A Potential Biomarker for Chronic Oxidative Stress Induced by High-LET Radiation
Kamendra Kumar, A. Fornace, S. Suman
2024DNA25 citations Open access
Semantic Scholar
Assessment of Saliva as a Potential Biofluid for Biodosimetry: A Pilot Metabolomics Study in Mice
E. Laiakis, S. Strawn, D. Brenner, A. Fornace
2016Radiation Research25 citations Open access
Semantic Scholar
Rapid and High-Throughput Detection and Quantitation of Radiation Biomarkers in Human and Nonhuman Primates by Differential Mobility Spectrometry-Mass Spectrometry
Zhi-Dan Chen, S. Coy, E. Pannkuk, E. Laiakis +3 more
2016Journal of the American Society for Mass Spectrometry24 citations Open access
Semantic Scholar
Heavy ion space radiation triggers ongoing DNA base damage by downregulating DNA repair pathways.
S. Suman, P. Jaruga, M. Dizdaroglu, A. Fornace +1 more
2020Life sciences and space research21 citations Open access
Semantic Scholar
Global Gene Expression Response in Mouse Models of DNA Repair Deficiency after Gamma Irradiation
N. Rudqvist, E. Laiakis, S. Ghandhi, Suresh Kumar +4 more
2018Radiation Research21 citations Open access
Semantic Scholar
Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine
S. Suman, Santosh Kumar, A. Fornace, Kamal Datta
2016Scientific Reports20 citations Open access
Semantic Scholar
Low and high dose rate heavy ion radiation-induced intestinal and colonic tumorigenesis in APC1638N/+ mice.
S. Suman, Santosh Kumar, Bo-Hyun Moon, A. Fornace +1 more
2017Life sciences and space research19 citations Open access
Semantic Scholar
Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis
A. Cheema, I. Maier, T. Dowdy, Yiwen Wang +5 more
2016PLoS ONE18 citations Open access
Semantic Scholar
Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome
E. Laiakis, I. Shuryak, Annabella Deziel, Yi-Wen Wang +5 more
2021International Journal of Molecular Sciences17 citations Open access
Semantic Scholar
Salivary metabolomics of total body irradiated non-human primates reveals long term normal tissue responses to radiation.
E. Laiakis, Denise Nishita, K. Bujold, Meth M. Jayatilake +5 more
2019International Journal of Radiation Oncology, Biology, Physics17 citations Open access
Semantic Scholar
Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells
E. Cho, A. Rowan-Carroll, Andrew Williams, J. Corton +4 more
2021Archives of Toxicology16 citations Open access
Semantic Scholar
Integration of the TGx-28.65 genomic biomarker with the flow cytometry micronucleus test to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human TK6 cells.
Julie K. Buick, Andrew Williams, B. Kuo, J. Wills +6 more
2017Mutation research16 citations
Semantic Scholar
Total body proton and heavy-ion irradiation causes cellular senescence and promotes pro-osteoclastogenic activity in mouse bone marrow
Kamendra Kumar, Kamal Datta, A. Fornace, S. Suman
2021Heliyon15 citations Open access
Semantic Scholar
Effects of dietary aspirin on high-LET radiation-induced prostaglandin E2 levels and gastrointestinal tumorigenesis in Apc1638N/+ mice
S. Suman, Santosh Kumar, Bo-Hyun Moon, Jerry J. Angdisen +3 more
2021Life sciences and space research14 citations Open access
Semantic Scholar
VADER: a variable dose-rate external 137Cs irradiator for internal emitter and low dose rate studies
G. Garty, Yanping Xu, Gary W. Johnson, L. Smilenov +16 more
2019Scientific Reports14 citations Open access
Semantic Scholar
Increased Transgenerational Intestinal Tumorigenesis in Offspring of Ionizing Radiation Exposed Parent APC1638N/+ Mice
S. Suman, Santosh Kumar, Bo-Hyun Moon, A. Fornace +2 more
2017Journal of Cancer14 citations Open access
Semantic Scholar
Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice
Kamendra Kumar, Bo-Hyun Moon, Santosh Kumar, Jerry J. Angdisen +3 more
2025Aging12 citations
Semantic Scholar
Biofluid Metabolomics and Lipidomics of Mice Exposed to External Very High-Dose Rate Radiation
E. Pannkuk, E. Laiakis, G. Garty, Shivani Bansal +6 more
2022Metabolites12 citations Open access
Semantic Scholar
A high-throughput and highly automated genotoxicity screening assay.
Ren-Xiang Chen, Yun-Tien Lin, A. Fornace, Heng-Hong Li
2021ALTEX12 citations Open access
Semantic Scholar
Fabric Phase Sorptive Extraction—A Metabolomic Preprocessing Approach for Ionizing Radiation Exposure Assessment
Alexandra Taraboletti, M. Goudarzi, A. Kabir, Bo-Hyun Moon +7 more
2019Journal of Proteome Research12 citations Open access
Semantic Scholar
Differential Mobility Spectrometry (DMS) Reveals the Elevation of Urinary Acetylcarnitine in Non-Human Primates (NHPs) Exposed to Radiation
Nicholas B. Vera, Zhi-Dan Chen, E. Pannkuk, E. Laiakis +5 more
2018Journal of Mass Spectrometry12 citations Open access
Semantic Scholar
Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development.
Seung-Ju Cho, B. Cha, Ok-Seon Kwon, Ji-Sun Lim +6 more
2017Biochimica et Biophysica Acta - Molecular Basis of Disease12 citations Open access
Semantic Scholar
Biomarker integration for improved biodosimetry of mixed neutron + photon exposures
I. Shuryak, S. Ghandhi, E. Laiakis, G. Garty +10 more
2023Scientific Reports11 citations Open access
Semantic Scholar
Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip® assay in TK6 cells
Julie K. Buick, A. Rowan-Carroll, R. Gagné, A. Williams +10 more
2022Frontiers in Toxicology11 citations Open access
Semantic Scholar
Small Molecule Responses to Sequential Irradiation with Neutrons and Photons for Biodosimetry Applications: An Initial Assessment
E. Laiakis, Mònica Pujol Canadell, V. Grilj, A. Harken +4 more
2021Radiation Research10 citations Open access
Semantic Scholar
Biofluid metabolomics of mice exposed to external low-dose rate radiation in a novel irradiation system, the VAriable Dose-rate External 137Cs irradiatoR (VADER)
E. Pannkuk, E. Laiakis, Michael Girgis, G. Garty +6 more
2021Journal of Proteome Research9 citations Open access
Semantic Scholar

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