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A. Hishiki · SciRah

Researcher profile · Semantic Scholar

A. Hishiki

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A. Hishiki — researcher profile on SciRah

h-index: 12
Works: 44
Citations: 736

Most-cited papers

Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen*
A. Hishiki, H. Hashimoto, T. Hanafusa, Keijiro Kamei +4 more
2009Journal of Biological Chemistry168 citations Open access
Semantic Scholar
Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication*
C. Punchihewa, A. Inoue, A. Hishiki, Yoshihiro Fujikawa +11 more
2012Journal of Biological Chemistry132 citations Open access
Semantic Scholar
A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin*
A. Inoue, S. Kikuchi, A. Hishiki, Youming Shao +6 more
2014Journal of Biological Chemistry94 citations Open access
Semantic Scholar
En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2–E3 pairs
Yuji Masuda, Miki Suzuki, Hidehiko Kawai, A. Hishiki +5 more
2012Nucleic Acids Research64 citations Open access
Semantic Scholar
Lipid Nanoparticle-mediated siRNA Transfer Against PCTAIRE1/PCTK1/Cdk16 Inhibits In Vivo Cancer Growth
T. Yanagi, Kiyoshi Tachikawa, Rachel P. Wilkie-Grantham, A. Hishiki +4 more
2016Molecular Therapy: Nucleic Acids42 citations Open access
Semantic Scholar
Crystal structure of zinc‐finger domain of Nanos and its functional implications
H. Hashimoto, K. Hara, A. Hishiki, Shigeta Kawaguchi +6 more
2010EMBO Reports39 citations Open access
Semantic Scholar
Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection.
T. Saito, Yutaka Shimizu, K. Tsukakoshi, K. Abe +14 more
2022Biosensors & bioelectronics32 citations Open access
Semantic Scholar
Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway
Yuji Masuda, Satoshi Mitsuyuki, Rie Kanao, A. Hishiki +2 more
2018Nucleic Acids Research30 citations Open access
Semantic Scholar
Structure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction.
K. Hara, M. Uchida, R. Tagata, H. Yokoyama +3 more
2018Acta Crystallographica Section F Structural Biology Communications22 citations Open access
Semantic Scholar
Orphan Nuclear Receptor NR4A1 Binds a Novel Protein Interaction Site on Anti-apoptotic B Cell Lymphoma Gene 2 Family Proteins*
P. Godoi, Rachel P. Wilkie-Grantham, A. Hishiki, R. Sano +9 more
2016Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor ( HLTF ) and Its Functional Implication in DNA Damage Tolerance *
A. Hishiki, H. Yokoyama, Toshiyuki Shimizu
201516 citations
Semantic Scholar
Title Lipid Nanoparticle-mediated siRNA Transfer AgainstPCTAIRE 1 / PCTK 1 / Cdk 16 Inhibits In Vivo Cancer Growth
T. Yanagi, Kiyoshi Tachikawa, Rachel P. Wilkie-Grantham, A. Hishiki +4 more
201814 citations
Semantic Scholar
Structure of HIRAN domain of human HLTF bound to duplex DNA provides structural basis for DNA unwinding to initiate replication fork regression.
A. Hishiki, M. Sato, H. Hashimoto
2020Journal of Biochemistry (Tokyo)9 citations
Semantic Scholar
A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA crosslink, enhances DNA double-strand break, and sensitizes cancer cells to cisplatin
A. Inoue, S. Kikuchi, A. Hishiki, Youming Shao +7 more
20148 citations
Semantic Scholar
The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO.
K. Hara, A. Hishiki, Takako Hoshino, Kiho Nagata +4 more
2023Journal of Biological Chemistry7 citations Open access
Semantic Scholar
Crystallographic study of G178S mutant of human proliferating cell nuclear antigen.
A. Hishiki, T. Shimizu, Aya Serizawa, H. Ohmori +2 more
2008Acta Crystallographica. Section F : Structural Biology and Crystallization Communications7 citations Open access
Semantic Scholar
Structural basis for intra- and intermolecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO
K. Hara, Kensuke Tatsukawa, Kiho Nagata, N. Iida +3 more
2024Journal of Biological Chemistry5 citations Open access
Semantic Scholar
Structure of the HLTF HIRAN domain and its functional implications in regression of a stalled replication fork.
A. Hishiki, M. Sato, H. Hashimoto
2020Acta Crystallographica Section D: Structural Biology5 citations
Semantic Scholar
Structural basis for the molecular interactions in DNA damage tolerances
H. Hashimoto, A. Hishiki, K. Hara, S. Kikuchi
2017Biophysics and Physicobiology4 citations Open access
Semantic Scholar
Crystallographic study of a novel DNA-binding domain of human HLTF involved in the template-switching pathway to avoid the replication arrest caused by DNA damage.
Y. Ikegaya, K. Hara, A. Hishiki, H. Yokoyama +1 more
2015Acta Crystallographica Section F Structural Biology Communications4 citations Open access
Semantic Scholar
Identification of a PCNA-binding motif in human translesion DNA polymerase REV1 and structural basis of its interaction with PCNA.
A. Hishiki, Naoya Hoshino, Kokona Okawara, Sotaro Fuchigami +2 more
2025Journal of Biochemistry (Tokyo)3 citations
Semantic Scholar
Structural basis for molecular interactions on the eukaryotic DNA sliding clamps PCNA and RAD9-RAD1-HUS1.
H. Hashimoto, K. Hara, A. Hishiki
2022Journal of Biochemistry (Tokyo)3 citations
Semantic Scholar
Initial crystallographic study of human PCNA in complex with a peptide containing the noncanonical PIP-box sequence of human DNA polymerase iota.
A. Hishiki, T. Shimizu, T. Hanafusa, H. Ohmori +2 more
2008Acta Crystallographica. Section F : Structural Biology and Crystallization Communications3 citations Open access
Semantic Scholar
Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile.
A. Hishiki, Sumire Okazaki, K. Hara, H. Hashimoto
2022Journal of Biochemistry (Tokyo)2 citations
Semantic Scholar
Crystal structure of zinc-finger domain of Nanos and its functional implications
H. Hashimoto, K. Hara, A. Hishiki, Shigeta Kawaguchi +5 more
20112 citations Open access
Semantic Scholar
Structural Basis for Novel Interactions Between Human Translesion Synthesis Polymerases and PCNA
A. Hishiki, H. Hashimoto, Keijiro Kamei, T. Hanafusa +4 more
20082 citations Open access
Semantic Scholar
Crystal structure of Nanos
H. Hashimoto, K. Hara, A. Hishiki, Shigeta Kawaguchi +6 more
20111 citations
Semantic Scholar
Abstract P362: Gata4 Dimerization May Be A Target For Heart Failure Therapy
Satoshi Shimizu, K. Hara, A. Hishiki, Yoichi Sunagawa +8 more
2021Circulation Research0 citations
Semantic Scholar
Crystal structure of HIRAN domain of HLTF in complex with duplex DNA
A. Hishiki, A. Hashimoto
20200 citations
Semantic Scholar
P1608Inhibition of GATA4 dimerization suppress hypertrophic responses
Satoshi Shimizu, Yoichi Sunagawa, K. Hara, A. Hishiki +9 more
2019European Heart Journal0 citations
Semantic Scholar
Title Lipid Nanoparticle-mediated siRNA Transfer AgainstPCTAIRE 1 / PCTK 1 / Cdk 16 Inhibits In Vivo Cancer Growth
T. Yanagi, Kiyoshi Tachikawa, Rachel P. Wilkie-Grantham, A. Hishiki +4 more
20190 citations
Semantic Scholar
The GATA4 Acetylation Site Plays a Key Role in the Development of Cardiomyocyte Hypertrophy
Satoshi Shimizu, Yoichi Sunagawa, K. Hara, A. Hishiki +9 more
20180 citations Open access
Semantic Scholar
Structural Basis for Molecular Interactions in DNA Damage Tolerance
H. Hashimoto, A. Hishiki, K. Hara, S. Kikuchi
20170 citations Open access
Semantic Scholar
Crystal structure of HIRAN domain of human HLTF in complex with DNA
A. Hishiki, H. Hashimoto
20150 citations
Semantic Scholar
Crystal structure of aldoxime dehydratase
H. Hashimoto, J. Nomura, Y. Hashimoto, Ken-Ichi Oinuma +4 more
20130 citations
Semantic Scholar
Structure of PCNA
H. Hashimoto, A. Hishiki, T. Shimizu, M. Sato +6 more
20120 citations
Semantic Scholar
Human VDR ligand binding domain in complex with maxacalcitol
A. Hishiki, H. Hashimoto, M. Sato, T. Shimizu
20110 citations
Semantic Scholar
Crystallization and X-ray diffraction studies of DNA-free and DNA-bound forms of EcoO109I DNA methyltransferase.
M. Iwamoto, A. Hishiki, T. Shimada, T. Imasaki +5 more
2010Acta Crystallographica. Section F : Structural Biology and Crystallization Communications0 citations Open access
Semantic Scholar
3P-001 Structural analysis of PCNA with G178S mutation(Protein:Structure,The 47th Annual Meeting of the Biophysical Society of Japan)
A. Hishiki, T. Shimizu, S. Akashi, S. Unzai +2 more
20090 citations Open access
Semantic Scholar
Structural Basis for Novel Interactions between Human TLS Polymerases and PCNA
A. Hishiki, H. Hashimoto, T. Hanafusa, Keijiro Kamei +4 more
20090 citations Open access
Semantic Scholar
Structural studies of human PCNA mutant , REV 6-1
A. Hishiki, H. Hashimoto, Yuji Masuda, S. Saijo +8 more
20080 citations
Semantic Scholar
2P-017 Structural studies of G178S mutant of human PCNA(The 46th Annual Meeting of the Biophysical Society of Japan)
A. Hishiki, H. Hashimoto, Yuji Masuda, Aya Serizawa +4 more
20080 citations Open access
Semantic Scholar
Structural studies of human PCNA mutant, REV6-1
A. Hishiki, H. Hashimoto, Yuji Masuda, S. Saijo +5 more
20080 citations Open access
Semantic Scholar
1P023 Structural insight of interaction between proliferating cell nuclear antigen and human TLS polymerases(1. Protein structure and dynamics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
A. Hishiki, H. Hashimoto, Keijiro Kamei, E. Ohashi +3 more
20060 citations Open access
Semantic Scholar

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H. Hashimoto×35
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M. Sato×18
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K. Hara×17
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T. Shimizu×14
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