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T. Gilmer · SciRah

Researcher profile · Semantic Scholar

T. Gilmer

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T. Gilmer — researcher profile on SciRah

h-index: 36
Works: 98
Citations: 9,445

Most-cited papers

A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib)
E. Wood, A. Truesdale, O. Mcdonald, D. Yuan +10 more
2004Cancer Research1,085 citations
Semantic Scholar
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
Martin L. Smith, I-Tsuen Chen, Q. Zhan, I. Bae +5 more
1994Science996 citations
Semantic Scholar
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells.
G. Konecny, M. Pegram, N. Venkatesan, R. Finn +11 more
2006Cancer Research948 citations Open access
Semantic Scholar
The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.
D. Rusnak, K. Lackey, K. Affleck, E. Wood +7 more
2001Molecular Cancer Therapeutics748 citations
Semantic Scholar
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
Rakesh Kumar, V. B. Knick, S. K. Rudolph, Jennifer H. Johnson +14 more
2007Molecular Cancer Therapeutics520 citations Open access
Semantic Scholar
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.
Li Liu, J. Greger, Hong Shi, Yuan Liu +6 more
2009Cancer Research494 citations Open access
Semantic Scholar
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
C. Canman, T. Gilmer, S. Coutts, M. Kastan
1995Genes & Development424 citations Open access
Semantic Scholar
Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations
J. Greger, S. Eastman, V. Zhang, Maureen R. Bleam +6 more
2012Molecular Cancer Therapeutics352 citations
Semantic Scholar
The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer.
D. Rusnak, K. Affleck, Stuart Cockerill, C. Stubberfield +21 more
2001Cancer Research304 citations
Semantic Scholar
Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity.
N. Rhodes, D. Heerding, D. Duckett, D. Eberwein +18 more
2008Cancer Research286 citations Open access
Semantic Scholar
Involvement of pp60c-src with two major signaling pathways in human breast cancer.
D. Luttrell, A. Lee, T. J. Lansing, R. Crosby +6 more
1994Proceedings of the National Academy of Sciences of the United States of America262 citations Open access
Semantic Scholar
A New Ligand for the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ), GW7845, Inhibits Rat Mammary Carcinogenesis
N. Suh, Yongping Wang, C. Williams, R. Risingsong +3 more
1999228 citations
Semantic Scholar
Phase II Study Evaluating 2 Dosing Schedules of Oral Foretinib (GSK1363089), cMET/VEGFR2 Inhibitor, in Patients with Metastatic Gastric Cancer
M. Shah, Z. Wainberg, D. Catenacci, H. Hochster +14 more
2013PLoS ONE207 citations Open access
Semantic Scholar
Induction of gene amplification by arsenic.
Te-Chang Lee, N. Tanaka, P. Lamb, T. Gilmer +1 more
1988Science206 citations
Semantic Scholar
Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma
J. Villanueva, J. Infante, C. Krepler, P. Reyes-Uribe +24 more
2013Cell Reports182 citations Open access
Semantic Scholar
Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb®, GW572016) in an expanded panel of human normal and tumour cell lines
D. Rusnak, K. Alligood, R. Mullin, G. Spehar +7 more
2007Cell Proliferation171 citations Open access
Semantic Scholar
In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1
T. J. Lansing, R. Mcconnell, D. Duckett, G. Spehar +8 more
2007Molecular Cancer Therapeutics150 citations Open access
Semantic Scholar
Peptide inhibitors of src SH3-SH2-phosphoprotein interactions.
T. Gilmer, M. Rodriguez, S. Jordan, R. Crosby +6 more
1995Journal of Biological Chemistry137 citations
Semantic Scholar
Identification of Both Positive and Negative Domains within the Epidermal Growth Factor Receptor COOH-terminal Region for Signal Transducer and Activator of Transcription (STAT) Activation*
L. Xia, Lijuan Wang, Alicia S. Chung, S. Ivanov +6 more
2002Journal of Biological Chemistry132 citations Open access
Semantic Scholar
The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization.
S. Goldman, C. Chen, T. J. Lansing, T. Gilmer +1 more
1996American Journal of Pathology115 citations
Semantic Scholar
Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles
P. Hegde, D. Rusnak, M. Bertiaux, K. Alligood +3 more
2007Molecular Cancer Therapeutics106 citations Open access
Semantic Scholar
Rous sarcoma virus transforming protein, p60src, expressed in E. coli, functions as a protein kinase
T. Gilmer, R. Erikson
1981Nature93 citations
Semantic Scholar
A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis.
N. Suh, Y. Wang, C. Williams, R. Risingsong +3 more
1999Cancer Research92 citations
Semantic Scholar
Overexpression of the Ras-related TC21/R-Ras2 protein may contribute to the development of human breast cancers.
G. Clark, M. Kinch, T. Gilmer, K. Burridge +1 more
1996Oncogene91 citations
Semantic Scholar
ras Mutations and expression in head and neck squamous cell carcinomas
W. Yarbrough, C. Shores, D. Witsell, M. Weissler +2 more
1994The Laryngoscope88 citations
Semantic Scholar
Inhibition of the growth of patient-derived pancreatic cancer xenografts with the MEK inhibitor trametinib is augmented by combined treatment with the epidermal growth factor receptor/HER2 inhibitor lapatinib.
D. Walters, James M. Lindberg, Sara J. Adair, T. Newhook +9 more
2013Neoplasia80 citations Open access
Semantic Scholar
Oncogene amplification in squamous cell carcinoma of the head and neck.
W. Merritt, M. Weissler, B. Turk, T. Gilmer
1990Archives of Otolaryngology - Head and Neck Surgery80 citations
Semantic Scholar
Synergistic Effects of Foretinib with HER-Targeted Agents in MET and HER1- or HER2-Coactivated Tumor Cells
Li Liu, Hong Shi, Yuan Liu, Amber Anderson +4 more
2011Molecular Cancer Therapeutics76 citations Open access
Semantic Scholar
Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib.
T. Gilmer, L. Cable, K. Alligood, D. Rusnak +7 more
2008Cancer Research68 citations Open access
Semantic Scholar
Evidence for multiple steps in neoplastic transformation of normal and preneoplastic Syrian hamster embryo cells following transfection with Harvey murine sarcoma virus oncogene (v-Ha-ras).
David G. Thomassen, T. Gilmer, L. Annab, J. Barrett
1985Cancer Research60 citations
Semantic Scholar
Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.
M. Gaul, Yu C. Guo, K. Affleck, G. Cockerill +12 more
2003Bioorganic & Medicinal Chemistry Letters56 citations Open access
Semantic Scholar
Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice.
Tracy E. Strecker, Qiang Shen, Yun Zhang, Jamal L. Hill +8 more
2009Journal of the National Cancer Institute54 citations Open access
Semantic Scholar
The Ras/p120 GTPase-activating Protein (GAP) Interaction Is Regulated by the p120 GAP Pleckstrin Homology Domain*
J. Drugan, K. Rogers-Graham, T. Gilmer, S. Campbell +1 more
2000Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Evaluation of Lapatinib and Topotecan Combination Therapy: Tissue Culture, Murine Xenograft, and Phase I Clinical Trial Data
J. Molina, S. Kaufmann, J. Reid, Stephen D. Rubin +11 more
2008Clinical Cancer Research50 citations Open access
Semantic Scholar
Molecular cloning of avian sarcoma virus closed circular DNA: structural and biological characterization of three recombinant clones
P. Highfield, L. F. Rafield, T. Gilmer, J. Parsons
1980Journal of Virology47 citations Open access
Semantic Scholar
Development of Anti-pp60src Serum with Antigen Produced in Escherichia coli
T. Gilmer, R. Erikson
1983Journal of Virology36 citations Open access
Semantic Scholar
Characterization of activated proto‐oncogenes in chemically transformed syrian hamster embryo cells
T. Gilmer, L. Annab, J. Barrett
1988Molecular Carcinogenesis26 citations
Semantic Scholar
Analysis of cellular integration sites in avian sarcoma virus infected duck embryo cells
T. Gilmer, J. Parsons
1979Journal of Virology25 citations Open access
Semantic Scholar
Potent dipeptide inhibitors of the pp60c-src SH2 domain.
Gregory J. Pacofsky, K. Lackey, K. Alligood, J. Berman +11 more
1998Journal of Medicinal Chemistry24 citations
Semantic Scholar
Construction of plasmids for expression of Rous sarcoma virus transforming protein, p60src, in Escherichia coli.
T. Gilmer, J. Parsons, R. Erikson
1982Proceedings of the National Academy of Sciences of the United States of America24 citations Open access
Semantic Scholar
Genome-wide DNA copy number predictors of lapatinib sensitivity in tumor-derived cell lines
J. Greshock, Jie Cheng, D. Rusnak, Anne-Marie Martin +5 more
2008Molecular Cancer Therapeutics20 citations Open access
Semantic Scholar
The formation of a covalent complex between a dipeptide ligand and the src SH2 domain.
K. Alligood, P. Charifson, R. Crosby, Thomas G. Consler +12 more
1998Bioorganic & Medicinal Chemistry Letters18 citations
Semantic Scholar
Correlation of anti-tumor and anti-angiogenic activity of VEGFR inhibitors with inhibition of VEGFR2 phosphorylation in mice
Rakesh Kumar, L. Harrington, T. Hopper, C. Miller +5 more
200517 citations
Semantic Scholar
The Discovery of Lapatinib (GW572016)
D. Rusnak, T. Gilmer
2011Molecular Cancer Therapeutics16 citations Open access
Semantic Scholar
A simple method for predicting serum protein binding of compounds from IC(50) shift analysis for in vitro assays.
D. Rusnak, Zhi-Hong V. Lai, T. J. Lansing, N. Rhodes +2 more
2004Bioorganic & Medicinal Chemistry Letters16 citations
Semantic Scholar
Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase.
D. K. Luttrell, W. Hausdorff, J. Moyers, T. Gilmer +3 more
1992Cellular Signalling16 citations
Semantic Scholar
Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis.
S. Kanner, T. Gilmer, A. B. Reynolds, J. Parsons
1989Oncogene16 citations
Semantic Scholar
Defective potassium currents in ataxia telangiectasia fibroblasts.
Nelson Rhodes, T. D'Souza, C. D. Foster, Y. Ziv +5 more
1998Genes & Development14 citations Open access
Semantic Scholar
Activation of pp60c-src tyrosine kinase specific activity in tumor-derived Syrian hamster embryo cells.
S. Kanner, Sarah J. Parsons, J. Parsons, T. Gilmer
1988Oncogene14 citations
Semantic Scholar
In vitro analysis of multistage carcinogenesis.
P. Nettesheim, D. Fitzgerald, H. Kitamura, C. Walker +3 more
1987Environmental Health Perspectives14 citations Open access
Semantic Scholar

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R. Mullin×7
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G. Spehar — researcher profile on SciRah