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David Edmund Szymkowski · SciRah

Researcher profile · Semantic Scholar

David Edmund Szymkowski

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David Edmund Szymkowski — researcher profile on SciRah

ORCID iD 0000-0002-8934-7902

h-index: 36
Works: 84
Citations: 4,544

Most-cited papers

Blocking Soluble Tumor Necrosis Factor Signaling with Dominant-Negative Tumor Necrosis Factor Inhibitor Attenuates Loss of Dopaminergic Neurons in Models of Parkinson's Disease
Melissa K. McCoy, Terina N. Martinez, K. Ruhn, David Edmund Szymkowski +4 more
2006Journal of Neuroscience376 citations Open access
Semantic Scholar
Inactivation of TNF Signaling by Rationally Designed Dominant-Negative TNF Variants
P. Steed, M. Tansey, J. Zalevsky, E. Zhukovsky +30 more
2003Science254 citations
Semantic Scholar
MUC17, a novel membrane-tethered mucin.
J. Gum, S. Crawley, J. Hicks, David Edmund Szymkowski +1 more
2002Biochemical and Biophysical Research Communications - BBRC223 citations
Semantic Scholar
Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination.
R. Brambilla, J. Ashbaugh, R. Magliozzi, A. Dellarole +3 more
2011Brain : a journal of neurology215 citations Open access
Semantic Scholar
Cloning of the Amino-terminal and 5′-Flanking Region of the HumanMUC5AC Mucin Gene and Transcriptional Up-regulation by Bacterial Exoproducts*
Daizong Li, M. Gallup, Nancy Fan, David Edmund Szymkowski +1 more
1998Journal of Biological Chemistry189 citations Open access
Semantic Scholar
Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies.
S. Chu, I. Voštiar, S. Karki, Gregory L. Moore +5 more
2008Molecular Immunology158 citations
Semantic Scholar
Dominant-Negative Inhibitors of Soluble TNF Attenuate Experimental Arthritis without Suppressing Innate Immunity to Infection
J. Zalevsky, T. Sécher, S. Ezhevsky, Laure Janot +9 more
2007Journal of Immunology157 citations
Semantic Scholar
Soluble TNF Mediates the Transition from Pulmonary Inflammation to Fibrosis
N. Oikonomou, V. Harokopos, J. Zalevsky, C. Valavanis +4 more
2006PLoS ONE154 citations Open access
Semantic Scholar
Co‐correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro.
M. Biggerstaff, David Edmund Szymkowski, R. Wood
1993EMBO Journal154 citations Open access
Semantic Scholar
Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination
Pernille M. Madsen, D. Motti, S. Karmally, David Edmund Szymkowski +3 more
2016Journal of Neuroscience150 citations Open access
Semantic Scholar
Antibody-Mediated Coengagement of FcγRIIb and B Cell Receptor Complex Suppresses Humoral Immunity in Systemic Lupus Erythematosus
H. Horton, S. Chu, E. Ortiz, E. Pong +7 more
2011Journal of Immunology147 citations Open access
Semantic Scholar
Differential human nucleotide excision repair of paired and mispaired cisplatin-DNA adducts.
J. Moggs, David Edmund Szymkowski, M. Yamada, P. Karran +1 more
1997Nucleic Acids Research134 citations Open access
Semantic Scholar
Phorbol 12-Myristate 13-Acetate Up-regulates the Transcription of MUC2 Intestinal Mucin via Ras, ERK, and NF-κB*
H. Lee, D. Ahn, S. Crawley, Jian-Dong Li +8 more
2002Journal of Biological Chemistry117 citations Open access
Semantic Scholar
Antisense Drug Technology: Principles, Strategies, and Applications
David Edmund Szymkowski
2002114 citations
Semantic Scholar
An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts.
David Edmund Szymkowski, K. Yarema, J. Essigmann, S. Lippard +1 more
1992Proceedings of the National Academy of Sciences of the United States of America108 citations Open access
Semantic Scholar
Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia
B. Clausen, M. Degn, N. Martin, Y. Couch +12 more
2014Journal of Neuroinflammation107 citations Open access
Semantic Scholar
Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy
D. Patel, Glenna J. Wallis, E. Dahle, P. McElroy +9 more
2017eNeuro99 citations Open access
Semantic Scholar
Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB.
E. Taoufik, V. Tseveleki, S. Chu, T. Tselios +4 more
2011Brain : a journal of neurology98 citations Open access
Semantic Scholar
The TNF superfamily in 2009: new pathways, new indications, and new drugs.
M. Tansey, David Edmund Szymkowski
2009Drug Discovery Today96 citations
Semantic Scholar
Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody.
S. Chu, H. Horton, E. Pong, Irene Leung +8 more
2012Journal of Allergy and Clinical Immunology92 citations
Semantic Scholar
Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia.
Maria Karamita, C. Barnum, Wiebke Möbius, M. Tansey +3 more
2017JCI Insight85 citations Open access
Semantic Scholar
Transmembrane TNF‐α is sufficient for articular inflammation and hypernociception in a mouse model of gout
F. Amaral, L. F. Bastos, T. Oliveira, A. C. Dias +9 more
2016European Journal of Immunology81 citations Open access
Semantic Scholar
Repair by human cell extracts of single (6-4) and cyclobutane thymine-thymine photoproducts in DNA.
David Edmund Szymkowski, C. W. Lawrence, R. Wood
1993Proceedings of the National Academy of Sciences of the United States of America81 citations Open access
Semantic Scholar
Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice
H. Novrup, V. Bracchi-Ricard, D. Ellman, J. Ricard +8 more
2014Journal of Neuroinflammation76 citations Open access
Semantic Scholar
Harnessing Fc receptor biology in the design of therapeutic antibodies.
P. Sondermann, David Edmund Szymkowski
2016Current Opinion in Immunology70 citations
Semantic Scholar
Neutralization of Membrane TNF, but Not Soluble TNF, Is Crucial for the Treatment of Experimental Colitis
C. Perrier, G. de Hertogh, J. Cremer, S. Vermeire +4 more
2013Inflammatory Bowel Diseases64 citations Open access
Semantic Scholar
Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15.
L. Vujanović, David Edmund Szymkowski, S. Alber, Simon C Watkins +2 more
2010Blood64 citations Open access
Semantic Scholar
Soluble TNF, but not membrane TNF, is critical in LPS-induced hepatitis.
Maria L. Olleros, D. Vesin, A. L. Fotio, M. Santiago‐Raber +3 more
2010Journal of Hepatology63 citations Open access
Semantic Scholar
Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti‐CD19 Antibody That Coengages B Cell Antigen Receptor Complex and Fcγ Receptor IIb Inhibitory Receptor
S. Chu, K. Yeter, Roshan Kotha, E. Pong +9 more
2013Arthritis & Rheumatology58 citations
Semantic Scholar
Inhibition of Soluble Tumor Necrosis Factor Ameliorates Synaptic Alterations and Ca2+ Dysregulation in Aged Rats
Diana M. Sama, Hafiz Mohmmad Abdul, J. Furman, Irina A. Artiushin +3 more
2012PLoS ONE57 citations Open access
Semantic Scholar
Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis.
Maria L. Olleros, D. Vesin, A. Lambou, J. Janssens +6 more
2009Journal of Infectious Diseases50 citations Open access
Semantic Scholar
Suppression of innate and adaptive B cell activation pathways by antibody coengagement of FcγRIIb and CD19
Dániel Szili, M. Cserhalmi, Z. Bankó, G. Nagy +2 more
2014mAbs46 citations Open access
Semantic Scholar
Developing antisense oligonucleotides from the laboratory to clinical trials
David Edmund Szymkowski
199642 citations
Semantic Scholar
Immunotherapy with Long-Lived Anti-CD123 × Anti-CD3 Bispecific Antibodies Stimulates Potent T Cell-Mediated Killing of Human AML Cell Lines and of CD123+ Cells in Monkeys: A Potential Therapy for Acute Myelogenous Leukemia
S. Chu, E. Pong, Hsing Chen, Sheryl Phung +10 more
201441 citations
Semantic Scholar
Creating the next generation of protein therapeutics through rational drug design.
David Edmund Szymkowski
2005Current opinion in drug discovery & development39 citations
Semantic Scholar
Roles of soluble and membrane TNF and related ligands in mycobacterial infections: effects of selective and non-selective TNF inhibitors during infection.
I. Garcia, Maria L. Olleros, V. Quesniaux, M. Jacobs +4 more
2011Advances in Experimental Medicine and Biology37 citations Open access
Semantic Scholar
Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice
M. Yli-Karjanmaa, B. Clausen, M. Degn, H. Novrup +7 more
2019Frontiers in Neuroscience36 citations Open access
Semantic Scholar
Tuning T Cell Affinity Improves Efficacy and Safety of Anti-CD38 × Anti-CD3 Bispecific Antibodies in Monkeys - a Potential Therapy for Multiple Myeloma
Gregory L. Moore, Sung‐Hyung Lee, Suzanne Schubbert, Yvonne Miranda +14 more
201531 citations
Semantic Scholar
Immune suppression in cynomolgus monkeys by XPro9523
M. Bernett, S. Chu, Irene Leung, Gregory L. Moore +9 more
2013mAbs28 citations Open access
Semantic Scholar
Suppression of mast cell degranulation through a dual-targeting tandem IgE-IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb.
S. Cemerski, S. Chu, Gregory L. Moore, U. Muchhal +2 more
2012Immunology Letters28 citations
Semantic Scholar
Tumour necrosis factor‐mediated macrophage activation in the target organ is critical for clinical manifestation of uveitis
T. Khera, D. Copland, J. Boldison, P. Lait +3 more
2012Clinical and Experimental Immunology27 citations Open access
Semantic Scholar
Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics.
I. Maillet, S. Schnyder-Candrian, I. Couillin, V. Quesniaux +7 more
2011American Journal of Respiratory Cell and Molecular Biology25 citations
Semantic Scholar
Non-specific antiviral activity of antisense molecules targeted to the E1 region of human papillomavirus.
E. Lewis, S. Agrawal, J. Bishop, J. Chadwick +15 more
2000Antiviral Research24 citations
Semantic Scholar
Inhibition of B cell activation following in vivo co-engagement of B cell antigen receptor and Fcγ receptor IIb in non-autoimmune-prone and SLE-prone mice
S. Chu, E. Pong, Christine Bonzon, N. Yu +5 more
2020Journal of Translational Autoimmunity23 citations Open access
Semantic Scholar
Altered Expression of Oligodendrocyte and Neuronal Marker Genes Predicts the Clinical Onset of Autoimmune Encephalomyelitis and Indicates the Effectiveness of Multiple Sclerosis–Directed Therapeutics
Maria Evangelidou, Maria Karamita, Sotiris-Spyros Vamvakas, David Edmund Szymkowski +1 more
2014Journal of Immunology21 citations Open access
Semantic Scholar
Immunotherapy with Long-Lived Anti-CD38 × Anti-CD3 Bispecific Antibodies Stimulates Potent T Cell-Mediated Killing of Human Myeloma Cell Lines and CD38+ Cells in Monkeys: A Potential Therapy for Multiple Myeloma
S. Chu, Yvonne Miranda, Sheryl Phung, Hsing Chen +11 more
201418 citations Open access
Semantic Scholar
Inhibition of TNF reduces mechanical orofacial hyperalgesia induced by Complete Freund’s Adjuvant by a TRPV1-dependent mechanism in mice
Krzysztof Lis, T. Grygorowicz, A. Cudna, David Edmund Szymkowski +1 more
2017Pharmacological Reports17 citations
Semantic Scholar
Nucleotide excision repair of DNA by mammalian cell extracts and purified proteins.
R. Wood, A. Aboussekhra, M. Biggerstaff, Christopher J. Jones +3 more
1993Cold Spring Harbor Symposia on Quantitative Biology17 citations
Semantic Scholar
Immunotherapy with Long-Lived Anti-CD20 × Anti-CD3 Bispecific Antibodies Stimulates Potent T Cell-Mediated Killing of Human B Cell Lines and of Circulating and Lymphoid B Cells in Monkeys: A Potential Therapy for B Cell Lymphomas and Leukemias
S. Chu, Sung‐Hyung Lee, R. Rashid, Hsing Chen +12 more
201416 citations
Semantic Scholar
A B7-H3–Targeted CD28 Bispecific Antibody Enhances the Activity of Anti–PD-1 and CD3 T-cell Engager Immunotherapies
Gregory L. Moore, Veronica G Zeng, Juan E Diaz, Christine Bonzon +15 more
2024Molecular Cancer Therapeutics15 citations Open access
Semantic Scholar

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