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D. Madar · SciRah

Researcher profile · Semantic Scholar

D. Madar

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D. Madar — researcher profile on SciRah

h-index: 16
Works: 31
Citations: 893

Most-cited papers

A Convergent Synthetic Route to (+)-Dynemicin A and Analogs of Wide Structural Variability
A. Myers, N. J. Tom, Mark E. Fraley, S. Cohen +1 more
1997150 citations Open access
Semantic Scholar
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
M. Bruncko, Le Wang, G. Sheppard, D. Phillips +26 more
2015Journal of Medicinal Chemistry143 citations Open access
Semantic Scholar
3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator.
S. Djuric, N. Bamaung, A. Basha, Hua-Qing Liu +25 more
2000Journal of Medicinal Chemistry122 citations
Semantic Scholar
Synthesis of (+)-dynemicin A and analogs of wide structural variability: establishment of the absolute configuration of natural dynemicin A.
A. Myers, Mark E. Fraley, N. J. Tom, S. Cohen +1 more
1995Chemistry and Biology59 citations Open access
Semantic Scholar
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
Z. Pei, Xiao-Fen Li, K. Longenecker, T. V. von Geldern +22 more
2006Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Z. Pei, Xiao-Fen Li, T. V. von Geldern, D. Madar +18 more
2006Journal of Medicinal Chemistry44 citations Open access
Semantic Scholar
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.
K. Longenecker, K. Stewart, D. Madar, C. Jakob +14 more
2006Biochemistry39 citations Open access
Semantic Scholar
Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721
D. Madar, H. Kopecká, D. Pireh, J. Pease +4 more
200137 citations
Semantic Scholar
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
D. Madar, H. Kopecká, D. Pireh, Hong Yong +27 more
2006Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
M. Bruncko, S. Tahir, Xiaohong Song, Jun Chen +11 more
2010Bioorganic & Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.
B. Backes, K. Longenecker, Gregory L. Hamilton, K. Stewart +16 more
2007Bioorganic & Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
TOTAL SYNTHESIS OF (+)-DAMAVARICIN D
W. Roush, D. Coffey, D. Madar
199731 citations
Semantic Scholar
Inhibition of p56lckTyrosine Kinase by Isothiazolones
J. Trevillyan, X. Chiou, S. Ballaron, Q.-M. Tang +14 more
199929 citations
Semantic Scholar
Insights into the Mechanism of DNA Cleavage by Dynemicin A as Revealed by DNA-Binding and -Cleavage Studies of Synthetic Analogs
A. Myers, S. Cohen, N. J. Tom, D. Madar +1 more
199526 citations
Semantic Scholar
Comparison of the oxidative folding of lysozyme at a high protein concentration using aromatic thiols versus glutathione.
D. Madar, Amar S Patel, W. Lees
2009Journal of Biotechnology19 citations
Semantic Scholar
Inhibition of p56(lck) tyrosine kinase by isothiazolones.
J. Trevillyan, X. Chiou, S. Ballaron, Q.-M. Tang +14 more
1999Archives of Biochemistry and Biophysics17 citations
Semantic Scholar
The Bcl-2 Family Inhibitor ABT-263 Shows Significant but Reversible Thrombocytopenia in Mice.
Alexander R. Shoemaker, M. Mitten, Jessica Adickes, A. Oleksijew +9 more
20069 citations
Semantic Scholar
Synthesis of highly functionalized naphthoate precursors to damavaricin D Observation of kinetically stable benzocyclohexadienones in the bromination reactions of highly functionalized β-naphthol derivatives
W. Roush, D. Madar, D. Coffey
20016 citations
Semantic Scholar
Towards the synthesis of streptovaricin D: Synthesis of fully elaborated aromatic precursors and coupling with ansa chain fragments
W. Roush, D. Madar
19936 citations Open access
Semantic Scholar
Correction to Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity.
M. Bruncko, Le Wang, G. Sheppard, D. Phillips +26 more
2015Journal of Medicinal Chemistry4 citations
Semantic Scholar
Studies on the Synthesis of the Streptovaricins: Total Synthesis of 24,27-Dimethyl Dihydrodamavaricin D
W. Roush, D. Coffey, D. Madar, A. D. Palkowitz
19964 citations Open access
Semantic Scholar
Total Synthesis of (+)-Damavaricin D.
W. Roush, D. Coffey, D. Madar
19982 citations
Semantic Scholar
Synthesis of N‐Arylated Oxazolidinones via a Palladium‐Catalyzed Cross‐Coupling Reaction. Application to the Synthesis of the Antibacterial Agent Dup‐721.
D. Madar, H. Kopecká, D. Pireh, J. Pease +4 more
20011 citations
Semantic Scholar
Diisopropyl 2‐Allyl‐1,3,2‐dioxaborolane‐4,5‐dicarboxylate
D. Madar, Guixia Liu, Wei Wang
20090 citations
Semantic Scholar
Indoles substituted in position 7 as inhibitors of mcl-1
S. Elmore, A. Souers, M. Bruncko, Xiaohong Song +8 more
20080 citations
Semantic Scholar
Indole derivatives unsubstituted in position 7 as inhibitors of Mcl-1
M. Bruncko, Xiaohong Song, H. Ding, Zhi-Fu Tao +6 more
20080 citations
Semantic Scholar
Crystal structure of human dipeptidyl peptidase 4 (DPP IV) with potent alkynyl cyanopyrrolidine (ABT-279)
K. Longenecker, D. Madar
20060 citations
Semantic Scholar
ABT‐279 is a potent and selective inhibitor of DPPIV
T. Lubben, S. Ballaron, Linus L. Shen, M. Stashko +4 more
20060 citations
Semantic Scholar
4‐Methoxytrityl Chloride
D. Madar
20020 citations
Semantic Scholar
Synthesis of Highly Functionalized Naphthoate Precursors to Damavaricin D — Observation of Kinetically Stable Benzocyclohexadienones in the Bromination Reactions of Highly Functionalized β-Naphthol Derivatives.
W. Roush, D. Madar, D. Coffey
20020 citations
Semantic Scholar
4,4′‐Dimethoxytrityl Chloride
D. Madar
20020 citations
Semantic Scholar

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S. Ballaron — researcher profile on SciRah
J. Trevillyan×9
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M. Stashko — researcher profile on SciRah

K. Longenecker×6

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Xiaohong Song — researcher profile on SciRah

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K. Stewart — researcher profile on SciRah