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W. Roush · SciRah

Researcher profile · Semantic Scholar

W. Roush

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W. Roush — researcher profile on SciRah

h-index: 64
Works: 958
Citations: 19K

Most-cited papers

Targeting the NLRP3 inflammasome in inflammatory diseases
M. Mangan, E. Olhava, W. Roush, H. Seidel +2 more
2018Nature reviews. Drug discovery1,639 citations
Semantic Scholar
Targeting the NLRP3 inflammasome in inflammatory diseases
M. Mangan, E. Olhava, W. Roush, H. Seidel +2 more
2018Nature reviews. Drug discovery397 citations Open access
Semantic Scholar
Systems analysis of intracellular pH vulnerabilities for cancer therapy
Erez Persi, Miquel Duran-Frigola, Mehdi Damaghi, W. Roush +4 more
2018Nature Communications367 citations Open access
Semantic Scholar
Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.
K. Renner, C. Bruss, Annette Schnell, G. Koehl +38 more
2019Cell Reports305 citations Open access
Semantic Scholar
Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer.
V. Quereda, S. Bayle, F. Vena, Sylvia M. Frydman +3 more
2019Cancer Cell253 citations Open access
Semantic Scholar
Advancing Biological Understanding and Therapeutics Discovery with Small Molecule Probes
S. Schreiber, J. Kotz, Min Li, J. Aubé +51 more
2015Cell147 citations Open access
Semantic Scholar
Endogenous and synthetic ABHD5 ligands regulate ABHD5-Perilipin interactions and lipolysis in fat and muscle
M. A. Sanders, Franck Madoux, Ljiljana Mladenović, Hua-Mei Zhang +9 more
2015Cell Metabolism111 citations Open access
Semantic Scholar
Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase
Laura-Isobel McCall, Amale El Aroussi, Jun-Yong Choi, D. F. Vieira +8 more
2015PLoS Neglected Tropical Diseases107 citations Open access
Semantic Scholar
Identification of HDAC Inhibitors with Benzoylhydrazide scaffold that Selectively Inhibit Class I HDACs
Yun-Fei Wang, Ryan L. Stowe, C. Pinello, Gui-Mei Tian +10 more
2015Chemistry and Biology103 citations Open access
Semantic Scholar
Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates
Alex R. Nanna, Xiu-Ling Li, E. Walseng, Lee Pedzisa +5 more
2017Nature Communications80 citations Open access
Semantic Scholar
Dual-mechanistic antibody-drug conjugate via site-specific selenocysteine/cysteine conjugation
Napon Nilchan, Xiu-Ling Li, Lee Pedzisa, Alex R. Nanna +2 more
2019Antibody Therapeutics65 citations Open access
Semantic Scholar
Therapeutic Targeting of Casein Kinase 1δ in Breast Cancer
L. H. Rosenberg, Marie Lafitte, V. Quereda, Wayne Grant +9 more
2015Science Translational Medicine65 citations Open access
Semantic Scholar
Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues
Xiu-Ling Li, James T. Patterson, Mohosin Sarkar, Lee Pedzisa +3 more
2015Bioconjugate chemistry59 citations Open access
Semantic Scholar
The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells.
Kamira Maharaj, John J. Powers, Alex N. Achille, Melanie Mediavilla-Varela +12 more
2020Blood Advances53 citations Open access
Semantic Scholar
4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency
C. M. Calvet, D. F. Vieira, Jun-Yong Choi, Danielle Kellar +9 more
2014Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
Antiproliferation Activity of a Small Molecule Repressor of Liver Receptor Homolog 1
Cesar A. Corzo, Yelenis Mari, Mi-Ra Chang, Tanya Khan +7 more
2015Molecular Pharmacology44 citations Open access
Semantic Scholar
Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain.
B. D. Jones, A. Tochowicz, Yinyan Tang, M. Cameron +6 more
2016ACS Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Casein Kinase 1δ Is an APC/CCdh1 Substrate that Regulates Cerebellar Granule Cell Neurogenesis
Clara Penas, E. Govek, Yin Fang, V. Ramachandran +16 more
2015Cell Reports34 citations Open access
Semantic Scholar
Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes
E. Rondini, Ljiljana Mladenovic-Lucas, W. Roush, Geoff T. Halvorsen +2 more
2017Journal of Pharmacology and Experimental Therapeutics31 citations Open access
Semantic Scholar
Chemically Programmed Bispecific Antibodies in Diabody Format *
E. Walseng, C. Nelson, Junpeng Qi, Alex R. Nanna +5 more
2016Journal of Biological Chemistry31 citations Open access
Semantic Scholar
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection
C. M. Calvet, Jun-Yong Choi, Diane Thomas, B. Suzuki +11 more
2017PLoS Neglected Tropical Diseases30 citations Open access
Semantic Scholar
In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors.
Spencer D Wood, Wayne Grant, I. Adrados, Jun-Yong Choi +3 more
2017ACS Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer
Andrii Monastyrskyi, Napon Nilchan, V. Quereda, Yoshihiko Noguchi +5 more
2017Bioorganic & Medicinal Chemistry27 citations Open access
Semantic Scholar
Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues
Dobeen Hwang, Napon Nilchan, Alex R. Nanna, Xiaohai Li +4 more
2019Cell Chemical Biology25 citations Open access
Semantic Scholar
The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis
Sandra Torres, M. Brol, F. Magdaleno, R. Schierwagen +15 more
2021Frontiers in Molecular Biosciences24 citations Open access
Semantic Scholar
Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells
Luping Wang, S. Schmidt, Petra P. Larsen, Johanna H. Meyer +4 more
2019Journal of molecular medicine24 citations
Semantic Scholar
Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases
Manishabrata Bhowmick, Dorota Tokmina‐Roszyk, Lillian C. Onwuha-Ekpete, K. Harmon +7 more
2017Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Identification of Cysteine Protease Inhibitors as New Drug Leads against Naegleria fowleri
Ingrid Zyserman, Deboprosad Mondal, F. Sarabia, J. McKerrow +2 more
2018Experimental parasitology22 citations Open access
Semantic Scholar
Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots
I. Getun, Zhen K. Wu, M. Fallahi, S. Ouizem +6 more
2016Molecular and Cellular Biology22 citations Open access
Semantic Scholar
A Human Serum Albumin Domain I Fusion Protein for Antibody Conjugation
James T. Patterson, H. Wilson, Shigehiro Asano, Napon Nilchan +4 more
2016Bioconjugate chemistry18 citations Open access
Semantic Scholar
Development of matrix metalloproteinase-13 inhibitors – A structure-activity/structure-property relationship study
R. Fuerst, Jun-Yong Choi, Anna M. Knapinska, Lyndsay Smith +4 more
2018Bioorganic & Medicinal Chemistry17 citations Open access
Semantic Scholar
Stolonidiol: Synthesis, Target Identification, and Mechanism for Choline Acetyltransferase Activation.
J. W. Mason, Cullen L. Schmid, L. Bohn, W. Roush
2017Journal of the American Chemical Society17 citations
Semantic Scholar
Assessment of Reagents for Selenocysteine Conjugation and the Stability of Selenocysteine Adducts
Lee Pedzisa, Xiu-Ling Li, C. Rader, W. Roush
2016Organic and biomolecular chemistry17 citations Open access
Semantic Scholar
Host-derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-induced Osteolysis and Reduces Overall Survival
Chen-Hao Lo, G. Shay, J. McGuire, Tao Li +7 more
2021Cancer Research15 citations Open access
Semantic Scholar
Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors
A. Jílková, P. Rubešová, J. Fanfrlík, Pavla Fajtová +10 more
2020ACS Infectious Diseases15 citations Open access
Semantic Scholar
Enantio- and Diastereoselective Synthesis of 1,5-syn-(Z)-Amino Alcohols via Imine Double Allylboration: Synthesis of trans-1,2,3,6-Tetrahydropyridines and Total Synthesis of Andrachcine.
C. Allais, W. Roush
2017Organic Letters15 citations
Semantic Scholar
Molecular Modeling of ABHD5 Structure and Ligand Recognition
Rezvan Shahoei, Susheel Pangeni, Matthew A. Sanders, Hua-Mei Zhang +6 more
2022Frontiers in Molecular Biosciences14 citations Open access
Semantic Scholar
Copper(I) Chloride
T. Ho, M. Fieser, L. Fieser, R. Danheiser +2 more
201712 citations
Semantic Scholar
Structure Based Design of CYP51 Inhibitors.
Jun-Yong Choi, W. Roush
2016Current Topics in Medicinal Chemistry12 citations
Semantic Scholar
Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors
Andrii Monastyrskyi, S. Bayle, V. Quereda, Wayne Grant +3 more
2017Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Development of a putative Zn2+-chelating but highly selective MMP-13 inhibitor.
R. Fuerst, Jun-Yong Choi, Anna M. Knapinska, M. Cameron +5 more
2022Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Structure-Based Development of Isoform Selective Inhibitors of Casein Kinase 1ε vs. Casein Kinase 1δ
Jun-Yong Choi, Yoshihiko Noguchi, James M Alburger, S. Bayle +6 more
2023Journal of Medicinal Chemistry9 citations Open access
Semantic Scholar
Targeting casein kinase 1 delta sensitizes pancreatic and bladder cancer cells to gemcitabine treatment by upregulating deoxycytidine kinase
F. Vena, S. Bayle, A. Nieto, V. Quereda +9 more
2020Molecular Cancer Therapeutics9 citations Open access
Semantic Scholar
GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation
Clara Penas, J. Mishra, Spencer D Wood, S. Schürer +2 more
2015Cell Cycle9 citations Open access
Semantic Scholar
CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma
K. Burger, Mario R. Fernandez, M. Meads, P. Sudalagunta +22 more
2023Cancer Research8 citations Open access
Semantic Scholar
Sculpting a uniquely reactive cysteine residue for site-specific antibody conjugation
Dobeen Hwang, Napon Nilchan, Hajeung Park, R. Roy +2 more
2022Bioconjugate chemistry8 citations Open access
Semantic Scholar
An Engineered Arginine Residue of Unusual pH-Sensitive Reactivity Facilitates Site-Selective Antibody Conjugation
Napon Nilchan, James M Alburger, W. Roush, C. Rader
2021Biochemistry6 citations Open access
Semantic Scholar
Rhodium(II) carboxylates
T. Ho, M. Fieser, L. Fieser, R. Danheiser +2 more
20176 citations
Semantic Scholar
hydrogen fluoride
T. Ho, M. Fieser, L. Fieser, R. Danheiser +1 more
2020Catalysis from A to Z4 citations
Semantic Scholar
Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors
R. Nair, J. Mishra, Fangzheng Li, M. Tortosa +6 more
2016MedChemComm4 citations Open access
Semantic Scholar

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