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Charles J. Rotter · SciRah

Researcher profile · Semantic Scholar

Charles J. Rotter

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Charles J. Rotter — researcher profile on SciRah

h-index: 18
Works: 31
Citations: 1,842

Most-cited papers

Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
M. Varma, R. Obach, Charles J. Rotter, Howard R. Miller +4 more
2010Journal of Medicinal Chemistry307 citations
Semantic Scholar
Development of a new permeability assay using low-efflux MDCKII cells.
L. Di, Carrie Whitney-Pickett, John P. Umland, Hui Zhang +16 more
2011Journal of Pharmacy and Science288 citations
Semantic Scholar
pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.
M. Varma, I. Gardner, Stefanus J. Steyn, Paul Nkansah +7 more
2012Molecular Pharmaceutics147 citations
Semantic Scholar
Improving on nature: making a cyclic heptapeptide orally bioavailable.
D. Nielsen, H. N. Hoang, R. Lohman, T. A. Hill +9 more
2014Angewandte Chemie126 citations
Semantic Scholar
pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1.
M. Varma, Charles J. Rotter, J. Chupka, Kevin M. Whalen +5 more
2011Molecular Pharmaceutics118 citations
Semantic Scholar
Targeting intestinal transporters for optimizing oral drug absorption.
M. Varma, C. Ambler, M. Ullah, Charles J. Rotter +4 more
2010Current drug metabolism114 citations
Semantic Scholar
Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance
Arthur C. Rand, S. Leung, H. Eng, Charles J. Rotter +12 more
2012MedChemComm109 citations Open access
Semantic Scholar
Quantitative assessment of the contribution of sodium‐dependent taurocholate co‐transporting polypeptide (NTCP) to the hepatic uptake of rosuvastatin, pitavastatin and fluvastatin
Y. Bi, Xi Qiu, Charles J. Rotter, Emi Kimoto +4 more
2013Biopharmaceutics & drug disposition87 citations
Semantic Scholar
Refining the in vitro and in vivo critical parameters for P-glycoprotein, [I]/IC50 and [I2]/IC50, that allow for the exclusion of drug candidates from clinical digoxin interaction studies.
J. Cook, B. Feng, K. Fenner, S. Kempshall +6 more
2010Molecular Pharmaceutics70 citations
Semantic Scholar
IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results
Alison Margolskee, A. Darwich, X. Pepin, L. Aarons +54 more
2017European Journal of Pharmaceutical Sciences66 citations Open access
Semantic Scholar
Quantitative Prediction of Repaglinide-Rifampicin Complex Drug Interactions Using Dynamic and Static Mechanistic Models: Delineating Differential CYP3A4 Induction and OATP1B1 Inhibition Potential of Rifampicin
M. Varma, Jian Lin, Y. Bi, Charles J. Rotter +5 more
2013Drug Metabolism And Disposition59 citations
Semantic Scholar
Development and evaluation of novel solid nanodispersion system for oral delivery of poorly water-soluble drugs.
Paul Nkansah, A. Antipas, Ying Lu, M. Varma +6 more
2013Journal of Controlled Release59 citations
Semantic Scholar
Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed.
T. A. Hill, R. Lohman, H. N. Hoang, D. Nielsen +17 more
2014ACS Medicinal Chemistry Letters56 citations Open access
Semantic Scholar
Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide
M. Varma, R. Scialis, Jian Lin, Y. Bi +3 more
2014AAPS Journal49 citations Open access
Semantic Scholar
IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes
A. Darwich, Alison Margolskee, X. Pepin, L. Aarons +53 more
2017European Journal of Pharmaceutical Sciences41 citations Open access
Semantic Scholar
Quantitative prediction of renal transporter-mediated clinical drug-drug interactions.
B. Feng, S. Hurst, Ya-Song Lu, M. Varma +4 more
2013Molecular Pharmaceutics35 citations
Semantic Scholar
Effect of chitosan glutamate, carbomer 974P, and EDTA on the in vitro Caco-2 permeability and oral pharmacokinetic profile of acyclovir in rats
Alexei G. Merzlikine, Charles J. Rotter, Brian Rago, Julie Poe +4 more
2009Drug Development and Industrial Pharmacy26 citations
Semantic Scholar
The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide–Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy
H. Eng, R. Scialis, Charles J. Rotter, Jian Lin +6 more
2016Drug Metabolism And Disposition20 citations Open access
Semantic Scholar
Toward a Unified Model of Passive Drug Permeation II: The Physiochemical Determinants of Unbound Tissue Distribution with Applications to the Design of Hepatoselective Glucokinase Activators
A. Ghosh, T. Maurer, John E. Litchfield, M. Varma +6 more
2014Drug Metabolism And Disposition17 citations Open access
Semantic Scholar
High specificity in response of the sodium-dependent multivitamin transporter to derivatives of pantothenic acid.
S. Chirapu, Charles J. Rotter, E. Miller, M. Varma +2 more
2013Current Topics in Medicinal Chemistry14 citations
Semantic Scholar
Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.
Benjamin D. Stevens, John E. Litchfield, J. Pfefferkorn, Karen Atkinson +16 more
2013Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Recent advances in drug transporter sciences: highlights from the year 2020
Paresh P. Chothe, Masanori Nakakariya, Charles J. Rotter, P. Sandoval +1 more
2021Drug metabolism reviews (Softcover ed.)6 citations
Semantic Scholar
Elucidation of the biochemical basis for a clinical drug–drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha
A. Kalgutkar, Danny Chen, M. Varma, B. Feng +9 more
2013Xenobiotica; the fate of foreign compounds in biological systems6 citations
Semantic Scholar
Drug transporters in drug disposition – the year 2022 in review
Paresh P. Chothe, Pallabi Mitra, Masanori Nakakariya, D. Ramsden +3 more
2023Drug metabolism reviews (Softcover ed.)4 citations
Semantic Scholar
Novel insights in drug transporter sciences: the year 2021 in review
Paresh P. Chothe, Pallabi Mitra, Masanori Nakakariya, D. Ramsden +3 more
2022Drug metabolism reviews (Softcover ed.)2 citations Open access
Semantic Scholar
Pharmacokinetics and Toxicokinetics in Drug Discovery and Development
M. Varma, Z. Radi, Charles J. Rotter, John E. Litchfield +1 more
20122 citations
Semantic Scholar
Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide
M. Varma, R. Scialis, Jian Lin, Y. Bi +3 more
2014AAPS Journal1 citations Open access
Semantic Scholar
Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: Delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin
M. Varma, Jian Lin, Charles J. Rotter, O. Fahmi +4 more
20131 citations
Semantic Scholar
DMD058032 1599..1610
A. Ghosh, T. Maurer, John E. Litchfield, M. Varma +6 more
20140 citations
Semantic Scholar
Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: Delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin
M. Varma, Jian Lin, Charles J. Rotter, O. Fahmi +4 more
20130 citations
Semantic Scholar
Quantitative Prediction of Repaglinide-Rifampicin Complex Drug Interactions Using Dynamic and Static Mechanistic Models: Delineating Differential CYP3A4 Induction and OATP1B1 Inhibition Potential of Rifampicin
M. Varma, Jian Lin, Y. Bi, Charles J. Rotter +5 more
20130 citations
Semantic Scholar

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