Researcher profile · Semantic Scholar

Brian Rago

h-index: 19
Works: 30
Citations: 891

Most-cited papers

Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs
D. Mori, Emi Kimoto, Brian Rago, Yusuke Kondo +11 more
2020Clinical pharmacology and therapy95 citations Open access
Semantic Scholar
Where Did the Linker-Payload Go? A Quantitative Investigation on the Destination of the Released Linker-Payload from an Antibody-Drug Conjugate with a Maleimide Linker in Plasma.
Cong Wei, Guodong Zhang, T. Clark, F. Barletta +4 more
2016Analytical Chemistry90 citations
Semantic Scholar
Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates
L. Tumey, Fengping Li, Brian Rago, Xiaogang Han +15 more
2017AAPS Journal67 citations
Semantic Scholar
Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism
L. Tumey, C. Leverett, B. Vetelino, Fengping Li +21 more
2016ACS Medicinal Chemistry Letters63 citations Open access
Semantic Scholar
Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads.
S. Puthenveetil, F. Loganzo, Hai-Yin He, K. Dirico +18 more
2016Bioconjugate chemistry62 citations
Semantic Scholar
Development and evaluation of novel solid nanodispersion system for oral delivery of poorly water-soluble drugs.
Paul Nkansah, A. Antipas, Ying Lu, M. Varma +6 more
2013Journal of Controlled Release59 citations
Semantic Scholar
Identification of Glycochenodeoxycholate 3‐O‐Glucuronide and Glycodeoxycholate 3‐O‐Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers
M. Neuvonen, Päivi Hirvensalo, A. Tornio, Brian Rago +9 more
2020Clinical pharmacology and therapy42 citations Open access
Semantic Scholar
In vivo biotransformations of antibody-drug conjugates.
L. Tumey, Brian Rago, Xiaogang Han
2015Bioanalysis40 citations
Semantic Scholar
Development of a high-throughput ultra performance liquid chromatography-mass spectrometry assay to profile 18 eicosanoids as exploratory biomarkers for atherosclerotic diseases.
Brian Rago, Ce-Xiong Fu
2013Journal of chromatography. B, Analytical technologies in the biomedical and life sciences36 citations
Semantic Scholar
Modulation of NMDA receptor function by inhibition of D-amino acid oxidase in rodent brain.
Christine A. Strick, Cheryl Li, Liam Scott, Brian D. Harvey +18 more
2011Neuropharmacology36 citations
Semantic Scholar
Biodistribution and Targeting of Anti-5T4 Antibody–Drug Conjugate Using Fluorescence Molecular Tomography
A. Giddabasappa, Vijay R Gupta, Rand Norberg, Parul Gupta +6 more
2016Molecular Cancer Therapeutics27 citations Open access
Semantic Scholar
Effect of chitosan glutamate, carbomer 974P, and EDTA on the in vitro Caco-2 permeability and oral pharmacokinetic profile of acyclovir in rats
Alexei G. Merzlikine, Charles J. Rotter, Brian Rago, Julie Poe +4 more
2009Drug Development and Industrial Pharmacy26 citations
Semantic Scholar
Quantitative Conjugated Payload Measurement Using Enzymatic Release of Antibody-Drug Conjugate with Cleavable Linker.
Brian Rago, L. Tumey, Cong Wei, F. Barletta +3 more
2017Bioconjugate chemistry25 citations
Semantic Scholar
Calculated conjugated payload from immunoassay and LC-MS intact protein analysis measurements of antibody-drug conjugate.
Brian Rago, T. Clark, L. King, Jenny Zhang +7 more
2016Bioanalysis25 citations
Semantic Scholar
Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.
J. Tuttle, M. Anderson, Bruce M. Bechle, B. Campbell +17 more
2013ACS Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
2017 White Paper on recent issues in bioanalysis: aren't BMV guidance/guidelines 'Scientific'? (Part 1 - LCMS: small molecules, peptides and small molecule biomarkers).
J. Welink, Eric Yang, Nicola C. Hughes, Brian Rago +42 more
2017Bioanalysis24 citations Open access
Semantic Scholar
2017 White Paper: rise of hybrid LBA/LCMS immunogenicity assays (Part 2: hybrid LBA/LCMS biotherapeutics, biomarkers & immunogenicity assays and regulatory agencies' inputs).
H. Neubert, An Song, Anita Y. H. Lee, Cong Wei +45 more
2017Bioanalysis24 citations Open access
Semantic Scholar
Preclinical Development of an anti-5T4 Antibody-Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice.
M. Leal, J. Wentland, Xiaogang Han, Yanhua Zhang +10 more
2015Bioconjugate chemistry24 citations
Semantic Scholar
Application of the dried spot sampling technique for rat cerebrospinal fluid sample collection and analysis.
Brian Rago, Jianhua Liu, Beijing Tan, C. Holliman
2011Journal of Pharmaceutical and Biomedical Analysis20 citations
Semantic Scholar
A multiplex HRMS assay for quantifying selected human plasma bile acids as candidate OATP biomarkers.
Brian Rago, Brendan Tierney, A. Rodrigues, C. Holliman +1 more
2018Bioanalysis19 citations
Semantic Scholar
Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates.
Anokha S. Ratnayake, Li-Ping Chang, L. Tumey, F. Loganzo +16 more
2018Bioconjugate chemistry18 citations
Semantic Scholar
Discovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokinetics
Jaclyn L. Henderson, A. Sawant-Basak, J. Tuttle, A. Dounay +17 more
201318 citations
Semantic Scholar
Characterization of Bile Acid Sulfate Conjugates as Substrates of Human Organic Anion Transporting Polypeptides.
C. Orozco, M. Neuvonen, Y. Bi, M. Cerny +7 more
2023Molecular Pharmaceutics10 citations
Semantic Scholar
A novel hydrophilic interaction chromatography assay characterization of 4-pyridoxic acid, an emergent renal organic anion transporter 1/3 transporter biomarker.
Justin Towner, Brian Rago, D. Rodrigues, M. Vourvahis +1 more
2021Bioanalysis8 citations
Semantic Scholar
Quantification of fumarate and investigation of endogenous and exogenous fumarate stability in rat plasma by LC-MS/MS.
Yao Shi, Susanna Tse, Brian Rago, Udeni Yapa +2 more
2016Bioanalysis7 citations
Semantic Scholar
Outsource-ability of high-resolution MS-based DMPK assays.
Brian Rago, Andre Negahban
2016Bioanalysis4 citations
Semantic Scholar
Protac tissue distribution
Stefanus J. Steyn, M. Niosi, Samantha Jordan, Christopher Healy +1 more
2025Drug Metabolism and Pharmacokinetics0 citations
Semantic Scholar
P231 - Study to assess the food effect on plasma levels of emerging endogenous biomarkers of transporter mediated drug-drug interactions
Amanda J. King-Ahmad, Brian Rago, Lina Luo, A. Rodrigues +1 more
20200 citations
Semantic Scholar
Characterization of bile acid sulfate conjugates as substrates of human organic anion-transporting polypeptides
Christine C. Orozco, Y. Bi, Matt Cerney, Sumathy Mathialagan +5 more
20180 citations
Semantic Scholar
Abstract 4293: Whole-body bio-distribution of anti-5T4-mcMMAF (anti-5T4-ADC) using fluorescence molecular tomography (FMT) imaging in a non-small cell lung cancer mice model
A. Giddabasappa, Rand Norberg, M. Leal, David Paterson +8 more
20140 citations
Semantic Scholar

F. Barletta

×5

Cong Wei×4

Fengping Li×4

F. Loganzo×4

S. Musto×4

Edmund I. Graziani×4

J. Lucas×4

P. Sapra×4