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R. Scialis · SciRah

Researcher profile · Semantic Scholar

R. Scialis

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R. Scialis — researcher profile on SciRah

h-index: 17
Works: 34
Citations: 653

Most-cited papers

Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: “SLC-Phenotyping” Using Primary Human Hepatocytes
Y. Bi, Chester Costales, Sumathy Mathialagan, M. West +12 more
2019Journal of Pharmacology and Experimental Therapeutics77 citations Open access
Semantic Scholar
Positive Allosteric Modulation of AMPA Receptors from Efficacy to Toxicity: The Interspecies Exposure-Response Continuum of the Novel Potentiator PF-4778574
Christopher L. Shaffer, R. S. Hurst, R. Scialis, Sarah M. Osgood +10 more
2013Journal of Pharmacology and Experimental Therapeutics56 citations
Semantic Scholar
Transporter‐Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug–Drug Interactions of Montelukast
M. Varma, E. Kimoto, R. Scialis, Y. Bi +6 more
2017Clinical pharmacology and therapy49 citations
Semantic Scholar
Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide
M. Varma, R. Scialis, Jian Lin, Y. Bi +3 more
2014AAPS Journal49 citations Open access
Semantic Scholar
Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes
Y. Bi, R. Scialis, Sarah Lazzaro, Sumathy Mathialagan +8 more
2017AAPS Journal44 citations
Semantic Scholar
Hepatic Disposition of Gemfibrozil and Its Major Metabolite Gemfibrozil 1-O-β-Glucuronide.
Emi Kimoto, Rui Li, R. Scialis, Yurong Lai +1 more
2015Molecular Pharmaceutics41 citations
Semantic Scholar
The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).
Christopher L. Shaffer, N. Patel, Jacob B. Schwarz, R. Scialis +22 more
2015Journal of Medicinal Chemistry28 citations
Semantic Scholar
Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
J. Pfefferkorn, John E. Litchfield, R. Hutchings, Xue-Min Cheng +37 more
2011Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1
Emi Kimoto, M. Vourvahis, R. Scialis, H. Eng +2 more
2019Drug Metabolism And Disposition23 citations Open access
Semantic Scholar
Detection of statin cytotoxicity is increased in cells expressing the OATP1B1 transporter.
Xun Zhang, R. Scialis, B. Feng, K. Leach
2013Toxicological Sciences23 citations
Semantic Scholar
Metabolism and Disposition of a Selective α7 Nicotinic Acetylcholine Receptor Agonist in Humans
C. L. Shaffer, Mithat Gunduz, R. Scialis, A. Fang
2007Drug Metabolism And Disposition23 citations
Semantic Scholar
Xenobiotic Transporters in the Kidney: Function and Role in Toxicity.
Hong Shen, R. Scialis, L. Lehman-Mckeeman
2019Seminars in Nephrology22 citations
Semantic Scholar
Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism‐based adverse events
C. L. Shaffer, R. Scialis, H. Rong, R. Obach
2012Biopharmaceutics & drug disposition22 citations
Semantic Scholar
Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators.
N. Patel, Jacob B. Schwarz, Xinjun Hou, D. Hoover +16 more
2013Journal of Medicinal Chemistry21 citations
Semantic Scholar
The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide–Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy
H. Eng, R. Scialis, Charles J. Rotter, Jian Lin +6 more
2016Drug Metabolism And Disposition20 citations Open access
Semantic Scholar
Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac
R. Scialis, I. Csanaky, Michael J. Goedken, J. Manautou
2015Drug Metabolism And Disposition19 citations Open access
Semantic Scholar
Toward a Unified Model of Passive Drug Permeation II: The Physiochemical Determinants of Unbound Tissue Distribution with Applications to the Design of Hepatoselective Glucokinase Activators
A. Ghosh, T. Maurer, John E. Litchfield, M. Varma +6 more
2014Drug Metabolism And Disposition17 citations Open access
Semantic Scholar
Elucidation of the Mechanisms through Which the Reactive Metabolite Diclofenac Acyl Glucuronide Can Mediate Toxicity
R. Scialis, J. Manautou
2016Journal of Pharmacology and Experimental Therapeutics15 citations Open access
Semantic Scholar
Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites
Rui Li, Y. Bi, Anna Vildhede, R. Scialis +5 more
2017Drug Metabolism And Disposition14 citations Open access
Semantic Scholar
Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis.
K. Lapham, Jonathan J. Novak, Lisa D. Marroquin, Rachel L Swiss +8 more
2016Chemical Research in Toxicology12 citations
Semantic Scholar
Evaluation of hepatic uptake of OATP1B substrates by short term-cultured plated human hepatocytes: Comparison with isolated suspended hepatocytes.
Takashi Yoshikado, Wooin Lee, Kota Toshimoto, Kiyoe Morita +14 more
2020Journal of Pharmacy and Science11 citations Open access
Semantic Scholar
Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites
R. Scialis, L. Aleksunes, I. Csanaky, C. Klaassen +1 more
2019Drug Metabolism And Disposition11 citations Open access
Semantic Scholar
Metabolism and disposition of a selective alpha(7) nicotinic acetylcholine receptor agonist in humans.
C. L. Shaffer, Mithat Gunduz, R. Scialis, A. Fang
2007Drug Metabolism And Disposition8 citations
Semantic Scholar
Mechanistic Investigation of Liver Injury Induced by BMS-932481, an Experimental ɣ-Secretase Modulator.
X. Zhuo, B. Howell, Hong Shen, J. Woodhead +11 more
2023Toxicological Sciences7 citations
Semantic Scholar
Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs
Wooin Lee, S. Koyama, Kiyoe Morita, Aya Kiriake +12 more
2020AAPS Journal6 citations Open access
Semantic Scholar
Elucidation of the biochemical basis for a clinical drug–drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha
A. Kalgutkar, Danny Chen, M. Varma, B. Feng +9 more
2013Xenobiotica; the fate of foreign compounds in biological systems6 citations
Semantic Scholar
The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites
R. Scialis, C. Ghanem, J. Manautou
2020Current Research in Toxicology1 citations Open access
Semantic Scholar
Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes
Y. Bi, R. Scialis, Sarah Lazzaro, Sumathy Mathialagan +8 more
2017AAPS Journal1 citations Open access
Semantic Scholar
Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide
M. Varma, R. Scialis, Jian Lin, Y. Bi +3 more
2014AAPS Journal1 citations Open access
Semantic Scholar
B106-14 Population Pharmacokinetics Analysis of Treprostinil Using Data From Phase 1 and 2 Studies of Treprostinil Palmitil Inhalation Powder
B. Mistry, R. Scialis, S. Au Yeung, G. O. Brien +5 more
2026American Journal of Respiratory and Critical Care Medicine0 citations
Semantic Scholar
P16-054New insights into the toxicokinetics and toxicodynamics of diclofenac acyl glucuronide: Role of drug transporters, cyclooxygenase and superoxide dismutase
J. Manautou, R. Scialis
20160 citations
Semantic Scholar
The Modulation of Non-steroidal Anti-inflammatory Toxicity as a Function of the Interplay between Uptake and Efflux Transporters
R. Scialis
20150 citations
Semantic Scholar
DMD058032 1599..1610
A. Ghosh, T. Maurer, John E. Litchfield, M. Varma +6 more
20140 citations
Semantic Scholar
Synthesis of 2,5-Bis(ethynyl)-1,3,4-trimethylpyrrole, (IIIb), the First Example of an Alkylpyrrole Bearing Two Terminal Acetylenic Groups in Conjugate Positions.
G. Ortaggi, M. Scarsella, R. Scialis, G. Sleiter
19890 citations
Semantic Scholar

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