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Giambattista Guaitoli · SciRah

Researcher profile · Semantic Scholar

Giambattista Guaitoli

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Giambattista Guaitoli — researcher profile on SciRah

h-index: 12
Works: 32
Citations: 674

Most-cited papers

A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover
E. Deyaert, Lina Wauters, Giambattista Guaitoli, A. Konijnenberg +13 more
2017Nature Communications156 citations Open access
Semantic Scholar
Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
Giambattista Guaitoli, Francesco Raimondi, Bernd K. Gilsbach, Y. Gómez-Llorente +18 more
2016Proceedings of the National Academy of Sciences of the United States of America144 citations Open access
Semantic Scholar
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase
D. Cardinale, Giambattista Guaitoli, D. Tondi, R. Luciani +14 more
2011Proceedings of the National Academy of Sciences of the United States of America93 citations Open access
Semantic Scholar
Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2
R. Singh, Ahmed Soliman, Giambattista Guaitoli, Eliza Störmer +16 more
2021bioRxiv44 citations Open access
Semantic Scholar
A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3
J. Weber, Matthias Golla, Giambattista Guaitoli, P. Wanichawan +12 more
2017Brain : a journal of neurology41 citations Open access
Semantic Scholar
Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
J. Lauer, S. Segeletz, Alice Cezanne, Giambattista Guaitoli +9 more
2019eLife31 citations Open access
Semantic Scholar
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.
E. Carosati, A. Tochowicz, G. Marverti, Giambattista Guaitoli +8 more
2012Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Ligand-based virtual screening and ADME-tox guided approach to identify triazolo-quinoxalines as folate cycle inhibitors.
E. Carosati, Gianluca Sforna, Massimiliano Pippi, G. Marverti +7 more
2010Bioorganic & Medicinal Chemistry24 citations Open access
Semantic Scholar
Dimer–monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transfer
F. Genovese, S. Ferrari, Giambattista Guaitoli, M. Caselli +2 more
2010Protein Science22 citations Open access
Semantic Scholar
Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization
Pragya Pathak, Krista K. Alexander, Leah G. Helton, Michalis Kentros +10 more
2023ACS Chemical Neuroscience15 citations Open access
Semantic Scholar
Biochemical and kinetic properties of the complex Roco G-protein cycle
Lina Wauters, S. Terheyden, Bernd K. Gilsbach, Margaux Leemans +6 more
2018Biological chemistry15 citations Open access
Semantic Scholar
Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells
G. Marverti, Giambattista Guaitoli, Alessio Ligabue, C. Frassineti +3 more
2011Amino Acids12 citations
Semantic Scholar
First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein.
Giambattista Guaitoli, Bernd K. Gilsbach, Francesco Raimondi, C. Gloeckner
2016Biochemical Society Transactions9 citations
Semantic Scholar
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding.
D. Cardinale, O. Salo-Ahen, Giambattista Guaitoli, S. Ferrari +6 more
2010Protein engineering, design & selection : PEDS9 citations Open access
Semantic Scholar
Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism
Bernd K. Gilsbach, F. Ho, Benjamin Riebenbauer, Xiaojuan Zhang +3 more
2024bioRxiv8 citations Open access
Semantic Scholar
Alanine Mutants of the Interface Residues of Human Thymidylate Synthase Decode Key Features of the Binding Mode of Allosteric Anticancer Peptides
A. Tochowicz, M. Santucci, P. Saxena, Giambattista Guaitoli +4 more
2014Journal of Medicinal Chemistry8 citations Open access
Semantic Scholar
Biophysical analysis reveals autophosphorylation as an important negative regulator of LRRK2 dimerization
Giambattista Guaitoli, Xiaojuan Zhang, F. Saitta, P. Miglionico +9 more
2023bioRxiv5 citations Open access
Semantic Scholar
Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies
C. Galicia, Giambattista Guaitoli, M. Fislage, C. Gloeckner +1 more
2024eLife4 citations Open access
Semantic Scholar
The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation
Felix Knab, Giambattista Guaitoli, M. Jarboui, Felix von Zweydorf +5 more
2024bioRxiv3 citations Open access
Semantic Scholar
Intersite communication in dimeric enzymes highlighted by structural and thermodynamic analysis of didansyltyrosine binding to thymidylate synthases.
A. Venturelli, Giambattista Guaitoli, D. Vanossi, F. Saitta +8 more
2024Bioorganic chemistry (Print)2 citations Open access
Semantic Scholar
Structural insights in the GTP-driven monomerization and activation of a bacterial LRRK2 homologue using allosteric nanobodies
C. Galicia, Giambattista Guaitoli, M. Fislage, C. Gloeckner +1 more
2024bioRxiv1 citations Open access
Semantic Scholar
Allosteric Structural Alterations and Auto-regulation of Rab5 GEF Activity in Rabex5
J. Lauer, Alice Cezanne, Giambattista Guaitoli, Francesco Raimondi +7 more
2019bioRxiv0 citations Open access
Semantic Scholar
Author response: Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
Janelle L. Lauer, S. Segeletz, Alice Cezanne, Giambattista Guaitoli +9 more
20190 citations Open access
Semantic Scholar
Zing meeting on Medicinal Chemistry 2012-Lanzarote-invitated lecture
Maria Paola Costi, S. Ferrari, G. Ponterini, D. Cardinale +2 more
20120 citations
Semantic Scholar
Crystal Structure of histidine-tagged human thymidylate synthase
C. Pozzi, D. Cardinale, Giambattista Guaitoli, D. Tondi +5 more
20110 citations
Semantic Scholar
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor
C. Pozzi, D. Cardinale, Giambattista Guaitoli, D. Tondi +5 more
20110 citations Open access
Semantic Scholar
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase.
Maria Paola Costi, F. Genovese, Silvia Franchini, A. Venturelli +11 more
20100 citations
Semantic Scholar
Allosteric Inhibition of human Thymidylate Synthase.
S. Henrich, O. S. Ahen, Divita Garg, D. Cardinale +9 more
20100 citations
Semantic Scholar
Crystallographic studies of new human Thymidylate synthase inhibitors
C. Pozzi, Giambattista Guaitoli, M. Benvenuti, S. Mangani +1 more
20080 citations
Semantic Scholar
Interfering with Human Thymidylate Synthase Dimerization against ovarian human carcinoma
Maria Paola Costi, D. Cardinale, Giambattista Guaitoli, D. Tondi +3 more
20070 citations
Semantic Scholar
Interfering with Human Thymidylate Synthase Dimerization anti peptide design in the search of anticancer agents against ovarian human carcinoma
D. Cardinale, O. S. Ahen, Giambattista Guaitoli, D. Tondi +3 more
20070 citations
Semantic Scholar
Small ligands to interfere with Thymidylate synthase dimer formation as new tools for development of anticancer agents against ovarian carcinoma.
Maria Paola Costi, D. Tondi, G. Ponterini, G. Marverti +9 more
20060 citations
Semantic Scholar

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