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E. Barone · SciRah

Researcher profile · Semantic Scholar

E. Barone

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E. Barone — researcher profile on SciRah

h-index: 42
Works: 121
Citations: 5,001

Most-cited papers

Elevated Risk of Type 2 Diabetes for Development of Alzheimer Disease: a Key Role for Oxidative Stress in Brain
D. Butterfield, F. Di Domenico, E. Barone
2014Biochimica et Biophysica Acta385 citations Open access
Semantic Scholar
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain
M. Perluigi, Gilda Pupo, A. Tramutola, C. Cini +5 more
2014Biochimica et Biophysica Acta156 citations Open access
Semantic Scholar
The Interplay Among Oxidative Stress, Brain Insulin Resistance and AMPK Dysfunction Contribute to Neurodegeneration in Type 2 Diabetes and Alzheimer Disease
E. Barone, F. Di Domenico, M. Perluigi, D. Butterfield
2021Free Radical Biology & Medicine150 citations Open access
Semantic Scholar
The Janus Face of the Heme Oxygenase/Biliverdin Reductase System in Alzheimer Disease: It’s Time for Reconciliation
E. Barone, F. Di Domenico, C. Mancuso, D. Butterfield
2013Neurobiology of Disease137 citations Open access
Semantic Scholar
Heme Oxygenase-1 Post-translational Modifications in the Brain of Subjects with Alzheimer Disease and Mild Cognitive Impairment
E. Barone, F. Di Domenico, R. Sultana, R. Coccia +3 more
2012Free Radical Biology & Medicine123 citations Open access
Semantic Scholar
Trans-ferulic acid-based solid lipid nanoparticles and their antioxidant effect in rat brain microsomes.
S. Trombino, R. Cassano, Teresa Ferrarelli, E. Barone +2 more
2013Colloids and Surfaces B: Biointerfaces116 citations
Semantic Scholar
mTOR in Alzheimer Disease and Its Earlier Stages: Links to Oxidative Damage in the Progression of this Dementing Disorder
M. Perluigi, F. Di Domenico, E. Barone, D. Butterfield
2021Free Radical Biology & Medicine108 citations Open access
Semantic Scholar
The Triangle of Death in Alzheimer's Disease Brain: The Aberrant Cross-Talk Among Energy Metabolism, Mammalian Target of Rapamycin Signaling, and Protein Homeostasis Revealed by Redox Proteomics
F. Di Domenico, E. Barone, M. Perluigi, D. Butterfield
2017Antioxidants and Redox Signaling107 citations
Semantic Scholar
Strategy to reduce free radical species in Alzheimer’s disease: an update of selected antioxidants
F. Di Domenico, E. Barone, M. Perluigi, D. Butterfield
2015Expert Review of Neurotherapeutics104 citations
Semantic Scholar
Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions
M. Dierssen, M. Fructuoso, María Martínez de Lagrán, M. Perluigi +1 more
2020Frontiers in Neuroscience103 citations Open access
Semantic Scholar
It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease
A. Tramutola, F. Di Domenico, E. Barone, M. Perluigi +1 more
2016Oxidative Medicine and Cellular Longevity103 citations Open access
Semantic Scholar
Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm.
E. Barone, F. Di Domenico, T. Cassano, A. Arena +5 more
2016Free Radical Biology & Medicine102 citations
Semantic Scholar
Valorization of Tomato Waste as a Source of Carotenoids
S. Trombino, R. Cassano, D. Procópio, M. D. di Gioia +1 more
2021Molecules98 citations Open access
Semantic Scholar
Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
A. Tramutola, Chiara Lanzillotta, E. Barone, A. Arena +6 more
2018Translational Neurodegeneration96 citations Open access
Semantic Scholar
Natural substances and Alzheimer's disease: from preclinical studies to evidence based medicine.
C. Mancuso, Raffaella Siciliano, E. Barone, P. Preziosi
2012Biochimica et Biophysica Acta86 citations Open access
Semantic Scholar
Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease
E. Barone, A. Tramutola, Francesca Triani, Silvio Calcagnini +7 more
2018Molecular Neurobiology85 citations
Semantic Scholar
STATINS MORE THAN CHOLESTEROL LOWERING AGENTS IN ALZHEIMER DISEASE: THEIR PLEIOTROPIC FUNCTIONS AS POTENTIAL THERAPEUTIC TARGETS
E. Barone, F. Di Domenico, D. Butterfield
2013Biochemical Pharmacology85 citations Open access
Semantic Scholar
Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways.
M. Perluigi, E. Barone, F. Di Domenico, D. Butterfield
2016Biochimica et Biophysica Acta84 citations Open access
Semantic Scholar
Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-A system: insights for transition to Alzheimer Disease
F. Di Domenico, Gilda Pupo, C. Mancuso, E. Barone +7 more
2015Journal of Alzheimer's Disease72 citations Open access
Semantic Scholar
Biliverdin reductase‐A: a novel drug target for atorvastatin in a dog pre‐clinical model of Alzheimer disease
E. Barone, C. Mancuso, F. Di Domenico, R. Sultana +3 more
2012Journal of Neurochemistry72 citations
Semantic Scholar
Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome
F. Di Domenico, A. Tramutola, E. Barone, Chiara Lanzillotta +9 more
2019Redox Biology64 citations Open access
Semantic Scholar
Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase.
E. Barone, S. Mosser, P. Fraering
2014Biochimica et Biophysica Acta63 citations Open access
Semantic Scholar
Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease.
Nidhi Sharma, A. Tramutola, Chiara Lanzillotta, A. Arena +6 more
2019Neurobiology of Disease57 citations Open access
Semantic Scholar
Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease.
Francesca Triani, A. Tramutola, F. Di Domenico, Nidhi Sharma +4 more
2018Biochimica et Biophysica Acta - Molecular Basis of Disease52 citations Open access
Semantic Scholar
Disturbance of redox homeostasis in Down Syndrome: role of iron dysmetabolism
E. Barone, A. Arena, E. Head, D. Butterfield +1 more
2017Free Radical Biology & Medicine51 citations Open access
Semantic Scholar
Redox Proteomics Analyses of the Influence of Co-Expression of Wild-Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease
F. Di Domenico, R. Sultana, A. Ferree, Katelyn Smith +11 more
2012Antioxidants and Redox Signaling51 citations Open access
Semantic Scholar
HO-1/BVR-A System Analysis in Plasma from Probable Alzheimer's Disease and Mild Cognitive Impairment Subjects: A Potential Biochemical Marker for the Prediction of the Disease
F. Di Domenico, E. Barone, C. Mancuso, M. Perluigi +4 more
2012Journal of Alzheimer's Disease49 citations
Semantic Scholar
Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: a harmful synergistic path in Down syndrome.
Chiara Lanzillotta, A. Tramutola, Graziella Di Giacomo, F. Marini +4 more
2021Free Radical Biology & Medicine47 citations
Semantic Scholar
Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology
A. Tramutola, F. Di Domenico, E. Barone, A. Arena +7 more
2017Antioxidants and Redox Signaling47 citations Open access
Semantic Scholar
Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down's Syndrome
A. Tramutola, Chiara Lanzillotta, A. Arena, E. Barone +2 more
2015Neurodegenerative Diseases44 citations
Semantic Scholar
The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia
M. Perluigi, A. Tramutola, Sara Pagnotta, E. Barone +1 more
2020Antioxidants42 citations Open access
Semantic Scholar
Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease.
A. Tramutola, Nidhi Sharma, E. Barone, Chiara Lanzillotta +9 more
2018Biochimica et Biophysica Acta - Molecular Basis of Disease40 citations Open access
Semantic Scholar
Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention.
Chiara Lanzillotta, Ilaria Zuliani, A. Tramutola, E. Barone +11 more
2020Progress in neurobiology37 citations Open access
Semantic Scholar
Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity.
F. A. Cimini, A. Arena, I. Barchetta, A. Tramutola +14 more
2019Biochimica et Biophysica Acta - Molecular Basis of Disease37 citations Open access
Semantic Scholar
Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease
I. Barchetta, V. Ceccarelli, F. A. Cimini, E. Barone +10 more
2020Journal of Endocrinological Investigation36 citations Open access
Semantic Scholar
Poly-ubiquitin profile in Alzheimer disease brain.
A. Tramutola, Francesca Triani, F. Di Domenico, E. Barone +4 more
2018Neurobiology of Disease36 citations Open access
Semantic Scholar
ACTIVATION OF p53 IN DOWN SYNDROME AND IN THE Ts65Dn MOUSE BRAIN IS ASSOCIATED WITH A PRO-APOPTOTIC PHENOTYPE
A. Tramutola, Gilda Pupo, F. Di Domenico, E. Barone +7 more
2016Journal of Alzheimer's Disease36 citations Open access
Semantic Scholar
Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology
A. Tramutola, A. Arena, C. Cini, D. Butterfield +1 more
2017Expert Review of Neurotherapeutics35 citations
Semantic Scholar
Heme Oxygenase-1 in Central Nervous System Malignancies
Giuseppe Sferrazzo, M. Di Rosa, E. Barone, Giovanni Li Volti +3 more
2020Journal of Clinical Medicine33 citations Open access
Semantic Scholar
Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal‐derived extracellular vesicles
M. Perluigi, A. Picca, E. Montanari, R. Calvani +11 more
2021Alzheimer's & Dementia32 citations Open access
Semantic Scholar
SEX DIFFERENCES IN BRAIN PROTEOMES OF NEURON-SPECIFIC STAT3-NULL MICE AFTER CEREBRAL ISCHEMIA / REPERFUSION
F. Di Domenico, Gabriella Casalena, Jia Jia, R. Sultana +9 more
2012Journal of Neurochemistry31 citations Open access
Semantic Scholar
The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome
Ilaria Zuliani, Chiara Lanzillotta, A. Tramutola, A. Francioso +4 more
2020Neurotherapeutics28 citations Open access
Semantic Scholar
High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures
Ilaria Zuliani, Chiara Lanzillotta, A. Tramutola, E. Barone +10 more
2021International Journal of Molecular Sciences27 citations Open access
Semantic Scholar
Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille's heel?
E. Barone, D. Butterfield
2015Neurobiology of Disease26 citations Open access
Semantic Scholar
BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain—Implications for Neurodegeneration
Chiara Lanzillotta, Ilaria Zuliani, C. Vasavda, S. Snyder +4 more
2020Antioxidants23 citations Open access
Semantic Scholar
Protein nitration profile of CD3+ lymphocytes from Alzheimer disease patients: Novel hints on immunosenescence and biomarker detection
A. Tramutola, G. Abate, Chiara Lanzillotta, Francesca Triani +11 more
2018Free Radical Biology & Medicine23 citations Open access
Semantic Scholar
CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome.
Sara Pagnotta, A. Tramutola, E. Barone, F. Di Domenico +8 more
2022Free Radical Biology & Medicine22 citations
Semantic Scholar
Greater circulating DPP4 activity is associated with impaired flow-mediated dilatation in adults with type 2 diabetes mellitus.
I. Barchetta, G. Ciccarelli, E. Barone, F. A. Cimini +9 more
2019NMCD. Nutrition Metabolism and Cardiovascular Diseases22 citations
Semantic Scholar
Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models
Chiara Lanzillotta, A. Tramutola, Shelby E. Meier, Frederick Schmitt +4 more
2018Journal of Alzheimer's Disease22 citations Open access
Semantic Scholar
Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer’s Disease-like Neuropathology in a Mouse Model for Down Syndrome
A. Tramutola, Simona Lanzillotta, Giuseppe Aceto, Sara Pagnotta +9 more
2023Antioxidants21 citations Open access
Semantic Scholar

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F. Di Domenico×38
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F. Di Domenico — researcher profile on SciRah
M. Perluigi×37
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M. Perluigi — researcher profile on SciRah
D. Butterfield×34
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A. Tramutola×27
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A. Tramutola — researcher profile on SciRah

Chiara Lanzillotta

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Ilaria Zuliani — researcher profile on SciRah

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R. Sultana — researcher profile on SciRah