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J. Sensintaffar · SciRah

Researcher profile · Semantic Scholar

J. Sensintaffar

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J. Sensintaffar — researcher profile on SciRah

h-index: 20
Works: 59
Citations: 4,553

Most-cited papers

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
A. Kamal, Lia Thao, J. Sensintaffar, Lin Zhang +3 more
2003Nature1,426 citations
Semantic Scholar
ARN-509: a novel anti-androgen for prostate cancer treatment
N. J. Clegg, John Wongvipat, J. Joseph, C. Tran +31 more
2012Cancer Research632 citations Open access
Semantic Scholar
A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509.
J. Joseph, N. Lu, J. Qian, J. Sensintaffar +7 more
2013Cancer Discovery567 citations
Semantic Scholar
A Novel MCL-1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia
Haley E. Ramsey, Melissa A. Fischer, Taekyu Lee, Agnieszka E. Gorska +10 more
2018Cancer Discovery288 citations Open access
Semantic Scholar
Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures.
J. M. Watson, J. Sensintaffar, J. Berek, O. Martínez-Maza
1990Cancer Research238 citations
Semantic Scholar
Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.
Andiliy G. Lai, M. Kahraman, S. Govek, J. Nagasawa +20 more
2015Journal of Medicinal Chemistry227 citations Open access
Semantic Scholar
BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
K. Lundgren, Hong Zhang, John Brekken, N. Huser +14 more
2009Molecular Cancer Therapeutics170 citations Open access
Semantic Scholar
Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods
N. Pelz, Zhiguo Bian, Bin Zhao, Subrata Shaw +12 more
2016Journal of Medicinal Chemistry137 citations Open access
Semantic Scholar
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
S. Kasibhatla, Kevin Hong, M. Biamonte, David J. Busch +14 more
2007Journal of Medicinal Chemistry113 citations Open access
Semantic Scholar
7'-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors.
Lin Zhang, Jun-Hua Fan, Khang X. Vu, Kevin Hong +16 more
2006Journal of Medicinal Chemistry107 citations Open access
Semantic Scholar
The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer
J. Joseph, B. Darimont, Wei Zhou, Alfonso Arrazate +42 more
2016eLife96 citations Open access
Semantic Scholar
Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927.
M. Kahraman, S. Govek, J. Nagasawa, Andiliy G. Lai +17 more
2018ACS Medicinal Chemistry Letters66 citations Open access
Semantic Scholar
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.
Taekyu Lee, P. Christov, Subrata Shaw, J. C. Tarr +23 more
2019Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design.
Subrata Shaw, Zhiguo Bian, Bin Zhao, J. C. Tarr +12 more
2018Journal of Medicinal Chemistry57 citations Open access
Semantic Scholar
Discovery and Biological Characterization of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors
Taekyu Lee, Zhiguo Bian, Bin Zhao, L. Hogdal +20 more
2016FEBS Letters56 citations Open access
Semantic Scholar
Discovery and Structure-Based Optimization of Potent and Selective WDR5 Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core
Jianhua Tian, Kevin B. Teuscher, Erin R. Aho, Joseph Alvarado +21 more
2019Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Optimization of an indazole series of selective estrogen receptor degraders: Tumor regression in a tamoxifen-resistant breast cancer xenograft.
S. Govek, J. Nagasawa, K. Douglas, Andiliy G. Lai +15 more
2015Bioorganic & Medicinal Chemistry Letters41 citations
Semantic Scholar
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models
Kevin B Teuscher, S. Chowdhury, Kenneth M. Meyers, Jianhua Tian +16 more
2022Proceedings of the National Academy of Sciences of the United States of America33 citations Open access
Semantic Scholar
Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer.
J. Nagasawa, S. Govek, M. Kahraman, Andiliy G. Lai +18 more
2018Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Orally active purine-based inhibitors of the heat shock protein 90.
M. Biamonte, Jiandong Shi, Kevin Hong, David Hurst +14 more
2006Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
XIAP is not required for human tumor cell survival in the absence of an exogenous death signal
J. Sensintaffar, F. Scott, R. Peach, J. Hager
2010BMC Cancer20 citations Open access
Semantic Scholar
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors
J. C. Tarr, James M. Salovich, M. Aichinger, K. Jeon +23 more
2024Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo Efficacy
Joachim Bröker, A. Waterson, Timothy R. Hodges, Jason R. Abbott +21 more
2025Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Structure of a Myeloid cell leukemia-1 (Mcl-1) inhibitor bound to drug site 3 of human serum albumin
Bin Zhao, J. Sensintaffar, Zhiguo Bian, J. Belmar +3 more
2017Bioorganic & Medicinal Chemistry16 citations Open access
Semantic Scholar
Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PLpro)
Ashley J Taylor, K. Amporndanai, T. Rietz, Bin Zhao +9 more
2024ACS Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Structure-Based Discovery of Potent Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors
Kevin B Teuscher, Jonathan J. Mills, Jianhua Tian, Chang-Ho Han +13 more
2023Journal of Medicinal Chemistry9 citations Open access
Semantic Scholar
Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2)
Krzysztof M Zak, A. Waterson, L. Geist, Nina Braun +15 more
2025Journal of Medicinal Chemistry6 citations Open access
Semantic Scholar
Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft.
S. Govek, C. Bonnefous, Jackaline D. Julien, J. Nagasawa +16 more
2019Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
BIIB021 is a small molecule inhibitor of the heat shock protein, Hsp90, that shows potent anti-tumor activity in preclinical models
K. Lundgren, Hong Zhang, A. Kamal, R. Lough +10 more
20074 citations
Semantic Scholar
Discovery of Fragment-Based Inhibitors of SARS-CoV‑2 PLPro
Qiangqiang Wei, Ashley J Taylor, M. Barmade, Kevin B Teuscher +16 more
2026Journal of Medicinal Chemistry3 citations Open access
Semantic Scholar
Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors that Demonstrate Potent Cellular Efficacy and In Vivo Activity in a Mouse Solid Tumor Xenograft Model
J. C. Tarr, K. Jeon, Nagarathanam Veerasamy, M. Aichinger +20 more
2025Journal of Medicinal Chemistry3 citations Open access
Semantic Scholar
Discovery of Spiro[chromane-2,4′-piperidine] Derivatives as Irreversible Inhibitors of SARS-CoV‑2 Papain-like Protease
Qiangqiang Wei, Ashley J Taylor, Nagaraju Miriyala, M. Barmade +13 more
2026Journal of Medicinal Chemistry2 citations
Semantic Scholar
Identification of KLHL12 Ligands Using Fragment-Based Methods
A. Waterson, A. Vadukoot, Somnath Jana, Jianwen Cui +23 more
2026Journal of Medicinal Chemistry2 citations Open access
Semantic Scholar
Identification of ligands for E3 ligases with restricted expression using fragment-based methods
A. Waterson, B. D. Lehmann, Zhenwei Lu, J. Sensintaffar +6 more
2025RSC Chemical Biology2 citations Open access
Semantic Scholar
Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer
J. Joseph, B. Darimont, Wei Zhou, Alfonso Arrazate +42 more
2019eLife2 citations Open access
Semantic Scholar
BAX-BAK heterodimer as a pharmacodynamic biomarker of on-target drug action of Mcl-1 inhibitors to evaluate in-vivo effectiveness.
A. Srivastava, J. Govindharajulu, M. Hollingshead, William J. Moore +9 more
20182 citations
Semantic Scholar
A high-affinity conformation of Hsp90 confers tumor selectivity on Hsp90 inhibitors
A. Kamal, J. Sensintaffar, P. Karjian, Lin Zhang +3 more
20042 citations
Semantic Scholar
Epithelial ovarian cancer cells constitutively produce interleukin-6 (IL6)
J. M. Watson, J. Sensintaffar, R. Knox, F. Takatsuki +2 more
19902 citations
Semantic Scholar
Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927
M. Kahraman, S. Govek, J. Nagasawa, Andiliy G. Lai +37 more
2018Cancer Chemistry1 citations
Semantic Scholar
Abstract 3727: Small molecule Mcl-1 inhibitors induce apoptosis and death in multiple cancer subtypesin vitro
J. Sensintaffar, Allison L. Arnold, Craig M. Goodwin, L. Hogdal +5 more
20161 citations
Semantic Scholar
Abstract 4757: A novel class of selective estrogen receptors degraders regresses tumors in pre-clinical models of endocrine-resistant breast cancer
J. Joseph, B. Darimont, S. Govek, D. Brigham +13 more
20141 citations
Semantic Scholar
Author ' s response to reviews Title : XIAP is not required for Human Tumor Cell Survival in the Absence of an Exogenous Death Signal
J. Hager, J. Sensintaffar, F. Scott, R. Peach
20091 citations
Semantic Scholar
The Synthetic Hest Shock Protein (Hsp) 90 Inhibitor EC141 Induces Degradation of the Bcr-Abl p190 Protein and Apoptosis of Philadelphia Chromosome (Ph)-Positive Acute Lymphoblastic Leukemia (ALL) Cells.
A. Ferrajoli, Yong-Tao Wang, S. O'Brien, S. Faderl +10 more
20071 citations
Semantic Scholar
CNF2024 - The first clinical stage synthetic oral Hsp90 inhibitor
K. Lundgren, A. Kamal, R. Lough, Noelito Timple +8 more
20061 citations
Semantic Scholar
Abstract 3987: Predicting MCL1 inhibitor sensitivity in large cell line panels using a gene expression signature
A. Wernitznig, D. Rudolph, Matthias Samwer, N. Schweifer +9 more
2019Clinical research0 citations
Semantic Scholar
Abstract 4331: Discovery of potent 2-Indole-acylsulfonamide Mcl-1 inhibitors using structure guided fragment-based methods
Subrata Shaw, J. C. Tarr, Nicholas Pelz, Zhiguo Bian +9 more
20160 citations
Semantic Scholar
Abstract 3726: Predicting cellular response to small molecule Mcl-1 antagonists
L. Hogdal, J. Sensintaffar, Allison L. Arnold, Craig M. Goodwin +6 more
20160 citations
Semantic Scholar
Abstract 3551: Discovery of orally bioavailable novel Mcl-1 inhibitors that exhibit selective anti-proliferative activity in Mcl-1 sensitive cancer cell lines
Taekyu Lee, Zhiguo Bian, J. Belmar, Subrata Shaw +11 more
20160 citations
Semantic Scholar
Abstract 1864: Selective estrogen receptor degrader (SERD) activity in ESR1 mutant models
Wei Zhou, R. Blake, J. Nonomiya, J. Qian +15 more
20150 citations
Semantic Scholar
Abstract 5053: Discovery of GDC-0810 a novel, non-steroidal selective estrogen receptor degrader with robust activity in pre-clinical models of endocrine-resistant breast cancer
J. Joseph, S. Govek, B. Darimont, D. Brigham +20 more
20150 citations
Semantic Scholar

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