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S. Govek · SciRah

Researcher profile · Semantic Scholar

S. Govek

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S. Govek — researcher profile on SciRah

h-index: 9
Works: 28
Citations: 747

Most-cited papers

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.
Andiliy G. Lai, M. Kahraman, S. Govek, J. Nagasawa +20 more
2015Journal of Medicinal Chemistry227 citations Open access
Semantic Scholar
Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers
T. Hamill, Stephen Krause, Christine Ryan, C. Bonnefous +16 more
2005Synapse137 citations
Semantic Scholar
The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer
J. Joseph, B. Darimont, Wei Zhou, Alfonso Arrazate +42 more
2016eLife96 citations Open access
Semantic Scholar
Total synthesis of asperazine.
S. Govek, L. Overman
2001Journal of the American Chemical Society71 citations Open access
Semantic Scholar
Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927.
M. Kahraman, S. Govek, J. Nagasawa, Andiliy G. Lai +17 more
2018ACS Medicinal Chemistry Letters66 citations Open access
Semantic Scholar
Optimization of an indazole series of selective estrogen receptor degraders: Tumor regression in a tamoxifen-resistant breast cancer xenograft.
S. Govek, J. Nagasawa, K. Douglas, Andiliy G. Lai +15 more
2015Bioorganic & Medicinal Chemistry Letters41 citations
Semantic Scholar
Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia.
S. Govek, C. Bonnefous, J. Hutchinson, Theodore M. Kamenecka +12 more
2005Bioorganic & Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer.
J. Nagasawa, S. Govek, M. Kahraman, Andiliy G. Lai +18 more
2018Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Water-soluble PDE4 inhibitors for the treatment of dry eye.
S. Govek, Guy Oshiro, J. Anzola, C. Beauregard +13 more
2010Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft.
S. Govek, C. Bonnefous, Jackaline D. Julien, J. Nagasawa +16 more
2019Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
Dipyridyl amines: potent metabotropic glutamate subtype 5 receptor antagonists.
Theodore M. Kamenecka, C. Bonnefous, S. Govek, J. Vernier +4 more
2005Bioorganic & Medicinal Chemistry Letters5 citations
Semantic Scholar
Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer
J. Joseph, B. Darimont, Wei Zhou, Alfonso Arrazate +42 more
2019eLife2 citations Open access
Semantic Scholar
Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927
M. Kahraman, S. Govek, J. Nagasawa, Andiliy G. Lai +37 more
2018Cancer Chemistry1 citations
Semantic Scholar
M480, a novel non-bile acid FXR agonist, shows improvement across multiple parameters in a diet-induced obese mouse model with biopsy-confirmed NASH
B. Wagner, D. Brigham, Kyoung-jin Lee, A. Ortiz +10 more
20171 citations
Semantic Scholar
Abstract 4757: A novel class of selective estrogen receptors degraders regresses tumors in pre-clinical models of endocrine-resistant breast cancer
J. Joseph, B. Darimont, S. Govek, D. Brigham +13 more
20141 citations
Semantic Scholar
Catalytic Asymmetric Synthesis of Quaternary Carbon Centers. Exploratory Studies of Intramolecular Heck Reactions of (Z)‐α,β‐Unsaturated Anilides and Mechanistic Investigations of Asymmetric Heck Reactions Proceeding via Neutral Intermediates.
A. Ashimori, B. Bachand, M. Calter, S. Govek +2 more
19981 citations
Semantic Scholar
P153 MET642, AN ORAL FXR AGONIST, IMPROVES COLITIS INDUCED BY ADOPTIVE T-CELL TRANSFER
Xueqing Liu, R. O'Connell, A. Bendele, Melissa Walker +14 more
2020Gastroenterology0 citations
Semantic Scholar
767 ACTIVATION OF FXR SUPPRESSES TNFA AND IL-6 SIGNALING PATHWAYS AND IMPROVES COLITIS IN TWO CHRONIC MOUSE MODELS OF IBD
Xueqing Liu, R. O'Connell, A. Bendele, Melissa Walker +16 more
20200 citations
Semantic Scholar
Sa1737 – Fxr Agonist M480, Exhibits Efficacy in Multiple Models of Inflammatory Bowel Disease (IBD) by Increasing Expression of Anti-Microbial Genes and Reducing Inflammatory Cytokine Expression in the Gut
Xueqing Liu, H. Dedman, R. O'Connell, A. Bendele +14 more
2019Gastroenterology0 citations
Semantic Scholar
Sa1747 – Fxr Agonists with Sustained Activity Exhibit Efficacy Comparable to Anti-Il-12P40 in Treating Colitis Induced by Adoptive T-Cell Transfer
Xueqing Liu, H. Dedman, R. O'Connell, A. Bendele +13 more
2019Gastroenterology0 citations Open access
Semantic Scholar
1051 - M480, an Oral Fxr Agonist, is Superior to Cyclosporine a and Equally Efficacious as Anti-Il-12/23 in the Adoptive Transfer Model of IBD Colitis
Xueqing Liu, H. Dedman, R. O'Connell, A. Bendele +12 more
20180 citations
Semantic Scholar
Abstract 5053: Discovery of GDC-0810 a novel, non-steroidal selective estrogen receptor degrader with robust activity in pre-clinical models of endocrine-resistant breast cancer
J. Joseph, S. Govek, B. Darimont, D. Brigham +20 more
20150 citations
Semantic Scholar
Abstract A37: A novel class of selective estrogen receptor degraders display activity in pre-clinical models of ERα+ ovarian cancer
J. Joseph, B. Darimont, S. Govek, D. Brigham +15 more
20130 citations
Semantic Scholar
Abstract P6-04-12: Novel selective estrogen receptors degraders regress tumors in pre-clinical models of endocrine-resistant breast cancer
J. Hager, B. Darimont, J. David, S. Govek +16 more
20120 citations
Semantic Scholar
Abstract A4: A novel class of selective ERα degraders acts as full antagonists/ inverse agonists and displays efficacy in pre-clinical models of endocrine-resistant breast cancer and endometrial cancer
B. Darimont, N. Lu, J. Sensintaffar, Kyoung-jin Lee +15 more
2012Clinical Cancer Research0 citations
Semantic Scholar
Estrogen receptor modulators and its applications
メフメトカフラマン, Kahraman Mehmet, ゴベク，スティーブン，ピー．, S. Govek +4 more
20110 citations
Semantic Scholar
Abstract A7: A novel class of selective estrogen receptors degraders regresses tumors in pre-clinical models of endocrine-resistant breast cancer
B. Darimont, S. Govek, Nihn Lu, J. Nagasawa +16 more
2011Clinical Cancer Research0 citations
Semantic Scholar
Synthesis of (+)-Asperazine
S. Govek, L. Overman
20070 citations
Semantic Scholar

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