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S. Kasibhatla · SciRah

Researcher profile · Semantic Scholar

S. Kasibhatla

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S. Kasibhatla — researcher profile on SciRah

h-index: 12
Works: 28
Citations: 1,028

Most-cited papers

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
K. Lundgren, Hong Zhang, John Brekken, N. Huser +14 more
2009Molecular Cancer Therapeutics170 citations Open access
Semantic Scholar
Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase.
Q. Dang, Yan Liu, Daniel K. Cashion, S. Kasibhatla +14 more
2011Journal of Medicinal Chemistry146 citations Open access
Semantic Scholar
MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes
M. Erion, P. Vanpoelje, Q. Dang, S. Kasibhatla +5 more
2005Proceedings of the National Academy of Sciences of the United States of America146 citations Open access
Semantic Scholar
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
S. Kasibhatla, Kevin Hong, M. Biamonte, David J. Busch +14 more
2007Journal of Medicinal Chemistry113 citations Open access
Semantic Scholar
7'-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors.
Lin Zhang, Jun-Hua Fan, Khang X. Vu, Kevin Hong +16 more
2006Journal of Medicinal Chemistry107 citations Open access
Semantic Scholar
Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes.
Q. Dang, S. Kasibhatla, K. Reddy, Tao Jiang +7 more
2007Journal of the American Chemical Society86 citations
Semantic Scholar
EC144 is a potent inhibitor of the heat shock protein 90.
Jiandong Shi, R. W. Van de Water, Kevin Hong, Ryan Lamer +25 more
2012Journal of Medicinal Chemistry66 citations Open access
Semantic Scholar
Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors.
C. Dickey, J. Eriksen, A. Kamal, F. Burrows +4 more
2005Current Alzheimer Research65 citations
Semantic Scholar
AMP deaminase inhibitors. 5. Design, synthesis, and SAR of a highly potent inhibitor series.
S. Kasibhatla, B. C. Bookser, Wei Xiao, M. Erion
2001Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Orally active purine-based inhibitors of the heat shock protein 90.
M. Biamonte, Jiandong Shi, Kevin Hong, David Hurst +14 more
2006Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
DISCOVERY OF AMP MIMETICS THAT EXHIBIT HIGH INHIBITORY POTENCY AND SPECIFICITY FOR AMP DEAMINASE
M. Erion, S. Kasibhatla, B. C. Bookser, P. Vanpoelje +3 more
199925 citations
Semantic Scholar
AMP deaminase inhibitors. 3. SAR of 3-(carboxyarylalkyl)coformycin aglycon analogues.
S. Kasibhatla, B. C. Bookser, G. Probst, J. Appleman +1 more
2000Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Abstract LB-118: SR8541A is a potent inhibitor of ENPP1 and exhibits dendritic cell mediated antitumor activity
A. Weston, Trason Thode, Ryan Rodriguez del Villar, Srikanta Dana +3 more
2020Bioinformatics, Convergence Science, and Systems Biology9 citations
Semantic Scholar
Abstract LB323: Inhibition of ENPP1 using small molecule, SR-8541A, enhances the effect of checkpoint inhibition in cancer models
A. Weston, Trason Thode, Serina Ng, Tithi Ghosh-Halder +8 more
2023Cancer Research6 citations
Semantic Scholar
Preparation of 8-(arylsulfanyl)adenines with diazonium salts under mild, aerobic conditions.
M. Biamonte, Jiandong Shi, David Hurst, Kevin Hong +2 more
2005Journal of Organic Chemistry6 citations Open access
Semantic Scholar
Enhancing the Oral Bioavailability of a Poorly Soluble Pan-CK2 Kinase Inhibitor: Leveraging a Phosphate Prodrug Strategy to Overcome Dissolution-Limited Absorption and Improve Systemic Exposure during Dose Escalation.
Murugaiah A. M. Subbaiah, Naveen Manjunath, Thangeswaran Ramar, Mathiazhagan Annadurai +14 more
2026Journal of Medicinal Chemistry4 citations
Semantic Scholar
BIIB021 is a small molecule inhibitor of the heat shock protein, Hsp90, that shows potent anti-tumor activity in preclinical models
K. Lundgren, Hong Zhang, A. Kamal, R. Lough +10 more
20074 citations
Semantic Scholar
CNF2024 - The first clinical stage synthetic oral Hsp90 inhibitor
K. Lundgren, A. Kamal, R. Lough, Noelito Timple +8 more
20061 citations
Semantic Scholar
AMP Deaminase Inhibitors. Part 4. Further N3‐Substituted Coformycin Aglycon Analogues: N3‐Alkylmalonates as Ribose 5′‐Monophosphate Mimetics.
B. C. Bookser, S. Kasibhatla, M. Erion
20001 citations
Semantic Scholar
Drug Delivery Strategy Exploiting Amino Acid Prodrugs: Improving Oral Bioavailability and Overcoming Nonlinear Pharmacokinetic Challenges Following Dose Escalation of a CK2 Inhibitor with Poor Solubility.
Murugaiah A. M. Subbaiah, Thangeswaran Ramar, Mathiazhagan Annadurai, Arunachalam Arumugam +15 more
2026Journal of Medicinal Chemistry0 citations
Semantic Scholar
Abstract 3931: TGN-1062 inhibits CDK7 and augments the effects of gemcitabine and nab-paclitaxel in pancreatic cancer models
A. Weston, Trason Thode, Ryan Rodriguez del Villar, Serina Ng +13 more
2022Cancer Research0 citations
Semantic Scholar
Abstract 3948: Development of bone-targeted Ron inhibitors to treat osseous metastases from breast cancers
Trason Thode, Jaime Fornetti, Ryan Rodriguez del Villar, A. Weston +8 more
2022Cancer Research0 citations
Semantic Scholar
Abstract 1254: Preclinical studies with TGN-1062, a selective and reversible small molecule inhibitor of CDK7
Ryan Rodriguez del Villar, Trason Thode, A. Weston, Serina Ng +7 more
2021Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Synthesis of MB06322
Q. Dang, S. Kasibhatla, K. Reddy, Tao Jiang +7 more
20080 citations
Semantic Scholar
AMP Deaminase Inhibitors. Part 5. Design, Synthesis, and SAR of a Highly Potent Inhibitor Series (I) and (II).
S. Kasibhatla, B. C. Bookser, Wei Xiao, M. Erion
20010 citations
Semantic Scholar
Promedicaments a base de bisamidate phosphonate
Tao Jiang, S. Kasibhatla, K. Reddy
20000 citations
Semantic Scholar
AMP Deaminase Inhibitors. Part 3. SAR of 3-(Carboxyarylalkyl)coformycin Aglycon Analogues.
S. Kasibhatla, B. C. Bookser, G. Probst, J. Appleman +1 more
20000 citations
Semantic Scholar
AMP Deaminase Inhibitors. Part 2. Initial Discovery of a Non‐Nucleotide Transition‐State Inhibitor Series.
B. C. Bookser, S. Kasibhatla, J. Appleman, M. Erion
20000 citations
Semantic Scholar

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