Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

J. Huck · SciRah

Researcher profile · Semantic Scholar

J. Huck

Share profile

J. Huck — researcher profile on SciRah

h-index: 3
Works: 9
Citations: 395

Most-cited papers

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
M. Hyer, M. Milhollen, J. Ciavarri, P. Fleming +35 more
2018Nature Medicine380 citations
Semantic Scholar
577 Characterization of the cellular mechanism of action of the first in class investigational inhibitor of the Ubiquitin Activating Enzyme, MLN7243
M. Milhollen, D. Sappal, J. Duffy, K. Hoar +6 more
20149 citations
Semantic Scholar
255 Pre-clinical in vivo characterization of MLN7243, an investigational ubiquitin activating enzyme inhibitor, in solid tumor models
T. Traore, J. Huck, J.-S. Shi, D. Sappal +13 more
20144 citations
Semantic Scholar
Abstract A164: The small molecule UAE inhibitor TAK-243 (MLN7243) prevents DNA damage repair and reduces cell viability/tumor growth when combined with radiation, carboplatin and docetaxel
M. Milhollen, Junfeng Shi, T. Traore, J. Huck +8 more
20152 citations
Semantic Scholar
561 Nonclinical characterization of the first in class investigational ubiquitin activating enzyme inhibitor MLN7243 in cellular and in vivo models of cancer in support of a phase I study
M. Milhollen, M. Hyer, J. Ciavarri, T. Traore +16 more
20141 citations
Semantic Scholar
231 Clinical pharmacodynamic assay development for the first in class investigational ubiquitin activating enzyme (UAE) inhibitor MLN7243
B. Bahamon, F. Gao, B. Stringer, Yu Yang +10 more
20141 citations
Semantic Scholar
Abstract 3719: TAK-243, a small molecule inhibitor of the ubiquitin activating enzyme (UAE), disrupts DNA damage repair and sensitizes tumor cells and xenografts to ionizing radiation
M. Milhollen, J. Shi, T. Traore, J. Huck +11 more
20160 citations
Semantic Scholar
Abstract C82: Identification and preclinical characterization of inhibitors of the ubiquitin-activating enzymes UBA1 and UBA6.
N. Bence, E. FlemingPaul, J. Ciavarri, M. Milhollen +15 more
20110 citations
Semantic Scholar
Antitumor activity of ubiquitin activating enzyme (UBA1) inhibitors and use of ubiquitin conjugates as pharmacodynamic biomarkers in human tumor xenografts
J. Huck, Li-Qiang Tou, T. Traore, Yu Yang +8 more
20110 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

T. Traore×8
Invite
T. Traore — researcher profile on SciRah
J. Ciavarri×7
Invite
J. Ciavarri — researcher profile on SciRah
D. Sappal×7
Invite
D. Sappal — researcher profile on SciRah
Neil F. Bence×7
Invite
Neil F. Bence — researcher profile on SciRah

×6

Invite

M. Hyer — researcher profile on SciRah

M. Milhollen×6

Invite

M. Milhollen — researcher profile on SciRah

Invite

P. Fleming — researcher profile on SciRah

Invite

Yu Yang — researcher profile on SciRah

Invite

J. Duffy — researcher profile on SciRah

Invite

Y. Ishii — researcher profile on SciRah

Invite

B. Stringer — researcher profile on SciRah

Invite

J. Shi — researcher profile on SciRah