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S. Meloche · SciRah

Researcher profile · Semantic Scholar

S. Meloche

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S. Meloche — researcher profile on SciRah

h-index: 62
Works: 180
Citations: 14K

Most-cited papers

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition
S. Meloche, J. Pouysségur
2007Oncogene1,157 citations
Semantic Scholar
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
T. Kunath, Marc K. Saba-El-Leil, Marwa Almousailleakh, Jason Wray +2 more
2007Development843 citations Open access
Semantic Scholar
Atypical mitogen-activated protein kinases: structure, regulation and functions.
P. Coulombe, S. Meloche
2007Biochimica et Biophysica Acta315 citations Open access
Semantic Scholar
Extracellular Signal-Regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth
I. Kehat, Jennifer Davis, M. Tiburcy, F. Accornero +7 more
2011Circulation Research267 citations Open access
Semantic Scholar
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo
N. Purcell, B. Wilkins, Allen J. York, Marc K. Saba-El-Leil +3 more
2007Proceedings of the National Academy of Sciences of the United States of America261 citations Open access
Semantic Scholar
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
C. Frémin, S. Meloche
2010Journal of Hematology & Oncology259 citations Open access
Semantic Scholar
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
D. Ceccarelli, Xiaojing Tang, Benoit Pelletier, S. Orlicky +21 more
2011Cell235 citations Open access
Semantic Scholar
The IKK-related kinases: from innate immunity to oncogenesis
J. Clément, S. Meloche, M. Servant
2008Cell Research209 citations
Semantic Scholar
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
L. Aubert, N. Nandagopal, Z. Steinhart, G. Lavoie +14 more
2020Nature Communications201 citations Open access
Semantic Scholar
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.
X. Deschênes-Simard, Marie-France Gaumont-Leclerc, V. Bourdeau, Frédéric Lessard +9 more
2013Genes & Development191 citations Open access
Semantic Scholar
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias
Vincent-Philippe Lavallée, I. Baccelli, J. Krosl, B. Wilhelm +8 more
2015Nature Genetics172 citations
Semantic Scholar
Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases.
Benjamin Turgeon, S. Meloche
2009Physiological Reviews171 citations
Semantic Scholar
A Novel Proteomics Approach to Identify SUMOylated Proteins and Their Modification Sites in Human Cells*
F. Galisson, Louiza Mahrouche, M. Courcelles, É. Bonneil +3 more
2010Molecular & Cellular Proteomics158 citations Open access
Semantic Scholar
ER stress affects processing of MHC class I-associated peptides
D. Granados, Pierre‐Luc Tanguay, Marie-Pierre Hardy, E. Caron +3 more
2009BMC Immunology148 citations Open access
Semantic Scholar
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APCCdh1 in G1 phase
G. Rodier, P. Coulombe, Pierre‐Luc Tanguay, Christel Boutonnet +1 more
2008EMBO Journal112 citations Open access
Semantic Scholar
The eIF4E RNA regulon promotes the Akt signaling pathway
B. Čuljković, Keith Tan, S. Orolicki, Abdellatif Amri +2 more
2008Journal of Cell Biology102 citations Open access
Semantic Scholar
Phosphorylation of IRF-3 on Ser 339 Generates a Hyperactive Form of IRF-3 through Regulation of Dimerization and CBP Association
J. Clément, A. Bibeau-Poirier, Simon-Pierre Gravel, N. Grandvaux +4 more
2008Journal of Virology101 citations Open access
Semantic Scholar
Genetic Demonstration of a Redundant Role of Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Mitogen-Activated Protein Kinases in Promoting Fibroblast Proliferation
Laure Voisin, Marc K. Saba-El-Leil, Catherine Julien, C. Frémin +1 more
2010Molecular and Cellular Biology96 citations Open access
Semantic Scholar
Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development.
C. Frémin, Marc K. Saba-El-Leil, Lévesque Kim, S. Ang +1 more
2015Cell Reports94 citations Open access
Semantic Scholar
Activation Loop Phosphorylation of ERK3/ERK4 by Group I p21-activated Kinases (PAKs) Defines a Novel PAK-ERK3/4-MAPK-activated Protein Kinase 5 Signaling Pathway*
P. Déléris, M. Trost, I. Topisirovic, Pierre‐Luc Tanguay +3 more
2010Journal of Biological Chemistry83 citations Open access
Semantic Scholar
Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5
P. Déléris, J. Rousseau, P. Coulombe, G. Rodier +2 more
2008Journal of Cellular Physiology83 citations
Semantic Scholar
Regulation of MAPK-activated Protein Kinase 5 Activity and Subcellular Localization by the Atypical MAPK ERK4/MAPK4*
Espen Åberg, Maria Perander, B. Johansen, Catherine Julien +3 more
2006Journal of Biological Chemistry83 citations Open access
Semantic Scholar
Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality
Sonia Klinger, Benjamin Turgeon, Lévesque Kim, G. Wood +2 more
2009Proceedings of the National Academy of Sciences of the United States of America82 citations Open access
Semantic Scholar
Involvement of the IκB Kinase (IKK)-Related Kinases Tank-Binding Kinase 1/IKKi and Cullin-Based Ubiquitin Ligases in IFN Regulatory Factor-3 Degradation1
A. Bibeau-Poirier, Simon-Pierre Gravel, J. Clément, Sébastien Rolland +6 more
2006Journal of Immunology79 citations
Semantic Scholar
Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.
Vincent-Philippe Lavallée, J. Krosl, S. Lemieux, G. Boucher +8 more
2016Blood78 citations Open access
Semantic Scholar
The Extracellular Signal-Regulated Kinase 3 (Mitogen-Activated Protein Kinase 6 [MAPK6])–MAPK-Activated Protein Kinase 5 Signaling Complex Regulates Septin Function and Dendrite Morphology
Frank Brand, S. Schumacher, S. Kant, Manoj B. Menon +6 more
2012Molecular and Cellular Biology70 citations Open access
Semantic Scholar
Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.
Jin-Yong Wang, Guangyao Kong, Yangang Liu, Juan Du +9 more
2013Blood67 citations Open access
Semantic Scholar
E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.
J. Chagraoui, S. Niessen, J. Lessard, S. Girard +4 more
2006Genes & Development65 citations Open access
Semantic Scholar
EN2 is a candidate oncogene in human breast cancer
Nicole L Martin, Marc K. Saba-El-Leil, S. Sadekova, S. Meloche +1 more
2005Oncogene65 citations Open access
Semantic Scholar
Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors
Laure Voisin, Catherine Julien, S. Duhamel, K. Gopalbhai +7 more
2008BMC Cancer64 citations Open access
Semantic Scholar
RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth
Y. Romeo, J. Moreau, P. Zindy, Marc K. Saba-El-Leil +6 more
2012Oncogene63 citations Open access
Semantic Scholar
Involvement of the IκB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation
A. Bibeau-Poirier, Simon-Pierre Gravel, J. Clément, S. Rolland +6 more
2006Journal of Immunology63 citations Open access
Semantic Scholar
Proteomic Profiling of the TRAF3 Interactome Network Reveals a New Role for the ER-to-Golgi Transport Compartments in Innate Immunity
Wendy J. van Zuylen, Priscilla Doyon, J. Clément, K. Khan +8 more
2012PLoS Pathogens58 citations Open access
Semantic Scholar
Liver fibrosis protects mice from acute hepatocellular injury.
Éric Bourbonnais, V. Raymond, C. Éthier, B. Nguyen +3 more
2012Gastroenterology54 citations Open access
Semantic Scholar
Redundancy in the World of MAP Kinases: All for One
Marc K. Saba-El-Leil, C. Frémin, S. Meloche
2016Front. Cell Dev. Biol.52 citations Open access
Semantic Scholar
p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2
G. Rodier, C. Makris, P. Coulombe, A. Scimè +3 more
2005Journal of Cell Biology47 citations Open access
Semantic Scholar
Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.
S. Duhamel, J. Hébert, L. Gaboury, A. Bouchard +4 more
2012Cancer Research46 citations Open access
Semantic Scholar
Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential
Simon Mathien, Chloé Tesnière, S. Meloche
2021Pharmacological Reviews44 citations Open access
Semantic Scholar
Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells.
S. Cellot, J. Krosl, J. Chagraoui, S. Meloche +2 more
2007Experimental Hematology44 citations Open access
Semantic Scholar
C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis.
Pierre‐Luc Tanguay, G. Rodier, S. Meloche
2010Biochemical Journal38 citations
Semantic Scholar
CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma
Thibault Houles, G. Lavoie, Sami Nourreddine, Winnie Cheung +9 more
2022Nature Communications36 citations Open access
Semantic Scholar
UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.
Marie-Ève Bordeleau, Romain Aucagne, J. Chagraoui, S. Girard +11 more
2014Blood34 citations Open access
Semantic Scholar
Targeted Inactivation of Mapk4 in Mice Reveals Specific Nonredundant Functions of Erk3/Erk4 Subfamily Mitogen-Activated Protein Kinases
J. Rousseau, Sonia Klinger, A. Rachalski, Benjamin Turgeon +8 more
2010Molecular and Cellular Biology34 citations Open access
Semantic Scholar
ProteoConnections: A bioinformatics platform to facilitate proteome and phosphoproteome analyses
M. Courcelles, S. Lemieux, Laure Voisin, S. Meloche +1 more
2011Proteomics32 citations
Semantic Scholar
Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis
Charlotte Girondel, Lévesque Kim, M. Langlois, S. Pasquin +7 more
2020Oncogene29 citations
Semantic Scholar
The Non-Classical MAP Kinase ERK3 Controls T Cell Activation
Miriam Marquis, S. Boulet, Simon Mathien, J. Rousseau +7 more
2014PLoS ONE29 citations Open access
Semantic Scholar
Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity
Simon Mathien, P. Déléris, M. Soulez, Laure Voisin +1 more
2017Molecular and Cellular Biology27 citations Open access
Semantic Scholar
Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia.
M. Trost, Martin Sauvageau, O. Hérault, P. Déléris +6 more
2012Blood27 citations Open access
Semantic Scholar
Artifactual Sulfation of Silver-stained Proteins
Marlène Gharib, M. Marcantonio, Sylvia G. Lehmann, M. Courcelles +3 more
2009Molecular & Cellular Proteomics25 citations Open access
Semantic Scholar
E4F1 is a master regulator of CHK1-mediated functions.
D. Grote, Céline Moison, S. Duhamel, J. Chagraoui +8 more
2015Cell Reports24 citations Open access
Semantic Scholar

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