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S. Orlicky · SciRah

Researcher profile · Semantic Scholar

S. Orlicky

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S. Orlicky — researcher profile on SciRah

h-index: 26
Works: 48
Citations: 4,187

Most-cited papers

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
Piers Nash, Xiaojing Tang, S. Orlicky, Qing-Hua Chen +5 more
2001Nature830 citations
Semantic Scholar
Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.
S. Orlicky, Xiaojing Tang, A. Willems, M. Tyers +1 more
2003Cell524 citations Open access
Semantic Scholar
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor
T. Mittag, S. Orlicky, W. Choy, Xiaojing Tang +5 more
2008Proceedings of the National Academy of Sciences of the United States of America343 citations Open access
Semantic Scholar
Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase
T. Mittag, J. Marsh, A. Grishaev, S. Orlicky +4 more
2010Structure271 citations Open access
Semantic Scholar
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
D. Ceccarelli, Xiaojing Tang, Benoit Pelletier, S. Orlicky +21 more
2011Cell235 citations Open access
Semantic Scholar
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.
Xiaojing Tang, S. Orlicky, Zhenyuan Lin, A. Willems +6 more
2007Cell217 citations Open access
Semantic Scholar
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function
Juang Yu-Chi, Marie-Claude Landry, M. Sanches, Vinayak Vittal +12 more
2012Molecules and Cells205 citations Open access
Semantic Scholar
Molecular Characterization of a Toluene-Degrading Methanogenic Consortium
Monica Ficker, K. Krastel, S. Orlicky, E. Edwards
1999Applied and Environmental Microbiology156 citations Open access
Semantic Scholar
An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase
S. Orlicky, Xiaojing Tang, Victor Neduva, Nadine H. Elowe +3 more
2010Nature Biotechnology151 citations Open access
Semantic Scholar
Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon induced antiviral activity
Hao Huang, E. Zeqiraj, Bei-Hua Dong, B. Jha +16 more
2014Molecules and Cells136 citations Open access
Semantic Scholar
Transcription Elongation through DNA Arrest Sites
D. Awrey, R. Weilbaecher, Sally A. Hemming, S. Orlicky +2 more
1997Journal of Biological Chemistry121 citations Open access
Semantic Scholar
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine
Daniel Y. L. Mao, D. Neculai, Michael S. Downey, S. Orlicky +13 more
2008Molecules and Cells113 citations Open access
Semantic Scholar
Functional characterization of a PROTAC directed against BRAF mutant V600E
G. Posternak, Xiaojing Tang, P. Maisonneuve, T. Jin +27 more
2020Nature Chemical Biology101 citations Open access
Semantic Scholar
Dissociable Rpb4-Rpb7 Subassembly of RNA Polymerase II Binds to Single-strand Nucleic Acid and Mediates a Post-recruitment Step in Transcription Initiation*
S. Orlicky, P. Tran, M. H. Sayre, A. Edwards
2001Journal of Biological Chemistry92 citations Open access
Semantic Scholar
E2 enzyme inhibition by stabilization of a low affinity interface with ubiquitin
Hao Huang, D. Ceccarelli, S. Orlicky, D. St-Cyr +9 more
2013Nature Chemical Biology87 citations Open access
Semantic Scholar
Discovery of an orally bioavailable and selective PKMYT1 inhibitor RP-6306
Janek Szychowski, R. Papp, Evelyne Dietrich, Bing-Can Liu +27 more
2022Journal of Medicinal Chemistry73 citations Open access
Semantic Scholar
Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1–F-box interface
Maryna Gorelik, S. Orlicky, M. A. Sartori, Xiaojing Tang +7 more
2016Proceedings of the National Academy of Sciences of the United States of America69 citations Open access
Semantic Scholar
Higher -Order Assembly of BRCC36–KIAA0157 Is Required for DUB Activity and Biological Function
E. Zeqiraj, L. Tian, Christopher A Piggott, M. Pillon +11 more
2015Molecules and Cells66 citations Open access
Semantic Scholar
Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase
Xiaojing Tang, S. Orlicky, T. Mittag, V. Csizmok +4 more
2012Proceedings of the National Academy of Sciences of the United States of America64 citations Open access
Semantic Scholar
Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry
N. Tavernier, Y. Thomas, S. Vigneron, P. Maisonneuve +15 more
2021Nature Communications41 citations Open access
Semantic Scholar
A substrate binding model for the KEOPS tRNA modifying complex
J. Beenstock, S. M. Oña, Jennifer Porat, S. Orlicky +13 more
2020Nature Communications37 citations Open access
Semantic Scholar
An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase
V. Csizmok, S. Orlicky, Jing Cheng, Jian-Hui Song +8 more
2017Nature Communications37 citations Open access
Semantic Scholar
Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases.
Xiaojing Tang, S. Orlicky, Qing-Quan Liu, A. Willems +2 more
2005Methods in Enzymology36 citations
Semantic Scholar
Use of limited proteolysis to identify protein domains suitable for structural analysis.
C. Koth, S. Orlicky, Stephanie M. Larson, A. Edwards
2003Methods in Enzymology32 citations
Semantic Scholar
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme–ubiquitin complex
Daniel J. St-Cyr, D. Ceccarelli, S. Orlicky, A. M. van der Sloot +10 more
2021Science Advances29 citations Open access
Semantic Scholar
Interaction of substance P and its N‐ and C‐terminal fragments with Ca2+: Implications for hormone action
Vettai S. Ananthanarayanan, S. Orlicky
1992Biopolymers28 citations
Semantic Scholar
FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation
P. Barbulescu, C. K. Chana, Matthew K Wong, I. Benmakhlouf +18 more
2024Nature Communications20 citations Open access
Semantic Scholar
SCFCdc4 Enables Mating Type Switching in Yeast by Cyclin-Dependent Kinase-Mediated Elimination of the Ash1 Transcriptional Repressor
Qing-Quan Liu, B. Larsen, Markéta Řičicová, S. Orlicky +8 more
2010Molecular and Cellular Biology18 citations Open access
Semantic Scholar
SCFFBXW7 regulates G2‐M progression through control of CCNL1 ubiquitination
Siobhan O'Brien, S. Kelso, Z. Steinhart, S. Orlicky +5 more
2022EMBO Reports16 citations Open access
Semantic Scholar
Interactome and interface protocol (2IP): A novel strategy for high sensitivity topology mapping of protein complexes
R. Weerasekera, Yi-Min She, Kelly A. Markham, Yu Bai +5 more
2007Proteomics16 citations
Semantic Scholar
Bi-partite binding of the N-terminus of Skp2 to cyclin A
S. Kelso, S. Orlicky, J. Beenstock, D. Ceccarelli +3 more
2021Structure9 citations Open access
Semantic Scholar
Engineered antigen‐binding fragments for enhanced crystallization of antibody:antigen complexes
H. Bruce, A. Singer, E. Filippova, Levi L. Blazer +12 more
2023bioRxiv7 citations Open access
Semantic Scholar
Expression, purification, and in vitro characterization of the human outer mitochondrial membrane receptor human translocase of the outer mitochondrial membrane 20.
Enrico Schleiff, R. Khanna, S. Orlicky, A. Vrielink
1999Archives of Biochemistry and Biophysics4 citations
Semantic Scholar
A Novel Confocal Scanning Protein–Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin
Joanna Koszela, N. Phạm, S. Shave, Daniel J. St-Cyr +6 more
2024Bioconjugate chemistry3 citations Open access
Semantic Scholar
The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4
C. K. Chana, I. Benmakhlouf, Jaeyoun Kim, April J. Y. Yu +17 more
2026Nature Chemical Biology2 citations
Semantic Scholar
"Fuzzy" complexes: How much disorder can a biologically relevant complex tolerate, and can it even be beneficial?
T. Mittag, J. Marsh, S. Orlicky, M. Borg +6 more
20102 citations
Semantic Scholar
Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.
Monica Bubenik, P. Mader, S. Orlicky, A. Perryman +15 more
2026ACS Medicinal Chemistry Letters1 citations
Semantic Scholar
Author Correction: A substrate binding model for the KEOPS tRNA modifying complex
J. Beenstock, S. M. Oña, Jennifer Porat, S. Orlicky +13 more
2025Nature Communications0 citations Open access
Semantic Scholar
SCFFBXW7 regulates G2-M progression through control of CCNL1 ubiquitination
Siobhan O'Brien, S. Kelso, Z. Steinhart, S. Orlicky +5 more
2022bioRxiv0 citations Open access
Semantic Scholar
Article Watch: April 2021.
C. Slaughter, E. DeBettigniesBatistaDeCarvalhoLA, B. Alvarez, A. Belov +62 more
2021Journal of Biomolecular Techniques0 citations Open access
Semantic Scholar
Skp1-F-box in complex with a ubiquitin variant
S. Orlicky, F. Sicheri
20160 citations
Semantic Scholar
Cdc34-ubiquitin-CC0651 complex
D. Ceccarelli, S. Orlicky, M. Tyers, Frank Sicheri
20130 citations
Semantic Scholar
βTrCP and cancer – creating novel inhibitors of the SCF E3 ligases
Jean O'Donoghue, J. Walton, S. Orlicky, D. Houston +12 more
20110 citations
Semantic Scholar
The Role of Dynamic Protein Complexes in the Ubiquitin-Proteasome Pathway
T. Mittag, S. Orlicky, Xiaojing Tang, F. Sicheri +2 more
20110 citations Open access
Semantic Scholar
Assignment and structural characterization of intrinsically disordered CDK inhibitor phosphoSic1 from yeast
T. Mittag, W. Choy, J. Marsh, S. Orlicky +5 more
20100 citations
Semantic Scholar
Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2
S. Orlicky, F. Sicheri, M. Tyers, Xiaojing Tang
20100 citations
Semantic Scholar
D domain of b-TrCP
D. Neculai, S. Orlicky, D. Ceccarelli
20070 citations
Semantic Scholar
Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex
X. Tang, S. Orlicky, T. Mittag, V. Csizmok +4 more
20030 citations
Semantic Scholar

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