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V. Leshchenko · SciRah

Researcher profile · Semantic Scholar

V. Leshchenko

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V. Leshchenko — researcher profile on SciRah

h-index: 17
Works: 95
Citations: 1,294

Most-cited papers

Discovery of a first-in-class EZH2 selective degrader
Anqi Ma, E. Stratikopoulos, Kwang-Su Park, Jieli Wei +11 more
2019Nature Chemical Biology200 citations Open access
Semantic Scholar
HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL.
M. Kalac, L. Scotto, E. Marchi, J. Amengual +8 more
2011Blood157 citations Open access
Semantic Scholar
Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma.
V. Leshchenko, Pei-Yu Kuo, R. Shaknovich, David T. Yang +17 more
2010Blood150 citations Open access
Semantic Scholar
Mutation-Derived Neoantigen Specific T cell Responses in Multiple Myeloma
Deepak Perumal, Naoko Imai, A. Laganà, J. Finnigan +13 more
2019Clinical Cancer Research79 citations Open access
Semantic Scholar
Akt Inhibitors MK-2206 and Nelfinavir overcome mTOR inhibitor resistance in DLBCL
A. Petrich, V. Leshchenko, Pei-Yu Kuo, Bing Xia +7 more
2012Clinical Cancer Research65 citations Open access
Semantic Scholar
Patient similarity network of newly diagnosed multiple myeloma identifies patient subgroups with distinct genetic features and clinical implications
Sherry Bhalla, D. Melnekoff, Adolfo Aleman, V. Leshchenko +13 more
2020Science Advances63 citations Open access
Semantic Scholar
High resolution Chromatin Immunoprecipitation (ChIP) sequencing reveals novel bindings targets and prognostic role for SOX11 in Mantle cell lymphoma
Pei-Yu Kuo, V. Leshchenko, M. Fazzari, Deepak Perumal +19 more
2014Oncogene59 citations Open access
Semantic Scholar
Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma
A. Laganà, Deepak Perumal, D. Melnekoff, B. Readhead +14 more
2018Leukemia58 citations
Semantic Scholar
Epigenetic therapy overcomes treatment resistance in T-cell prolymphocytic leukemia
Z. Hasanali, B. Saroya, A. Stuart, S. Shimko +7 more
2015Science Translational Medicine50 citations Open access
Semantic Scholar
A phase 2 study of panobinostat with lenalidomide and weekly dexamethasone in myeloma.
A. Chari, H. Cho, Amishi Dhadwal, Gillian F. Morgan +15 more
2017Blood Advances44 citations Open access
Semantic Scholar
SOX11 augments BCR signaling to drive MCL-like tumor development.
Pei-Yu Kuo, Shashidhar S. Jatiani, A. Rahman, D. Edwards +8 more
2018Blood42 citations Open access
Semantic Scholar
Precision Medicine for Relapsed Multiple Myeloma on the Basis of an Integrative Multiomics Approach
A. Laganà, I. Beno, D. Melnekoff, V. Leshchenko +15 more
2018JCO Precision Oncology27 citations Open access
Semantic Scholar
Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma
Deepak Perumal, Pei-Yu Kuo, V. Leshchenko, Zewei Jiang +9 more
2016Cancer Research27 citations Open access
Semantic Scholar
A Phase II Study of Panobinostat with Lenalidomide and Weekly Dexamethasone in Myeloma
A. Chari, H. Cho, Siyang Leng, Amishi Dhadwal +19 more
201523 citations
Semantic Scholar
Integrative Genomic Analysis of Temozolomide Resistance in Diffuse Large B-Cell Lymphoma
V. Leshchenko, Pei-Yu Kuo, Zewei Jiang, V. Thirukonda +1 more
2013Clinical Cancer Research20 citations Open access
Semantic Scholar
Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma
V. Leshchenko, Pei-Yu Kuo, Zewei Jiang, M. Weniger +5 more
2015OncoTarget19 citations Open access
Semantic Scholar
A Three-Gene Signature Predicts Response to Selinexor in Multiple Myeloma
Paula Restrepo, Sherry Bhalla, Y. Ghodke-Puranik, Adolfo Aleman +14 more
2022medRxiv18 citations Open access
Semantic Scholar
A phase II study of pomalidomide, daily oral cyclophosphamide, and dexamethasone in relapsed/refractory multiple myeloma
Oliver Van Oekelen, S. Parekh, H. Cho, Nivetha Vishnuvardhan +22 more
2020Leukemia and Lymphoma17 citations Open access
Semantic Scholar
Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency
Sarah Aminov, Orsi Giricz, D. Melnekoff, R. Sica +23 more
2024Journal of Clinical Investigation14 citations Open access
Semantic Scholar
Combined Vitamins B12b and C Induce the Glutathione Depletion and the Death of Epidermoid Human Larynx Carcinoma Cells HEp-2
V. Akatov, Yury V. Evtodienko, V. Leshchenko, V. Teplova +4 more
2000Bioscience Reports12 citations
Semantic Scholar
Weighted Gene Co-Expression Network Analysis (WGCNA) Identifies Highly Proliferative Myeloma Subgroup Responsive to CDK4/ARK5 Inhibition
Deepak Perumal, V. Leshchenko, Pei-Yu Kuo, Zewei Jiang +11 more
201411 citations
Semantic Scholar
E2F1 Is a Biomarker of Selinexor Resistance in Relapsed/Refractory Multiple Myeloma Patients
A. Laganà, Seongjee Park, D. Edwards, V. Leshchenko +13 more
2018Blood9 citations Open access
Semantic Scholar
[Growth inhibition and induction of tumor cell death by phospholipase A2 and lipoxygenase inhibitors].
V. Shaposhnikova, L. N. Kublik, A. Narimanov, M. Kh Levitman +4 more
2001Izvestiia Akademii nauk. Seriia biologicheskaia9 citations
Semantic Scholar
P-175 Improving Anti-BCMA CAR-T functionality with novel immunomodulatory agent Iberdomide (CC220) in Multiple Myeloma
Adolfo Aleman, Ariel Kogan-Zajdman, B. Upadhyaya, Oliver Van Oekelen +4 more
2023Clinical Lymphoma, Myeloma & Leukemia7 citations
Semantic Scholar
Triple MAPK inhibition salvaged a relapsed post-BCMA CAR-T cell therapy multiple myeloma patient with a BRAF V600E subclonal mutation
Muhammad Elnaggar, Sarita Agte, Paula Restrepo, Meghana Ram +10 more
2022Journal of Hematology & Oncology7 citations Open access
Semantic Scholar
Small Heat Shock Protein hsp27 as a Possible Mediator of Intercellular Adhesion-Induced Drug Resistance in Human Larynx Carcinoma HEp-2 Cells
В. В. Мазуров, M. Solovieva, V. Leshchenko, A. Kruglov +3 more
2003Bioscience Reports7 citations
Semantic Scholar
Increased HLA-E Expression Correlates with Early Relapse in Multiple Myeloma
A. Laganà, D. Ruan, D. Melnekoff, V. Leshchenko +16 more
2018Blood6 citations Open access
Semantic Scholar
MAGE-a Mediate Resistance to Chemotherapy in Multiple Myeloma through Regulation of Bcl-2 Proteins
H. Cho, A. Mei, J. Fukui, Kaity H. Tung +8 more
20166 citations
Semantic Scholar
Regression of smoldering myeloma with treatment of Gaucher disease
Kevin Barley, Anshuman Parekh, S. P. Salam, D. Mendu +12 more
2024Blood Advances5 citations Open access
Semantic Scholar
SOX11 inhibitors are cytotoxic in mantle cell lymphoma
Shashidhar S. Jatiani, S. Christie, V. Leshchenko, R. Jain +14 more
2021Clinical Cancer Research5 citations Open access
Semantic Scholar
ADAR1 can drive Multiple Myeloma progression by acting both as an RNA editor of specific transcripts and as a DNA mutator of their cognate genes
Rafail Nikolaos Tasakis, A. Laganà, Dimitra Stamkopoulou, D. Melnekoff +5 more
2020bioRxiv5 citations Open access
Semantic Scholar
Final Results of a Phase 1-2 Study of Vorinostat (SAHA), Cladribine, and Rituximab (SCR) Relapsed B-Cell Non-Hodgkin’s Lymphoma and Previously Untreated Mantle Cell Lymphoma
S. Spurgeon, K. Sharma, D. Claxton, C. Ehmann +8 more
20145 citations
Semantic Scholar
Combined Epigenetic and Immunotherapy For Newly Diagnosed Mantle Cell Lymphoma: Correlative Studies Suggest The Importance Of Enhanced ADCC, Mechanisms of Resistance and Cyclin D1 Nuclear Localization Genotype
K. Sharma, V. Leshchenko, Z. Hasanali, A. Stuart +4 more
20135 citations
Semantic Scholar
Long-term remission after cilta-cel in multiple myeloma is linked to diverse T cells and low myeloid suppression
Junia Vieira Dos Santos, D. Melnekoff, Adolfo Aleman, Tarek H. Mouhieddine +25 more
2025Blood Advances4 citations
Semantic Scholar
SOX11 modulates BCR signaling through the PAX5/CD19 axis for therapeutic targeting in BTK-resistant mantle cell lymphoma
R. P. Dutta, Heng-Huan Lee, V. Leshchenko, R. P. Shukla +8 more
2025Blood Advances4 citations Open access
Semantic Scholar
Multimodal Single-Cell Transcriptomic and Proteomic Correlatives of Patients Outcomes Following Anti-BCMA Cellular Therapy with Ciltacabtagene Autoleucel (Cilta-cel) in Relapsed Multiple Myeloma
Junia Vieira Dos Santos, D. Melnekoff, Adolfo Aleman, Sherry Bhalla +20 more
2023Blood4 citations Open access
Semantic Scholar
A Phase I/II Study of Vorinostat (SAHA), Cladribine (2-CdA), and Rituximab Shows Significant Activity in Previously Untreated Mantle Cell Lymphoma
S. Spurgeon, Andy I. Chen, C. Okada, S. Parekh +6 more
20114 citations
Semantic Scholar
Genomic and Pathway Connectivity Analyses Identify Novel Strategies to Overcome mTOR Inhibitor Resistance In DLBCL
A. Petrich, V. Leshchenko, Pei-Yu Kuo, B. Ye +2 more
20104 citations
Semantic Scholar
A Machine Learning Approach Identifies a 30-Gene Model That Predicts Sensitivity to Selinexor in Multiple Myeloma
A. Laganà, Sherry Bhalla, Adolfo Aleman, A. Mei +11 more
2019Blood3 citations Open access
Semantic Scholar
Single-Cell RNA Sequencing Reveals Distinct Transcriptomic Profiles of Multiple Myeloma with Implications for Personalized Medicine
D. Melnekoff, A. Laganà, Wissam Hamou, Kimaada Allette +11 more
20173 citations
Semantic Scholar
Inhibiting SOX11-DNA Interaction in Mantle Cell Lymphoma
S. Christie, Shashidhar S. Jatiani, Pei-Yu Kuo, V. Leshchenko +5 more
20163 citations
Semantic Scholar
SOX11 Directly Represses Wnt/β-Catenin Signaling and Identifies a Subgroup of Mantle Cell Lymphoma Patients with Improved Survival with Intensive Treatment
Pei-Yu Kuo, V. Leshchenko, M. Fazzari, Tobias A. Gellen +15 more
20123 citations
Semantic Scholar
Aberrant Cell Cycle Programming Confers Rapid Lethality in the EuSOX11+ CCND1 MCL Mouse Model
D. Edwards, Pei-Yu Kuo, A. Laganà, Seongjee Park +6 more
20202 citations
Semantic Scholar
Clonal Evolution in Newly Diagnosed Multiple Myeloma Patients: A Follow-up Study from the Mmrf Commpass Genomics Project
A. Laganà, D. Melnekoff, I. Beno, V. Leshchenko +12 more
20172 citations
Semantic Scholar
Integrative Network Analysis of Newly Diagnosed Multiple Myeloma Identifies a Novel RNA-Seq Based High Riskgene Signature
A. Laganà, Deepak Perumal, D. Melnekoff, B. Readhead +14 more
20162 citations
Semantic Scholar
Network Modeling Reveals CDC42BPA and CLEC11A As Novel Driver Genes of t(4; 14) Multiple Myeloma
Deepak Perumal, A. Laganà, D. Melnekoff, B. Readhead +13 more
20162 citations
Semantic Scholar
High-Resolution Sequencing Identifies NOXA1 De-Methylation As a Novel Strategy to Overcome Bortezomib Resistance in Mantle Cell Lymphoma
V. Leshchenko, Pei-Yu Kuo, N. Ulahannan, E. Braunschweig +8 more
20112 citations
Semantic Scholar
Growth Inhibition and Death Induction in Tumor Cells by Inhibitors of Phospholipase A2 and Lipoxygenase
V. Shaposhnikova, L. Kublik, A. Narimanov, M. Levitman +4 more
2001Biology Bulletin of the Russian Academy of Sciences2 citations
Semantic Scholar
Combined Treatment with Vitamin B12b and Ascorbic Acid Causes in Vitro DNA Degradation in Tumor Cells
A. I. Medvedev, V. Akatov, N. Kreshchenko, M. E. Solov’eva +3 more
2001Bulletin of experimental biology and medicine2 citations
Semantic Scholar
The novel immunocompetent Eμ-SOX11CCND1 mouse model phenotypically and molecularly resembles human mantle cell lymphoma
Hedieh Jafari, Fiona Brown-Burke, Betsy A Pray, S. Sloan +25 more
2025Clinical Cancer Research1 citations
Semantic Scholar

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