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Anqi Ma · SciRah

Researcher profile · Semantic Scholar

Anqi Ma

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Anqi Ma — researcher profile on SciRah

h-index: 26
Works: 53
Citations: 2,450

Most-cited papers

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
Kyle D. Konze, Anqi Ma, Feng-Ling Li, D. Barsyte-Lovejoy +19 more
2013ACS Chemical Biology452 citations Open access
Semantic Scholar
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.
Bo-Wen Xu, Doan M. On, Anqi Ma, Trevor Parton +14 more
2014Blood233 citations Open access
Semantic Scholar
Discovery of a first-in-class EZH2 selective degrader
Anqi Ma, E. Stratikopoulos, Kwang-Su Park, Jieli Wei +11 more
2019Nature Chemical Biology200 citations Open access
Semantic Scholar
EZH2 non-canonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
Jun Wang, Xu-Fen Yu, W. Gong, Xi-Juan Liu +13 more
2022Nature Cell Biology164 citations Open access
Semantic Scholar
Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy for p53 activation in high-risk Neuroblastoma
V. Veschi, Zhi-Hui Liu, T. Voss, L. Ozbun +14 more
2017Cancer Cell97 citations Open access
Semantic Scholar
Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
Anqi Ma, Wen-Yu Yu, Feng-Ling Li, Rachel M. Bleich +11 more
2014Journal of Medicinal Chemistry91 citations Open access
Semantic Scholar
The lipid kinase PIP5K1C regulates pain signaling and sensitization
Brittany D. Wright, L. Loo, Sarah E. Street, Anqi Ma +6 more
2014Neuron75 citations Open access
Semantic Scholar
ATRX in-frame fusion neuroblastoma is sensitive to EZH2 inhibition via modulation of neuronal gene signatures
Zulekha A. Qadeer, David Valle-García, D. Hasson, Zhen Sun +27 more
2019Cancer Cell73 citations Open access
Semantic Scholar
Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition
Ola Rizq, N. Mimura, M. Oshima, A. Saraya +11 more
2017Clinical Cancer Research70 citations Open access
Semantic Scholar
Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors
Feng Liu, Feng-Ling Li, Anqi Ma, E. Dobrovetsky +11 more
2013Journal of Medicinal Chemistry69 citations Open access
Semantic Scholar
PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation.
Z. Ren, J. Ahn, Hequn Liu, Yi-Hsuan Tsai +16 more
2019Blood68 citations Open access
Semantic Scholar
VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression
M. Morini, C. Giampietro, M. Corada, F. Pisati +17 more
2017Circulation Research64 citations Open access
Semantic Scholar
Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target
P. Agarwal, M. Alzrigat, Alba Atienza Párraga, S. Enroth +10 more
2016OncoTarget64 citations Open access
Semantic Scholar
Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2.
Brandon Dale, Chris Anderson, Kwang-Su Park, H. Kaniskan +7 more
2022ACS Pharmacology & Translational Science55 citations Open access
Semantic Scholar
EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions
M. Alzrigat, Alba Atienza Párraga, P. Agarwal, H. Zureigat +8 more
2016OncoTarget55 citations Open access
Semantic Scholar
Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors.
Xiao-Bao Yang, Feng-Ling Li, Kyle D. Konze, Jamel Meslamani +7 more
2016Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity
J. Beak, Wei Huang, J. Parker, Sean T. Hicks +5 more
2017JACC: Basic to Translational Science50 citations Open access
Semantic Scholar
Histone Lysine Methylation Dynamics Control EGFR DNA Copy Number Amplification
Thomas L. Clarke, Ran Tang, Damayanti Chakraborty, Capucine Van Rechem +8 more
2019Cancer Discovery45 citations Open access
Semantic Scholar
EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells
B. Katona, Yuanyuan Liu, Anqi Ma, Jian Jin +1 more
2014Cancer Biology & Therapy45 citations Open access
Semantic Scholar
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells
Evelyne Lima-Fernandes, Alex Murison, Tiago da Silva Medina, Ya-Dong Wang +15 more
2019Nature Communications42 citations Open access
Semantic Scholar
The dynamic conformational landscape of the protein methyltransferase SETD8
Shi Chen, Rafal P. Wiewiora, Fan-Wang Meng, N. Babault +20 more
2019eLife40 citations Open access
Semantic Scholar
Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice.
Qingrong Huang, Shan He, Yuanyuan Tian, Yuting Gu +15 more
2017Blood34 citations Open access
Semantic Scholar
EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma
Yuko Kusakabe, T. Chiba, M. Oshima, S. Koide +29 more
2021Scientific Reports32 citations Open access
Semantic Scholar
Structure Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase
K. Butler, Anqi Ma, Wen-Yu Yu, Feng-Ling Li +10 more
2016Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways
Mohamed A. I. Abou El Hassan, Katherine Huang, Manoja B. K. Eswara, Michael Zhao +11 more
2015PLoS ONE31 citations Open access
Semantic Scholar
Structure-activity relationship studies of SETD8 inhibitors.
Anqi Ma, Wen-Yu Yu, Yan Xiong, K. Butler +2 more
2014MedChemComm29 citations Open access
Semantic Scholar
The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains
M. Alzrigat, Alba Atienza Párraga, M. Majumder, Anqi Ma +8 more
2017OncoTarget25 citations Open access
Semantic Scholar
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma
Laurie Herviou, Sara Ovejero, Fanny Izard, O. Karmous-Gadacha +11 more
2019Clinical Epigenetics24 citations Open access
Semantic Scholar
Combined functional genomic and chemical screens identify SETD8 as a therapeutic target in MYC-driven medulloblastoma.
Bethany L. Veo, Etienne P. Danis, Angela M. Pierce, Ismail Sola +7 more
2019JCI Insight23 citations Open access
Semantic Scholar
A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
P. Nylund, Alba Atienza Párraga, Jakob Haglöf, E. De Bruyne +8 more
2021Cell Death and Disease22 citations Open access
Semantic Scholar
Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma
M. Rizk, Ola Rizq, M. Oshima, Yaeko Nakajima-Takagi +9 more
2019Cancer Science22 citations Open access
Semantic Scholar
Dissecting and Targeting Noncanonical Functions of EZH2 in Multiple Myeloma via an EZH2 Degrader
Xu-Fen Yu, Jun Wang, W. Gong, Anqi Ma +7 more
2023Oncogene20 citations Open access
Semantic Scholar
PVT1 interacts with polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
P. Nylund, Berta Garrido-Zabala, Alba Atienza Párraga, L. Vasquez +7 more
2023Haematologica13 citations Open access
Semantic Scholar
Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma.
Na Qiang, Jun-Jie Ao, Masato Nakamura, T. Chiba +22 more
2023International Immunopharmacology10 citations Open access
Semantic Scholar
Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation
Alba Atienza Párraga, P. Nylund, Klev Diamanti, Berta Garrido-Zabala +13 more
2025Scientific Reports8 citations Open access
Semantic Scholar
EnsembleKQC: An Unsupervised Ensemble Learning Method for Quality Control of Single Cell RNA-seq Sequencing Data
Anqi Ma, Zuolang Zhu, Meiqin Ye, Fei Wang
2019International Conference on Intelligent Computing5 citations
Semantic Scholar
The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8
Shi Chen, Rafal P. Wiewiora, Fan-Wang Meng, N. Babault +20 more
2018bioRxiv5 citations Open access
Semantic Scholar
EZH2 Inhibition and the Combination with Proteasome Inhibition Are Novel Potential Strategies for the Treatment of Multiple Myeloma
Ola Rizq, N. Mimura, S. Koide, Anqi Ma +4 more
20144 citations
Semantic Scholar
Discovery of a Potent, Selective and In Vivo Efficacious Covalent Inhibitor for Lysine Methyltransferase SETD8
He Chen, R. P. Dutta, Zhi-Zhong Li, Yue Zhong +12 more
2026Journal of Medicinal Chemistry1 citations Open access
Semantic Scholar
SGSS05-NS3, a covalent SETD8 inhibitor that activates p53 pathway in neuroblastoma
Zhi-Hui Liu, Sukriti Bagchi, Chun-Hua Yan, Ying Hu +10 more
2025Journal of experimental & clinical cancer research : CR1 citations Open access
Semantic Scholar
Akt Inhibition Differently Controls PRC2 Components and Synergizes with Dual EZH2/1 Inhibitor in the Treatment of Multiple Myeloma
M. Rizk, Ola Rizq, M. Oshima, Yaeko Nakajima-Takagi +9 more
2019Blood1 citations Open access
Semantic Scholar
GENE-05. ATRX IN-FRAME FUSION NEUROBLASTOMA IS SENSITIVE TO EZH2 INHIBITION VIA MODULATION OF NEURONAL GENE SIGNATURES
Zulekha A. Qadeer, David Valle-García, D. Hasson, A. Soriano +25 more
2019Neuro-Oncology1 citations Open access
Semantic Scholar
Abstract 3867: Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy to reactivate p53 in high-risk neuroblastoma
V. Veschi, Zhi-Hui Liu, T. Voss, L. Ozbun +14 more
20171 citations
Semantic Scholar
Molecular Mechanism behind the Synergistic Activity of Proteasome Inhibition and PRC2 Inhibition in the Treatment of Multiple Myeloma
Ola Rizq, N. Mimura, M. Oshima, A. Saraya +10 more
20161 citations
Semantic Scholar
Mo1647 Inhibition of EZH2/EZH1 by UNC1999 Enhances the Potency of the EGFR Inhibitor Gefitinib in Colon Cancer Cells
B. Katona, Yuanyuan Liu, Anqi Ma, Jian Jin +1 more
20141 citations Open access
Semantic Scholar
Epigenetic targeting of SETD8 in multiple myeloma
R. P. Dutta, He Chen, Yue Zhong, Anqi Ma +11 more
2025Blood0 citations
Semantic Scholar
Abstract 1646: Development of small-molecule HPK1 inhibitors to unleash tumor-specific T cell responses
George E. Katibah, Yamini M. Ohol, Cyril Bucher, Lavanya Adusumilli +32 more
2021Immunology0 citations
Semantic Scholar
Author response: The dynamic conformational landscape of the protein methyltransferase SETD8
Shi Chen, Rafal P. Wiewiora, Fan-Wang Meng, N. Babault +20 more
20190 citations Open access
Semantic Scholar
HEMATOPOIESIS AND STEM CELLS Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice
Qingrong Huang, Shan He, Yuanyuan Tian, Yuting Gu +15 more
20170 citations
Semantic Scholar
Complex of SETD8 with MS453
Wen-Yu Yu, W. Tempel, N. Babault, Anqi Ma +6 more
20160 citations
Semantic Scholar

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