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H. Wheadon · SciRah

Researcher profile · Semantic Scholar

H. Wheadon

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H. Wheadon — researcher profile on SciRah

h-index: 19
Works: 94
Citations: 2,026

Most-cited papers

Regulation of Embryonic Stem Cell Self-renewal by Phosphoinositide 3-Kinase-dependent Signaling*
N. R. D. Paling, H. Wheadon, H. Bone, M. Welham
2004Journal of Biological Chemistry439 citations Open access
Semantic Scholar
Tissue specificity of X-chromosome inactivation patterns.
R. Gale, H. Wheadon, P. Boulos, D. Linch
1994Blood205 citations Open access
Semantic Scholar
JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.
P. Gallipoli, Amy Cook, S. Rhodes, L. Hopcroft +5 more
2014Blood143 citations Open access
Semantic Scholar
Oncogenic Properties of Apoptotic Tumor Cells in Aggressive B Cell Lymphoma
Catriona A. Ford, S. Petrova, J. Pound, Jorine Voss +18 more
2015Current Biology125 citations Open access
Semantic Scholar
X‐chromosome inactivation patterns using HPRT and PGK polymorphisms in haematologically normal and post‐chemotherapy females
R. Gale, H. Wheadon, D. Linch
1991British Journal of Haematology124 citations
Semantic Scholar
Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence
Natasha S Lewis, Emily El Lewis, M. Mullin, H. Wheadon +2 more
2017Journal of Tissue Engineering77 citations Open access
Semantic Scholar
Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia
D. Irvine, Bin Zhang, Ross Kinstrie, Anuradha Tarafdar +11 more
2016Scientific Reports70 citations Open access
Semantic Scholar
CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy
Ross Kinstrie, G. Horne, H. Morrison, D. Irvine +12 more
2020Leukemia58 citations Open access
Semantic Scholar
A Quiescent, Regeneration-Responsive Tissue Engineered Mesenchymal Stem Cell Bone Marrow Niche Model via Magnetic Levitation.
E. E. L. Lewis, H. Wheadon, Natasha S Lewis, Jing-Li Yang +5 more
2016ACS Nano57 citations Open access
Semantic Scholar
Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes
Katerina E. Miari, M. Guzman, H. Wheadon, Mark T. S. Williams
2021Frontiers in Cell and Developmental Biology54 citations Open access
Semantic Scholar
Frequency of clonal remission in acute myeloid leukaemia.
R. Gale, H. Wheadon, A. Goldstone, D. Linch +1 more
1993The Lancet54 citations
Semantic Scholar
Patterns of Wnt/Fzd/LRP Gene Expression During Embryonic Hematopoiesis
Pamela M. Corrigan, Edwina Dobbin, R. Freeburn, H. Wheadon
2009Stem Cells and Development48 citations
Semantic Scholar
The application of BH3 mimetics in myeloid leukemias
Narissa Parry, H. Wheadon, M. Copland
2021Cell Death and Disease47 citations Open access
Semantic Scholar
Molecular interactions of SHP1 and SHP2 in IL-3-signalling.
H. Wheadon, N. R. D. Paling, M. Welham
2002Cellular Signalling39 citations
Semantic Scholar
Inhibition of NF-κB–Mediated Signaling by the Cyclin-Dependent Kinase Inhibitor CR8 Overcomes Prosurvival Stimuli to Induce Apoptosis in Chronic Lymphocytic Leukemia Cells
E. Cosimo, Alison M. McCaig, Luke J. M. Carter-Brzezinski, H. Wheadon +8 more
2013Clinical Cancer Research32 citations Open access
Semantic Scholar
The Functional Response of Mesenchymal Stem Cell to Electron-Beam Patterned Elastomeric Surfaces Presenting Micron to Nanoscale Heterogeneous Rigidity
M. Biggs, Marc A. Fernandez-Yague, Dilip Thomas, Ryan C. Cooper +9 more
2017Advances in Materials29 citations Open access
Semantic Scholar
Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self-Renewal of Mouse Embryonic Stem Cells
K. Kranc, Daniel V. Oliveira, A. Armesilla-Diaz, I. Pacheco-Leyva +9 more
2014Stem Cells28 citations Open access
Semantic Scholar
Targeting self-renewal pathways in myeloid malignancies
W. Sands, M. Copland, H. Wheadon
2013Cell Communication and Signaling26 citations Open access
Semantic Scholar
Canonical Wnt Signaling Promotes Early Hematopoietic Progenitor Formation and Erythroid Specification during Embryonic Stem Cell Differentiation
Anuradha Tarafdar, Edwina Dobbin, Pamela M. Corrigan, R. Freeburn +1 more
2013PLoS ONE26 citations Open access
Semantic Scholar
Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells
H. Donnelly, E. Ross, Yin-Bo Xiao, Rio Hermantara +16 more
2024bioRxiv20 citations Open access
Semantic Scholar
The role of the bone morphogenetic proteins in leukaemic stem cell persistence.
Parto Toofan, D. Irvine, L. Hopcroft, M. Copland +1 more
2014Biochemical Society Transactions18 citations
Semantic Scholar
Differential Hox Expression in Murine Embryonic Stem Cell Models of Normal and Malignant Hematopoiesis
H. Wheadon, Joanne M. Ramsey, Edwina Dobbin, Glenda J Dickson +3 more
2011Stem Cells and Development18 citations
Semantic Scholar
Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).
H. Wheadon, C. Edmead, M. Welham
2003Biochemical Journal18 citations Open access
Semantic Scholar
Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML
W. Chantkran, Ya-Ching Hsieh, D. Zheleva, S. Frame +2 more
2021Cell Death Discovery17 citations Open access
Semantic Scholar
Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal
Parto Toofan, C. Busch, H. Morrison, S. O'brien +3 more
2018Cell Death and Disease17 citations Open access
Semantic Scholar
The coupling of TEL/PDGFβR to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases
H. Wheadon, M. Welham
200317 citations Open access
Semantic Scholar
Changes in signal transduction downstream from the granulocyte-macrophage colony-stimulating factor receptor during differentiation of primary hemopoietic cells.
H. Wheadon, P. J. Roberts, Michael J. Watts, D. Linch
1999Experimental Hematology17 citations Open access
Semantic Scholar
Using topic modeling to detect cellular crosstalk in scRNA-seq
Alexandrina Pancheva, H. Wheadon, Simon Rogers, Thomas Otto
2021bioRxiv14 citations Open access
Semantic Scholar
Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis.
Parto Toofan, H. Wheadon
2016Biochemical Society Transactions14 citations
Semantic Scholar
Tel/PDGFRbeta induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways.
Edwina Dobbin, Ciaren Graham, Pamela M. Corrigan, Keith G. Thomas +2 more
2009Experimental Hematology14 citations Open access
Semantic Scholar
Frequency of clonal remission in acute myeloid leukemia
R. Gale, H. Wheadon, A. Goldstone, A. Burnett +1 more
199314 citations
Semantic Scholar
Complexities of modelling the bone marrow microenvironment to facilitate haematopoietic research.
C. Busch, Kudzai Nyamondo, H. Wheadon
2024Experimental Hematology13 citations Open access
Semantic Scholar
Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach
C. Busch, T. Mulholland, M. Zagnoni, M. Dalby +2 more
2023Cell Communication and Signaling13 citations Open access
Semantic Scholar
Micro‐environment alterations through time leading to myeloid malignancies
Kudzai Nyamondo, H. Wheadon
2022British Journal of Pharmacology11 citations Open access
Semantic Scholar
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche
Amy Dawson, Martha M. Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre +24 more
2024Nature Communications10 citations Open access
Semantic Scholar
Classical Complement Pathway
Odette Middleton, H. Wheadon, A. Michie
201610 citations
Semantic Scholar
BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia
Narissa Parry, C. Busch, Victoria Assmann, Jennifer E. Cassels +4 more
2022Cell Death Discovery9 citations Open access
Semantic Scholar
M2-like Macrophages Transfer Mitochondria to Acute Myeloid Leukaemia Cells Via Tunnelling Nanotubes Promoting Therapy Resistance
E. Nwarunma, Katerina E. Miari, Athanasia Papadopoulou, L. Martinez +16 more
2024Blood8 citations
Semantic Scholar
Bone marrow niche crosses paths with BMPs: a road to protection and persistence in CML.
C. Busch, H. Wheadon
2019Biochemical Society Transactions8 citations Open access
Semantic Scholar
Differentiation‐linked changes in granulocyte‐macrophage colony‐stimulating factor receptor mediated signalling in the HL‐60 promyelocytic cell line
H. Wheadon, P. J. Roberts, D. Linch
1998British Journal of Haematology8 citations
Semantic Scholar
Acute Loss of Cited 2 Impairs Nanog Expression and Decreases Self-Renewal of Mouse Embryonic Stem Cells
Daniel, V., Oliveira, AL Armesilla +7 more
20157 citations
Semantic Scholar
Tel/PDGFRbeta inhibits self-renewal and directs myelomonocytic differentiation of ES cells.
Edwina Dobbin, Pamela M. Corrigan, C. Walsh, M. Welham +2 more
2008Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis7 citations
Semantic Scholar
Evaluation of current mouse in vivo models and advanced in vitro models for leukaemia research.
Xenia Bubnova, Lauren Hope, H. Wheadon
2025Blood reviews6 citations Open access
Semantic Scholar
JAK 2 / STAT 5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD 34 + cells in vitro and in vivo
P. Gallipoli, Amy Cook, S. Rhodes, L. Hopcroft +6 more
20146 citations
Semantic Scholar
Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer
M. McAllister, V. Constâncio, Samantha Patek, Hao Gan +5 more
2020The Prostate5 citations Open access
Semantic Scholar
The coupling of TEL/PDGFbetaR to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases.
H. Wheadon, M. Welham
2003Blood4 citations
Semantic Scholar
Correction: CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy
Ross Kinstrie, G. Horne, H. Morrison, D. Irvine +12 more
2020Leukemia2 citations Open access
Semantic Scholar
Identification of JAK2 dependent transcriptional regulators in CML
S. Rhodes, M. Copland, L. Hopcroft, P. Sayeski +1 more
20132 citations Open access
Semantic Scholar
Regulation of embryonic stem cell self-renewal by phosphoinostide 3-kinase-dependent signalling
N. R. D. Paling, H. Wheadon, H. Bone, J. Melanie +1 more
20042 citations
Semantic Scholar
Granulocyte‐macrophage colony stimulating factor receptor α and β chain complexes can form both high and intermediate affinity functional receptors
H. Wheadon, S. Devereux, A. Khwaja, D. Linch
19972 citations
Semantic Scholar

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M. Copland×11
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M. Welham×6
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Edwina Dobbin×6
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L. Hopcroft×5
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Pamela M. Corrigan×5

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Karen M. Dunn — researcher profile on SciRah