Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

P. Sayeski · SciRah

Researcher profile · Semantic Scholar

P. Sayeski

Share profile

P. Sayeski — researcher profile on SciRah

h-index: 30
Works: 106
Citations: 2,392

Most-cited papers

Dependence on the Motif YIPP for the Physical Association of Jak2 Kinase with the Intracellular Carboxyl Tail of the Angiotensin II AT1 Receptor*
M. S. Ali, P. Sayeski, Laurie B. Dirksen, David J. Hayzer +2 more
1997Journal of Biological Chemistry228 citations Open access
Semantic Scholar
Angiotensin II signal transduction pathways.
P. Sayeski, MS Ali, Dan J. Semeniuk, T. Doan +1 more
1998Regulatory Peptides74 citations
Semantic Scholar
Conditional Deletion of Jak2 Reveals an Essential Role in Hematopoiesis throughout Mouse Ontogeny: Implications for Jak2 Inhibition in Humans
S. Park, H. L. Wamsley, K. Bae, Zhong-Bo Hu +6 more
2013PLoS ONE73 citations Open access
Semantic Scholar
Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis
S. Klein, J. Rick, J. Lehmann, R. Schierwagen +12 more
2015Gut67 citations
Semantic Scholar
Whole-exome sequencing in evaluation of patients with venous thromboembolism.
Eun-Ju Lee, Daniel J. Dykas, A. Leavitt, R. Camire +22 more
2017Blood Advances62 citations Open access
Semantic Scholar
Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling.
Kai He, Xiangdong Wang, Jing Jiang, R. Guan +3 more
2003Molecular Endocrinology60 citations Open access
Semantic Scholar
Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1 Receptor*
M. S. Ali, P. Sayeski, K. Bernstein
2000Journal of Biological Chemistry60 citations Open access
Semantic Scholar
Phosphorylation of p130Cas by angiotensin II is dependent on c-Src, intracellular Ca2+, and protein kinase C.
P. Sayeski, M. S. Ali, J. Harp, Mario B. Marrero +1 more
1998Circulation Research60 citations
Semantic Scholar
The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation.
P. Sayeski, M. S. Ali
2003Experimental Cell Research59 citations
Semantic Scholar
Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophophorylation
E. Sandberg, Xian-Yue Ma, Kai He, S. Frank +2 more
200554 citations
Semantic Scholar
A conformationally sensitive GHR [growth hormone (GH) receptor] antibody: impact on GH signaling and GHR proteolysis.
Jing Jiang, Xiangdong Wang, Kai He, Xin Li +4 more
2004Molecular Endocrinology50 citations Open access
Semantic Scholar
Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species.
Annet Kirabo, Patrick N. Kearns, Y. Jarajapu, J. Sasser +7 more
2011Cardiovascular Research46 citations Open access
Semantic Scholar
The Constitutive Activation of Jak2-V617F is Mediated by a π Stacking Mechanism Involving Phe 595 and Phe 617
Kavitha Gnanasambandan, A. Magis, P. Sayeski
2010Biochemistry46 citations Open access
Semantic Scholar
Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening
R. Kiss, Tímea Polgár, Annet Kirabo, Jacqueline Sayyah +8 more
2009Bioorganic & Medicinal Chemistry Letters45 citations Open access
Semantic Scholar
A True Jak of All Trades
E. Sandberg, Tiffany A. Wallace, Michael D. Godeny, P. Sayeski
200441 citations
Semantic Scholar
Recent developments on JAK2 inhibitors: a patent review
R. Kiss, P. Sayeski, G. Keserű
2010Expert Opinion on Therapeutic Patents39 citations
Semantic Scholar
Identification of tubulin as a substrate of Jak2 tyrosine kinase and its role in Jak2-dependent signaling.
Xian-Yue Ma, P. Sayeski
2007Biochemistry39 citations
Semantic Scholar
The angiotensin II-dependent association of Jak2 and c-Src requires the N-terminus of Jak2 and the SH2 domain of c-Src.
P. Sayeski, M. S. Ali, Kim Hawks, S. Frank +1 more
1999Circulation Research39 citations Open access
Semantic Scholar
Cloning and partial characterization of the mouse glutamine:fructose-6-phosphate amidotransferase (GFAT) gene promoter.
P. Sayeski, Dong-Yan Wang, Kai-Hong Su, I. Han +1 more
1997Nucleic Acids Research39 citations Open access
Semantic Scholar
The Recent Medicinal Chemistry Development of Jak2 Tyrosine Kinase Small Molecule Inhibitors
R. Baskin, Anurima Majumder, P. Sayeski
2010Current Medicinal Chemistry38 citations Open access
Semantic Scholar
The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.
Michael D. Godeny, Jacqueline Sayyah, Dannielle VonDerLinden, Melissa Johns +3 more
2007Cellular Signalling38 citations
Semantic Scholar
ANG II-induced cell proliferation is dually mediated by c-Src/Yes/Fyn-regulated ERK1/2 activation in the cytoplasm and PKCzeta-controlled ERK1/2 activity within the nucleus.
Michael D. Godeny, P. Sayeski
2006American Journal of Physiology - Cell Physiology37 citations
Semantic Scholar
Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells.
E. Sandberg, P. Sayeski
2004Journal of Biological Chemistry37 citations
Semantic Scholar
Jak2 Tyrosine Kinase Mediates Angiotensin II-dependent Inactivation of ERK2 via Induction of Mitogen-activated Protein Kinase Phosphatase 1*
E. Sandberg, Xian-Yue Ma, Dannielle VonDerLinden, Michael D. Godeny +1 more
2004Journal of Biological Chemistry37 citations Open access
Semantic Scholar
A Catalytically Active Jak2 Is Required for the Angiotensin II-dependent Activation of Fyn*
P. Sayeski, M. S. Ali, A. Safavi, M. Lyles +3 more
1999Journal of Biological Chemistry37 citations Open access
Semantic Scholar
ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1.
Michael D. Godeny, P. Sayeski
2006American Journal of Physiology - Cell Physiology36 citations
Semantic Scholar
Jak2 Tyrosine Kinase Mediates Oxidative Stress-induced Apoptosis in Vascular Smooth Muscle Cells*
E. Sandberg, P. Sayeski
2004Journal of Biological Chemistry36 citations Open access
Semantic Scholar
The Angiotensin II-dependent Nuclear Translocation of Stat1 Is Mediated by the Jak2 Protein Motif231YRFRR*
P. Sayeski, M. S. Ali, S. Frank, Kenneth E. Bernstein
2001Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Jak2 Inhibitors: Rationale and Role as Therapeutic Agents in Hematologic Malignancies
Jacqueline Sayyah, P. Sayeski
2009Current Oncology Reports33 citations Open access
Semantic Scholar
A Structure-Function Perspective of Jak2 Mutations and Implications for Alternate Drug Design Strategies: The Road not Taken
Kavitha Gnanasambandan, P. Sayeski
2011Current Medicinal Chemistry30 citations Open access
Semantic Scholar
Vascular Smooth Muscle Jak2 Deletion Prevents Angiotensin II-mediated Neointima Formation Following Injury in Mice
Annet Kirabo, S. Oh, H. Kasahara, Kay-Uwe Wagner +1 more
2011Journal of Molecular and Cellular Cardiology29 citations Open access
Semantic Scholar
Z3, a Novel Jak2 Tyrosine Kinase Small Molecule Inhibitor that Suppresses Jak2-mediated Pathologic Cell Growth
Jacqueline Sayyah, A. Magis, D. Ostrov, R. Allan +2 more
2008Molecular Cancer Therapeutics29 citations Open access
Semantic Scholar
Review: Signal transduction mechanisms of the angiotensin II type AT1-receptor: looking beyond the heterotrimeric G protein paradigm
P. Sayeski, K. Bernstein
200127 citations Open access
Semantic Scholar
Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1
R. Baskin, P. Sayeski
2011Cellular Signalling26 citations Open access
Semantic Scholar
Microarray analyses identify JAK2 tyrosine kinase as a key mediator of ligand-independent gene expression.
Tiffany A. Wallace, Dannielle VonDerLinden, Kai He, S. Frank +1 more
2004American Journal of Physiology - Cell Physiology26 citations
Semantic Scholar
Aldosterone: Renal Action & Physiological Effects
Jermaine G. Johnston, A. Welch, B. Cain, P. Sayeski +2 more
2023Comprehensive Physiology24 citations Open access
Semantic Scholar
New insights into the cellular signaling of seven transmembrane receptors: the role of tyrosine phosphorylation.
Kenneth E. Bernstein, M. S. Ali, P. Sayeski, Dan J. Semeniuk +1 more
1998Laboratory investigation; a journal of technical methods and pathology24 citations
Semantic Scholar
Janus kinase 2 (Jak2) must be catalytically active to associate with the AT1 receptor in response to angiotensin II.
Moiez Ali, P. Sayeski, A. Safavi, M. Lyles +1 more
1998Biochemical and Biophysical Research Communications - BBRC23 citations
Semantic Scholar
Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation].
E. Sandberg, Xian-Yue Ma, Kai He, S. Frank +2 more
2005Journal of Medicinal Chemistry22 citations
Semantic Scholar
Signal transduction pathways of angiotensin II in the kidney.
Kenneth E. Bernstein, P. Sayeski, T. Doan, P. Farmer +1 more
2001Contributions to Nephrology22 citations
Semantic Scholar
Signal transduction mechanisms of the angiotensin II type AT(1)-receptor: looking beyond the heterotrimeric G protein paradigm.
P. Sayeski, K. Bernstein
2001Journal of the Renin-Angiotensin-Aldosterone System21 citations
Semantic Scholar
Elevated Levels of Mast Cells Are Involved in Pruritus Associated with Polycythemia Vera in JAK2V617F Transgenic Mice
Xi Jin, Wanke Zhao, Annet Kirabo, S. Park +3 more
2014Journal of Immunology19 citations Open access
Semantic Scholar
The Stilbenoid Tyrosine Kinase Inhibitor, G6, Suppresses Jak2-V617F-mediated Human Pathological Cell Growth in Vitro and in Vivo*
Annet Kirabo, J. Embury, R. Kiss, Tímea Polgár +6 more
2010Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Structure-Function Correlation of G6, a Novel Small Molecule Inhibitor of Jak2
Anurima Majumder, L. Govindasamy, A. Magis, R. Kiss +8 more
2010Journal of Biological Chemistry16 citations Open access
Semantic Scholar
A functional Jak2 tyrosine kinase domain is essential for mouse development.
Kristen E. Frenzel, Tiffany A. Wallace, I. Mcdoom, Hong D. Xiao +3 more
2006Experimental Cell Research15 citations
Semantic Scholar
Mutation of glutamic acid residue 1046 abolishes Jak2 tyrosine kinase activity
Dannielle VonDerLinden, Xian-Yue Ma, E. Sandberg, K. Gernert +2 more
2002Molecular and Cellular Biochemistry15 citations Open access
Semantic Scholar
Myeloid-Specific JAK2 Contributes to Inflammation and Salt-Sensitivity of Blood Pressure
Mohammad Saleem, Luul A Aden, Ashley L. Mutchler, Chitra Basu +24 more
2024Circulation Research14 citations Open access
Semantic Scholar
The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.
Annet Kirabo, S. Park, Anurima Majumder, Meghanath Gali +7 more
2011Neoplasia14 citations Open access
Semantic Scholar
Identification of Tyrosine 972 as a Novel Site of Jak2 Tyrosine Kinase Phosphorylation and its Role in Jak2 Activation
I. Mcdoom, Xian-Yue Ma, Annet Kirabo, Kuang-Yung Lee +2 more
2008Biochemistry14 citations Open access
Semantic Scholar
Phosphorylation of p 130 Cas by Angiotensin II Is Dependent on cSrc , Intracellular Ca 2 1 , and Protein Kinase C
P. Sayeski, M. Showkat, Ali, J. Harp +3 more
199813 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

Kenneth E. Bernstein×9
Invite
Kenneth E. Bernstein — researcher profile on SciRah
M. S. Ali×8
Invite
M. S. Ali — researcher profile on SciRah
S. Frank×8
Invite
S. Frank — researcher profile on SciRah
Annet Kirabo×8
Invite
Annet Kirabo — researcher profile on SciRah

×7

Invite

K. Bernstein — researcher profile on SciRah

Invite

E. Sandberg — researcher profile on SciRah

Invite

Xian-Yue Ma — researcher profile on SciRah

Invite

Kai He — researcher profile on SciRah

Invite

D. Ostrov — researcher profile on SciRah

Invite

G. Keserű — researcher profile on SciRah

Michael D. Godeny×5

Invite

Michael D. Godeny — researcher profile on SciRah

Kay-Uwe Wagner×4

Invite

Kay-Uwe Wagner — researcher profile on SciRah