Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

T. Holyoake · SciRah

Researcher profile · Semantic Scholar

T. Holyoake

Share profile

T. Holyoake — researcher profile on SciRah

h-index: 68
Works: 332
Citations: 21K

Most-cited papers

The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts.
C. Abboud, E. Berman, Adam D. Cohen, J. Cortes +115 more
2013Blood587 citations Open access
Semantic Scholar
Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemic stem cells
E. M. Kuntz, Pablo Baquero, A. Michie, Karen M. Dunn +4 more
2017Nature Medicine482 citations Open access
Semantic Scholar
The chronic myeloid leukemia stem cell: stemming the tide of persistence.
T. Holyoake, D. Vetrie
2017Blood290 citations Open access
Semantic Scholar
Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia.
H. Herrmann, I. Sadovnik, S. Cerny-Reiterer, T. Rülicke +12 more
2014Blood218 citations Open access
Semantic Scholar
Dual targeting of p53 and c-Myc selectively eliminates leukaemic stem cells
Sheela A. Abraham, L. Hopcroft, Emma Carrick, M. Drotar +14 more
2016Nature214 citations Open access
Semantic Scholar
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells.
P. Neviani, J. Harb, Joshua J. Oaks, R. Santhanam +41 more
2013Journal of Clinical Investigation211 citations Open access
Semantic Scholar
Bone Marrow Niche Trafficking of miR-126 Controls Self-Renewal of Leukemia Stem Cells in Chronic Myelogenous Leukemia
Bin Zhang, L. Nguyen, Ling Li, Dan-Dan Zhao +28 more
2018Nature Medicine148 citations Open access
Semantic Scholar
JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.
P. Gallipoli, Amy Cook, S. Rhodes, L. Hopcroft +5 more
2014Blood143 citations Open access
Semantic Scholar
Epigenetic reprogramming sensitizes CML stem cells to combined EZH2 and tyrosine kinase inhibition
Mary T. Scott, K. Korfi, P. Saffrey, L. Hopcroft +13 more
2016Cancer Discovery126 citations Open access
Semantic Scholar
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.
Elisabeth Bolton-Gillespie, M. Schemionek, Hans-Ulrich Klein, S. Flis +14 more
2013Blood120 citations Open access
Semantic Scholar
Targeting Quiescent Leukemic Stem Cells using Second Generation Autophagy Inhibitors
Pablo Baquero, A. Dawson, A. Mukhopadhyay, E. M. Kuntz +16 more
2018Leukemia115 citations Open access
Semantic Scholar
Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane.
Hannah Schachtner, S. Calaminus, A. Sinclair, J. Monypenny +11 more
2013Blood106 citations
Semantic Scholar
ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells
M. Karvela, Pablo Baquero, E. M. Kuntz, A. Mukhopadhyay +9 more
2016Autophagy104 citations Open access
Semantic Scholar
Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition
Rebecca J. Mitchell, L. Hopcroft, Pablo Baquero, E. Allan +20 more
2017Journal of the National Cancer Institute99 citations Open access
Semantic Scholar
Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor-treated CML stem cells.
Bin Zhang, S. Chu, Puneet Agarwal, V. Campbell +6 more
2016Blood99 citations Open access
Semantic Scholar
Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation.
P. Gallipoli, F. Pellicanò, H. Morrison, K. Laidlaw +5 more
2013Blood99 citations Open access
Semantic Scholar
The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors
F. Pellicanò, Mary T. Scott, G. Helgason, L. Hopcroft +7 more
2014Stem Cells95 citations Open access
Semantic Scholar
Targeting Primitive Chronic Myeloid Leukemia Cells by Effective Inhibition of a New AHI-1–BCR-ABL–JAK2 Complex
Min Chen, P. Gallipoli, Donna DeGeer, I. Sloma +18 more
2013Journal of the National Cancer Institute88 citations Open access
Semantic Scholar
Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.
Amélie V. Guitart, Chithra Subramani, A. Armesilla-Diaz, Gillian Smith +9 more
2013Blood84 citations Open access
Semantic Scholar
Targeting survival pathways in chronic myeloid leukaemia stem cells
A. Sinclair, A. Latif, T. Holyoake
2013British Journal of Pharmacology82 citations Open access
Semantic Scholar
Adult hematopoietic stem cells lacking Hif-1α self-renew normally.
Milica Vukovic, Catarina Sepulveda, Chithra Subramani, Amélie V. Guitart +11 more
2016Blood80 citations Open access
Semantic Scholar
CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression.
Anuradha Tarafdar, L. Hopcroft, P. Gallipoli, F. Pellicanò +7 more
2017Blood76 citations Open access
Semantic Scholar
The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia.
A. Giannoudis, Lihui Wang, A. Jorgensen, G. Xinarianos +11 more
2013Blood74 citations
Semantic Scholar
Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia
D. Irvine, Bin Zhang, Ross Kinstrie, Anuradha Tarafdar +11 more
2016Scientific Reports70 citations Open access
Semantic Scholar
BRD4-mediated repression of p53 is a target for combination therapy in AML
A. Latif, Ashley A. Newcombe, Sha Li, K. Gilroy +27 more
2020Nature Communications67 citations Open access
Semantic Scholar
Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance
Milica Vukovic, Amélie V. Guitart, Catarina Sepulveda, Arnaud Villacreces +18 more
2015Journal of Experimental Medicine67 citations Open access
Semantic Scholar
CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.
A. Sinclair, Laura Park, Mansi Shah, M. Drotar +13 more
2016Blood64 citations Open access
Semantic Scholar
Autophagy in blood cancers: biological role and therapeutic implications
A. Nencioni, M. Cea, F. Montecucco, V. Longo +4 more
2013Haematologica63 citations Open access
Semantic Scholar
DPPIV (CD26) as a novel stem cell marker in Ph+ chronic myeloid leukaemia
P. Valent, I. Sadovnik, Z. Ráčil, H. Herrmann +6 more
2014European Journal of Clinical Investigation59 citations
Semantic Scholar
CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy
Ross Kinstrie, G. Horne, H. Morrison, D. Irvine +12 more
2020Leukemia58 citations Open access
Semantic Scholar
Identification of CD25 as STAT5-Dependent Growth-Regulator of Leukemic Stem Cells in Ph+ CML
I. Sadovnik, Andrea Hoelbl-Kovacic, H. Herrmann, G. Eisenwort +17 more
2015Clinical Cancer Research58 citations Open access
Semantic Scholar
Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival.
Yao-Yu Chen, Cong Peng, Sheela A. Abraham, Shan Yi +6 more
2014Journal of Clinical Investigation58 citations Open access
Semantic Scholar
Do we need more drugs for chronic myeloid leukemia?
T. Holyoake, G. Helgason
2015Immunological Reviews46 citations
Semantic Scholar
hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival.
F. Pellicanò, Laura Park, L. Hopcroft, Mansi Shah +13 more
2018Blood42 citations Open access
Semantic Scholar
Autophagy in Chronic Myeloid Leukaemia: Stem Cell Survival and Implication in Therapy
G. Helgason, A. Mukhopadhyay, M. Karvela, P. Salomoni +2 more
2013Current Cancer Drug Targets42 citations Open access
Semantic Scholar
Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor–Sensitive and -Resistant Chronic Myeloid Leukemia
I. Ben-Batalla, R. Erdmann, H. Jørgensen, Rebecca J. Mitchell +18 more
2016Clinical Cancer Research41 citations Open access
Semantic Scholar
Role of autophagy in cancer prevention, development and therapy.
G. Helgason, T. Holyoake, Kevin M. Ryan
2013Essays in Biochemistry39 citations
Semantic Scholar
Mtss1 is a critical epigenetically regulated tumor suppressor in CML
M. Schemionek, O. Herrmann, M. Reher, N. Chatain +15 more
2016Leukemia35 citations
Semantic Scholar
Concise Review: Cancer Cells Escape from Oncogene Addiction: Understanding the Mechanisms Behind Treatment Failure for More Effective Targeting
F. Pellicanò, L. Mukherjee, T. Holyoake
2014Stem Cells34 citations
Semantic Scholar
Preclinical approaches in chronic myeloid leukemia: from cells to systems
Cassie J. Clarke, T. Holyoake
2017Experimental Hematology32 citations Open access
Semantic Scholar
A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5
F. Griaud, A. Pierce, M. B. González Sánchez, Mary T. Scott +5 more
2013Leukemia26 citations Open access
Semantic Scholar
Synergistic effects of proteasome inhibitor carfilzomib in combination with tyrosine kinase inhibitors in imatinib-sensitive and -resistant chronic myeloid leukemia models
L. Crawford, E. Chan, M. Aujay, T. Holyoake +5 more
2014Oncogenesis24 citations Open access
Semantic Scholar
A Specific PTPRC/CD45 Phosphorylation Event Governed by Stem Cell Chemokine CXCL12 Regulates Primitive Hematopoietic Cell Motility*
A. Williamson, A. Pierce, E. Jaworska, Cong Zhou +9 more
2013Molecular & Cellular Proteomics22 citations Open access
Semantic Scholar
Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines
M. Aspinall-O'Dea, A. Pierce, F. Pellicanò, A. Williamson +4 more
2014Nature Protocols21 citations Open access
Semantic Scholar
A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type γ in chronic myeloid leukemia patients
M. Vezzalini, A. Mafficini, L. Tomasello, E. Lorenzetto +12 more
2017Journal of Hematology & Oncology19 citations Open access
Semantic Scholar
Spirit 2: An NCRI Randomised Study Comparing Dasatinib with Imatinib in Patients with Newly Diagnosed CML
S. O'Brien, Corinne Hedgley, Sarah Adams, L. Foroni +9 more
201415 citations Open access
Semantic Scholar
Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia
K. Laidlaw, S. Berhan, Su-Hu Liu, Giovannino Silvestri +7 more
2016OncoTarget14 citations Open access
Semantic Scholar
Dual Glutathione‐S‐Transferase‐θ1 and ‐μ1 Gene Deletions Determine Imatinib Failure in Chronic Myeloid Leukemia
Andrea Davies, A. Giannoudis, J. Zhang, G. Austin +7 more
2014Clinical pharmacology and therapy14 citations
Semantic Scholar
Redirecting traffic using the XPO1 police.
Sheela A. Abraham, T. Holyoake
2013Blood13 citations
Semantic Scholar
Quantitative proteomics analysis of BMS‐214662 effects on CD34 positive cells from chronic myeloid leukaemia patients
S. Balabanov, C. Evans, Sheela A. Abraham, F. Pellicanò +4 more
2013Proteomics10 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

F. Pellicanò×12
Invite
F. Pellicanò — researcher profile on SciRah
G. Helgason×11
Invite
G. Helgason — researcher profile on SciRah
L. Hopcroft×10
Invite
L. Hopcroft — researcher profile on SciRah
M. Copland×10
Invite
M. Copland — researcher profile on SciRah

Sheela A. Abraham

×9

Invite

Sheela A. Abraham — researcher profile on SciRah

H. Jørgensen×9

Invite

H. Jørgensen — researcher profile on SciRah

Karen M. Dunn×7

Invite

Karen M. Dunn — researcher profile on SciRah

Invite

A. Whetton — researcher profile on SciRah

Invite

R. Bhatia — researcher profile on SciRah

Invite

K. Kranc — researcher profile on SciRah

Pablo Baquero×5

Invite

Pablo Baquero — researcher profile on SciRah

Invite

A. Michie — researcher profile on SciRah