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N. Meanwell · SciRah

Researcher profile · Semantic Scholar

N. Meanwell

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N. Meanwell — researcher profile on SciRah

h-index: 57
Works: 434
Citations: 21K

Most-cited papers

The expanding role of prodrugs in contemporary drug design and development
J. Rautio, N. Meanwell, L. Di, M. Hageman
2018Nature reviews. Drug discovery634 citations
Semantic Scholar
Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.
Benjamin M. Johnson, Yue-Zhong Shu, X. Zhuo, N. Meanwell
2020Journal of Medicinal Chemistry495 citations Open access
Semantic Scholar
Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design.
Murugaiah A. M. Subbaiah, N. Meanwell
2021Journal of Medicinal Chemistry491 citations Open access
Semantic Scholar
New insights into protein–protein interaction modulators in drug discovery and therapeutic advance
H. Nada, Yongseok Choi, Sungdo Kim, K. Jeong +2 more
2024Signal Transduction and Targeted Therapy210 citations Open access
Semantic Scholar
Applications of fluorine-containing amino acids for drug design.
Hai-Bo Mei, Jian-Lin Han, K. Klika, K. Izawa +3 more
2019European journal of medicinal chemistry171 citations
Semantic Scholar
Applications of Bioisosteres in the Design of Biologically Active Compounds.
N. Meanwell
2023Journal of Agricultural and Food Chemistry153 citations
Semantic Scholar
Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity.
Martins S Oderinde, Edna Mao, Antonio Ramirez, J. Pawluczyk +10 more
2020Journal of the American Chemical Society99 citations Open access
Semantic Scholar
Tailor-Made Amino Acids and Fluorinated Motifs as Prominent Traits in the Modern Pharmaceuticals.
Hai-Bo Mei, Jian-Lin Han, S. White, D. Graham +5 more
2020Chemistry97 citations
Semantic Scholar
Utilization of C( sp 3 )‐Carboxylic Acids and Their Redox‐Active Esters in Decarboxylative Carbon−Carbon Bond Formation
S. Karmakar, A. Silamkoti, N. Meanwell, A. Mathur +1 more
202182 citations
Semantic Scholar
Cyclic tailor-made amino acids in the design of modern pharmaceuticals.
Jiang Liu, Jian-Lin Han, K. Izawa, Tatsunori Sato +3 more
2020European journal of medicinal chemistry65 citations Open access
Semantic Scholar
Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates.
Murugaiah A. M. Subbaiah, J. Rautio, N. Meanwell
2024Chemical Society Reviews58 citations
Semantic Scholar
Artificial Intelligence in Drug Discovery: Into the Great Wide Open.
J. Bajorath, S. Kearnes, W. Walters, N. Meanwell +2 more
2020Journal of Medicinal Chemistry57 citations
Semantic Scholar
The pyridazine heterocycle in molecular recognition and drug discovery
N. Meanwell
2023Medicinal Chemistry Research56 citations Open access
Semantic Scholar
Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity.
Martins S Oderinde, Antonio Ramirez, T. Dhar, Lyndon A. M. Cornelius +8 more
2020Journal of Organic Chemistry53 citations Open access
Semantic Scholar
Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.
Yong-Jin Wu, N. Meanwell
2021Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 1.
N. Meanwell, O. Loiseleur
2022Journal of Agricultural and Food Chemistry50 citations
Semantic Scholar
Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 2.
N. Meanwell, O. Loiseleur
2022Journal of Agricultural and Food Chemistry34 citations
Semantic Scholar
5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.
K. Peese, C. Allard, T. Connolly, Barry L. Johnson +17 more
2019Journal of Medicinal Chemistry34 citations
Semantic Scholar
A Data-Driven Perspective on Bioisostere Evaluation: Mapping the Benzene Bioisostere Landscape with BioSTAR
Pol Hernández-Lladó, N. Meanwell, Angela J. Russell
2025Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.
Murugaiah A. M. Subbaiah, S. Mandlekar, Sridhar Desikan, Thangeswaran Ramar +16 more
2019Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell–mediated antitumor immunity
Michael Wichroski, Joseph L. Benci, Si-Qi Liu, Louis Chupak +26 more
2023Science Translational Medicine26 citations
Semantic Scholar
Metallaphotoredox Decarboxylative Arylation of Natural Amino Acids via an Elusive Mechanistic Pathway
Manivel Pitchai, Antonio Ramirez, Don M. Mayder, S. Ulaganathan +8 more
2022ACS Catalysis26 citations
Semantic Scholar
The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.
Alicia Regueiro-Ren, Sing-Yuen Sit, Yan Chen, Jie Chen +30 more
2022Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement
D. Donnelly, Joonyoung Kim, Tritin Tran, P. Scola +16 more
2023European Journal of Nuclear Medicine and Molecular Imaging24 citations
Semantic Scholar
Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
E. Gillis, Kyle Parcella, Michael Bowsher, James H. Cook +25 more
2023Journal of Medicinal Chemistry24 citations
Semantic Scholar
Advances in the synthesis of three-dimensional molecular architectures by dearomatizing photocycloadditions
Martins S Oderinde, Soomin Jin, T. Dhar, N. Meanwell +2 more
202122 citations
Semantic Scholar
GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile
Ira B. Dicker, J. Jeffrey, Tricia L. Protack, Zeyu Lin +10 more
2021Antimicrobial Agents and Chemotherapy22 citations Open access
Semantic Scholar
Ligand-Enabled β-C(sp3)─H Lactamization of Tosyl-Protected Aliphatic Amides Using a Practical Oxidant
Zhe Zhuang, Shuang Liu, Jinpei Cheng, Kap-Sun Yeung +3 more
2022Angewandte Chemie20 citations Open access
Semantic Scholar
Second Generation Inhibitors of HIV-1 Maturation.
Alicia Regueiro-Ren, I. Dicker, U. Hanumegowda, N. Meanwell
2019ACS Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Virtual Screening: Hope, Hype, and the Fine Line In Between
H. Nada, N. Meanwell, M. Gabr
2025Expert Opinion on Drug Discovery17 citations Open access
Semantic Scholar
Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
Li-Qiang Sun, E. Mull, S. D'Andrea, B. Zheng +33 more
2020Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
A survey of core replacements in indole-based HIV-1 attachment inhibitors.
Tao Wang, O. B. Wallace, Z. Zhang, Haiquan Fang +10 more
2019Bioorganic & Medicinal Chemistry Letters17 citations
Semantic Scholar
Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization.
L. Chupak, Michael Wichroski, Xiao-Fan Zheng, Min Ding +10 more
2023ACS Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Intramolecular [2+2] Cycloaddition of N-Allylcinnamamines and N -Allylcinnamamides by Visible-Light Photocatalysis
Martins S Oderinde, J. Kempson, Daniel J. Smith, N. Meanwell +9 more
2019Annalen der Pharmacie15 citations
Semantic Scholar
Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Jacob J. Swidorski, Susan M Jenkins, U. Hanumegowda, D. Parker +9 more
2021Bioorganic & Medicinal Chemistry Letters13 citations
Semantic Scholar
Multigram Synthesis of BMS-929075, an Allosteric, Palm Site Inhibitor of HCV NS5B Replicase, Involving the Synthesis of a Highly Functionalized Benzofuran through a Telescoped Process
Daniel J. Smith, Subramaniam Krishnananthan, N. Meanwell, A. Mathur +1 more
202013 citations
Semantic Scholar
Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
Guo Li, N. Meanwell, M. Krystal, D. Langley +16 more
2020Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir
Tao Wang, J. Kadow, N. Meanwell
2021Medicinal Chemistry Research12 citations Open access
Semantic Scholar
Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors
X. Zhuo, Yingzi Wang, Kap-Sun Yeung, Juliang Zhu +7 more
2018Xenobiotica; the fate of foreign compounds in biological systems12 citations
Semantic Scholar
Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.
B. Naidu, Manoj Patel, Brian Mcauliffe, B. Ding +12 more
2022Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
Kyle Parcella, Tao Wang, K. Eastman, Z. Zhang +27 more
2022ACS Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
In Praise of Remarkably Powerful Centamolecular Therapeutic Agents.
N. Meanwell, W. Ewing
2019ACS Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer
Joonyoung Kim, D. Donnelly, Tritin Tran, Adrienne Pena +14 more
2023Molecular Imaging and Biology9 citations Open access
Semantic Scholar
Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.
Manoj Patel, B. Naidu, Ira B. Dicker, Helen Higley +11 more
2020Bioorganic & Medicinal Chemistry9 citations Open access
Semantic Scholar
Carbon atom σ-hole tetrel bonding – a non-bonded interaction with potential application in drug design
N. Meanwell
2025Medicinal Chemistry Research8 citations
Semantic Scholar
Anagrelide: A Clinically Effective cAMP Phosphodiesterase 3A Inhibitor with Molecular Glue Properties.
N. Meanwell
2023ACS Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Design, Synthesis and SAR Study of Novel C2-Pyrazolopyrimidine Amides and Amide Isosteres as Allosteric Integrase Inhibitors.
Manoj Patel, C. Cianci, C. Allard, D. Parker +8 more
2020Bioorganic & Medicinal Chemistry Letters8 citations
Semantic Scholar
Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS).
J. Kempson, Rulin Zhao, J. Pawluczyk, Bei Wang +17 more
2024Journal of Organic Chemistry7 citations
Semantic Scholar
Sub-stoichiometric Modulation of Viral Targets-Potent Antiviral Agents That Exploit Target Vulnerability.
N. Meanwell
2023ACS Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Photo-Initiated Nickel Catalysis (PiNiC): Unmasking Dimethylnickel with Light
Martins S Oderinde, S. Jin, J. Das, Christine Jorge +8 more
2022ACS Catalysis7 citations
Semantic Scholar

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