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J. Kadow · SciRah

Researcher profile · Semantic Scholar

J. Kadow

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J. Kadow — researcher profile on SciRah

h-index: 33
Works: 196
Citations: 3,039

Most-cited papers

In Vitro Antiviral Characteristics of HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068
B. Nowicka-Sans, Yi-Fei Gong, Brian Mcauliffe, I. Dicker +17 more
2012Antimicrobial Agents and Chemotherapy137 citations Open access
Semantic Scholar
Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir.
N. Meanwell, M. Krystal, B. Nowicka-Sans, D. Langley +6 more
2018Journal of Medicinal Chemistry124 citations Open access
Semantic Scholar
Envelope Conformational Changes Induced by Human Immunodeficiency Virus Type 1 Attachment Inhibitors Prevent CD4 Binding and Downstream Entry Events
H. Ho, L. Fan, B. Nowicka-Sans, Brian Mcauliffe +16 more
2006Journal of Virology106 citations Open access
Semantic Scholar
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity
Tao Wang, Z. Yin, Z. Zhang, J. A. Bender +22 more
2009Journal of Medicinal Chemistry94 citations Open access
Semantic Scholar
A base-catalyzed, direct synthesis of 3,5-disubstituted 1,2,4-triazoles from nitriles and hydrazides
Kap-Sun Yeung, Michelle E. Farkas, J. Kadow, N. Meanwell
200579 citations
Semantic Scholar
Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.
R. Gentles, Min Ding, J. A. Bender, C. Bergstrom +42 more
2014Journal of Medicinal Chemistry78 citations Open access
Semantic Scholar
Maraviroc, a chemokine CCR5 receptor antagonist for the treatment of HIV infection and AIDS.
N. Meanwell, J. Kadow
2007Current opinion in investigational drugs63 citations
Semantic Scholar
Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase
J. Lemm, Meng-Ping Liu, R. Gentles, Min Ding +13 more
2014Antimicrobial Agents and Chemotherapy59 citations Open access
Semantic Scholar
Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action
D. Langley, S. Kimura, P. Sivaprakasam, N. Zhou +6 more
2014Proteins: Structure, Function, and Bioinformatics55 citations Open access
Semantic Scholar
In Vivo Patterns of Resistance to the HIV Attachment Inhibitor BMS-488043
N. Zhou, B. Nowicka-Sans, Sharon Zhang, L. Fan +13 more
2010Antimicrobial Agents and Chemotherapy54 citations Open access
Semantic Scholar
Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A
Jin-Hua Sun, D. O'Boyle, R. Fridell, D. Langley +18 more
2015Nature50 citations
Semantic Scholar
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 6. Preclinical and human pharmacokinetic profiling of BMS-663749, a phosphonooxymethyl prodrug of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043)
J. Kadow, Yasutsugu Ueda, N. Meanwell, T. Connolly +14 more
2012Journal of Medicinal Chemistry48 citations
Semantic Scholar
Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives.
Tao Wang, J. Kadow, Z. Zhang, Z. Yin +13 more
2009Bioorganic & Medicinal Chemistry Letters46 citations
Semantic Scholar
Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.
Kap-Sun Yeung, Zhilei Qiu, Quifen Xue, Haiquan Fang +14 more
2013Bioorganic & Medicinal Chemistry Letters45 citations
Semantic Scholar
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 12. Structure-activity relationships associated with 4-fluoro-6-azaindole derivatives leading to the identification of 1-(4-benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1h-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (B
Alicia Regueiro-Ren, Q. Xue, Jacob J. Swidorski, Yi-Fei Gong +17 more
2013Journal of Medicinal Chemistry44 citations
Semantic Scholar
Small-molecule HIV-1 gp120 inhibitors to prevent HIV-1 entry: an emerging opportunity for drug development.
J. Kadow, Hwei-gene Heidi Wang, P. Lin
2006Current opinion in investigational drugs43 citations
Semantic Scholar
The discovery of BMS-275183: an orally efficacious novel taxane.
H. Mastalerz, D. Cook, C. Fairchild, S. Hansel +10 more
2003Bioorganic & Medicinal Chemistry43 citations
Semantic Scholar
Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir.
Tao Wang, Yasutsugu Ueda, Z. Zhang, Z. Yin +13 more
2018Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Xiao-Fan Zheng, T. Hudyma, Scott W. Martin, Carl T. Bergstrom +24 more
2011Bioorganic & Medicinal Chemistry Letters40 citations
Semantic Scholar
New dual inhibitors of EGFR and HER2 protein tyrosine kinases.
B. Fink, G. Vite, H. Mastalerz, J. Kadow +9 more
2005Bioorganic & Medicinal Chemistry Letters38 citations Open access
Semantic Scholar
Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors.
Kap-Sun Yeung, Zhilei Qiu, Z. Yin, A. Trehan +17 more
2013Bioorganic & Medicinal Chemistry Letters34 citations
Semantic Scholar
Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative.
Kap-Sun Yeung, Zhilei Qiu, Zheng Yang, L. Zadjura +9 more
2013Bioorganic & Medicinal Chemistry Letters33 citations
Semantic Scholar
AlMe(3)-promoted formation of amides from acids and amines.
Jianqing Li, K. Subramaniam, Daniel J. Smith, Jennifer X. Qiao +5 more
2012Organic Letters33 citations
Semantic Scholar
Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
Kap-Sun Yeung, Brett R. Beno, Kyle Parcella, J. A. Bender +33 more
2017Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties.
Murugaiah A. M. Subbaiah, N. Meanwell, J. Kadow
2017European journal of medicinal chemistry29 citations Open access
Semantic Scholar
Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores.
Tao Wang, Zhong Yang, Z. Zhang, Yi-Fei Gong +9 more
2013Bioorganic & Medicinal Chemistry Letters29 citations
Semantic Scholar
Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.
Murugaiah A. M. Subbaiah, S. Mandlekar, Sridhar Desikan, Thangeswaran Ramar +16 more
2019Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Acetonitrile derivatives as carbonyl synthons. One-pot preparation of diheteroaryl ketones via a strategy of sequential SNAr substitution and oxidation.
Z. Yin, Z. Zhang, J. Kadow, N. Meanwell +1 more
2004Journal of Organic Chemistry28 citations
Semantic Scholar
Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
E. Gillis, Kyle Parcella, Michael Bowsher, James H. Cook +25 more
2023Journal of Medicinal Chemistry24 citations
Semantic Scholar
An efficient one-pot synthesis of 3-glyoxylic acids of electron-deficient substituted azaindoles by ionic liquid imidazolium chloroaluminate-promoted Friedel–Crafts acylation
Kap-Sun Yeung, Zhilei Qiu, Michelle E. Farkas, Q. Xue +5 more
200824 citations
Semantic Scholar
Dialkylaminoacetonitrile derivatives as amide synthons. A one-pot preparation of heteroaryl amides via a strategy of sequential SNAr substitution and oxidation.
Z. Zhang, Z. Yin, J. Kadow, N. Meanwell +1 more
2004Journal of Organic Chemistry24 citations Open access
Semantic Scholar
Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.
Min Ding, F. He, T. Hudyma, Xiao-Fan Zheng +15 more
2012Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
An effective procedure for the preparation of 3-substituted-4- or 6-azaindoles from ortho-methyl nitro pyridines
Juliang Zhu, H. Wong, Z. Zhang, Z. Yin +3 more
200622 citations
Semantic Scholar
Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties.
Zheng Yang, L. Zadjura, A. Marino, C. D’arienzo +8 more
2010Journal of Pharmacy and Science19 citations
Semantic Scholar
A one-pot synthesis of nitrogen-containing heteroaryl α-keto amides from heteroaryl halides
Juliang Zhu, H. Wong, Z. Zhang, Z. Yin +3 more
200519 citations
Semantic Scholar
Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.
Kyle Parcella, K. Eastman, Kap-Sun Yeung, Katharine A Grant-Young +21 more
2017ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Inhibitors of HIV-1 attachment. Part 11: the discovery and structure-activity relationships associated with 4,6-diazaindole cores.
J. A. Bender, Zhong Yang, Betsy J. Eggers, Yi-Fei Gong +6 more
2013Bioorganic & Medicinal Chemistry Letters18 citations
Semantic Scholar
Increased sensitivity of HIV variants selected by attachment inhibitors to broadly neutralizing antibodies.
N. Zhou, L. Fan, H. Ho, B. Nowicka-Sans +12 more
2010Virology18 citations Open access
Semantic Scholar
Inhibition of Envelope-Mediated CD4+-T-Cell Depletion by Human Immunodeficiency Virus Attachment Inhibitors
L. Alexander, Sharon Zhang, Brian Mcauliffe, D. Connors +5 more
2009Antimicrobial Agents and Chemotherapy18 citations Open access
Semantic Scholar
A survey of core replacements in indole-based HIV-1 attachment inhibitors.
Tao Wang, O. B. Wallace, Z. Zhang, Haiquan Fang +10 more
2019Bioorganic & Medicinal Chemistry Letters17 citations
Semantic Scholar
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 13. Synthesis and profiling of a novel amminium prodrug of the HIV-1 attachment inhibitor BMS-585248.
Alicia Regueiro-Ren, Jean Simmermacher-Mayer, M. Sinz, Kim A. Johnson +7 more
2013Journal of Medicinal Chemistry17 citations
Semantic Scholar
Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.
Murugaiah A. M. Subbaiah, N. Meanwell, J. Kadow, Lakshumanan Subramani +14 more
2018Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
K. Eastman, Kyle Parcella, Kap-Sun Yeung, Katharine A Grant-Young +27 more
2017MedChemComm14 citations Open access
Semantic Scholar
Enabled clinical use of an HIV-1 attachment inhibitor through drug delivery.
P. Timmins, Jonathan Brown, N. Meanwell, G. Hanna +2 more
2014Drug Discovery Today13 citations
Semantic Scholar
Antiviral Properties of HIV-1 Capsid Inhibitor GSK878
Chunfu Wang, Haichang Huang, Kirsten Mallon, L. Valera +6 more
2023Antimicrobial Agents and Chemotherapy12 citations Open access
Semantic Scholar
Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir
Tao Wang, J. Kadow, N. Meanwell
2021Medicinal Chemistry Research12 citations Open access
Semantic Scholar
Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors
X. Zhuo, Yingzi Wang, Kap-Sun Yeung, Juliang Zhu +7 more
2018Xenobiotica; the fate of foreign compounds in biological systems12 citations
Semantic Scholar
Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.
B. Naidu, Manoj Patel, Brian Mcauliffe, B. Ding +12 more
2022Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
Kyle Parcella, Tao Wang, K. Eastman, Z. Zhang +27 more
2022ACS Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Chapter 20 Progress towards the Discovery and Development of Specifically Targeted Inhibitors of Hepatitis C Virus
N. Meanwell, J. Kadow, P. Scola
200910 citations
Semantic Scholar

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