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M. Akimoto · SciRah

Researcher profile · Semantic Scholar

M. Akimoto

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M. Akimoto — researcher profile on SciRah

h-index: 15
Works: 49
Citations: 638

Most-cited papers

Signaling through dynamic linkers as revealed by PKA
M. Akimoto, Rajeevan Selvaratnam, E. T. McNicholl, Geeta Verma +2 more
2013Proceedings of the National Academy of Sciences of the United States of America100 citations Open access
Semantic Scholar
A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP*
M. Akimoto, Zai-Yong Zhang, Stephen Boulton, Rajeevan Selvaratnam +5 more
2014Journal of Biological Chemistry74 citations Open access
Semantic Scholar
A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis
Stephen Boulton, M. Akimoto, Rajeevan Selvaratnam, Amir Bashiri +1 more
2014Scientific Reports59 citations Open access
Semantic Scholar
Allosteric inhibition explained through conformational ensembles sampling distinct “mixed” states
J. Byun, B. VanSchouwen, M. Akimoto, G. Melacini
2020Computational and Structural Biotechnology Journal30 citations Open access
Semantic Scholar
Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα
M. Akimoto, E. T. McNicholl, Avinash Ramkissoon, Kody Moleschi +2 more
2015PLoS Biology30 citations Open access
Semantic Scholar
Measurement of State-Specific Association Constants in Allosteric Sensors through Molecular Stapling and NMR.
Kody Moleschi, M. Akimoto, G. Melacini
2015Journal of the American Chemical Society27 citations
Semantic Scholar
Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels*♦
B. VanSchouwen, M. Akimoto, M. Sayadi, F. Fogolari +1 more
2015Journal of Biological Chemistry24 citations Open access
Semantic Scholar
Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective
Alveena Ahmed, Stephen Boulton, Hong-Zhao Shao, M. Akimoto +3 more
2019Cells22 citations Open access
Semantic Scholar
Molecular Mechanism for the Suppression of Alpha Synuclein Membrane Toxicity by an Unconventional Extracellular Chaperone.
Rashik Ahmed, Jin-Feng Huang, Daniel K. Weber, T. Gopinath +9 more
2020Journal of the American Chemical Society21 citations
Semantic Scholar
A Novel Non-canonical Forkhead-associated (FHA) Domain-binding Interface Mediates the Interaction between Rad53 and Dbf4 Proteins*
L. Matthews, Rajeevan Selvaratnam, Darryl R. Jones, M. Akimoto +4 more
2013Journal of Biological Chemistry20 citations Open access
Semantic Scholar
cAMP-dependent allostery and dynamics in Epac: an NMR view.
Rajeevan Selvaratnam, M. Akimoto, B. VanSchouwen, G. Melacini
2012Biochemical Society Transactions20 citations
Semantic Scholar
Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia
Stephen Boulton, M. Akimoto, Sam Akbarizadeh, G. Melacini
2017Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase
J. Byun, Katherine Van, Jin-Feng Huang, Philipp Henning +5 more
2020Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Allosteric linkers in cAMP signalling
M. Akimoto, Kody Moleschi, Stephen Boulton, B. VanSchouwen +3 more
2014Biochemical Society Transactions16 citations Open access
Semantic Scholar
Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.
Stephen Boulton, M. Akimoto, B. VanSchouwen, Kody Moleschi +3 more
2014Biochemical Society Transactions16 citations
Semantic Scholar
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations
Naeimeh Jafari, J. D. Del Rio, M. Akimoto, J. Byun +10 more
2021Proceedings of the National Academy of Sciences of the United States of America14 citations Open access
Semantic Scholar
Allosteric pluripotency as revealed by protein kinase A
J. Byun, M. Akimoto, B. VanSchouwen, T. S. Lazarou +2 more
2020Science Advances14 citations Open access
Semantic Scholar
Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization
K. Matsumura, Takushi Shimomura, Y. Kubo, Takayuki Oka +11 more
2020bioRxiv13 citations Open access
Semantic Scholar
CHESPA/CHESCA-SPARKY: automated NMR data analysis plugins for SPARKY to map protein allostery
Hong-Zhao Shao, Stephen Boulton, C. Olivieri, Hebatallah B. Mohamed +6 more
2020Bioinform.12 citations Open access
Semantic Scholar
Atomic Resolution Map of Hierarchical Self-Assembly for an Amyloidogenic Protein Probed through Thermal 15N-R2 Correlation Matrices.
Rashik Ahmed, Jin-Feng Huang, M. Akimoto, Tongyu Shi +1 more
2021Journal of the American Chemical Society11 citations
Semantic Scholar
The structure of the apo cAMP‐binding domain of HCN4 – a stepping stone toward understanding the cAMP‐dependent modulation of the hyperpolarization‐activated cyclic‐nucleotide‐gated ion channels
M. Akimoto, B. VanSchouwen, G. Melacini
2018The FEBS Journal11 citations
Semantic Scholar
Allosteric pluripotency as revealed by protein kinase A.
J. Byun, M. Akimoto, B. VanSchouwen, T. S. Lazarou +2 more
2020Science Advances10 citations Open access
Semantic Scholar
An auto-inhibited state of protein kinase G and implications for selective activation
Rajesh Sharma, J. J. Kim, Liying Qin, Philipp Henning +9 more
2022bioRxiv9 citations Open access
Semantic Scholar
Allosteric Mechanisms of Nonadditive Substituent Contributions to Protein-Ligand Binding.
Stephen Boulton, Katherine Van, B. VanSchouwen, Jerry Augustine +2 more
2020Biophysical Journal9 citations Open access
Semantic Scholar
Non-Canonical Allostery in Cyclic Nucleotide Dependent Kinases.
Mariia Khamina, Karla Martinez Pomier, M. Akimoto, B. VanSchouwen +1 more
2022Journal of Molecular Biology7 citations
Semantic Scholar
State-selective frustration as a key driver of allosteric pluripotency
J. Byun, B. VanSchouwen, N. Parikh, M. Akimoto +2 more
2021Chemical Science6 citations Open access
Semantic Scholar
A Highly Dynamic Loop of the Pseudomonas aeruginosa PA14 Type IV Pilin Is Essential for Pilus Assembly.
Y. Nguyen, Stephen Boulton, E. Tyler McNicholl, M. Akimoto +4 more
2018ACS Infectious Diseases6 citations
Semantic Scholar
Allosteric pluripotency: challenges and opportunities.
M. Akimoto, Karla Martinez Pomier, B. VanSchouwen, J. Byun +2 more
2022Biochemical Journal4 citations
Semantic Scholar
QSAR models reveal new EPAC-selective allosteric modulators
Hebatallah B. Mohamed, Hong-Zhao Shao, M. Akimoto, Patrick Darveau +3 more
2022RSC Chemical Biology4 citations Open access
Semantic Scholar
An NMR based phosphodiesterase assay.
M. Akimoto, T. Yu, Kody Moleschi, Katherine Van +2 more
2020Chemical Communications4 citations
Semantic Scholar
Resonance assignments of asymmetric tetrameric platelet factor 4 (PF4)
Qiu-Lin Ma, Jin-Feng Huang, Stephen Boulton, Ellen Mak +10 more
2025Biomolecular NMR Assignments2 citations
Semantic Scholar
Early-Onset Parkinson Mutation Remodels Monomer–Fibril Interactions to Allosterically Amplify Synuclein’s Amyloid Cascade
Jin-Feng Huang, Rashik Ahmed, M. Akimoto, Karla Martinez Pomier +1 more
2023JACS Au2 citations Open access
Semantic Scholar
Allosteric Regulation of Cyclic Nucleotide Dependent Protein Kinases
Karla Martinez Pomier, M. Akimoto, J. Byun, Mariia Khamina +1 more
2022Canadian journal of chemistry (Print)2 citations Open access
Semantic Scholar
Backbone resonance assignment of the cAMP-binding domains of the protein kinase A regulatory subunit Iα
E. T. McNicholl, Rahul K. Das, Soumita SilDas, J. Byun +3 more
2021Biomolecular NMR Assignments2 citations
Semantic Scholar
Follistatin improves vascular function by inhibiting oxidative stress and inducing browning of perivascular adipose tissue in essential hypertension
Ann Kuganathan, Vincent Lu, Melissa Macdonald, S. Farkona +7 more
2026bioRxiv1 citations Open access
Semantic Scholar
Recurrent Acrodysostosis-Related PKA RIα Mutant Reveals a Novel Mechanism of Aberrant PKA Deactivation
Leonardo Della Libera, Karla Martinez Pomier, M. Akimoto, G. Anand +2 more
2025Journal of Molecular Biology1 citations
Semantic Scholar
A cryptic symmetry switch allosterically controls how the PF4 self-protein turns into a pathogenic antigen
Qiu-Lin Ma, Jin-Feng Huang, Ellen Mak, Karla Martinez Pomier +5 more
2026Nature Communications0 citations Open access
Semantic Scholar
Mechanism of Protein Kinase G Allosteric Inhibitors with Therapeutic Potential in Retinal Degeneration
Karla Martinez Pomier, M. Akimoto, Alexandra Fachinger, Mariia Khamina +7 more
2026Mechanism of Protein Kinase G Allosteric Inhibitors with Therapeutic Potential in Retinal Degeneration0 citations Open access
Semantic Scholar
NMR reveals allosteric mechanisms of protein kinase G mutations associated with aortopathies and altered cGMP dependence
Karla Martinez Pomier, Leopold Jahn, B. VanSchouwen, H. Mohamed +8 more
2026NMR reveals allosteric mechanisms of protein kinase G mutations associated with aortopathies and altered cGMP dependence0 citations Open access
Semantic Scholar
Follistatin Alleviates Vascular Dysfunction by Reducing Oxidative Stress and Promoting Browning in Perivascular Adipose Tissue.
Ann Kuganathan, Chao Lu, Melissa Macdonald, S. Farkona +7 more
2026HYPERTENSION0 citations
Semantic Scholar
In situ NMR and integrative proteomics reveal the interaction signature of serum α-synuclein
Jin-Feng Huang, Rashik Ahmed, M. Akimoto, J. Bozelli +2 more
2026Proceedings of the National Academy of Sciences of the United States of America0 citations Open access
Semantic Scholar
Aortic disease-linked mutations reveal unexpected convergent allosteric mechanisms of protein kinase G misregulation
Karla Martinez Pomier, Leopold Jahn, B. VanSchouwen, Hebatallah B. Mohamed +8 more
2026Science Advances0 citations Open access
Semantic Scholar
Non-Classical Protein Kinase a Activation by Aggregation of the PKA R-Subunits as a Mechanism of Inherited Carney Complex Mutations
Naeimeh Jafari, J. D. Del Rio, M. Akimoto, Olivia Byun +9 more
20210 citations Open access
Semantic Scholar
Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization
K. Matsumura, Takushi Shimomura, Y. Kubo, Takayuki Oka +11 more
2021BMC Molecular and Cell Biology0 citations Open access
Semantic Scholar
Structural Basis of Alpha Synuclein Assembly Toxicity Inhibition by Human Serum Albumin
Rashik Ahmed, Jin-Feng Huang, A. Khondker, M. Rheinstadter +6 more
20200 citations Open access
Semantic Scholar
Backbone resonance assignments of the Pseudomonas aeruginosa major pilin PilA from strain PA14
Y. Nguyen, Tyler McNicholl, M. Akimoto, Francisca Aidoo +2 more
20180 citations
Semantic Scholar
A Tool Set to Map Dynamic Allosteric Networks through the NMR Chemical Shift Covariance Analysis (CHESCA)
Stephen Boulton, M. Akimoto, Rajeevan Selvaratnam, Amir Bashiri +1 more
20150 citations Open access
Semantic Scholar
ALLOSTERIC MECHANISMS FOR THE cAMP-DEPENDENT CONTROL OF FUNCTIONAL INTER-DOMAIN LINKERS
M. Akimoto
20150 citations
Semantic Scholar
Apo Structure of human HCN4 CNBD solved by NMR
M. Akimoto, Z. Zhang, Stephen Boulton, Rajeevan Selvaratnam +5 more
20140 citations
Semantic Scholar

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G. Melacini×44
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B. VanSchouwen×17
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Stephen Boulton×14
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Rajeevan Selvaratnam

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E. T. McNicholl×4

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Mariia Khamina — researcher profile on SciRah