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R. Natrajan · SciRah

Researcher profile · Semantic Scholar

R. Natrajan

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R. Natrajan — researcher profile on SciRah

h-index: 64
Works: 179
Citations: 14K

Most-cited papers

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity
I. Bajrami, J. Frankum, Asha Konde, Rowan E. Miller +13 more
2013Cancer Research344 citations Open access
Semantic Scholar
Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C
N. Dryden, Laura R. Broome, F. Dudbridge, N. Johnson +16 more
2014Genome Research245 citations Open access
Semantic Scholar
Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes
M. Clarke, A. Mackay, B. Ismer, Jessica C. Pickles +110 more
2020Cancer Discovery215 citations Open access
Semantic Scholar
SF3B1 mutations constitute a novel therapeutic target in breast cancer
S. Maguire, A. Leonidou, Patty Wai, C. Marchiò +6 more
2014Journal of Pathology184 citations Open access
Semantic Scholar
Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors
T. Yap, Brent O'Carrigan, M. Penney, J. Lim +19 more
2020Journal of Clinical Oncology181 citations Open access
Semantic Scholar
Genomic and mutational profiling of ductal carcinomas in situ and matched adjacent invasive breast cancers reveals intra-tumour genetic heterogeneity and clonal selection
Lucía Hernández, P. Wilkerson, M. Lambros, Adriana Campion-Flora +11 more
2012Journal of Pathology166 citations Open access
Semantic Scholar
Adenoid cystic carcinomas constitute a genomically distinct subgroup of triple‐negative and basal‐like breast cancers
D. Wetterskog, M. Á. López-García, M. Lambros, R. A'Hern +13 more
2012Journal of Pathology160 citations
Semantic Scholar
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response
S. Nagarajan, S. Rao, Joseph Sutton, D. Cheeseman +19 more
2020Nature Genetics156 citations Open access
Semantic Scholar
Genomic landscape of adenoid cystic carcinoma of the breast
L. Martelotto, M. D. de Filippo, C. Ng, R. Natrajan +17 more
2015Journal of Pathology154 citations Open access
Semantic Scholar
The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas
C. Ng, S. Piscuoglio, F. Geyer, K. Burke +11 more
2017Clinical Cancer Research147 citations Open access
Semantic Scholar
Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification
C. Ng, L. Martelotto, A. Gauthier, H. Wen +19 more
2015Genome Biology134 citations Open access
Semantic Scholar
Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology–Genomic Integration Analysis
R. Natrajan, Heba Z. Sailem, F. Mardakheh, M. Arias Garcia +4 more
2016PLoS Medicine130 citations Open access
Semantic Scholar
Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast
R. Natrajan, P. Wilkerson, C. Marchiò, S. Piscuoglio +23 more
2014Journal of Pathology110 citations Open access
Semantic Scholar
An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer
C. Maley, K. Koelble, R. Natrajan, A. Aktipis +1 more
2015Breast Cancer Research107 citations Open access
Semantic Scholar
E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer
I. Bajrami, Rebecca Marlow, M. van de Ven, R. Brough +27 more
2018Cancer Discovery106 citations Open access
Semantic Scholar
Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
James Campbell, Colm J. Ryan, R. Brough, I. Bajrami +19 more
2016Cell Reports104 citations Open access
Semantic Scholar
Metastatic breast carcinomas display genomic and transcriptomic heterogeneity
B. Weigelt, C. Ng, R. Shen, T. Popova +7 more
2014Modern Pathology83 citations Open access
Semantic Scholar
SWATH mass spectrometry as a tool for quantitative profiling of the matrisome
Lukas Krasny, Philip Bland, Naoko Kogata, Patty Wai +3 more
2018Journal of Proteomics81 citations Open access
Semantic Scholar
Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast
S. Piscuoglio, C. Ng, F. Geyer, K. Burke +12 more
2017npj Breast Cancer77 citations Open access
Semantic Scholar
Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib
A. Daemen, D. Wolf, J. Korkola, O. Griffith +11 more
2012Breast Cancer Research and Treatment72 citations Open access
Semantic Scholar
A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor negative and positive breast cancers
R. Natrajan, A. Mackay, M. Lambros, B. Weigelt +29 more
2012Journal of Pathology71 citations Open access
Semantic Scholar
Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers
Saira Khalique, Kalnisha Naidoo, A. Attygalle, D. Kriplani +11 more
2018The Journal of Pathology: Clinical Research68 citations Open access
Semantic Scholar
Genomic profiling of histological special types of breast cancer
H. Horlings, B. Weigelt, E. Anderson, M. Lambros +6 more
2013Breast Cancer Research and Treatment68 citations
Semantic Scholar
Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response Targeted Therapies in Breast Cancer
Kalnisha Naidoo, Patty Wai, S. Maguire, F. Daley +16 more
2017Molecular Cancer Therapeutics59 citations Open access
Semantic Scholar
Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors
J. P. Wong, Jason R. Todd, M. Finetti, F. McCarthy +15 more
2016Cell Reports59 citations Open access
Semantic Scholar
Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast
S. Piscuoglio, C. Ng, L. Martelotto, Carey A. Eberle +9 more
2014Molecular Oncology56 citations Open access
Semantic Scholar
Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation.
W. Dalton, Eric Helmenstine, N. Walsh, Lukasz P. Gondek +28 more
2019Journal of Clinical Investigation55 citations Open access
Semantic Scholar
ATARI trial: ATR inhibitor in combination with olaparib in gynecological cancers with ARID1A loss or no loss (ENGOT/GYN1/NCRI)
Susana Banerjee, J. Stewart, N. Porta, C. Toms +9 more
2021International Journal of Gynecological Cancer54 citations Open access
Semantic Scholar
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis
F. Geyer, M. Lacroix-Triki, P. Colombo, N. Patani +14 more
2012Histopathology52 citations Open access
Semantic Scholar
Subclonal heterogeneity and evolution in breast cancer
I. Mavrommati, F. Johnson, G. Echeverria, R. Natrajan
2021npj Breast Cancer51 citations Open access
Semantic Scholar
Comparative proteomic assessment of matrisome enrichment methodologies
Lukas Krasny, A. Paul, Patty Wai, Beatrice A. Howard +2 more
2016Biochemical Journal48 citations Open access
Semantic Scholar
Three‐dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model
S. Maguire, B. Peck, Patty Wai, James Campbell +9 more
2016Journal of Pathology45 citations Open access
Semantic Scholar
SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response
Philip Bland, Harry Saville, Patty Wai, Lucinda Curnow +35 more
2023Nature Genetics41 citations Open access
Semantic Scholar
Mutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but no KIT mutations
D. Wetterskog, P. Wilkerson, D. Rodrigues, M. Lambros +15 more
2013Histopathology41 citations Open access
Semantic Scholar
Splicing dysregulation as a driver of breast cancer
A. Read, R. Natrajan
2018Endocrine-Related Cancer38 citations Open access
Semantic Scholar
Translational genomics of ovarian clear cell carcinoma.
Saira Khalique, C. Lord, Susana Banerjee, R. Natrajan
2019Seminars in Cancer Biology37 citations Open access
Semantic Scholar
The spatio-temporal evolution of lymph node spread in early breast cancer
P. Barry, A. Vatsiou, I. Spiteri, D. Nichol +21 more
2018Clinical Cancer Research35 citations Open access
Semantic Scholar
Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer
Jason R. Todd, K. Ryall, S. Vyse, J. P. Wong +4 more
2016OncoTarget35 citations Open access
Semantic Scholar
Robust BRCA1‐like classification of copy number profiles of samples repeated across different datasets and platforms
P. Schouten, A. Grigoriadis, T. Kuilman, H. Mirza +22 more
2015Molecular Oncology35 citations Open access
Semantic Scholar
An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer
I. Garcia-Murillas, R. Sharpe, A. Pearson, James Campbell +3 more
2013Oncogene33 citations Open access
Semantic Scholar
Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies
K. Shiu, D. Wetterskog, A. Mackay, R. Natrajan +14 more
2014Oncogene28 citations Open access
Semantic Scholar
Superior breast cancer metastasis risk stratification using an epithelial-mesenchymal-amoeboid transition gene signature
A. Emad, T. Ray, Tor W. Jensen, Meera Parat +3 more
2020Breast Cancer Research24 citations Open access
Semantic Scholar
A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts
Lukas Krasny, Philip Bland, J. Burns, N. Lima +13 more
2020Disease Models & Mechanisms23 citations Open access
Semantic Scholar
Characterisation of the Stromal Microenvironment in Lobular Breast Cancer
L. Gómez-Cuadrado, Esme Bullock, Zeanap Mabruk, Hong Zhao +12 more
2022Cancers22 citations Open access
Semantic Scholar
From integrative genomics to therapeutic targets
R. Natrajan, P. Wilkerson
2013Cancer Research22 citations Open access
Semantic Scholar
Quantitative Assessment and Prognostic Associations of the Immune Landscape in Ovarian Clear Cell Carcinoma
Saira Khalique, S. Nash, D. Mansfield, Julian Wampfler +19 more
2021Cancers20 citations Open access
Semantic Scholar
Genomic profiling of mitochondrion-rich breast carcinoma: chromosomal changes may be relevant for mitochondria accumulation and tumour biology
F. Geyer, D. de Biase, M. Lambros, M. Ragazzi +9 more
2012Breast Cancer Research and Treatment19 citations Open access
Semantic Scholar
Enhanced RAD21 Cohesin Expression Confers Poor Prognosis and Resistance to Chemotherapy in High Grade Luminal, Basal, and HER 2 Breast Cancers
R. Rahbari, Hui-Ling Xu, M. Yan, J. Patra +14 more
201416 citations
Semantic Scholar
3D functional genomics screens identify CREBBP as a targetable driver in aggressive triple-negative breast cancer
B. Peck, Philip Bland, I. Mavrommati, Gareth Muirhead +38 more
2021Cancer Research15 citations Open access
Semantic Scholar
Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer
P. Wilkerson, K. Dedes, E. Samartzis, I. Dedes +9 more
2016OncoTarget14 citations Open access
Semantic Scholar

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