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T. Kuilman · SciRah

Researcher profile · Semantic Scholar

T. Kuilman

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T. Kuilman — researcher profile on SciRah

h-index: 21
Works: 41
Citations: 9,239

Most-cited papers

BRAFE600-associated senescence-like cell cycle arrest of human naevi
C. Michaloglou, Liesbeth C. W. Vredeveld, M. Soengas, C. Denoyelle +6 more
2005Nature2,235 citations Open access
Semantic Scholar
The essence of senescence.
T. Kuilman, C. Michaloglou, W. Mooi, D. Peeper
2010Genes & Development2,113 citations Open access
Semantic Scholar
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.
T. Kuilman, C. Michaloglou, Liesbeth C. W. Vredeveld, Sirith Douma +5 more
2008Cell2,039 citations Open access
Semantic Scholar
Senescence-messaging secretome: SMS-ing cellular stress
T. Kuilman, D. Peeper
2009Nature Reviews. Cancer903 citations
Semantic Scholar
Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases
F. Weeber, M. van de Wetering, M. Hoogstraat, K. Dijkstra +9 more
2015Proceedings of the National Academy of Sciences of the United States of America438 citations Open access
Semantic Scholar
Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.
David W. Vredevoogd, T. Kuilman, M. Ligtenberg, J. Boshuizen +18 more
2019Cell237 citations Open access
Semantic Scholar
Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors
J. Boshuizen, L. Koopman, O. Krijgsman, A. Shahrabi +16 more
2018Nature Medicine205 citations
Semantic Scholar
Cancer Drug Addiction is Relayed by an ERK2-Dependent Phenotype Switch
X. Kong, T. Kuilman, A. Shahrabi, J. Boshuizen +7 more
2017Nature137 citations Open access
Semantic Scholar
Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients
Ekaterina A. Semenova, Min-chul Kwon, K. Monkhorst, Ji-Ying Song +16 more
2016Cell Reports137 citations Open access
Semantic Scholar
Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts
K. Kemper, O. Krijgsman, P. Cornelissen-Steijger, A. Shahrabi +11 more
2015EMBO Molecular Medicine129 citations Open access
Semantic Scholar
XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data
R. Kluin, K. Kemper, T. Kuilman, J. D. de Ruiter +13 more
2018BMC Bioinformatics127 citations Open access
Semantic Scholar
TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells
A. Biroccio, Julien Cherfils‐Vicini, Adeline Augereau, S. Pinte +32 more
2013Nature Cell Biology119 citations
Semantic Scholar
Identification of Cdk targets that control cytokinesis
T. Kuilman, Alessio Maiolica, Molly Godfrey, Noémie Scheidel +2 more
2014EMBO Journal59 citations Open access
Semantic Scholar
BRAFV600E Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts
K. Kemper, O. Krijgsman, X. Kong, P. Cornelissen-Steijger +16 more
2016Cell Reports53 citations Open access
Semantic Scholar
RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells
Zheng-Kui Zhang, Xiangjun Kong, M. Ligtenberg, S. E. van Hal-van Veen +13 more
2022Cell Reports Medicine48 citations Open access
Semantic Scholar
CopywriteR: DNA copy number detection from off-target sequence data
T. Kuilman, A. Velds, K. Kemper, M. Ranzani +13 more
2015Genome Biology36 citations Open access
Semantic Scholar
Robust BRCA1‐like classification of copy number profiles of samples repeated across different datasets and platforms
P. Schouten, A. Grigoriadis, T. Kuilman, H. Mirza +22 more
2015Molecular Oncology35 citations Open access
Semantic Scholar
SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response
Sofía Ibáñez-Molero, A. van Vliet, J. Pozniak, K. Hummelink +12 more
2022Oncoimmunology32 citations Open access
Semantic Scholar
An adverse tumor-protective effect of IDO1 inhibition
J. Kenski, Xin-Yao Huang, David W. Vredevoogd, B. de Bruijn +19 more
2023Cell Reports Medicine31 citations Open access
Semantic Scholar
Detailed imaging and genetic analysis reveal a secondary BRAFL505H resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib
M. Hoogstraat, C. G. Gadellaa-van Hooijdonk, I. Ubink, N. Besselink +13 more
2015Pigment Cell & Melanoma Research27 citations Open access
Semantic Scholar
Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.
David W. Vredevoogd, T. Kuilman, M. Ligtenberg, J. Boshuizen +18 more
2020Cell25 citations Open access
Semantic Scholar
Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies
T. Kuilman, Deborah S. Schrikkema, Jules Gadiot, Raquel Gomez-Eerland +29 more
2025Nature Communications21 citations Open access
Semantic Scholar
Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation
T. Severson, E. Nevedomskaya, J. Peeters, T. Kuilman +13 more
2016OncoTarget16 citations Open access
Semantic Scholar
Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma
W. Theelen, O. Krijgsman, K. Monkhorst, T. Kuilman +9 more
2020Journal of Translational Medicine11 citations Open access
Semantic Scholar
Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer
W. Theelen, T. Kuilman, K. Schulze, W. Zou +13 more
2019PLoS ONE11 citations Open access
Semantic Scholar
Nur1 Dephosphorylation Confers Positive Feedback to Mitotic Exit Phosphatase Activation in Budding Yeast
Molly Godfrey, T. Kuilman, F. Uhlmann
2015PLoS Genetics10 citations Open access
Semantic Scholar
The Elongin BC complex negatively regulates AXL and marks a differentiated phenotype in melanoma.
Sebastiaan M Schieven, J. Traets, Alex V. Vliet, Mart van Baalen +4 more
2023Molecular Cancer Research6 citations Open access
Semantic Scholar
Non-clinical evaluation of NT-112, an autologous T cell product engineered to express an HLA-C*08:02-restricted TCR targeting KRAS G12D and resistant to TGF-b inhibition.
Jennifer Ma, Vanessa Tubb, Michelle Mojadidi, K. Meade +15 more
2024Journal of Clinical Oncology4 citations
Semantic Scholar
Non-clinical evaluation of NT-175, an autologous T cell product engineered to express an HLA-A*02:01-restricted TCR targeting TP53 R175H and resistant to TGF-b inhibition.
Vanessa Tubb, Jennifer Ma, Karen Buchner, Sander Eshuis +16 more
2024Journal of Clinical Oncology3 citations Open access
Semantic Scholar
Predictive Immune-Checkpoint Blockade Classifiers Identify Tumors Responding to Inhibition of PD-1 and/or CTLA-4
O. Krijgsman, K. Kemper, J. Boshuizen, David W. Vredevoogd +15 more
2021Clinical Cancer Research2 citations
Semantic Scholar
Phenotypic diversity drives paracrine drug tolerance
T. Kuilman, D. Peeper
2017EMBO Molecular Medicine1 citations Open access
Semantic Scholar
241 Development of a personalized neoantigen-specific TCR discovery platform
R. Spaapen, T. Kuilman, Bo Schrikkema, Jules Gadiot +13 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
PREDICTIVE IMMUNE CHECKPOINT BLOCKADE CLASSIFIERS DISTINGUISHING MONO- VERSUS COMBINATION THERAPY REQUIREMENT
O. Krijgsman, K. Kemper, J. Boshuizen, David W. Vredevoogd +15 more
2020bioRxiv0 citations Open access
Semantic Scholar
Abstract B033: T-cell-induced tumor vulnerability discovery in an IFNγ-independent genomic landscape
D. Peeper, David W. Vredevoogd, T. Kuilman
2019Convergence of Technology and Cancer Immunotherapy0 citations
Semantic Scholar
Abstract 1041: XenofilteR: Computational dissection of mouse and human reads in PDX and xenograft sequence data
O. Krijgsman, R. Kluin, K. Kemper, T. Kuilman +13 more
2018Tumor Biology0 citations Open access
Semantic Scholar
Abstract 5627: Uncovering novel signaling pathways that mediate tumor cell killing by T effector cells
T. Kuilman, David W. Vredevoogd, D. Peeper
20170 citations
Semantic Scholar
Abstract P6-08-06: Neoadjuvant tamoxifen therapy synchronizes ERα binding and gene expression profiles
S. Linn, T. Severson, E. Nevedomskaya, J. Peeters +11 more
20160 citations
Semantic Scholar
Abstract A38: Effects on epigenomic, transcriptomic, and genomic landscape of neoadjuvant tamoxifen in estrogen receptor alpha breast cancer
T. Severson, E. Nevedomskaya, J. Peeters, Annelot G. J. van Rossum +9 more
20160 citations
Semantic Scholar
The role of secreted factors in oncogene-induced cellular senescence
T. Kuilman
20090 citations
Semantic Scholar
Novel functional genomic screens to identify pathways that protect mouse and human cells against oncogenic transformation by mutant RAS
D. Peeper, T. van Laar, L. Vredeveld, T. Kuilman +1 more
20010 citations
Semantic Scholar
Resource BRAFV 600 E Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts Graphical
K. Kemper, O. Krijgsman, X. Kong, P. Cornelissen-Steijger +16 more
0 citations
Semantic Scholar

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