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M. Niso · SciRah

Researcher profile · Semantic Scholar

M. Niso

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M. Niso — researcher profile on SciRah

h-index: 31
Works: 121
Citations: 2,642

Most-cited papers

Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials.
N. Colabufo, F. Berardi, M. Cantore, M. Contino +3 more
2010Journal of Medicinal Chemistry118 citations
Semantic Scholar
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
N. Colabufo, F. Berardi, M. Cantore, M. Perrone +8 more
2008Bioorganic & Medicinal Chemistry76 citations Open access
Semantic Scholar
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor.
C. Abate, M. Niso, V. Infantino, Alessio Menga +1 more
2015European Journal of Pharmacology70 citations
Semantic Scholar
ABC pumps and their role in active drug transport.
N. Colabufo, F. Berardi, M. Contino, M. Niso +1 more
2009Current Topics in Medicinal Chemistry70 citations
Semantic Scholar
Sigma‐2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity
M. Niso, C. Abate, M. Contino, S. Ferorelli +4 more
2013ChemMedChem58 citations
Semantic Scholar
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells.
G. Cassano, G. Gasparre, M. Niso, M. Contino +2 more
2009Cell Calcium55 citations
Semantic Scholar
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview
Pantaleo Di Pilato, M. Niso, W. Adriani, Emilia Romano +7 more
2014Reviews in the Neurosciences53 citations
Semantic Scholar
Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers.
C. Abate, M. Niso, E. Lacivita, P. Mosier +2 more
2011Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Multi‐Drug‐Resistance‐Reverting Agents: 2‐Aryloxazole and 2‐Arylthiazole Derivatives as Potent BCRP or MRP1 Inhibitors
N. Colabufo, F. Berardi, M. Perrone, M. Cantore +4 more
2009ChemMedChem50 citations
Semantic Scholar
Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.
R. Fruttero, Marco Crosetti, K. Chegaev, Stefano Guglielmo +6 more
2010Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).
F. Berardi, C. Abate, S. Ferorelli, V. Uricchio +3 more
2009Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ₂ receptors.
C. Abate, S. Selivanova, Adrienne Müller, Stefanie D. Krämer +6 more
2013European journal of medicinal chemistry46 citations Open access
Semantic Scholar
Sigma‐2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma‐2 receptor ligands to PGRMC1
Maria Laura Pati, Diana Groza, C. Riganti, J. Kopecka +9 more
2017Pharmacological Research45 citations Open access
Semantic Scholar
1‐Cyclohexyl‐4‐(4‐arylcyclohexyl)piperazines: Mixed σ and Human Δ8–Δ7 Sterol Isomerase Ligands with Antiproliferative and P‐Glycoprotein Inhibitory Activity
C. Abate, M. Niso, M. Contino, N. Colabufo +3 more
2011ChemMedChem45 citations
Semantic Scholar
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins.
N. Colabufo, V. Pagliarulo, F. Berardi, M. Contino +6 more
2008European Journal of Pharmacology45 citations
Semantic Scholar
Sigma-2 receptor: past, present and perspectives on multiple therapeutic exploitations.
C. Abate, M. Niso, F. Berardi
2018Future Medicinal Chemistry42 citations
Semantic Scholar
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
F. Berardi, C. Abate, S. Ferorelli, Anna F. de Robertis +4 more
2008Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer
Maria Laura Pati, John R. Hornick, M. Niso, F. Berardi +3 more
2017BMC Cancer39 citations Open access
Semantic Scholar
Multifunctional Thiosemicarbazones and Deconstructed Analogues as a Strategy to Study the Involvement of Metal Chelation, Sigma-2 (σ2) Receptor and P-gp Protein in the Cytotoxic Action: in vitro and in vivo Activity in Pancreatic Tumors
Maria Laura Pati, M. Niso, D. Spitzer, F. Berardi +4 more
2017European journal of medicinal chemistry38 citations Open access
Semantic Scholar
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
E. Lacivita, Daniela Patarnello, N. Stroth, Antonia Caroli +10 more
2012Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein.
R. Pellicani, A. Stefanachi, M. Niso, A. Carotti +6 more
2012Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration.
G. Mangiatordi, F. Intranuovo, P. Delre, F. S. Abatematteo +6 more
2020Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells
C. Abate, John R. Hornick, D. Spitzer, W. Hawkins +3 more
2011Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Synthesis, radiolabeling and in vivo evaluation of [(11)C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT(7) receptor.
H. D. Hansen, E. Lacivita, Pantaleo Di Pilato, M. Herth +11 more
2014European journal of medicinal chemistry31 citations
Semantic Scholar
2‐Aminopyridine Derivatives as Potential σ2 Receptor Antagonists
C. Abate, S. Ferorelli, M. Niso, C. Lovicario +4 more
2012ChemMedChem29 citations
Semantic Scholar
Interaction of the σ2 Receptor Ligand PB28 with the Human Nucleosome: Computational and Experimental Probes of Interaction with the H2A/H2B Dimer
C. Abate, J. Elenewski, M. Niso, F. Berardi +4 more
2010ChemMedChem29 citations
Semantic Scholar
Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives
F. S. Abatematteo, M. Niso, M. Contino, M. Leopoldo +1 more
2021International Journal of Molecular Sciences27 citations Open access
Semantic Scholar
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships
C. Abate, M. Niso, F. S. Abatematteo, M. Contino +2 more
2020Frontiers in Pharmacology27 citations Open access
Semantic Scholar
Novel and Selective Fluorescent σ2‐Receptor Ligand with a 3,4‐Dihydroisoquinolin‐1‐one Scaffold: A Tool to Study σ2 Receptors in Living Cells
M. Niso, C. Riganti, Maria Laura Pati, D. Ghigo +2 more
2015ChemBioChem27 citations Open access
Semantic Scholar
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor.
E. Lacivita, M. Niso, H. D. Hansen, Pantaleo Di Pilato +9 more
2014Bioorganic & Medicinal Chemistry25 citations Open access
Semantic Scholar
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.
P. Tardia, A. Stefanachi, M. Niso, D. Stolfa +11 more
2014Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2.
N. Stroth, M. Niso, N. Colabufo, R. Perrone +3 more
2015Bioorganic & Medicinal Chemistry23 citations Open access
Semantic Scholar
σ2 Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach
F. S. Abatematteo, M. Niso, E. Lacivita, C. Abate
2021Molecules22 citations Open access
Semantic Scholar
Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and σ receptors binding properties.
C. Abate, M. Niso, R. Marottoli, C. Riganti +7 more
2014Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma.
N. Colabufo, C. Abate, M. Contino, Carmela Inglese +3 more
2008Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder.
E. Lacivita, M. Niso, Margherita Mastromarino, Andrea García-Silva +6 more
2021ACS Chemical Neuroscience20 citations Open access
Semantic Scholar
Novel metal chelators thiosemicarbazones with activity at the σ2 receptors and P-glycoprotein: an innovative strategy for resistant tumor treatment
Maria Laura Pati, M. Niso, S. Ferorelli, C. Abate +1 more
201520 citations Open access
Semantic Scholar
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes
Barbara Schininà, A. Martorana, N. Colabufo, M. Contino +10 more
201520 citations
Semantic Scholar
A New Class of 1‐Aryl‐5,6‐dihydropyrrolo[2,1‐a]isoquinoline Derivatives as Reversers of P‐Glycoprotein‐Mediated Multidrug Resistance in Tumor Cells
Alisa A. Nevskaya, Maria D. Matveeva, T. Borisova, M. Niso +7 more
2018ChemMedChem19 citations Open access
Semantic Scholar
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives.
N. Colabufo, M. Contino, M. Niso, F. Berardi +2 more
2011Frontiers in Bioscience18 citations Open access
Semantic Scholar
A Benzopyrane Derivative as a P‐Glycoprotein Stimulator: A Potential Agent to Decrease β‐Amyloid Accumulation in Alzheimer’s Disease
M. Contino, M. Cantore, Elena Capparelli, M. Perrone +6 more
2012ChemMedChem17 citations
Semantic Scholar
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase.
F. Intranuovo, Leonardo Brunetti, P. Delre, G. Mangiatordi +15 more
2022Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models
M. Niso, J. Kopecka, F. S. Abatematteo, F. Berardi +2 more
2021Cellular Oncology16 citations Open access
Semantic Scholar
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line
V. Pagliarulo, P. Ancona, M. Niso, N. Colabufo +4 more
2013Molecular Cancer16 citations Open access
Semantic Scholar
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1.
Mariagrazia Rullo, M. Niso, L. Pisani, Antonio Carrieri +3 more
2019European journal of medicinal chemistry15 citations Open access
Semantic Scholar
Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study.
E. Lacivita, Sabina Podlewska, L. Speranza, M. Niso +5 more
2016European journal of medicinal chemistry15 citations Open access
Semantic Scholar
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome.
E. Lacivita, M. Niso, M. L. Stama, Anna L. Arzuaga +6 more
2020European journal of medicinal chemistry14 citations Open access
Semantic Scholar
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters
E. Lacivita, Paola De Giorgio, Daniela Patarnello, M. Niso +7 more
2013Experimental Brain Research14 citations
Semantic Scholar
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on Ureidopropanamide Scaffold Have Potential to Protect Against Inflammation-associated Oxidative Stress
M. L. Stama, E. Lacivita, Liliya N. Kirpotina, M. Niso +4 more
2017ChemMedChem13 citations Open access
Semantic Scholar
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracers
M. Niso, Maria Laura Pati, F. Berardi, C. Abate
201613 citations
Semantic Scholar

Frequent co-authors

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F. Berardi×35
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F. Berardi — researcher profile on SciRah
N. Colabufo×29
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N. Colabufo — researcher profile on SciRah
R. Perrone×29
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R. Perrone — researcher profile on SciRah
C. Abate×25
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C. Abate — researcher profile on SciRah

×19

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M. Contino — researcher profile on SciRah

M. Leopoldo×14

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M. Leopoldo — researcher profile on SciRah

E. Lacivita×13

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E. Lacivita — researcher profile on SciRah

S. Ferorelli×7

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S. Ferorelli — researcher profile on SciRah

Carmela Inglese×6

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Carmela Inglese — researcher profile on SciRah

Maria Laura Pati×6

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Maria Laura Pati — researcher profile on SciRah

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C. Riganti — researcher profile on SciRah

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A. Azzariti — researcher profile on SciRah