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R. Fruttero · SciRah

Researcher profile · Semantic Scholar

R. Fruttero

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R. Fruttero — researcher profile on SciRah

h-index: 37
Works: 290
Citations: 5,393

Most-cited papers

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
B. Molon, S. Ugel, Federica Del Pozzo, C. Soldani +15 more
2011Journal of Experimental Medicine634 citations Open access
Semantic Scholar
Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors.
S. Dallavalle, Vladimir Dobričić, L. Lazzarato, E. Gazzano +5 more
2020Drug resistance updates261 citations Open access
Semantic Scholar
Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance.
C. Riganti, B. Rolando, J. Kopecka, I. Campia +5 more
2013Molecular Pharmaceutics73 citations Open access
Semantic Scholar
Folate‐targeted liposomal nitrooxy‐doxorubicin: An effective tool against P‐glycoprotein‐positive and folate receptor‐positive tumors
E. Gazzano, B. Rolando, K. Chegaev, I. Salaroglio +13 more
2018Journal of Controlled Release72 citations Open access
Semantic Scholar
Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts.
E. Gazzano, Ilaria Buondonno, A. Marengo, B. Rolando +13 more
2019Cancer Letters62 citations Open access
Semantic Scholar
Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis.
Guilherme Felipe dos Santos Fernandes, P. C. de Souza, L. Mariño, K. Chegaev +6 more
2016European journal of medicinal chemistry61 citations Open access
Semantic Scholar
Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma
Ilaria Buondonno, E. Gazzano, E. Tavanti, K. Chegaev +8 more
2018Cellular and Molecular Life Sciences57 citations Open access
Semantic Scholar
H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance.
K. Chegaev, B. Rolando, Daniel Cortese, E. Gazzano +9 more
2016Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
New Praziquantel Derivatives Containing NO-donor Furoxans and Related Furazans as Active Agents against Schistosoma mansoni
Stefano Guglielmo, Daniel Cortese, Francesca Vottero, B. Rolando +4 more
2014European journal of medicinal chemistry50 citations Open access
Semantic Scholar
Leishmanicidal Activities of Novel Synthetic Furoxan and Benzofuroxan Derivatives
L. A. Dutra, L. D. de Almeida, T. G. Passalacqua, Juliana Santana Reis +9 more
2014Antimicrobial Agents and Chemotherapy47 citations Open access
Semantic Scholar
Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance.
K. Chegaev, Aurore Fraix, E. Gazzano, G. F. Abd-Ellatef +7 more
2017ACS Medicinal Chemistry Letters44 citations Open access
Semantic Scholar
Synthesis and Biological Evaluation of the First Example of NO-Donor Histone Deacetylase Inhibitor.
Emily Borretto, L. Lazzarato, Francesco Spallotta, C. Cencioni +4 more
2013ACS Medicinal Chemistry Letters39 citations Open access
Semantic Scholar
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.
M. Bozdağ, Tobias Dreker, C. Henry, P. Tosco +5 more
2013Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Light‐Tunable Generation of Singlet Oxygen and Nitric Oxide with a Bichromophoric Molecular Hybrid: a Bimodal Approach to Killing Cancer Cells
Aurore Fraix, Marco Blangetti, Stefano Guglielmo, L. Lazzarato +7 more
2016ChemMedChem35 citations Open access
Semantic Scholar
Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae.
S. Sortino, Cristina Parisi, Mariacristina Failla, Aurore Fraix +8 more
2019Chemistry33 citations Open access
Semantic Scholar
A Nonmetal-Containing Nitric Oxide Donor Activated with Single-Photon Green Light.
Marco Blangetti, Aurore Fraix, L. Lazzarato, E. Marini +5 more
2017Chemistry33 citations Open access
Semantic Scholar
Doxorubicin-antioxidant co-drugs.
K. Chegaev, C. Riganti, B. Rolando, L. Lazzarato +5 more
2013Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Designing Multitarget Anti‐inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists–COX‐2 Inhibitors
M. Bertinaria, Mohammed Abrar Abdul Gaffar Shaikh, C. Buccellati, C. Cena +8 more
2012ChemMedChem32 citations Open access
Semantic Scholar
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.
M. Lolli, M. Giorgis, P. Tosco, A. Foti +2 more
2012European journal of medicinal chemistry31 citations Open access
Semantic Scholar
Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents.
K. Chegaev, L. Lazzarato, Y. Tamboli, D. Boschi +7 more
2014Bioorganic & Medicinal Chemistry30 citations Open access
Semantic Scholar
New nitric oxide or hydrogen sulfide releasing aspirins.
L. Lazzarato, K. Chegaev, E. Marini, B. Rolando +6 more
2011Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria.
M. Bertinaria, Stefano Guglielmo, B. Rolando, M. Giorgis +7 more
2011European journal of medicinal chemistry29 citations Open access
Semantic Scholar
Liposomal nitrooxy-doxorubicin: one step over caelyx in drug-resistant human cancer cells.
Isabella Pedrini, E. Gazzano, K. Chegaev, B. Rolando +6 more
2014Molecular Pharmaceutics28 citations Open access
Semantic Scholar
Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells.
C. Riganti, M. Contino, Stefano Guglielmo, M. Perrone +8 more
2018Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
A Nitric Oxide-Donor Furoxan Moiety Improves the Efficacy of Edaravone against Early Renal Dysfunction and Injury Evoked by Ischemia/Reperfusion
F. Chiazza, K. Chegaev, M. Rogazzo, J. Cutrin +4 more
2015Oxidative Medicine and Cellular Longevity27 citations Open access
Semantic Scholar
A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light.
Cristina Parisi, Mariacristina Failla, Aurore Fraix, A. Rescifina +7 more
2019Bioorganic chemistry (Print)25 citations Open access
Semantic Scholar
Overcoming multidrug resistance by targeting mitochondria with NO-donating doxorubicins.
E. Gazzano, K. Chegaev, B. Rolando, Marco Blangetti +4 more
2016Bioorganic & Medicinal Chemistry25 citations Open access
Semantic Scholar
1,2,5-Oxadiazole analogues of leflunomide and related compounds.
M. Giorgis, M. Lolli, B. Rolando, A. Rao +5 more
2011European journal of medicinal chemistry24 citations Open access
Semantic Scholar
NO in Viral Infections: Role and Development of Antiviral Therapies
Federica Sodano, E. Gazzano, R. Fruttero, L. Lazzarato
2022Molecules23 citations Open access
Semantic Scholar
Furoxan Nitric Oxide Donors Disperse Pseudomonas aeruginosa Biofilms, Accelerate Growth, and Repress Pyoverdine Production.
W. Poh, N. Barraud, Stefano Guglielmo, L. Lazzarato +3 more
2017ACS Chemical Biology23 citations Open access
Semantic Scholar
MRP5 nitration by NO-releasing gemcitabine encapsulated in liposomes confers sensitivity in chemoresistant pancreatic adenocarcinoma cells.
Francesca Masetto, K. Chegaev, E. Gazzano, Nidula Mullappilly +5 more
2020Biochimica et biophysica acta. Molecular cell research22 citations Open access
Semantic Scholar
NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease.
K. Chegaev, A. Federico, E. Marini, B. Rolando +12 more
2015Bioorganic & Medicinal Chemistry22 citations Open access
Semantic Scholar
One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells.
M. Contino, Stefano Guglielmo, C. Riganti, Giulia Antonello +5 more
2020European journal of medicinal chemistry20 citations Open access
Semantic Scholar
Structural and biological characterization of new hybrid drugs joining an HDAC inhibitor to different NO-donors.
S. Atlante, K. Chegaev, C. Cencioni, Stefano Guglielmo +6 more
2018European journal of medicinal chemistry20 citations Open access
Semantic Scholar
Water‐Soluble Nitric‐Oxide‐Releasing Acetylsalicylic Acid (ASA) Prodrugs
B. Rolando, L. Lazzarato, Monica Donnola, E. Marini +5 more
2013ChemMedChem20 citations Open access
Semantic Scholar
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues.
Y. Tamboli, L. Lazzarato, E. Marini, Stefano Guglielmo +5 more
2012Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Combination of PDT and NOPDT with a Tailored BODIPY Derivative
L. Lazzarato, E. Gazzano, Marco Blangetti, Aurore Fraix +6 more
2019Antioxidants19 citations Open access
Semantic Scholar
NO-Donor Dihydroartemisinin Derivatives as Multitarget Agents for the Treatment of Cerebral Malaria
M. Bertinaria, Pamela Orjuela-Sanchez, E. Marini, Stefano Guglielmo +7 more
2015Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Tuning the Hydrophobicity of a Mitochondria‐Targeted NO Photodonor
Federica Sodano, B. Rolando, F. Spyrakis, Mariacristina Failla +6 more
2018ChemMedChem18 citations Open access
Semantic Scholar
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein.
Stefano Guglielmo, L. Lazzarato, M. Contino, M. Perrone +5 more
2016Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives.
D. Boschi, Stefano Guglielmo, S. Aiello, G. Morace +2 more
2011Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
A Molecular Hybrid for Mitochondria‐Targeted NO Photodelivery
Federica Sodano, E. Gazzano, Aurore Fraix, B. Rolando +7 more
2018ChemMedChem17 citations Open access
Semantic Scholar
New Tetrahydroisoquinoline Derivatives Overcome Pgp Activity in Brain-Blood Barrier and Glioblastoma Multiforme in Vitro
I. Salaroglio, E. Gazzano, J. Kopecka, K. Chegaev +4 more
2018Molecules17 citations Open access
Semantic Scholar
In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition.
M. Hoxha, C. Buccellati, V. Capra, D. Garella +7 more
2016Pharmacological Research17 citations Open access
Semantic Scholar
6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity.
D. Boschi, P. Tosco, N. Chandra, S. Chaurasia +4 more
2013European journal of medicinal chemistry16 citations Open access
Semantic Scholar
Carnosine analogues containing NO-donor substructures: synthesis, physico-chemical characterization and preliminary pharmacological profile.
M. Bertinaria, B. Rolando, M. Giorgis, Gabriele Montanaro +6 more
2012European journal of medicinal chemistry16 citations Open access
Semantic Scholar
New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands.
M. Contino, Stefano Guglielmo, M. Perrone, Roberta Giampietro +9 more
2018MedChemComm15 citations Open access
Semantic Scholar
Tuning NO release of organelle-targeted furoxan derivatives and their cytotoxicity against lung cancer cells.
Federica Sodano, E. Gazzano, B. Rolando, E. Marini +4 more
2021Bioorganic chemistry (Print)14 citations
Semantic Scholar
A multi-photoresponsive molecular-hybrid for dual-modal photoinactivation of cancer cells
Aurore Fraix, Stefano Guglielmo, V. Cardile, A. Graziano +5 more
201413 citations Open access
Semantic Scholar
Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents
Gabriele Montanaro, M. Bertinaria, B. Rolando, R. Fruttero +5 more
2013Bioorganic & Medicinal Chemistry13 citations Open access
Semantic Scholar

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A. Gasco×32
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A. Gasco — researcher profile on SciRah
B. Rolando×31
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B. Rolando — researcher profile on SciRah
L. Lazzarato×26
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L. Lazzarato — researcher profile on SciRah
K. Chegaev×20
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K. Chegaev — researcher profile on SciRah

×19

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C. Riganti — researcher profile on SciRah

Stefano Guglielmo×18

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Stefano Guglielmo — researcher profile on SciRah

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E. Gazzano — researcher profile on SciRah

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S. Sortino — researcher profile on SciRah

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E. Marini — researcher profile on SciRah

Aurore Fraix×8

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Aurore Fraix — researcher profile on SciRah

Marco Blangetti×7

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Marco Blangetti — researcher profile on SciRah

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J. Kopecka — researcher profile on SciRah