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C. Abate · SciRah

Researcher profile · Semantic Scholar

C. Abate

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C. Abate — researcher profile on SciRah

h-index: 28
Works: 98
Citations: 2,624

Most-cited papers

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
D. Gordon, J. Hiatt, Mehdi Bouhaddou, V. Rezelj +194 more
2020Science675 citations Open access
Semantic Scholar
Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines
N. Colabufo, F. Berardi, M. Contino, M. Niso +3 more
2004Naunyn-Schmiedeberg's Archives of Pharmacology103 citations
Semantic Scholar
Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer
John R. Hornick, S. Vangveravong, D. Spitzer, C. Abate +4 more
2012Journal of experimental & clinical cancer research : CR73 citations Open access
Semantic Scholar
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor.
C. Abate, M. Niso, V. Infantino, Alessio Menga +1 more
2015European Journal of Pharmacology70 citations
Semantic Scholar
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cyclohexylpiperazine as σ Receptor Ligands with Agonist σ2 Activity
F. Berardi, S. Ferorelli, C. Abate, N. Colabufo +3 more
200464 citations Open access
Semantic Scholar
Sigma‐2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity
M. Niso, C. Abate, M. Contino, S. Ferorelli +4 more
2013ChemMedChem58 citations
Semantic Scholar
Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers.
C. Abate, M. Niso, E. Lacivita, P. Mosier +2 more
2011Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Is the sigma2 receptor a histone binding protein?
N. Colabufo, F. Berardi, C. Abate, M. Contino +2 more
2006Journal of Medicinal Chemistry48 citations
Semantic Scholar
Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).
F. Berardi, C. Abate, S. Ferorelli, V. Uricchio +3 more
2009Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ₂ receptors.
C. Abate, S. Selivanova, Adrienne Müller, Stefanie D. Krämer +6 more
2013European journal of medicinal chemistry46 citations Open access
Semantic Scholar
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure-Affinity Relationship (SAfiR) and Structure-Activity Relationship (SAR) Studies.
Francesco Spinelli, Elena Capparelli, C. Abate, N. Colabufo +1 more
2017Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
Sigma‐2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma‐2 receptor ligands to PGRMC1
Maria Laura Pati, Diana Groza, C. Riganti, J. Kopecka +9 more
2017Pharmacological Research45 citations Open access
Semantic Scholar
1‐Cyclohexyl‐4‐(4‐arylcyclohexyl)piperazines: Mixed σ and Human Δ8–Δ7 Sterol Isomerase Ligands with Antiproliferative and P‐Glycoprotein Inhibitory Activity
C. Abate, M. Niso, M. Contino, N. Colabufo +3 more
2011ChemMedChem45 citations
Semantic Scholar
Sigma-2 receptor: past, present and perspectives on multiple therapeutic exploitations.
C. Abate, M. Niso, F. Berardi
2018Future Medicinal Chemistry42 citations
Semantic Scholar
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
F. Berardi, C. Abate, S. Ferorelli, Anna F. de Robertis +4 more
2008Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries.
Christian Moritz, F. Berardi, C. Abate, F. Peri
2015Neuroscience Letters41 citations Open access
Semantic Scholar
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer
Maria Laura Pati, John R. Hornick, M. Niso, F. Berardi +3 more
2017BMC Cancer39 citations Open access
Semantic Scholar
Multifunctional Thiosemicarbazones and Deconstructed Analogues as a Strategy to Study the Involvement of Metal Chelation, Sigma-2 (σ2) Receptor and P-gp Protein in the Cytotoxic Action: in vitro and in vivo Activity in Pancreatic Tumors
Maria Laura Pati, M. Niso, D. Spitzer, F. Berardi +4 more
2017European journal of medicinal chemistry38 citations Open access
Semantic Scholar
Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity.
C. Abate, R. Perrone, F. Berardi
2012Current pharmaceutical design36 citations
Semantic Scholar
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration.
G. Mangiatordi, F. Intranuovo, P. Delre, F. S. Abatematteo +6 more
2020Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells
C. Abate, John R. Hornick, D. Spitzer, W. Hawkins +3 more
2011Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines
C. Cantonero, P. Camello, C. Abate, F. Berardi +3 more
2020Cancers33 citations Open access
Semantic Scholar
Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers.
C. Abate, S. Ferorelli, M. Contino, R. Marottoli +3 more
2011European journal of medicinal chemistry32 citations Open access
Semantic Scholar
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor.
F. Berardi, S. Ferorelli, C. Abate, M. Pedone +3 more
2005Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
2‐Aminopyridine Derivatives as Potential σ2 Receptor Antagonists
C. Abate, S. Ferorelli, M. Niso, C. Lovicario +4 more
2012ChemMedChem29 citations
Semantic Scholar
Interaction of the σ2 Receptor Ligand PB28 with the Human Nucleosome: Computational and Experimental Probes of Interaction with the H2A/H2B Dimer
C. Abate, J. Elenewski, M. Niso, F. Berardi +4 more
2010ChemMedChem29 citations
Semantic Scholar
A structure-affinity and comparative molecular field analysis of sigma-2 (sigma2) receptor ligands.
C. Abate, P. Mosier, F. Berardi, R. Glennon
2009Central Nervous System Agents in Medicinal Chemistry29 citations
Semantic Scholar
Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies.
S. Ferorelli, C. Abate, N. Colabufo, M. Niso +3 more
2007Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review
F. Berardi, C. Abate, S. Ferorelli, N. Colabufo +1 more
200928 citations
Semantic Scholar
Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives
F. S. Abatematteo, M. Niso, M. Contino, M. Leopoldo +1 more
2021International Journal of Molecular Sciences27 citations Open access
Semantic Scholar
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships
C. Abate, M. Niso, F. S. Abatematteo, M. Contino +2 more
2020Frontiers in Pharmacology27 citations Open access
Semantic Scholar
Novel and Selective Fluorescent σ2‐Receptor Ligand with a 3,4‐Dihydroisoquinolin‐1‐one Scaffold: A Tool to Study σ2 Receptors in Living Cells
M. Niso, C. Riganti, Maria Laura Pati, D. Ghigo +2 more
2015ChemBioChem27 citations Open access
Semantic Scholar
Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor
Chia-Chi Liu, Ching-Fang Yu, Shu-Chi Wang, Hsueh-Yin Li +4 more
2019BMC Cancer26 citations Open access
Semantic Scholar
Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines.
N. Colabufo, F. Berardi, M. Contino, M. Niso +3 more
2004Naunyn-Schmiedeberg's Archives of Pharmacology24 citations
Semantic Scholar
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells.
I. Salaroglio, C. Abate, B. Rolando, L. Battaglia +9 more
2019Molecular Pharmaceutics23 citations Open access
Semantic Scholar
σ2 Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach
F. S. Abatematteo, M. Niso, E. Lacivita, C. Abate
2021Molecules22 citations Open access
Semantic Scholar
MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor
C. Riganti, Roberta Giampietro, J. Kopecka, C. Costamagna +3 more
2020International Journal of Molecular Sciences22 citations Open access
Semantic Scholar
Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and σ receptors binding properties.
C. Abate, M. Niso, R. Marottoli, C. Riganti +7 more
2014Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists.
E. Lacivita, Imane Ghafir El Idrissi, Sabina Podlewska, C. Abate +2 more
2023Current Medicinal Chemistry21 citations Open access
Semantic Scholar
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma.
N. Colabufo, C. Abate, M. Contino, Carmela Inglese +3 more
2008Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R).
Francesco Spinelli, Roberta Giampietro, A. Stefanachi, C. Riganti +12 more
2020European journal of medicinal chemistry20 citations Open access
Semantic Scholar
Novel metal chelators thiosemicarbazones with activity at the σ2 receptors and P-glycoprotein: an innovative strategy for resistant tumor treatment
Maria Laura Pati, M. Niso, S. Ferorelli, C. Abate +1 more
201520 citations Open access
Semantic Scholar
4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity.
F. Berardi, S. Ferorelli, C. Abate, N. Colabufo +3 more
2004Journal of Medicinal Chemistry19 citations
Semantic Scholar
Interaction of chiral MS-245 analogs at h5-HT6 receptors.
C. Abate, R. Kolanos, M. Dukat, V. Setola +2 more
2005Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase.
F. Intranuovo, Leonardo Brunetti, P. Delre, G. Mangiatordi +15 more
2022Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models
M. Niso, J. Kopecka, F. S. Abatematteo, F. Berardi +2 more
2021Cellular Oncology16 citations Open access
Semantic Scholar
Quantum Dot Based Luminescent Nanoprobes for Sigma-2 Receptor Imaging.
Maria Laura Pati, E. Fanizza, Sonja Hager, Diana Groza +7 more
2018Molecular Pharmaceutics16 citations
Semantic Scholar
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity
G. Skuza, W. Sadaj, M. Kabziński, G. Cassano +3 more
2014Pharmacological Reports16 citations
Semantic Scholar
Effects of PB 190 and PB 212 , new receptor ligands , on glucocorticoid receptor-mediated gene transcription in LMCAT cells
G. Skuza, M. Szymańska, Bogusława Budziszewska, C. Abate +1 more
201216 citations
Semantic Scholar
Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease
N. J. Izzo, Martí Colom‐Cadena, A. Riad, Jin-Bin Xu +7 more
2020eNeuro14 citations Open access
Semantic Scholar

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F. Berardi×37
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M. Niso×28
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R. Perrone×21
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N. Colabufo×19
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S. Ferorelli×13

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F. S. Abatematteo×7

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Maria Laura Pati×6

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Maria Laura Pati — researcher profile on SciRah

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D. Spitzer — researcher profile on SciRah

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