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K. Politi · SciRah

Researcher profile · Semantic Scholar

K. Politi

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K. Politi — researcher profile on SciRah

h-index: 50
Works: 190
Citations: 19K

Most-cited papers

Immunotherapy in Non-Small Cell Lung Cancer: Facts and Hopes
D. Doroshow, M. Sanmamed, K. Hastings, K. Politi +5 more
2019Clinical Cancer Research532 citations Open access
Semantic Scholar
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
Jin Wei, M. M. Alfajaro, Peter C. DeWeirdt, Ruth E. Hanna +27 more
2020Cell485 citations Open access
Semantic Scholar
Cycling cancer persister cells arise from lineages with distinct programs
Yaara Oren, Michael Tsabar, Michael S. Cuoco, L. Amir-Zilberstein +19 more
2021Nature440 citations Open access
Semantic Scholar
Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA
S. Goldberg, Azeet Narayan, A. Kole, R. Decker +15 more
2018Clinical Cancer Research376 citations Open access
Semantic Scholar
EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer
K. Hastings, H.-A. Yu, W. Wei, F. Sanchez-Vega +27 more
2019Annals of Oncology330 citations Open access
Semantic Scholar
Expression analysis and significance of PD-1, LAG-3 and TIM-3 in human non-small cell lung cancer using spatially-resolved and multiparametric single-cell analysis.
I. Datar, M. Sanmamed, Jun Wang, B. Henick +21 more
2019Clinical Cancer Research265 citations Open access
Semantic Scholar
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
S. Gettinger, J. Choi, N. Mani, M. Sanmamed +18 more
2018Nature Communications175 citations Open access
Semantic Scholar
The Impact of Smoking and TP53 mutations in lung adenocarcinoma patients with targetable mutations – the Lung Cancer Mutation Consortium (LCMC2)
D. Aisner, L. Sholl, L. Berry, M. Rossi +23 more
2017Clinical Cancer Research175 citations Open access
Semantic Scholar
Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
C. Bartolacci, C. Andreani, G. Vale, Stefano Berto +18 more
2022Nature Communications164 citations Open access
Semantic Scholar
Clinical Features and Management of Acquired Resistance to PD-1 Axis Inhibitors in 26 Patients With Advanced Non–Small Cell Lung Cancer
S. Gettinger, A. Wurtz, S. Goldberg, D. Rimm +8 more
2018Journal of Thoracic Oncology120 citations Open access
Semantic Scholar
Anti–PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC
Eric Tu, K. McGlinchey, Ji-Xin Wang, Philip Martin +13 more
2022JCI Insight110 citations Open access
Semantic Scholar
Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
F. de Miguel, C. Gentile, W. Feng, Shannon J. Silva +22 more
2023Cancer Cell97 citations Open access
Semantic Scholar
Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo
Giorgia Foggetti, Chuan Li, Hong-Chen Cai, J. Hellyer +16 more
2020bioRxiv83 citations Open access
Semantic Scholar
Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop
D. Bedognetti, M. Ceccarelli, L. Galluzzi, Rongze Lu +51 more
2019Journal of Immunotherapy for Cancer83 citations Open access
Semantic Scholar
miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma
Wen-Cai Zhang, J. Wells, Kin-hoe Chow, He Huang +8 more
2019Nature Metabolism80 citations Open access
Semantic Scholar
PTEN loss confers resistance to anti-PD-1 therapy in non-small cell lung cancer by increasing tumor infiltration of regulatory T cells.
F. Expósito, M. Redrado, Maeva Houry, K. Hastings +22 more
2023Cancer Research75 citations Open access
Semantic Scholar
Co-occurring Alterations in Multiple Tumor Suppressor Genes are Associated with Worse Outcomes in Patients with EGFR-mutant Lung Cancer
P. Stockhammer, Michael J. Grant, A. Wurtz, Giorgia Foggetti +12 more
2023Journal of Thoracic Oncology63 citations Open access
Semantic Scholar
Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis
E. Wingrove, Zong-Zhi Z. Liu, Kiran D. Patel, A. Arnal-Estapé +9 more
2019Cell Reports62 citations Open access
Semantic Scholar
Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection
Jin Wei, M. M. Alfajaro, Ruth E. Hanna, Peter C. DeWeirdt +23 more
2020bioRxiv60 citations Open access
Semantic Scholar
Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer
S. Adua, A. Arnal-Estapé, Minghui Zhao, Bowen Qi +16 more
2022Nature Communications58 citations Open access
Semantic Scholar
The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma
A. Truini, J. Starrett, T. Stewart, Kumar D. Ashtekar +11 more
2019Clinical Cancer Research58 citations Open access
Semantic Scholar
Circulating tumor DNA (ctDNA) kinetics predict progression-free and overall survival in EGFR TKI-treated patients with EGFR-mutant NSCLC (SWOG S1403)
P. Mack, Jieling Miao, M. Redman, J. Moon +8 more
2022Clinical Cancer Research52 citations Open access
Semantic Scholar
Drug sensitivity and allele-specificity of first-line osimertinib resistance EGFR mutations
J. Starrett, A. Guernet, M. Cuomo, Kamrine E. Poels +20 more
2020Cancer Research50 citations Open access
Semantic Scholar
YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
Pang-Dian Fan, Giuseppe Narzisi, A. Jayaprakash, E. Venturini +19 more
2018Proceedings of the National Academy of Sciences of the United States of America50 citations Open access
Semantic Scholar
Randomized Trial of Afatinib Plus Cetuximab Versus Afatinib Alone for First-Line Treatment of EGFR-Mutant Non-Small-Cell Lung Cancer: Final Results From SWOG S1403.
S. Goldberg, M. Redman, R. Lilenbaum, K. Politi +12 more
2020Journal of Clinical Oncology49 citations Open access
Semantic Scholar
Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations
Iris K. van Alderwerelt van Rosenburgh, David M. Lu, M. J. Grant, S. Stayrook +7 more
2022Nature Communications46 citations Open access
Semantic Scholar
Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment
Michael Chiorazzi, J. Martínek, B. Krasnick, Yunjiang Zheng +30 more
2023Journal for ImmunoTherapy of Cancer40 citations Open access
Semantic Scholar
Hesperidin and Naringin Improve Broiler Meat Fatty Acid Profile and Modulate the Expression of Genes Involved in Fatty Acid β-oxidation and Antioxidant Defense in a Dose Dependent Manner
A. Hager-Theodorides, T. Massouras, P. Simitzis, Katerina Moschou +6 more
2021Foods39 citations Open access
Semantic Scholar
Deconstructing tumor heterogeneity: the stromal perspective
Renee E. Vickman, Douglas V. Faget, P. Beachy, D. Beebe +24 more
2020OncoTarget37 citations Open access
Semantic Scholar
Efficacy of osimertinib in patients with lung cancer positive for uncommon EGFR exon 19 deletion mutations
M. J. Grant, J. Aredo, J. Starrett, P. Stockhammer +17 more
2023Clinical Cancer Research36 citations Open access
Semantic Scholar
Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors
Deborah Ayeni, Braden Miller, Alexandra Kuhlmann, Ping-Chih Ho +13 more
2018Journal of Immunotherapy for Cancer31 citations Open access
Semantic Scholar
Therapy-induced E-cadherin downregulation alters expression of programmed death ligand-1 in lung cancer cells
K. Suda, L. Rozeboom, C. Rivard, Hui Yu +8 more
2017Lung Cancer31 citations Open access
Semantic Scholar
Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment
A. Papadas, Gauri Deb, Alexander Cicala, Adam Officer +16 more
2021bioRxiv29 citations Open access
Semantic Scholar
Challenges and opportunities for modelling aging and cancer
Olga Anczuków, S. Airhart, Jeffrey H. Chuang, L. Coussens +12 more
2023Cancer Cell21 citations Open access
Semantic Scholar
Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma
Brooks P. Leitner, K. Givechian, Shyryn Ospanova, Aray Beisenbayeva +2 more
2022npj Precision Oncology19 citations Open access
Semantic Scholar
Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein
B. Tripathi, Meghan F Anderman, D. Bhargava, Luciarita Boccuzzi +9 more
2021Nature Communications19 citations Open access
Semantic Scholar
YES1 is a druggable oncogenic target in Small Cell Lung Cancer.
E. Redin, E. M. Garrido-Martin, K. Valencia, M. Redrado +14 more
2022Journal of Thoracic Oncology18 citations Open access
Semantic Scholar
Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development.
A. Arnal-Estapé, Giorgia Foggetti, J. Starrett, Don X. Nguyen +1 more
2021Cold Spring Harbor Perspectives in Medicine18 citations Open access
Semantic Scholar
Increased EGFR Phosphorylation Correlates with Higher Programmed Death Ligand-1 Expression: Analysis of TKI-Resistant Lung Cancer Cell Lines
K. Suda, L. Rozeboom, K. Furugaki, Hui Yu +6 more
2017BioMed Research International17 citations Open access
Semantic Scholar
The New NCI Precision Medicine Trials
L. Harris, C. Blanke, H. Erba, J. Ford +21 more
2023Clinical Cancer Research16 citations Open access
Semantic Scholar
Oncogenic context shapes the fitness landscape of tumor suppression
Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran +20 more
2022bioRxiv15 citations Open access
Semantic Scholar
Effect of Dietary Supplementation with a Mixture of Natural Antioxidants on Milk Yield, Composition, Oxidation Stability and Udder Health in Dairy Ewes
A. Karageorgou, M. Tsafou, M. Goliomytis, A. Hager-Theodorides +2 more
2023Antioxidants13 citations Open access
Semantic Scholar
Genetic Diversity and Epidemiological Significance of Wild Boar HEV-3 Strains Circulating in Poland
I. Kozyra, E. Bigoraj, A. Jabłoński, K. Politi +1 more
2021Viruses13 citations Open access
Semantic Scholar
An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1
Fareesa Aftab, Alice Rodriguez-Fuguet, Luis Silva, I. Kobayashi +6 more
2023British Journal of Cancer10 citations Open access
Semantic Scholar
ERBB signaling interrupted: targeting ligand-induced pathway activation
F. H. Wilson, K. Politi
2018Cancer Discovery10 citations Open access
Semantic Scholar
Residual circulating tumor DNA (ctDNA) after two months of therapy to predict progression-free and overall survival in patients treated on S1403 with afatinib +/- cetuximab.
P. Mack, M. Redman, J. Moon, S. Goldberg +7 more
20209 citations
Semantic Scholar
LATIFY: Phase 3 study of ceralasertib + durvalumab vs docetaxel in patients with locally advanced or metastatic non-small-cell lung cancer that progressed on or after anti-PD-(L)1 and platinum-based therapy.
B. Besse, G. Castro, E. Felip, K. Politi +7 more
2023Journal of Clinical Oncology8 citations
Semantic Scholar
OA10.04 Afatinib With or Without Cetuximab for EGFR-Mutant Non-Small Cell Lung Cancer: Safety and Efficacy Results from SWOG S1403
S. Goldberg, M. Redman, R. Lilenbaum, K. Politi +10 more
2018Journal of Thoracic Oncology8 citations Open access
Semantic Scholar
OA 12.01 The Preclinical and Clinical Activity of Poziotinib, a Potent, Selective Inhibitor of EGFR Exon 20 Mutant NSCLC
Y. Elamin, J. Robichaux, V. Lam, A. Tsao +18 more
20178 citations Open access
Semantic Scholar
Tolerance and Resistance to Targeted Therapy in NSCLC: Emerging Concepts and Strategies
M. Sanchez-Cespedes, William W. Lockwood, K. Suda, E. E. Gardner +9 more
2025JTO Clinical and Research Reports6 citations Open access
Semantic Scholar

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