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Gary G. Chiang · SciRah

Researcher profile · Semantic Scholar

Gary G. Chiang

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Gary G. Chiang — researcher profile on SciRah

h-index: 30
Works: 76
Citations: 6,463

Most-cited papers

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
Christine C. Hudson, Mei Liu, Gary G. Chiang, D. Otterness +4 more
2002Molecular and Cellular Biology1,174 citations Open access
Semantic Scholar
Discovery of a potent catalytic p300/CBP inhibitor that targets lineage-specific tumors
Loren M. Lasko, C. Jakob, Rohinton P. Edalji, W. Qiu +35 more
2017Nature731 citations Open access
Semantic Scholar
Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 Is Mediated by p70S6 Kinase*
Gary G. Chiang, R. Abraham
2005Journal of Biological Chemistry581 citations Open access
Semantic Scholar
Targeting the mTOR signaling network in cancer.
Gary G. Chiang, R. Abraham
2007Trends in Molecular Medicine357 citations
Semantic Scholar
Comparative Metabolic Flux Profiling of Melanoma Cell Lines
D. Scott, A. Richardson, F. Filipp, Christine A. Knutzen +4 more
2011Journal of Biological Chemistry339 citations Open access
Semantic Scholar
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.
You-Wei Zhang, D. Otterness, Gary G. Chiang, Wei-Lin Xie +3 more
2005Molecules and Cells315 citations Open access
Semantic Scholar
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.
Christine C. Hudson, Mei Liu, Gary G. Chiang, D. Otterness +4 more
2002Molecular and Cellular Biology260 citations
Semantic Scholar
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Yu-Peng He, Sujatha Selvaraju, M. Curtin, C. Jakob +34 more
2017Nature Chemical Biology198 citations Open access
Semantic Scholar
Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells.
Aimee L. Edinger, C. Linardic, Gary G. Chiang, C. Thompson +1 more
2003Cancer Research180 citations
Semantic Scholar
Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.
R. F. Sweis, Marina A. Pliushchev, P. Brown, Jun Guo +9 more
2014ACS Medicinal Chemistry Letters167 citations Open access
Semantic Scholar
Specific Dephosphorylation of the Lck Tyrosine Protein Kinase at Tyr-394 by the SHP-1 Protein-tyrosine Phosphatase*
Gary G. Chiang, B. Sefton
2001Journal of Biological Chemistry160 citations Open access
Semantic Scholar
mTOR Activator Rheb Is Frequently Overexpressed In Human Carcinomas And Is Critical And Sufficient For Skin Epithelial Carcinogenesis
Zhi-Hong Lu, M. B. Shvartsman, Andrew Y. Lee, J. Shao +7 more
2010Cancer Research156 citations Open access
Semantic Scholar
REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A–DDB1 ubiquitin ligase
S. Katiyar, Enbo Liu, Christine A. Knutzen, Elizabeth S. Lang +6 more
2009EMBO Reports153 citations Open access
Semantic Scholar
Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold.
Zachary A. Knight, Gary G. Chiang, Peter J. Alaimo, Denise M. Kenski +4 more
2004Bioorganic & Medicinal Chemistry153 citations
Semantic Scholar
Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
S. Reich, P. Sprengeler, Gary G. Chiang, J. Appleman +25 more
2018Journal of Medicinal Chemistry143 citations Open access
Semantic Scholar
The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
Amy L. Howes, Gary G. Chiang, Elizabeth S. Lang, C. Ho +3 more
2007Molecular Cancer Therapeutics137 citations Open access
Semantic Scholar
Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
J. Ernst, P. A. Thompson, C. Nilewski, P. Sprengeler +19 more
2020Journal of Medicinal Chemistry122 citations Open access
Semantic Scholar
The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
Kenneth D. Bromberg, Taylor R. H. Mitchell, A. Upadhyay, C. Jakob +27 more
2017Nature Chemical Biology113 citations Open access
Semantic Scholar
Control of mTORC1 signaling by the Opitz syndrome protein MID1
Enbo Liu, Christine A. Knutzen, S. Krauß, S. Schweiger +1 more
2011Proceedings of the National Academy of Sciences of the United States of America94 citations Open access
Semantic Scholar
The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia
W. Pappano, Jun Guo, Yu-Peng He, D. Ferguson +11 more
2015PLoS ONE88 citations Open access
Semantic Scholar
The role of Dbf4/Drf1-dependent kinase Cdc7 (Ddk) in DNA damage checkpoint control
T. Tsuji, E. Lau, Gary G. Chiang, Wei Jiang
2008Molecules and Cells71 citations Open access
Semantic Scholar
Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin.
P. Wipf, Daniel J Minion, R. Halter, M. Berggren +5 more
2004Organic and biomolecular chemistry71 citations
Semantic Scholar
Tyrosine Phosphorylation of RNA Polymerase II Carboxyl-terminal Domain by the Abl-related Gene Product*
R. Baskaran, Gary G. Chiang, T. Mysliwiec, G. Kruh +1 more
1997Journal of Biological Chemistry66 citations Open access
Semantic Scholar
Identification of a binding site in c-Ab1 tyrosine kinase for the C-terminal repeated domain of RNA polymerase II
R. Baskaran, Gary G. Chiang, Jean Y. J. Wang
1996Molecular and Cellular Biology66 citations Open access
Semantic Scholar
Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.
R. F. Sweis, Zhi Wang, Mikkel A. Algire, C. Arrowsmith +11 more
2015ACS Medicinal Chemistry Letters60 citations Open access
Semantic Scholar
Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
Loren M. Lasko, C. Jakob, Rohinton P. Edalji, W. Qiu +35 more
2018Nature46 citations Open access
Semantic Scholar
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A
P. A. Thompson, B. Eam, N. Young, S. Fish +21 more
2020Molecular Cancer Therapeutics41 citations
Semantic Scholar
Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors
A. Gerson‐Gurwitz, N. Young, V. Goel, B. Eam +9 more
2021Frontiers in Oncology40 citations Open access
Semantic Scholar
Phosphorylation of a Src Kinase at the Autophosphorylation Site in the Absence of Src Kinase Activity*
Gary G. Chiang, B. Sefton
2000Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors
J. Wilsbacher, Min Cheng, Dong Cheng, Samuel A. J. Trammell +29 more
2017Molecular Cancer Therapeutics30 citations
Semantic Scholar
The FRB domain of mTOR: NMR solution structure and inhibitor design.
M. Leone, Kevin J. Crowell, Jinhua Chen, Dawoon Jung +4 more
2006Biochemistry30 citations
Semantic Scholar
The FRB Domain of mTOR: NMR Solution Structure and Inhibitor Design†,‡
M. Leone, Kevin J. Crowell, Jinhua Chen, Dawoon Jung +4 more
200629 citations
Semantic Scholar
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.
M. Curtin, Marina A. Pliushchev, Huan-Qiu Li, M. Torrent +17 more
2017Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors.
Heng-Miao Cheng, Puhui Li, Ping Chen, Adriana Irimia +12 more
2023ACS Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Tuberous Sclerosis Complex 1: An Epithelial Tumor Suppressor Essential to Prevent Spontaneous Prostate Cancer in Aged Mice
R. Kladney, R. Cardiff, D. Kwiatkowski, Gary G. Chiang +3 more
2010Cancer Research22 citations Open access
Semantic Scholar
eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, Is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL)
K. Webster, V. Goel, I. Hung, G. Parker +14 more
201520 citations
Semantic Scholar
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
M. Curtin, H. Heyman, Richard F. Clark, Bryan K. Sorensen +29 more
2017Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival.
E. Lau, Gary G. Chiang, R. Abraham, Wei Jiang
2009Molecular Biology of the Cell18 citations Open access
Semantic Scholar
Determination of the catalytic activities of mTOR and other members of the phosphoinositide-3-kinase-related kinase family.
Gary G. Chiang, R. Abraham
2004Methods in molecular biology18 citations
Semantic Scholar
mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation
Sujata Jana, R. Deo, Rowan P. Hough, Yuzhen Liu +7 more
2021JCI Insight14 citations Open access
Semantic Scholar
Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome
D. Kuzuoglu-Ozturk, Zhi-Qiang Hu, M. Rama, Emily Devericks +7 more
2021Cell Reports13 citations Open access
Semantic Scholar
A phase II, open-label study of tomivosertib (eFT508) added on to continued checkpoint inhibitor therapy in patients (pts) with insufficient response to single-agent treatment.
A. El-Khoueiry, N. Tchekmedyian, R. Sanborn, J. Peguero +9 more
202011 citations
Semantic Scholar
Preclinical Evaluation of eFT226, a Novel, Potent and Selective eIF4A Inhibitor with Anti-Tumor Activity in B-Cell Malignancies
P. A. Thompson, B. Eam, N. Young, S. Fish +22 more
201711 citations
Semantic Scholar
Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways
Yong-Mei Feng, E. Barile, S. De, J. Stebbins +8 more
2011Pigment Cell & Melanoma Research11 citations Open access
Semantic Scholar
A phase 1 dose escalation study of eFT508, an inhibitor of mitogen-activated protein kinase-interacting serine/threonine kinase-1 (MNK-1) and MNK-2 in patients with advanced solid tumors.
G. Falchook, J. Infante, F. Meric-Bernstam, L. Miller +8 more
20179 citations
Semantic Scholar
eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer
Jacob A Boyer, E. Rosen, Malvika Sharma, M. Dorso +23 more
2025Proceedings of the National Academy of Sciences of the United States of America8 citations Open access
Semantic Scholar
A phase II, open label, randomized, noncomparative study of eFT508 (tomivosertib) alone or in combination with avelumab in subjects with relapsed/refractory microsatellite stable colorectal cancer (MSS CRC).
J. Hubbard, M. Patel, T. Bekaii-Saab, G. Falchook +9 more
2019Journal of Clinical Oncology7 citations
Semantic Scholar
Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Yu-Peng He, Sujatha Selvaraju, M. Curtin, C. Jakob +34 more
2017Nature Chemical Biology6 citations Open access
Semantic Scholar
Abstract 2698: eFT226, a potent and selective inhibitor of eIF4A, is efficacious in preclinical models of lymphoma
P. A. Thompson, B. Eam, N. Young, S. Fish +20 more
2019Experimental and Molecular Therapeutics5 citations
Semantic Scholar
Abstract 4343: A focused CRISPR screen to identify synthetic lethal interactions with the novel eIF4A inhibitor eFT226 in KRAS driven NSCLC
N. Young, C. Stumpf, Joan W Chen, Gary G. Chiang +2 more
2019Molecular and Cellular Biology / Genetics4 citations
Semantic Scholar

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