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D. Hochhauser · SciRah

Researcher profile · Semantic Scholar

D. Hochhauser

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D. Hochhauser — researcher profile on SciRah

h-index: 41
Works: 223
Citations: 8,344

Most-cited papers

Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer
T. Golan, P. Hammel, M. Reni, E. Van Cutsem +15 more
2019New England Journal of Medicine1,903 citations Open access
Semantic Scholar
Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial.
K. Shitara, M. Özgüroğlu, Y. Bang, M. Di Bartolomeo +149 more
2018The Lancet1,100 citations Open access
Semantic Scholar
Efficacy and Safety of Pembrolizumab for Heavily Pretreated Patients With Advanced, Metastatic Adenocarcinoma or Squamous Cell Carcinoma of the Esophagus: The Phase 2 KEYNOTE-180 Study
Manish A. Shah, T. Kojima, D. Hochhauser, P. Enzinger +16 more
2019JAMA Oncology462 citations Open access
Semantic Scholar
Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy
N. Murugaesu, G. Wilson, N. Birkbak, T. Watkins +14 more
2015Cancer Discovery247 citations Open access
Semantic Scholar
Overall Survival Results From the POLO Trial: A Phase III Study of Active Maintenance Olaparib Versus Placebo for Germline BRCA-Mutated Metastatic Pancreatic Cancer
H. Kindler, P. Hammel, M. Reni, E. Van Cutsem +15 more
2022Journal of Clinical Oncology186 citations Open access
Semantic Scholar
The diagnosis and management of gastric cancer
S. G. Thrumurthy, M. Chaudry, D. Hochhauser, M. Mughal
2013British medical journal156 citations
Semantic Scholar
Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer
M. Lawler, D. Alsina, R. Adams, A. Anderson +85 more
2017Gut80 citations Open access
Semantic Scholar
WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway
Alejandra Tomas, S. Vaughan, T. Burgoyne, A. Sorkin +3 more
2015Nature Communications75 citations Open access
Semantic Scholar
Overall survival from the phase 3 POLO trial: Maintenance olaparib for germline BRCA-mutated metastatic pancreatic cancer.
T. Golan, P. Hammel, M. Reni, E. Van Cutsem +15 more
202170 citations
Semantic Scholar
Efficacy of Pembrolizumab Monotherapy for Advanced Gastric/Gastroesophageal Junction Cancer with Programmed Death Ligand 1 Combined Positive Score ≥10
Z. Wainberg, C. Fuchs, J. Tabernero, K. Shitara +16 more
2021Clinical Cancer Research70 citations Open access
Semantic Scholar
Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue.
K. Litchfield, S. Stanislaw, L. Spain, L. Gallegos +176 more
2020Cell Reports70 citations Open access
Semantic Scholar
Geographic and Ethnic Heterogeneity of Germline BRCA1 or BRCA2 Mutation Prevalence Among Patients With Metastatic Pancreatic Cancer Screened for Entry Into the POLO Trial.
T. Golan, H. Kindler, Joonoh Park, M. Reni +11 more
2020Journal of Clinical Oncology68 citations Open access
Semantic Scholar
NF-Y activates genes of metabolic pathways altered in cancer cells
Paolo Benatti, M. Chiaramonte, M. Lorenzo, J. Hartley +5 more
2015OncoTarget67 citations Open access
Semantic Scholar
mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism
A. Lampada, J. Oprey, G. Szabadkai, K. Ryan +2 more
2017Cell Death and Differentiation63 citations Open access
Semantic Scholar
Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer
V. Santoro, R. Jia, H. Thompson, A. Nijhuis +5 more
2015Journal of the National Cancer Institute58 citations Open access
Semantic Scholar
A Phase II Study of Temozolomide in Patients with Advanced Aerodigestive Tract and Colorectal Cancers and Methylation of the O6-Methylguanine-DNA Methyltransferase Promoter
D. Hochhauser, R. Glynne-Jones, V. Potter, C. Grávalos +5 more
2013Molecular Cancer Therapeutics53 citations
Semantic Scholar
The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1)
F. Vena, Eleonora Li Causi, M. Rodríguez-Justo, S. Goodstal +3 more
2015Clinical Cancer Research49 citations Open access
Semantic Scholar
Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial
K. Gurusamy, N. Corrigan, J. Croft, M. Twiddy +13 more
2018Trials48 citations Open access
Semantic Scholar
MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models
F. Vena, R. Jia, A. Esfandiari, J. J. García-Gómez +8 more
2018OncoTarget48 citations Open access
Semantic Scholar
Outcomes of the 2019 novel coronavirus in patients with or without a history of cancer: a multi-centre North London experience
N. Joharatnam-Hogan, D. Hochhauser, K. Shiu, H. Rush +12 more
2020medRxiv41 citations Open access
Semantic Scholar
Measurement of tumor antioxidant capacity and prediction of chemotherapy resistance in preclinical models of ovarian cancer by positron emission tomography
Hannah E. Greenwood, P. Mccormick, Thibault Gendron, M. Glaser +9 more
2019Clinical Cancer Research36 citations Open access
Semantic Scholar
Multiple criteria decision analysis in the context of health technology assessment: a simulation exercise on metastatic colorectal cancer with multiple stakeholders in the English setting
A. Angelis, G. Montibeller, D. Hochhauser, P. Kanavos
2017BMC Medical Informatics and Decision Making33 citations Open access
Semantic Scholar
Importance of EGFR/ERCC1 Interaction Following Radiation-Induced DNA Damage
G. Liccardi, J. Hartley, D. Hochhauser
2014Clinical Cancer Research33 citations
Semantic Scholar
Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans
J. Vicencio, R. Evans, R. Green, Z. An +36 more
2022Cell Death and Disease31 citations Open access
Semantic Scholar
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment
L. Ip, George Poulogiannis, Felipe Cia Viciano, J. Sasaki +6 more
2015OncoTarget31 citations Open access
Semantic Scholar
Effect of Remote Ischaemic Conditioning in Oncology Patients Undergoing Chemotherapy: Rationale and Design of the ERIC‐ONC Study—A Single‐Center, Blinded, Randomized Controlled Trial
R. Chung, A. Maulik, Ashraf Hamarneh, D. Hochhauser +3 more
2016Clinical Cardiology29 citations Open access
Semantic Scholar
Molecular effects of Lapatinib in the treatment of HER2 overexpressing oesophago-gastric adenocarcinoma
Nadeera de Silva, L. Schulz, A. Paterson, Wendi Qain +9 more
2015British Journal of Cancer29 citations Open access
Semantic Scholar
Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation
Sylwia Jones, Peter J. King, C. Antonescu, Michael G. Sugiyama +8 more
2020Scientific Reports28 citations Open access
Semantic Scholar
Societal challenges of precision medicine: Bringing order to chaos
R. Salgado, H. Moore, J. Martens, T. Lively +39 more
2017European Journal of Cancer28 citations Open access
Semantic Scholar
Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT.
B. Davidson, K. Gurusamy, N. Corrigan, J. Croft +14 more
2020Health Technology Assessment25 citations Open access
Semantic Scholar
An extended pyrrolobenzodiazepine-polyamide conjugate with selectivity for a DNA sequence containing the ICB2 transcription factor binding site.
F. Brucoli, Rachel M. Hawkins, C. James, P. Jackson +8 more
2013Journal of Medicinal Chemistry25 citations
Semantic Scholar
Biological and Prognostic Significance of the Morphological Types and Vascular Patterns in Colorectal Liver Metastases (CRLM)
P. Siriwardana, T. Luong, J. Watkins, H. Turley +5 more
2016Medicine24 citations Open access
Semantic Scholar
POLO: A randomized phase III trial of olaparib maintenance monotherapy in patients (pts) with metastatic pancreatic cancer (mPC) who have a germline BRCA1/2 mutation (gBRCAm).
T. Golan, D. Oh, M. Reni, T. Macarulla +10 more
201620 citations
Semantic Scholar
Olaparib as maintenance treatment following first-line platinum-based chemotherapy (PBC) in patients (pts) with a germline BRCA mutation and metastatic pancreatic cancer (mPC): Phase III POLO trial.
H. Kindler, P. Hammel, M. Reni, E. Van Cutsem +15 more
2019Journal of Clinical Oncology19 citations
Semantic Scholar
COVID-19 in cancer patients on systemic anti-cancer therapies: outcomes from the CAPITOL (COVID-19 Cancer PatIenT Outcomes in North London) cohort study
V. Crolley, D. Hanna, N. Joharatnam-Hogan, N. Chopra +13 more
2020Therapeutic Advances in Medical Oncology18 citations Open access
Semantic Scholar
Geographic and ethnic heterogeneity in the BRCA1/2 pre-screening population for the randomized phase III POLO study of olaparib maintenance in metastatic pancreatic cancer (mPC).
T. Golan, H. Kindler, Joonoh Park, M. Reni +7 more
201818 citations
Semantic Scholar
Stress-specific p38 MAPK activation is sufficient to drive EGFR endocytosis but not its nuclear translocation
Alejandra Tomas, Sylwia Jones, S. Vaughan, D. Hochhauser +1 more
2017Journal of Cell Science18 citations Open access
Semantic Scholar
Efficacy of pembrolizumab (pembro) monotherapy versus chemotherapy for PD-L1–positive (CPS ≥10) advanced G/GEJ cancer in the phase II KEYNOTE-059 (cohort 1) and phase III KEYNOTE-061 and KEYNOTE-062 studies.
Z. Wainberg, C. Fuchs, J. Tabernero, K. Shitara +16 more
202016 citations
Semantic Scholar
Nuclear Localization and Gene Expression Modulation by a Fluorescent Sequence-Selective p-Anisyl-benzimidazolecarboxamido Imidazole-Pyrrole Polyamide.
K. Kiakos, Luke Pett, V. Satam, Pravin Patil +3 more
2015Chemistry and Biology16 citations Open access
Semantic Scholar
Treatment with Gefitinib or Lapatinib Induces Drug Resistance through Downregulation of Topoisomerase IIα Expression
J. Bhosle, K. Kiakos, A. Porter, J. Wu +3 more
2013Molecular Cancer Therapeutics15 citations Open access
Semantic Scholar
Significant Therapeutic Efficacy with Combined Radioimmunotherapy and Cetuximab in Preclinical Models of Colorectal Cancer
V. Vassileva, V. Rajkumar, M. Mazzantini, M. Robson +7 more
2015Journal of Nuclear Medicine14 citations Open access
Semantic Scholar
PANTHER: AZD8931, inhibitor of EGFR, ERBB2 and ERBB3 signalling, combined with FOLFIRI: a Phase I/II study to determine the importance of schedule and activity in colorectal cancer
D. Propper, Fangfei Gao, M. Saunders, D. Sarker +12 more
2022British Journal of Cancer13 citations Open access
Semantic Scholar
Multimodal Treatment in Metastatic Colorectal Cancer (mCRC) Improves Outcomes—The University College London Hospital (UCLH) Experience
N. Joharatnam-Hogan, W. Wilson, K. Shiu, G. Fusai +4 more
2020Cancers13 citations Open access
Semantic Scholar
HER2-HER3 Heterodimer Quantification by FRET-FLIM and Patient Subclass Analysis of the COIN Colorectal Trial
P. Barber, G. Weitsman, K. Lawler, James E. Barrett +14 more
2019Journal of the National Cancer Institute13 citations Open access
Semantic Scholar
Drug delivery, biodistribution and anti-EGFR activity: theragnostic nanoparticles for simultaneous in vivo delivery of tyrosine kinase inhibitors and kinase activity biosensors
Robin Bofinger, G. Weitsman, R. Evans, M. Glaser +8 more
2021Nanoscale10 citations Open access
Semantic Scholar
Health-related quality of life in patients with a germline BRCA mutation and metastatic pancreatic cancer receiving maintenance olaparib.
P. Hammel, H. Kindler, M. Reni, E. Van Cutsem +16 more
2019Annals of Oncology10 citations Open access
Semantic Scholar
Pembrolizumab in previously treated metastatic esophageal cancer: Longer term follow-up from the phase 2 KEYNOTE-180 Study.
Ken Kato, T. Kojima, D. Hochhauser, J. Bennouna +12 more
2019Journal of Clinical Oncology9 citations
Semantic Scholar
Autophagy and receptor tyrosine kinase signalling: A mTORC2 matter
A. Lampada, D. Hochhauser, P. Salomoni
2017Cell Cycle9 citations Open access
Semantic Scholar
The role of PARP inhibitors in gastrointestinal cancers.
D. Hanna, N. Chopra, D. Hochhauser, K. Khan
2022Critical reviews in oncology/hematology8 citations
Semantic Scholar
T cell-inflamed gene expression profile and PD-L1 expression and pembrolizumab efficacy in advanced esophageal cancer.
Manish A. Shah, T. Kojima, D. Hochhauser, P. Enzinger +17 more
2022Future Oncology8 citations Open access
Semantic Scholar

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J. Hartley×12
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J. Hartley — researcher profile on SciRah
E. Van Cutsem×9
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E. Van Cutsem — researcher profile on SciRah
T. Golan×8
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T. Golan — researcher profile on SciRah
M. Reni×8
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M. Reni — researcher profile on SciRah

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M. Hall — researcher profile on SciRah

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H. Kindler — researcher profile on SciRah

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P. Hammel — researcher profile on SciRah

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D. Arnold — researcher profile on SciRah

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G. Locker — researcher profile on SciRah

T. Macarulla×6

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T. Macarulla — researcher profile on SciRah

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Joonoh Park — researcher profile on SciRah

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D. Oh — researcher profile on SciRah