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K. Khan · SciRah

Researcher profile · Semantic Scholar

K. Khan

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K. Khan — researcher profile on SciRah

h-index: 24
Works: 88
Citations: 4,173

Most-cited papers

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
G. Vlachogiannis, S. Hedayat, A. Vatsiou, Y. Jamin +39 more
2018Science1,886 citations Open access
Semantic Scholar
Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer
A. Woolston, K. Khan, G. Spain, L. Barber +35 more
2018bioRxiv235 citations Open access
Semantic Scholar
Targeting the PI3K-AKT-mTOR signaling network in cancer
K. Khan, T. Yap, Li Yan, D. Cunningham
2013Chinese journal of cancer212 citations Open access
Semantic Scholar
Longitudinal liquid biopsy and mathematical modelling of clonal evolution forecast waiting time to treatment failure in the PROSPECT-C phase II colorectal cancer clinical trial
K. Khan, D. Cunningham, B. Werner, G. Vlachogiannis +32 more
2018Cancer Discovery202 citations Open access
Semantic Scholar
Cancer therapeutics: Targeting the apoptotic pathway.
K. Khan, M. Blanco-Codesido, L. Molife
2014Critical reviews in oncology/hematology148 citations
Semantic Scholar
Anti-tumour activity in RAS-driven tumours by blocking AKT and MEK
A. Tolcher, K. Khan, M. Ong, U. Banerji +21 more
2014Clinical Cancer Research128 citations Open access
Semantic Scholar
Challenges in the treatment of gastric cancer in the older patient.
N. Joharatnam-Hogan, K. Shiu, K. Khan
2020Cancer Treatment Reviews120 citations Open access
Semantic Scholar
CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids
R. Gonzalez-Exposito, Maria Semiannikova, Beatrice Griffiths, K. Khan +24 more
2019Journal of Immunotherapy for Cancer112 citations Open access
Semantic Scholar
MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma
A. Lampis, P. Carotenuto, G. Vlachogiannis, L. Cascione +30 more
2017Gastroenterology110 citations Open access
Semantic Scholar
Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study
K. Khan, M. Rata, D. Cunningham, D. Koh +28 more
2017Gut72 citations Open access
Semantic Scholar
Immunotherapy in gastrointestinal cancer: The current scenario and future perspectives.
M. Abdul-Latif, K. Townsend, C. Dearman, K. Shiu +1 more
2020Cancer Treatment Reviews70 citations
Semantic Scholar
FOLFIRINOX for locally advanced or metastatic pancreatic ductal adenocarcinoma: the Royal Marsden experience.
S. Moorcraft, K. Khan, C. Peckitt, D. Watkins +3 more
2014Clinical colorectal cancer69 citations
Semantic Scholar
Targeting EGFR pathway in metastatic colorectal cancer- tumour heterogeniety and convergent evolution.
K. Khan, N. Valeri, C. Dearman, S. Rao +4 more
2019Critical reviews in oncology/hematology62 citations
Semantic Scholar
Hyperglycemia and Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) Inhibitors in Phase I Trials: Incidence, Predictive Factors, and Management.
K. Khan, M. Wong, K. Rihawi, S. Bodla +3 more
2016The Oncologist60 citations Open access
Semantic Scholar
Phase I Trial of Cyclophosphamide as an Immune Modulator for Optimizing Oncolytic Reovirus Delivery to Solid Tumors
V. Roulstone, K. Khan, H. Pandha, S. Rudman +7 more
2014Clinical Cancer Research57 citations Open access
Semantic Scholar
Colorectal cancer with liver metastases: neoadjuvant chemotherapy, surgical resection first or palliation alone?
K. Khan, A. Wale, Gina Brown, I. Chau
2014World Journal of Gastroenterology53 citations Open access
Semantic Scholar
miR-21 expression and clinical outcome in locally advanced pancreatic cancer: exploratory analysis of the pancreatic cancer Erbitux, radiotherapy and UFT (PERU) trial
K. Khan, D. Cunningham, C. Peckitt, S. Barton +12 more
2016OncoTarget46 citations Open access
Semantic Scholar
Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) experience
K. Khan, C. Peckitt, F. Sclafani, D. Watkins +7 more
2015BMC Cancer44 citations Open access
Semantic Scholar
Outcomes of the 2019 novel coronavirus in patients with or without a history of cancer: a multi-centre North London experience
N. Joharatnam-Hogan, D. Hochhauser, K. Shiu, H. Rush +12 more
2020medRxiv41 citations Open access
Semantic Scholar
miR-31-3p Expression and Benefit from Anti-EGFR Inhibitors in Metastatic Colorectal Cancer Patients Enrolled in the Prospective Phase II PROSPECT-C Trial
G. Anandappa, A. Lampis, D. Cunningham, K. Khan +23 more
2019Clinical Cancer Research41 citations Open access
Semantic Scholar
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer
S. Wagner, G. Vlachogiannis, A. K. de Haven Brandon, M. Valenti +19 more
2018Oncogene36 citations Open access
Semantic Scholar
Targeting Angiogenic Pathways in Colorectal Cancer: Complexities, Challenges and Future Directions.
K. Khan, D. Cunningham, I. Chau
2016Current Drug Targets35 citations
Semantic Scholar
A Phase I study of the safety, pharmacokinetics and efficacy of navitoclax plus docetaxel in patients with advanced solid tumors.
M. Puglisi, L. Molife, M. D. de Jonge, K. Khan +8 more
2021Future Oncology27 citations Open access
Semantic Scholar
The immunomodulatory role of IDO1-Kynurenine-NAD+ pathway in switching cold tumor microenvironment in PDAC
R. Anu, K. Shiu, K. Khan
2023Frontiers in Oncology24 citations Open access
Semantic Scholar
Phase I trial outcomes in older patients with advanced solid tumours
K. Khan, T. Yap, A. Ring, L. Molife +8 more
2016British Journal of Cancer20 citations Open access
Semantic Scholar
Survival Outcomes in Asymptomatic Patients With Normal Conventional Imaging but Raised Carcinoembryonic Antigen Levels in Colorectal Cancer Following Positron Emission Tomography-Computed Tomography Imaging.
K. Khan, A. Athauda, K. Aitken, D. Cunningham +6 more
2016The Oncologist20 citations Open access
Semantic Scholar
Metastatic Melanoma: A Regional Review and Future Directions
K. Khan, R. Goody, H. Hameed, A. Jalil +2 more
2012Tumori19 citations
Semantic Scholar
COVID-19 in cancer patients on systemic anti-cancer therapies: outcomes from the CAPITOL (COVID-19 Cancer PatIenT Outcomes in North London) cohort study
V. Crolley, D. Hanna, N. Joharatnam-Hogan, N. Chopra +13 more
2020Therapeutic Advances in Medical Oncology18 citations Open access
Semantic Scholar
Longitudinal liquid biopsy and mathematical modelling of clonal evolution forecast waiting time to treatment failure in the PROSPECT-C phase II colorectal cancer clinical trial
K. Khan, D. Cunningham, Benjamin Werner, G. Vlachogiannis +34 more
201917 citations
Semantic Scholar
Multiplexed single cell protein expression analysis in solid tumours using a miniaturised microfluidic assay
A. Magness, J. Squires, Beatrice Griffiths, K. Khan +5 more
2017Convergent Science Physical Oncology15 citations Open access
Semantic Scholar
Efficacy and Cardiotoxic Safety Profile of Raltitrexed in Fluoropyrimidines‐Pretreated or High‐Risk Cardiac Patients With GI Malignancies: Large Single‐Center Experience
K. Khan, J. Rane, D. Cunningham, S. Rao +8 more
2019Clinical colorectal cancer14 citations Open access
Semantic Scholar
Multimodal Treatment in Metastatic Colorectal Cancer (mCRC) Improves Outcomes—The University College London Hospital (UCLH) Experience
N. Joharatnam-Hogan, W. Wilson, K. Shiu, G. Fusai +4 more
2020Cancers13 citations Open access
Semantic Scholar
Reversible Posterior Leukoencephalopathy Syndrome following Sunitinib Therapy: A Case Report and Review of the Literature
K. Khan, A. Fenton, E. Murtagh, J. Mcaleer +1 more
2012Tumori13 citations
Semantic Scholar
DCE-MRI is more sensitive than IVIM-DWI for assessing anti-angiogenic treatment-induced changes in colorectal liver metastases
M. Rata, K. Khan, D. Collins, D. Koh +11 more
2021Cancer Imaging11 citations Open access
Semantic Scholar
Imaging and clinical correlates with regorafenib in metastatic colorectal cancer.
K. Khan, S. Cascinu, D. Cunningham, Sunyoung Kim +7 more
2020Cancer Treatment Reviews11 citations Open access
Semantic Scholar
COVID-19 and Its Impact on Upper Gastrointestinal (GI) Cancer Management
S. Fernando, M. Veli, B. Mohammadi, A. Millar +1 more
2021Cancers10 citations Open access
Semantic Scholar
AREG and EREG as Predictive Biomarkers for RAS Wild-Type Colorectal Cancer Treated With Panitumumab: A Fresh Approach to an Old Puzzle.
E. Smyth, K. Khan, D. Cunningham
2016JAMA Oncology10 citations
Semantic Scholar
First-in-human, first-in-class phase 1 study of a novel oral multi-AGC kinase inhibitor AT13148 in patients (pts) with advanced solid tumors.
Rajiv Kumar, J. Mateo, A. Smith, K. Khan +12 more
201410 citations
Semantic Scholar
Clinical outcomes of adolescents and young adults with advanced solid tumours participating in phase I trials.
R. Sundar, T. McVeigh, D. Dolling, A. Petruckevitch +13 more
2018European Journal of Cancer9 citations Open access
Semantic Scholar
The role of PARP inhibitors in gastrointestinal cancers.
D. Hanna, N. Chopra, D. Hochhauser, K. Khan
2022Critical reviews in oncology/hematology8 citations
Semantic Scholar
Phase I Trials in Patients with Relapsed, Advanced Upper Gastrointestinal Carcinomas – Experience in a Specialist Unit
K. Khan, J. Ang, N. Starling, F. Sclafani +7 more
2014Gastric Cancer8 citations Open access
Semantic Scholar
Translational research and application of basic biology to clinical trial development in GI cancers.
E. Smyth, K. Khan, N. Valeri
2018Annals of Translational Medicine7 citations Open access
Semantic Scholar
Early switch to oral antibiotic therapy in patients with low risk neutropenic sepsis (EASI-SWITCH): A randomized non-inferiority trial.
V. Coyle, C. Forde, D. McAuley, R. Wilson +54 more
2023Clinical Microbiology and Infection6 citations Open access
Semantic Scholar
Establishing a colorectal cancer research database from routinely collected health data: the process and potential from a pilot study
A. Tamm, H. Jones, W. Perry, D. Campbell +28 more
2022BMJ Health & Care Informatics6 citations Open access
Semantic Scholar
Establishment of CORONET, COVID-19 Risk in Oncology Evaluation Tool, to Identify Patients With Cancer at Low Versus High Risk of Severe Complications of COVID-19 Disease On Presentation to Hospital
R. Lee, Oskar Wysocki, Cong Zhou, R. Shotton +73 more
2022JCO Clinical Cancer Informatics6 citations Open access
Semantic Scholar
COVID-19 cancer conundrum—evidence driving decisions or the lack of it?
N. Joharatnam-Hogan, K. Khan
2020BMC Medicine6 citations Open access
Semantic Scholar
Re-challenge chemotherapy with gemcitabine plus carboplatin in patients with non-small cell lung cancer
K. Khan, G. Hanna, L. Campbell, P. Scullin +3 more
2013Chinese journal of cancer5 citations Open access
Semantic Scholar
CORONET; COVID-19 in Oncology evaluatiON Tool: Use of machine learning to inform management of COVID-19 in patients with cancer.
Rebecca Lee, Oskar Wysocki, Cong Zhou, A. Calles +15 more
20214 citations
Semantic Scholar
Retrospective analysis of resected primary colorectal cancer revealed no correlation between node harvest and node involvement.
K. Khan, M. Rathore, M. I. Bhatti, E. Hand +4 more
2011JPMA. The Journal of the Pakistan Medical Association4 citations
Semantic Scholar
CEA expression patterns determine response and resistance to the CEA-TCB bispecific immunotherapy antibody in colorectal cancer patient derived organoids.
Reyes Gonzalez Exposito, Maria Semmianikova, Beatrice Griffiths, K. Khan +16 more
2019Journal of Clinical Oncology3 citations
Semantic Scholar

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