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L. Spain · SciRah

Researcher profile · Semantic Scholar

L. Spain

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L. Spain — researcher profile on SciRah

h-index: 31
Works: 133
Citations: 8,086

Most-cited papers

Management of toxicities from immunotherapy: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
J. Haanen, M. Obeid, L. Spain, F. Carbonnel +8 more
2022Annals of Oncology1,603 citations Open access
Semantic Scholar
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
S. Turajlic, Hang Xu, K. Litchfield, A. Rowan +45 more
2018Cell749 citations Open access
Semantic Scholar
Neoadjuvant Nivolumab and Ipilimumab in Resectable Stage III Melanoma.
C. Blank, M. Lucas, R. Scolyer, B. A. van de Wiel +64 more
2024New England Journal of Medicine448 citations Open access
Semantic Scholar
Pervasive chromosomal instability and karyotype order in tumour evolution
T. Watkins, Emilia L. Lim, Marina Petković, S. Elizalde +51 more
2020Nature331 citations Open access
Semantic Scholar
Ultrasensitive plasma-based monitoring of tumor burden using machine learning-guided signal enrichment
Adam J. Widman, M. Shah, A. Frydendahl, Daniel Halmos +57 more
2024Nature Medicine124 citations Open access
Semantic Scholar
Hematological immune related adverse events after treatment with immune checkpoint inhibitors.
Rafaela Kramer, A. Zaremba, Alvaro Moreira, S. Ugurel +29 more
2021European Journal of Cancer98 citations
Semantic Scholar
Avelumab Combined with Stereotactic Ablative Body Radiotherapy in Metastatic Castration-resistant Prostate Cancer: The Phase 2 ICE-PAC Clinical Trial.
E. Kwan, L. Spain, A. Anton, C. Gan +18 more
2021European Urology74 citations
Semantic Scholar
Selection of metastasis competent subclones in the tumour interior
Yue Zhao, Xiao Fu, J. López, A. Rowan +22 more
2021Nature Ecology & Evolution72 citations Open access
Semantic Scholar
Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue.
K. Litchfield, S. Stanislaw, L. Spain, L. Gallegos +176 more
2020Cell Reports70 citations Open access
Semantic Scholar
Spatial patterns of tumour growth impact clonal diversification
Xiao Fu, Yue Zhao, J. López, A. Rowan +45 more
2021Nature Ecology & Evolution56 citations Open access
Semantic Scholar
British Society of Gastroenterology endorsed guidance for the management of immune checkpoint inhibitor-induced enterocolitis.
N. Powell, H. Ibraheim, T. Raine, R. A. Speight +15 more
2020The Lancet Gastroenterology and Hepatology54 citations Open access
Semantic Scholar
Lutetium-177–PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial
Edmond M. Kwan, Sarah W. S. Ng, S. Tolmeijer, L. Emmett +72 more
2025Nature Medicine44 citations
Semantic Scholar
Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways
L. Spain, A. Coulton, Irene Lobon, A. Rowan +66 more
2023Cancer Discovery44 citations Open access
Semantic Scholar
How we treat neurological toxicity from immune checkpoint inhibitors
L. Spain, Z. Tippu, J. Larkin, A. Carr +1 more
2019ESMO Open43 citations Open access
Semantic Scholar
Five-year review of corticosteroid duration and complications in the management of immune checkpoint inhibitor-related diarrhoea and colitis in advanced melanoma
D. Favara, L. Spain, L. Au, J. Clark +7 more
2020ESMO Open39 citations Open access
Semantic Scholar
Characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis: A retrospective multicentre cohort study.
L. Müller-Jensen, S. Zierold, J. Versluis, Wolfgang Boehmerle +29 more
2022European Journal of Cancer36 citations Open access
Semantic Scholar
Rare Immune-Related Adverse Events (irAEs): Approach to Diagnosis and Management
Anadil Javaid, Catherine Bennett, A. Rao, L. Spain
2024Pharmaceutical Medicine24 citations Open access
Semantic Scholar
Grade 4 Neutropenia Secondary to Immune Checkpoint Inhibition — A Descriptive Observational Retrospective Multicenter Analysis
A. Zaremba, Rafaela Kramer, V. DeTemple, S. Bertram +35 more
2021Frontiers in Oncology22 citations Open access
Semantic Scholar
Real‐world first‐line systemic therapy patterns in metastatic castration‐resistant prostate cancer
A. Anton, S. Pillai, Marie C. Semira, Shirley S. Wong +13 more
2021BJUI Compass19 citations Open access
Semantic Scholar
Navigating the Current Landscape of Non-Clear Cell Renal Cell Carcinoma: A Review of the Literature
Alexius John, L. Spain, A. Hamid
2023Current Oncology17 citations Open access
Semantic Scholar
The Genetic Evolution of Metastasis.
A. Rogiers, Irene Lobon, L. Spain, S. Turajlic
2022Cancer Research17 citations Open access
Semantic Scholar
577O PRINCE: Interim analysis of the phase Ib study of 177Lu-PSMA-617 in combination with pembrolizumab for metastatic castration resistant prostate cancer (mCRPC)
S. Sandhu, A. Joshua, L. Emmett, L. Spain +16 more
2021Annals of Oncology16 citations Open access
Semantic Scholar
Error-corrected flow-based sequencing at whole genome scale and its application to circulating cell-free DNA profiling
A. P. Cheng, Adam J. Widman, Anushri Arora, I. Rusinek +43 more
2025Nature Methods15 citations
Semantic Scholar
Updates in the pathogenesis and management of immune-related enterocolitis, hepatitis and cardiovascular toxicities
J. Mckenzie, Emmy Sneath, Andrew Trinh, M. Nolan +1 more
2024Immuno-Oncology Technology15 citations Open access
Semantic Scholar
Safety of Lutetium-177 prostate-specific membrane antigen-617 (PSMA-617) radioligand therapy in the setting of severe renal impairment: a case report and literature review
Duncan E. K. Sutherland, R. Kashyap, P. Jackson, J. Buteau +8 more
2023Therapeutic Advances in Medical Oncology15 citations Open access
Semantic Scholar
Predicting development of ipilimumab-induced hypophysitis: utility of T4 and TSH index but not TSH
M. S. Siddiqui, Z. Lai, L. Spain, V. Greener +3 more
2020Journal of Endocrinological Investigation15 citations Open access
Semantic Scholar
Machine learning guided signal enrichment for ultrasensitive plasma tumor burden monitoring
Adam J. Widman, M. Shah, N. Øgaard, C. Khamnei +38 more
2022bioRxiv14 citations Open access
Semantic Scholar
New survival standards for advanced melanoma
L. Spain, J. Larkin, S. Turajlic
2020British Journal of Cancer14 citations Open access
Semantic Scholar
Real-world incidence of symptomatic skeletal events and bone-modifying agent use in castration-resistant prostate cancer - an Australian multi-centre observational study.
A. Anton, Shirley S. Wong, J. Shapiro, A. Weickhardt +12 more
2021European Journal of Cancer11 citations
Semantic Scholar
[177Lu]Lu-PSMA-617 in combination with pembrolizumab for treatment of metastatic castration resistant prostate cancer (PRINCE): a single-arm, phase 1b/2 study.
S. Sandhu, A. Joshua, L. Emmett, M. Bressel +26 more
2026The Lancet Oncology10 citations Open access
Semantic Scholar
Consensus-based disease definitions for endocrine immune-related adverse events of immune checkpoint inhibitors
Ling Zhu, Y. Cheung, Cherie Chiang, E. Gallagher +33 more
2025Journal for ImmunoTherapy of Cancer10 citations Open access
Semantic Scholar
Systemic treatments in favorable and very favorable risk metastatic renal cell carcinoma (mRCC): Real world evidence from the International mRCC Database Consortium (IMDC).
M. Zarba, Evan Ferrier, Connor Wells, T. El Zarif +16 more
2024Journal of Clinical Oncology10 citations
Semantic Scholar
Imaging for assessment of cancer treatment response to immune checkpoint inhibitors can be complementary in identifying hypophysitis
A. Galligan, A. Iravani, A. Lasocki, R. Wallace +12 more
2023Frontiers in Endocrinology10 citations Open access
Semantic Scholar
A protocol for representative sampling of solid tumors to improve the accuracy of sequencing results
L. Gallegos, A. Gilchrist, L. Spain, S. Stanislaw +9 more
2021STAR Protocols8 citations Open access
Semantic Scholar
Treatment outcomes for patients with metastatic castrate‐resistant prostate cancer following docetaxel for hormone‐sensitive disease
A. Schmidt, A. Anton, J. Shapiro, Shirley S. Wong +13 more
2020Asia-Pacific Journal of Clinical Oncology8 citations Open access
Semantic Scholar
Timing of brain metastases development in metastatic renal cell cancer patients treated with targeted therapies and survival outcomes: An Australian multicenter study
F. Ha, L. Spain, A. Dowling, E. Kwan +6 more
2019Asia-Pacific Journal of Clinical Oncology8 citations Open access
Semantic Scholar
PSMA-Guided Metastasis-Directed Therapy for Oligometastatic Renal Cell Carcinoma: The Proof-of-Concept PEDESTAL Study
C. Udovicich, M. Bressel, J. Manji, Muhammad Ali +16 more
2025Journal of Nuclear Medicine6 citations Open access
Semantic Scholar
Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma
W. Cross, Iben Lyskjær, Christopher Davies, A. Bunkum +242 more
2025Genome Biology6 citations Open access
Semantic Scholar
Hitting the sweet spot: optimal use of corticosteroids for immune checkpoint inhibitor side-effects.
A. Schmitt, L. Spain, J. Larkin
2022The Lancet Oncology6 citations
Semantic Scholar
Beyond cabazitaxel: Late line treatments in metastatic castration resistant prostate cancer: A retrospective multicentre analysis
G. Chazan, A. Anton, Shirley S. Wong, J. Shapiro +11 more
2022Asia-Pacific Journal of Clinical Oncology6 citations
Semantic Scholar
Neuroimaging features of immune-related adverse events due to immune checkpoint inhibitor therapy
A. Lasocki, L. Spain
2025Insights into Imaging5 citations Open access
Semantic Scholar
Impact of Comorbidities and Drug Interactions in Patients With Metastatic Castration-Resistant Prostate Cancer Receiving Androgen Receptor Pathway Inhibitors
Ying-Yan Zhong, A. Anton, O. Xie, N. Tan +7 more
2024JCO Oncology Practice5 citations
Semantic Scholar
Dataset of a retrospective multicenter cohort study on characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis
L. Müller-Jensen, S. Zierold, J. Versluis, W. Boehmerle +29 more
2022Data in Brief5 citations Open access
Semantic Scholar
The neurotoxic effects of immune checkpoint inhibitor therapy for melanoma
L. Spain, R. Wong
2019Melanoma Management5 citations Open access
Semantic Scholar
PWE-025 Microscopic colonic inflammation in immune check point inhibitor-induced diarrhoea/colitis
H. Ibraheim, L. Spain, A. Samani, S. Papa +5 more
2018IBD5 citations Open access
Semantic Scholar
Real‐world use of first‐generation antiandrogens: impact on patient outcomes and subsequent therapies in metastatic castration‐resistant prostate cancer
R. Kelly, A. Anton, Shirley S. Wong, J. Shapiro +14 more
2021BJU International4 citations Open access
Semantic Scholar
Post-SRS haemorrhage and oncological outcome of patients with melanoma brain metastases undergoing stereotactic radiotherapy
C. Schröder, J. Sia, C. Phillips, Michelle P. Li +2 more
2025Strahlentherapie und Onkologie (Print)3 citations
Semantic Scholar
Neoadjuvant Pembrolizumab and Stereotactic Radiotherapy Prior to Nephrectomy for Renal Cell Carcinoma (NAPSTER): A Phase II Randomised Clinical Trial
M. Ali, D. Pryor, S. Wood, M. Bressel +16 more
2025International Journal of Radiation Oncology, Biology, Physics3 citations
Semantic Scholar
Abstract 5709: Whole genome error-corrected sequencing for sensitive circulating tumor DNA cancer monitoring
A. Cheng, Adam J. Widman, Anushri Arora, I. Rusinek +30 more
2023Cancer Research3 citations
Semantic Scholar
Efficacy of systemic therapy following [177Lu] Lu-PSMA in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).
Louise Kostos, W.-Y. Lai, Peter Lambroglou, Elizabeth Medhurst +14 more
2023Journal of Clinical Oncology3 citations Open access
Semantic Scholar

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