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M. Pearson · SciRah

Researcher profile · Semantic Scholar

M. Pearson

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M. Pearson — researcher profile on SciRah

h-index: 29
Works: 72
Citations: 6,979

Most-cited papers

Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
E. Langley, M. Pearson, M. Faretta, Uta-Maria Bauer +4 more
2002EMBO Journal916 citations Open access
Semantic Scholar
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
M. Pearson, R. Carbone, Carla Sebastiani, M. Cioce +7 more
2000Nature891 citations
Semantic Scholar
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.
C. Mitsiades, N. Mitsiades, C. McMullan, V. Poulaki +11 more
2004Cancer Cell656 citations Open access
Semantic Scholar
In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase.
C. García-echeverría, M. Pearson, A. Marti, Thomas J. Meyer +14 more
2004Cancer Cell576 citations Open access
Semantic Scholar
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition
Philipp Rathert, Mareike Roth, Tobias Neumann, Felix Muerdter +19 more
2015Nature486 citations Open access
Semantic Scholar
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
William Farnaby, M. Koegl, M. Roy, Claire Whitworth +33 more
2019Nature Chemical Biology464 citations Open access
Semantic Scholar
Drugging an undruggable pocket on KRAS
D. Kessler, M. Gmachl, A. Mantoulidis, Laetitia J. Martin +38 more
2019Proceedings of the National Academy of Sciences of the United States of America388 citations Open access
Semantic Scholar
BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition
M. H. Hofmann, M. Gmachl, J. Ramharter, F. Savarese +29 more
2020Cancer Discovery333 citations Open access
Semantic Scholar
PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage
R. Carbone, M. Pearson, S. Minucci, P. Pelicci
2002Oncogene203 citations
Semantic Scholar
Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
Laetitia J. Martin, M. Koegl, G. Bader, X. Cockcroft +22 more
2016Journal of Medicinal Chemistry197 citations Open access
Semantic Scholar
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Nina Kerres, S. Steurer, S. Schlager, G. Bader +45 more
2017Cell Reports179 citations Open access
Semantic Scholar
Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition
Anja F. Hohmann, Laetitia J. Martin, Jessica L. Minder, Jae-seok Roe +11 more
2016Nature Chemical Biology163 citations Open access
Semantic Scholar
PML interaction with p53 and its role in apoptosis and replicative senescence
M. Pearson, P. Pelicci
2001Oncogene134 citations
Semantic Scholar
Impairment of p53 acetylation, stability and function by an oncogenic transcription factor
Alessandra Insinga, S. Monestiroli, S. Ronzoni, R. Carbone +6 more
2004EMBO Journal131 citations Open access
Semantic Scholar
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
Simone Lieb, Silvia Blaha-Ostermann, Elizabeth Kamper, Janine Rippka +16 more
2019bioRxiv125 citations Open access
Semantic Scholar
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk
Atsushi Kaneda, C. Wang, Raymond Cheong, W. Timp +11 more
2007Proceedings of the National Academy of Sciences of the United States of America115 citations Open access
Semantic Scholar
Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions.
Johannes Popow, Heribert Arnhof, G. Bader, Helmut Berger +20 more
2019Journal of Medicinal Chemistry112 citations Open access
Semantic Scholar
Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts
P. van der Lelij, Simone Lieb, J. Jude, G. Wutz +14 more
2017bioRxiv109 citations Open access
Semantic Scholar
Deconstructing PML‐induced premature senescence
Oliver Bischof, Olivier Kirsh, M. Pearson, K. Itahana +2 more
2002EMBO Journal101 citations Open access
Semantic Scholar
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
Jark Böttcher, D. Dilworth, Ulrich Reiser, Ralph A. Neumüller +40 more
2019Nature Chemical Biology84 citations
Semantic Scholar
Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis.
Harald Weinstabl, Matthias Treu, J. Rinnenthal, S. Zahn +38 more
2019Journal of Medicinal Chemistry69 citations Open access
Semantic Scholar
Selective and potent CDK8/19 inhibitors enhance NK cell activity and promote tumor surveillance
M. H. Hofmann, Rajeswaran Mani, H. Engelhardt, M. Impagnatiello +20 more
2020Molecular Cancer Therapeutics51 citations Open access
Semantic Scholar
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling
B. Wilding, D. Scharn, Dietrich Böse, A. Baum +39 more
2022Nature Cancer49 citations
Semantic Scholar
Targeting protein kinases in cancer therapy: a success?
M. Pearson, D. Fabbro
2004Expert Review of Anticancer Therapy47 citations
Semantic Scholar
Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4
Josefina Castex, D. Willmann, Toufike Kanouni, L. Arrigoni +11 more
2017Cell Death and Disease44 citations Open access
Semantic Scholar
SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines
Katharina Ehrenhöfer-Wölfer, T. Puchner, Cornelia Schwarz, Janine Rippka +18 more
2019Scientific Reports42 citations Open access
Semantic Scholar
Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist
J. M. García-Martínez, Shirley Wang, C. Weishaeupl, A. Wernitznig +14 more
2020Molecular Cancer Therapeutics34 citations Open access
Semantic Scholar
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers
P. van der Lelij, J. Newman, Simone Lieb, J. Jude +10 more
2020Life Science Alliance29 citations Open access
Semantic Scholar
Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis
S. Schlager, Carina Salomon, Sabine Olt, Christoph Albrecht +19 more
2020OncoTarget29 citations Open access
Semantic Scholar
Abstract 1091: BI-3406 and BI 1701963: Potent and selective SOS1::KRAS inhibitors induce regressions in combination with MEK inhibitors or irinotecan
D. Gerlach, M. Gmachl, J. Ramharter, Jessica L. F. Teh +17 more
2020Tumor Biology24 citations
Semantic Scholar
Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods
D. Kessler, M. Mayer, S. Zahn, M. Zeeb +23 more
2020ChemMedChem23 citations Open access
Semantic Scholar
Investigation of the molecular mechanisms underlying growth factor synergy: the role of ERK 2 activation in synergy.
M. Pearson, Anne-Marie O'Farrell, T. Dexter, A. Whetton +2 more
1998Growth Factors23 citations
Semantic Scholar
Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance
Venu Thatikonda, Hengyu Lu, S. Jurado, K. Kostyrko +24 more
2023bioRxiv22 citations Open access
Semantic Scholar
Reply to Tran et al.: Dimeric KRAS protein–protein interaction stabilizers
D. Kessler, A. Gollner, M. Gmachl, A. Mantoulidis +38 more
2020Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
Semantic Scholar
RIOK1 kinase activity is required for cell survival irrespective of MTAP status
Alexandra Hörmann, Barbara Hopfgartner, T. Köcher, Maja Corcokovic +12 more
2018OncoTarget17 citations Open access
Semantic Scholar
Protein Tyrosine Kinases as Targets for Cancer and Other Indications
M. Pearson, C. García-echeverría, D. Fabbro
200614 citations
Semantic Scholar
Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
William Farnaby, M. Koegl, M. Roy, Claire Whitworth +33 more
2019Nature Chemical Biology13 citations Open access
Semantic Scholar
The PML / RARa ! Oncoprotein Is a Direct Molecular Target of Retinoic Acid in Acute Promyelocytic Leukemia Cells
J. Raelson, C. Nervi, A. Rosenauer, L. Benedetti +4 more
200213 citations
Semantic Scholar
Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients
Jesse J. Lipp, Limei Wang, Hai-Tang Yang, Feng Yao +13 more
2021Oncoimmunology11 citations Open access
Semantic Scholar
Interrogation of cancer gene dependencies reveals novel paralog interactions of autosome and sex 1 chromosome encoded genes 2
Anna Köferle, A. Schlattl, Alexandra Hörmann, Fiona Spreitzer +14 more
202110 citations
Semantic Scholar
Macrophage inflammatory protein-1 alpha mediated growth inhibition in a haemopoietic stem cell line is associated with inositol 1,4,5 triphosphate generation.
C. M. Heyworth, M. Pearson, T. Dexter, G. Wark +2 more
1995Growth Factors10 citations
Semantic Scholar
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
William Farnaby, M. Koegl, Michael J. Roy, Claire Whitworth +37 more
20198 citations
Semantic Scholar
Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors
M. H. Hofmann, M. Gmachl, J. Ramharter, F. Savarese +22 more
20196 citations
Semantic Scholar
Abstract A085: BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in preclinical models and validates wild-type amplified KRAS as a therapeutic target
Antonio Tedeschi, Lorenz Herdeis, Valeria Santoro, F. Savarese +23 more
2023Molecular Cancer Therapeutics4 citations
Semantic Scholar
Abstract LB-206: A bromodomain-swap allele demonstrates that on-target chemical inhibition of BRD9 limits the proliferation of acute myeloid leukemia cells
Anja F. Hohmann, Laetitia J. Martin, Jessica L. Minder, Jae-seok Roe +11 more
20163 citations
Semantic Scholar
An investigation into the mechanisms of rouleaux formation and the development of improved techniques for its quantitation.
M. Pearson
19963 citations
Semantic Scholar
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
William Farnaby, M. Koegl, M. Roy, Claire Whitworth +37 more
20192 citations
Semantic Scholar
Abstract 2051: BI 905711, a novel CDH17-targeting TRAILR2 agonist, effectively triggers tumor cell apoptosis and tumor regressions selectively in CDH17-positive colorectal cancer models
J. M. García-Martínez, A. Wernitznig, Joerg Rinnenthal, M. Impagnatiello +5 more
2019Experimental and Molecular Therapeutics2 citations
Semantic Scholar
Abstract A087: BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRAS G12V-driven preclinical models
David H. Peng, Antonio Tedeschi, Lorenz Herdeis, F. Savarese +25 more
2023Molecular Cancer Therapeutics1 citations
Semantic Scholar
Abstract 1472: Novel EGFR WT sparing, HER2 selective inhibitors for the treatment of HER2 exon 20 insertion driven tumors address a clear unmet medical need
Ralph A. Neumüller, B. Wilding, D. Scharn, Dietrich Böse +13 more
2021Experimental and Molecular Therapeutics1 citations
Semantic Scholar

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