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B. Wilding · SciRah

Researcher profile · Semantic Scholar

B. Wilding

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B. Wilding — researcher profile on SciRah

h-index: 11
Works: 36
Citations: 383

Most-cited papers

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)
N. Chessum, S. Sharp, J. Caldwell, A. E. Pasqua +13 more
2017Journal of Medicinal Chemistry80 citations Open access
Semantic Scholar
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen
M. Cheeseman, N. Chessum, C. S. Rye, A. E. Pasqua +22 more
2016Journal of Medicinal Chemistry66 citations Open access
Semantic Scholar
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling
B. Wilding, D. Scharn, Dietrich Böse, A. Baum +39 more
2022Nature Cancer49 citations
Semantic Scholar
Nitrile Reductase from Geobacillus kaustophilus: A Potential Catalyst for a New Nitrile Biotransformation Reaction
B. Wilding, M. Winkler, Barbara Petschacher, R. Kratzer +2 more
201230 citations
Semantic Scholar
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies
A. E. Pasqua, S. Sharp, N. Chessum, A. Hayes +19 more
2023Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Targeting the substrate binding site of E. coli nitrile reductase QueF by modeling, substrate and enzyme engineering.
B. Wilding, M. Winkler, Barbara Petschacher, R. Kratzer +6 more
2013Chemistry23 citations
Semantic Scholar
Newest Developments in the Preparation of Thieno[2,3-d]pyrimidines
B. Wilding, N. Klempier
201722 citations
Semantic Scholar
An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechain.
B. Wilding, A. B. Veselá, J. Perry, G. Black +3 more
2015Organic and biomolecular chemistry16 citations Open access
Semantic Scholar
A practical synthesis of 5-functionalized thieno[2,3-d]pyrimidines
B. Wilding, Stefan Faschauner, N. Klempier
201514 citations
Semantic Scholar
Privileged Structures and Polypharmacology within and between Protein Families
Joshua Meyers, N. Chessum, S. Ali, Yi N. Mok +16 more
2018ACS Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime
Melissa Horvat, Victoria Weilch, Robert Rädisch, Sebastian Hecko +7 more
2021Catalysis science & technology11 citations Open access
Semantic Scholar
The Nitrile‐Forming Enzyme 7‐Cyano‐7‐Deazaguanine Synthase from Geobacillus kaustophilus: A Reverse Nitrilase?
M. Winkler, Katharina Dokulil, Hansjörg Weber, T. Pavkov-Keller +1 more
2015ChemBioChem10 citations
Semantic Scholar
Kinetic Analysis and Probing with Substrate Analogues of the Reaction Pathway of the Nitrile Reductase QueF from Escherichia coli*
Jih-Ye Jung, Tibor Czabany, B. Wilding, N. Klempier +1 more
2016Journal of Biological Chemistry8 citations Open access
Semantic Scholar
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1
B. Wilding, A. E. Pasqua, Nicola E. A. Chessum, O. Pierrat +17 more
2021Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Targeting Protein Synthesis, Folding, and Degradation Pathways in Cancer
A. E. Pasqua, B. Wilding, M. Cheeseman, Keith Jones
20175 citations
Semantic Scholar
A convenient synthetic route to substituted pyrrolo[2,3-b]pyridines via a novel ethylene-bridged compound
B. Wilding, Carina Vidovič, N. Klempier
20153 citations
Semantic Scholar
Abstract 1472: Novel EGFR WT sparing, HER2 selective inhibitors for the treatment of HER2 exon 20 insertion driven tumors address a clear unmet medical need
Ralph A. Neumüller, B. Wilding, D. Scharn, Dietrich Böse +13 more
2021Experimental and Molecular Therapeutics1 citations
Semantic Scholar
Abstract 2976: Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin
S. Sharp, N. Chessum, J. Caldwell, M. Powers +12 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen
Matthew Cheeseman, N. Chessum, C. S. Rye, Elisa Pasqua +22 more
20170 citations
Semantic Scholar
A Practical Synthesis of 5-Functionalized Thieno[2,3-d]pyrimidines.
B. Wilding, Stefan Faschauner, N. Klempier
20150 citations
Semantic Scholar
Unconventional substrates for enzymatic reduction: carboxylates and nitriles
M. Winkler, Kamilla Napora-Wijata, B. Wilding, N. Klempier
20140 citations
Semantic Scholar
Synthesis of structural analogues of 7-cyano-7-deazaguanine to investigate the active site binding and substrate scope of nitrile reductase queF
B. Wilding
20130 citations
Semantic Scholar
Exploring the Active Binding Site of Nitrile Reductases
B. Wilding, Barbara Petschacher, M. Winkler, Gerlinde Offenmüller +6 more
20130 citations
Semantic Scholar
Back Cover: Targeting the Substrate Binding Site of E. coli Nitrile Reductase QueF by Modeling, Substrate and Enzyme Engineering (Chem. Eur. J. 22/2013)
B. Wilding, M. Winkler, Barbara Petschacher, R. Kratzer +6 more
20130 citations Open access
Semantic Scholar
Biological nitrile reduction – exploring a remarkable reaction
B. Wilding, Barbara Petschacher, M. Winkler, R. Kratzer +5 more
20130 citations
Semantic Scholar
Investigations of the substrate scope of nitrile reductase queF
B. Wilding, M. Winkler, R. Kratzer, Barbara Petschacher +8 more
20120 citations
Semantic Scholar
Enzymatic Nitrile Reduction
B. Wilding, Barbara Petschacher, M. Winkler, S. Egger +7 more
20120 citations
Semantic Scholar
Biocatalytic nitrile reduction with wild type and mutant nitrile reductases
N. Klempier, B. Wilding, M. Winkler, R. Kratzer +5 more
20120 citations
Semantic Scholar
Nitrile Reduction using Nitrile Reductase
B. Wilding, M. Winkler, Barbara Petschacher, R. Kratzer +7 more
20110 citations
Semantic Scholar
Enzymatic Nitrile Reduction using wild type and mutant Nitrile Reductase QueF
B. Wilding, N. Klempier, Barbara Petschacher, M. Winkler +6 more
20110 citations
Semantic Scholar
Biotransformation of Purine and Pyrimidine Carbonitriles
N. Klempier, B. Wilding, M. Winkler
20100 citations
Semantic Scholar
Development of Heterogeneous Catalysts for the Continuous Production of Pharmaceutical Substances
Heidrun Gruber-Wölfler, R. J. Eder, B. Wilding, I. Pflüger +5 more
20090 citations
Semantic Scholar
Hybrid Organic-Inorganic Materials for Heterogeneous Catalysis: Development of supported Ti and Pd-Catalysts
Heidrun Gruber-Wölfler, R. J. Eder, B. Wilding, I. Pflüger +5 more
20090 citations
Semantic Scholar
Development of Heterogeneous Organometallic Catalysts by Functionalisation of Silicon‐based Solid Supports
H. Gruber-Woelfler, R. J. Eder, B. Wilding, I. Pflüger +2 more
20080 citations Open access
Semantic Scholar
Preparation of Catalytic Active Particel by Immobilization of Organometallic Catalysts
I. Pflüger, B. Wilding, Heidrun Gruber-Wölfler, J. Khinast
20080 citations
Semantic Scholar
Development of Chiral Heterogeneous Titanocenes for the Synthesis of Pharmaceutical Intermediates
Heidrun Gruber-Wölfler, R. J. Eder, B. Wilding, I. Pflüger +2 more
20080 citations
Semantic Scholar

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N. Klempier×19
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N. Klempier — researcher profile on SciRah
M. Winkler×14
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M. Winkler — researcher profile on SciRah
R. Kratzer×10
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B. Nidetzky×10
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Barbara Petschacher

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A. Lyskowski×9

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A. E. Pasqua×7

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N. Chessum — researcher profile on SciRah

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