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M. Zeeb · SciRah

Researcher profile · Semantic Scholar

M. Zeeb

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M. Zeeb — researcher profile on SciRah

h-index: 21
Works: 43
Citations: 1,612

Most-cited papers

Drugging an undruggable pocket on KRAS
D. Kessler, M. Gmachl, A. Mantoulidis, Laetitia J. Martin +38 more
2019Proceedings of the National Academy of Sciences of the United States of America388 citations Open access
Semantic Scholar
Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
Laetitia J. Martin, M. Koegl, G. Bader, X. Cockcroft +22 more
2016Journal of Medicinal Chemistry197 citations Open access
Semantic Scholar
One target-two different binding modes: structural insights into gevokizumab and canakinumab interactions to interleukin-1β.
M. Blech, D. Peter, P. Fischer, M. Bauer +3 more
2013Journal of Molecular Biology99 citations
Semantic Scholar
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
Jark Böttcher, D. Dilworth, Ulrich Reiser, Ralph A. Neumüller +40 more
2019Nature Chemical Biology84 citations
Semantic Scholar
T-rich DNA single strands bind to a preformed site on the bacterial cold shock protein Bs-CspB.
K. Max, M. Zeeb, R. Bienert, J. Balbach +1 more
2006Journal of Molecular Biology73 citations
Semantic Scholar
Protein folding studied by real-time NMR spectroscopy.
M. Zeeb, J. Balbach
2004Methods66 citations
Semantic Scholar
One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists
J. Schiebel, N. Radeva, Helene Köster, A. Metz +15 more
2015ChemMedChem61 citations
Semantic Scholar
Common mode of DNA binding to cold shock domains
Klaas E. A. Max, M. Zeeb, R. Bienert, J. Balbach +1 more
2007The FEBS Journal59 citations
Semantic Scholar
Single‐stranded DNA binding of the cold‐shock protein CspB from Bacillus subtilis: NMR mapping and mutational characterization
M. Zeeb, J. Balbach
2003Protein Science53 citations Open access
Semantic Scholar
Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution
M. Zeeb, K. Max, U. Weininger, Christian Löw +2 more
2006Nucleic Acids Research51 citations Open access
Semantic Scholar
Protein folding and stability of human CDK inhibitor p19(INK4d).
M. Zeeb, Heike I. Rösner, W. Żesławski, Denis Canet +2 more
2002Journal of Molecular Biology49 citations
Semantic Scholar
Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis
Martin Rübbelke, D. Fiegen, M. Bauer, F. Binder +5 more
2020Proceedings of the National Academy of Sciences of the United States of America41 citations Open access
Semantic Scholar
Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule.
C. Tautermann, F. Binder, Frank H. Büttner, C. Eickmeier +15 more
2018Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Folding mechanism of an ankyrin repeat protein: scaffold and active site formation of human CDK inhibitor p19(INK4d).
Christian Löw, U. Weininger, M. Zeeb, Wei Zhang +3 more
2007Journal of Molecular Biology38 citations
Semantic Scholar
Folding and association of an extremely stable dimeric protein from Sulfolobus islandicus.
M. Zeeb, G. Lipps, H. Lilie, J. Balbach
2004Journal of Molecular Biology38 citations
Semantic Scholar
Structural Basis for Interaction of the Tandem Zinc Finger Domains of Human Muscleblind with Cognate RNA from Human Cardiac Troponin T
Sangho Park, P. Phukan, M. Zeeb, M. Martinez-Yamout +2 more
2017Biochemistry29 citations Open access
Semantic Scholar
NMR spectroscopic characterization of millisecond protein folding by transverse relaxation dispersion measurements.
M. Zeeb, J. Balbach
2005Journal of the American Chemical Society28 citations
Semantic Scholar
MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput
Roman P. Simon, Martin Winter, C. Kleiner, Lucie Wehrle +12 more
2020SLAS discovery : advancing life sciences R & D24 citations Open access
Semantic Scholar
A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state
G. Schnapp, H. Neubauer, Frank H. Büttner, S. Handschuh +10 more
2020Communications Chemistry24 citations Open access
Semantic Scholar
Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods
D. Kessler, M. Mayer, S. Zahn, M. Zeeb +23 more
2020ChemMedChem23 citations Open access
Semantic Scholar
15N relaxation study of the cold shock protein CspB at various solvent viscosities
M. Zeeb, Maik H. Jacob, T. Schindler, J. Balbach
2003Journal of Biomolecular NMR22 citations
Semantic Scholar
Cooperativity of a protein folding reaction probed at multiple chain positions by real-time 2D NMR spectroscopy.
C. Steegborn, Henriette Schneider-Hassloff, M. Zeeb, Jochen Balbach
2000Biochemistry19 citations
Semantic Scholar
Reply to Tran et al.: Dimeric KRAS protein–protein interaction stabilizers
D. Kessler, A. Gollner, M. Gmachl, A. Mantoulidis +38 more
2020Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
Semantic Scholar
Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
Martin Rübbelke, J. Hamilton, F. Binder, M. Bauer +3 more
2021Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
R. Ebenhoch, S. Prinz, Susanne Kaltwasser, D. Mills +8 more
2020Proceedings of the National Academy of Sciences of the United States of America15 citations Open access
Semantic Scholar
Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications.
M. Blech, Daniel Seeliger, B. Kistler, M. Bauer +5 more
2012Biochemical Journal14 citations
Semantic Scholar
A hybrid screening approach for very small fragments - X-ray and Computational Screening on FKBP51.
S. Draxler, M. Bauer, C. Eickmeier, Simon Nadal +5 more
2020Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Single-stranded DNA bound to bacterial cold-shock proteins: preliminary crystallographic and Raman analysis.
R. Bienert, M. Zeeb, Lubomír Dostál, A. Feske +5 more
2004Acta Crystallographica Section D: Biological Crystallography10 citations
Semantic Scholar
Design and characterization of a soluble fragment of the extracellular ligand-binding domain of the peptide hormone receptor guanylyl cyclase-C.
T. Lauber, Naomi Tidten, Irena Matečko, M. Zeeb +2 more
2008Protein engineering, design & selection : PEDS8 citations Open access
Semantic Scholar
Structure-based stability analysis of an extremely stable dimeric DNA binding protein from Sulfolobus islandicus.
U. Weininger, M. Zeeb, P. Neumann, Christian Löw +3 more
2009Biochemistry7 citations
Semantic Scholar
Millisecond protein folding studied by NMR spectroscopy.
M. Zeeb, J. Balbach
2005Protein Peptide Letters5 citations
Semantic Scholar
Kinetic Protein Folding Studies using NMR Spectroscopy
M. Zeeb, J. Balbach
20083 citations
Semantic Scholar
Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab
M. Blech, D. Peter, P. Fischer, M. Bauer +3 more
20121 citations
Semantic Scholar
Tuning the open-close equilibrium of Cereblon with small molecules influences protein degradation
Suzanne O'Connor, Zoe J. Rutter, A. Cowan, M. Zeeb +22 more
2025bioRxiv0 citations Open access
Semantic Scholar
Solution structure of MLKL executioner domain in complex with a fragment
M. Ruebbelke, M. Bauer, J. Hamilton, F. Binder +2 more
20210 citations
Semantic Scholar
Front Cover: Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods (9/2021)
D. Kessler, M. Mayer, S. Zahn, M. Zeeb +23 more
2021ChemMedChem0 citations Open access
Semantic Scholar
Solution structure of MLKL executioner domain in complex with a covalent inhibitor
M. Ruebbelke, M. Bauer, J. Hamilton, F. Binder +2 more
20200 citations
Semantic Scholar
Solution structure of unliganded MLKL executioner domain
M. Ruebbelke, M. Bauer, H. Nar, M. Zeeb
20200 citations
Semantic Scholar
Solution structure of the zinc fingers 1 and 2 of MBNL1
P. Phukan, S. Park, M. Martinez-Yamout, M. Zeeb +2 more
20170 citations
Semantic Scholar
Solution structure of the zinc fingers 3 and 4 of MBNL1
P. Phukan, S. Park, M. Martinez-Yamout, M. Zeeb +2 more
20170 citations
Semantic Scholar
Solution structure of the zinc fingers 1 and 2 of MBNL1 in complex with human cardiac troponin T pre-mRNA
P. Phukan, S. Park, M. Martinez-Yamout, M. Zeeb +2 more
20170 citations
Semantic Scholar
Solution structure of cold shock protein CspB from Bacillus subtilis in complex with heptathymidine
M. Zeeb, H. Sticht, J. Balbach
20060 citations
Semantic Scholar
Binding of ssDNA to Bacterial Cold Shock Proteins (CSP): Structural Insights into Sequence Recognition Suggest Conserved Functions and Specificities with the group of CSP and eukaryotic Y-box factors
K. Max, M. Zeeb, R. Bienert, A. Feske +3 more
20050 citations
Semantic Scholar

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