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A. Hallsworth · SciRah

Researcher profile · Semantic Scholar

A. Hallsworth

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A. Hallsworth — researcher profile on SciRah

h-index: 16
Works: 31
Citations: 1,117

Most-cited papers

The ALKF1174L mutation potentiates the oncogenic activity of MYCN in neuroblastoma
Teeara Berry, W. Luther, Namrata Bhatnagar, Y. Jamin +23 more
2012Cancer Cell320 citations Open access
Semantic Scholar
This Work Is Licensed under a Creative Commons Attribution 3.0 Unported License Combined Myc and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease
Hill Rm, K. S, Li Jc, Petrie K +58 more
166 citations
Semantic Scholar
CCT244747 is a novel, potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs
M. Walton, Paul D. Eve, A. Hayes, M. Valenti +16 more
2012Clinical Cancer Research91 citations Open access
Semantic Scholar
Cyclin-dependent kinase inhibitor AT7519 as a potential drug for MYCN-dependent neuroblastoma
M. Dolman, E. Poon, M. E. Ebus, I. den Hartog +11 more
2015Clinical Cancer Research60 citations Open access
Semantic Scholar
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma
E. Poon, Tong Liang, Y. Jamin, S. Walz +39 more
2020Journal of Clinical Investigation57 citations Open access
Semantic Scholar
Application of Meso Scale Technology for the Measurement of Phosphoproteins in Human Tumor Xenografts
Sharon M. Gowan, A. Hardcastle, A. Hallsworth, M. Valenti +7 more
2007Assay and drug development technologies50 citations
Semantic Scholar
In vivo modelling of chemo-resistant neuroblastoma provides new insights into chemo-refractory disease and metastasis.
O. Yogev, G. S. Almeida, K. Barker, Sally L. George +21 more
2019Cancer Research43 citations Open access
Semantic Scholar
Evaluation of Clinically Translatable Magnetic Resonance Imaging Biomarkers of Therapeutic Response in the TH-MYCN Transgenic Mouse Model of Neuroblastoma
Y. Jamin, E. Tucker, E. Poon, S. Popov +10 more
2012Radiology37 citations Open access
Semantic Scholar
p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance.
O. Yogev, K. Barker, Arti Sikka, G. S. Almeida +13 more
2016Cancer Research36 citations
Semantic Scholar
Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease
R. Hill, S. Kuijper, J. Lindsey, K. Petrie +28 more
2015Cancer Cell36 citations Open access
Semantic Scholar
miRNA Expression Profiling of the Murine TH-MYCN Neuroblastoma Model Reveals Similarities with Human Tumors and Identifies Novel Candidate MiRNAs
M. Terrile, K. Bryan, L. Vaughan, A. Hallsworth +3 more
2011PLoS ONE36 citations Open access
Semantic Scholar
MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma
David King, Xiao-Dun Li, G. S. Almeida, C. Kwok +12 more
2020OncoTarget32 citations Open access
Semantic Scholar
Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage
P. Carotenuto, Francesco Amato, A. Lampis, Colin Rae +34 more
2021Nature Communications31 citations Open access
Semantic Scholar
Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736.
A. Moore, A. Faisal, Grace W. Y. Mak, F. Miraki-Moud +14 more
2020Blood Advances24 citations Open access
Semantic Scholar
Identification of ovarian high-grade serous carcinoma cell lines that show estrogen-sensitive growth as xenografts in immunocompromised mice
A. K. de Haven Brandon, G. Box, A. Hallsworth, W. Court +5 more
2020Scientific Reports23 citations Open access
Semantic Scholar
Molecular and In Vivo Characterization of Cancer-Propagating Cells Derived from MYCN-Dependent Medulloblastoma
Zai Ahmad, Lukasz Jasnos, V. Gil, L. Howell +4 more
2015PLoS ONE23 citations Open access
Semantic Scholar
Intrinsic Susceptibility MRI Identifies Tumors with ALKF1174L Mutation in Genetically-Engineered Murine Models of High-Risk Neuroblastoma
Y. Jamin, Laura Glass, A. Hallsworth, R. George +4 more
2014PLoS ONE16 citations Open access
Semantic Scholar
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo
R. Huckvale, Alice C. Harnden, Kwai-Ming J. Cheung, O. Pierrat +26 more
2022Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform
G. S. Almeida, R. Panek, A. Hallsworth, H. Webber +5 more
2017British Journal of Cancer11 citations Open access
Semantic Scholar
Response of GEM models of neuroblastoma to cabozantinib assessed by multiparametric magnetic resonance imaging
Gilberto S. Almeida, P. King, A. Hallsworth, H. Webber +7 more
2025Neoplasia5 citations Open access
Semantic Scholar
Discovery and validation of biomarkers to support clinical development of NXP800: A first-in-class orally active, small-molecule HSF1 pathway inhibitor
P. Workman, P. Clarke, R. T. Poele, M. Powers +12 more
2022European Journal of Cancer4 citations Open access
Semantic Scholar
Correction: MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma
David King, Xiao-Dun Li, G. S. Almeida, C. Kwok +12 more
2023OncoTarget2 citations Open access
Semantic Scholar
Abstract 1010: A study of combinatorial growth inhibition, cell death and DNA damage repair caused by CHK1 inhibitor SRA737 and WEE1 inhibitor adavosertib in TP53 mutated cell lines
A. Stewart, L. Pickard, A. Hallsworth, S. Sauvaigo +3 more
2021Experimental and Molecular Therapeutics1 citations
Semantic Scholar
HG-67PRECLINICAL EFFICACY OF ALK2 INHIBITORS IN ACVR1 MUTANT DIPG
Diana M. Carvalho, Kathryn R. Taylor, N. Olaciregui, M. Valenti +19 more
20161 citations Open access
Semantic Scholar
Possible increase in hookworm prevalence in cattle in the UK.
Michael Millar, Dominica Harrison, Benedetta Amato, Robert Brafield +10 more
2025The Veterinary Record0 citations Open access
Semantic Scholar
Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of response to DNA damage
A. Lampis, P. Carotenuto, S. Hedayat, M. Previdi +16 more
2019Annals of Oncology0 citations Open access
Semantic Scholar
Abstract 491: Tumor response to cabozantinib in the TH-MYCN GEM model of neuroblastoma
G. S. Almeida, P. King, Y. Jamin, A. Hallsworth +5 more
20150 citations
Semantic Scholar
MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically
R. Hill, S. Kuijper, J. Lindsey, E. Schwalbe +27 more
20140 citations
Semantic Scholar
Abstract 5037: Intrinsic susceptibility magnetic resonance imaging identifies tumors with ALKF1174L mutation in transgenic murine models of high-risk neuroblastoma.
Y. Jamin, Laura Glass, A. Hallsworth, R. George +4 more
20130 citations
Semantic Scholar
Abstract LB-87: A novel epigenetic blood test to monitor minimal residual disease in high-risk neuroblastoma.
K. Petrie, M. Field, Zai Ahmad, M. Dezfouli +10 more
20130 citations
Semantic Scholar
Abstract A228: CCT244747 is a novel, potent and selective inhibitor of CHK1 with oral efficacy both alone in neuroblastoma and in combination with genotoxic chemotherapeutic agents.
M. Walton, Paul Eve, A. Hayes, M. Valenti +16 more
20110 citations
Semantic Scholar

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