L. Vaughan

Most-cited papers

1. The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo

   A. Faisal, L. Vaughan, V. Bavetsias, Chong-Bo Sun +10 more

   2011Molecular Cancer Therapeutics88 citations Open access

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2. HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

   K. Myant, P. Cammareri, M. Hodder, J. Wills +14 more

   2016EMBO Molecular Medicine74 citations Open access

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3. Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors

   L. Vaughan, P. Clarke, K. Barker, Yvan H. Chanthery +13 more

   2016OncoTarget60 citations Open access

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4. HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion

   L. Vaughan, C. Tan, Anna Chapman, Daisuke F. Nonaka +5 more

   2014Cell Reports59 citations Open access

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5. Evaluation of Clinically Translatable Magnetic Resonance Imaging Biomarkers of Therapeutic Response in the TH-MYCN Transgenic Mouse Model of Neuroblastoma

   Y. Jamin, E. Tucker, E. Poon, S. Popov +10 more

   2012Radiology37 citations Open access

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6. miRNA Expression Profiling of the Murine TH-MYCN Neuroblastoma Model Reveals Similarities with Human Tumors and Identifies Novel Candidate MiRNAs

   M. Terrile, K. Bryan, L. Vaughan, A. Hallsworth +3 more

   2011PLoS ONE36 citations Open access

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7. Abstract 5255: NVP-BEZ235 a dual PI3K/mTOR inhibitor destabilises Mycn in vitro and is growth inhibitory in the TH-MYCN murine neuroblastoma model

   L. Vaughan, E. Cullis, K. Barker, Y. Jamin +3 more

   20102 citations

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8. Evaluation of Clinically Translatable Magnetic Resonance Imaging Biomarkers of Therapeutic Response in the TH-MYCN Transgenic Mouse Model of Neuroblastoma

   Y. Jamin, E. Tucker, E. Poon, S. Popov +11 more

   20150 citations

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9. Abstract 4345: AZD8055, a combined TORC1/TORC2 inhibitor regulates Mycn protein expression and prevents neuroblastoma growth in vitro and in vivo

   L. Vaughan, K. Barker, H. Webber, Y. Jamin +3 more

   20110 citations

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10. Abstract 5290: Imaging biomarkers of response to chemotherapy in neuroblastoma

    Y. Jamin, E. Cullis, L. Vaughan, H. Webber +5 more

    20110 citations

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11. MRI Characterisation of a Novel Transgenic Mouse Model of Neuroblastoma

    Y. Jamin, E. R. Cullis, L. Vaughan, L. Chesler +1 more

    20100 citations

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12. Abstract LB-387: MYCN dependence of tumor propagating cells in an orthotopic model of medulloblastoma

    Zai Ahmad, Amy C. Moore, K. Barker, L. Vaughan +3 more

    20100 citations

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13. Native T 1 is a Generic Imaging Biomarker of Response to Chemotherapy in Neuroblastoma

    Y. Jamin, E. Cullis, L. Vaughan, H. Webber +5 more

    20100 citations

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14. Abstract 4189: Characterization of tumor progression and chemoresponse in a novel transgenic mouse model of neuroblastoma (TH-MYCN) using magnetic resonance imaging

    Y. Jamin, E. Cullis, L. Vaughan, D. Koh +2 more

    20100 citations

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