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A. Stewart · SciRah

Researcher profile · Semantic Scholar

A. Stewart

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A. Stewart — researcher profile on SciRah

h-index: 12
Works: 41
Citations: 634

Most-cited papers

A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with Advanced Solid Tumors
B. Venugopal, R. Baird, R. Kristeleit, R. Plummer +13 more
2013Clinical Cancer Research116 citations Open access
Semantic Scholar
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
A. Acar, D. Nichol, J. Fernández-Mateos, George D. Cresswell +15 more
2020Nature Communications111 citations Open access
Semantic Scholar
The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer
C. Carden, A. Stewart, P. Thavasu, E. Kipps +11 more
2012Molecular Cancer Therapeutics92 citations Open access
Semantic Scholar
A Phase I Pharmacokinetic and Pharmacodynamic Study of CHR-3996, an Oral Class I Selective Histone Deacetylase Inhibitor in Refractory Solid Tumors
U. Banerji, L. van Doorn, D. Papadatos-Pastos, R. Kristeleit +10 more
2012Clinical Cancer Research72 citations Open access
Semantic Scholar
A phase I study of CPI-0610, a bromodomain and extra terminal protein (BET) inhibitor in patients with relapsed or refractory lymphoma
K. Blum, J. Abramson, M. Maris, I. Flinn +18 more
201840 citations Open access
Semantic Scholar
AKT inhibition synergistically enhances growth-inhibitory effects of gefitinib and increases apoptosis in non-small cell lung cancer cell lines.
M. Puglisi, P. Thavasu, A. Stewart, J. de Bono +4 more
2014Lung Cancer29 citations
Semantic Scholar
Inactivation of NF1 promotes resistance to EGFR inhibition in KRAS/NRAS/BRAFV600-wildtype colorectal cancer
A. Georgiou, A. Stewart, D. Cunningham, U. Banerji +1 more
2020Molecular Cancer Research26 citations Open access
Semantic Scholar
Titration of signalling output: insights into clinical combinations of MEK and AKT inhibitors
A. Stewart, P. Thavasu, J. de Bono, U. Banerji
2015Annals of Oncology23 citations Open access
Semantic Scholar
Abstract CT143: Phase I study of the combination of a RAF-MEK inhibitor CH5126766 and FAK inhibitor defactinib in an intermittent dosing schedule with expansions inKRASmutant cancers
Rajiv Shinde, Angelika Terbuch, M. Little, Reece Caldwell +20 more
2020Tumor Biology16 citations
Semantic Scholar
Differences in signaling patterns on PI3K inhibition reveal context specificity in KRAS mutant cancers
A. Stewart, E. Coker, S. Pölsterl, A. Georgiou +8 more
2019Molecular Cancer Therapeutics16 citations Open access
Semantic Scholar
Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes
E. Coker, A. Stewart, Bugra Ozer, A. Minchom +9 more
2022Molecular Cancer Therapeutics15 citations Open access
Semantic Scholar
A study of PD-L1 expression in KRAS mutant non-small cell lung cancer cell lines exposed to relevant targeted treatments
A. Minchom, P. Thavasu, Zai Ahmad, A. Stewart +7 more
2017PLoS ONE14 citations Open access
Semantic Scholar
Exploiting evolutionary herding to control drug resistance in cancer
A. Acar, D. Nichol, J. Fernández-Mateos, George D. Cresswell +12 more
2019bioRxiv12 citations Open access
Semantic Scholar
Insights into significance of combined inhibition of MEK and m-TOR signalling output in KRAS mutant non-small-cell lung cancer
S. Broutin, A. Stewart, P. Thavasu, A. Paci +2 more
2016British Journal of Cancer11 citations Open access
Semantic Scholar
Utilizing the Luminex Magnetic Bead-Based Suspension Array for Rapid Multiplexed Phosphoprotein Quantification.
A. Stewart, U. Banerji
2017Methods in molecular biology10 citations
Semantic Scholar
A phospho-proteomic study of cetuximab resistance in KRAS/NRAS/BRAFV600 wild-type colorectal cancer
A. Georgiou, A. Stewart, G. Vlachogiannis, L. Pickard +4 more
2021Cellular Oncology9 citations Open access
Semantic Scholar
Characterisation of the Phosphatidylinositol 3-Kinase Pathway in Non-Small Cell Lung Cancer Cells Isolated from Pleural Effusions
M. Puglisi, A. Stewart, P. Thavasu, M. Frow +10 more
2016Oncology6 citations
Semantic Scholar
Unbiased differential proteomic profiling between cancer-associated fibroblasts and cancer cell lines.
Rachel Lau, Lu Yu, Theo Roumeliotis, A. Stewart +6 more
2023Journal of Proteomics5 citations Open access
Semantic Scholar
Dual targeting of RAF-MEK-ERK and PI3K-AKT-mTOR pathways in RAS-mutant cancers: Preclinical insights and institutional experience from a clinical trial of binimetinib (MEK162) plus BYL719.
U. Banerji, A. Smith, A. Zivi, D. Lorente +10 more
20143 citations
Semantic Scholar
Abstract 3461: Preclinical and clinical evaluation of the RAF/MEK clamp avutometinib (VS-6766) in combination with the mTOR inhibitor everolimus for the treatment of KRAS mutated non-small cell lung cancer
S. Rodney, A. Stewart, V. S. Pérez, Cienne Morton +12 more
2023Cancer Research1 citations
Semantic Scholar
1697P Drug-induced evolutionary dynamics in BRCA-mutant/non-mutant ovarian cancer models
A. Garces, Salvatore Milite, E. Oliveira, J. Fernández-Mateos +9 more
2022Annals of Oncology1 citations Open access
Semantic Scholar
P52.05 Dual RAF/MEK Inhibitor VS-6766 for Treatment of KRAS Mutant NSCLC: Novel Combinations Targeting G12C or G12V Variants
S. Coma, S. Chowdhury, M. Musteanu, A. Stewart +6 more
2021Journal of Thoracic Oncology1 citations Open access
Semantic Scholar
Abstract 1010: A study of combinatorial growth inhibition, cell death and DNA damage repair caused by CHK1 inhibitor SRA737 and WEE1 inhibitor adavosertib in TP53 mutated cell lines
A. Stewart, L. Pickard, A. Hallsworth, S. Sauvaigo +3 more
2021Experimental and Molecular Therapeutics1 citations
Semantic Scholar
KRAS mutant and RAS/BRAF wild type colorectal cancer cells exhibit differences in the rewiring of signal transduction that can impact on future therapeutic strategies.
Alexandros Georgiou, A. Stewart, P. Thavasu, E. Coker +5 more
2018Annals of Oncology1 citations Open access
Semantic Scholar
Unravelling the context specificity of signalling in KRAS mutant cancers: Implications for design of clinical trials
U. Banerji, A. Stewart, E. Coker, A. Minchom +3 more
20181 citations Open access
Semantic Scholar
Abstract 5343: The effect of horizontal and vertical inhibition of nodes within the MAPK and PI3K-AKT pathways in NSCLC models
S. Broutin, A. Stewart, P. Thavasu, A. Paci +2 more
20151 citations
Semantic Scholar
Abstract 3187: Understanding the role of cancer-associated fibroblasts (CAFs) on pathogenesis of KRAS mutated cancers by defining differences in the basal state proteome and secretome
Rachel Lau, Lu Yu, Theo Roumeliotis, L. Pickard +3 more
2022Cancer Research0 citations
Semantic Scholar
Abstract 3790: A study of evolutionary dynamics induced by carboplatin, olaparib and paclitaxel in high-grade serous ovarian cancer cell line models
Á. Garces, Salvatore Milite, J. Fernández-Mateos, Bingjie Chen +8 more
2022Cancer Research0 citations
Semantic Scholar
Abstract 2646: Proteomic approaches to study cetuximab resistance inRAS/BRAFwild type colorectal cancer
A. Georgiou, A. Stewart, G. Vlachogiannis, L. Pickard +4 more
2019Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
Abstract 996: A translational phosphoproteomic approach to study differences inKRASsignaling in pancreatic, colorectal and lung cancers
A. Stewart, E. Coker, A. Minchom, S. Pölsterl +4 more
20170 citations
Semantic Scholar
Abstract 2627: A study of dynamic changes in PD-L1 expression inKRASmutant adenocarcinoma of the lung exposed to signal transduction inhibitors
A. Minchom, P. Thavasu, Zai Ahmad, A. Stewart +7 more
20170 citations
Semantic Scholar
Characterization of the PI 3 K Pathway in Non-small Cell Lung Cancer Cells isolated from Pleural Effusions
M. Puglisi, A. Stewart, P. Thavasu, M. Frow +11 more
20160 citations
Semantic Scholar
Abstract 4383: SOCRATES: integrating ex vivo and in silico analysis to identify optimal drug combinations for patients
E. Coker, A. Stewart, A. Minchom, M. O'Brien +4 more
20160 citations
Semantic Scholar
Abstract 3099:KRASand clinical context: Differential dynamic signaling output ofKRASmutant lung, colorectal and pancreatic cancer cell lines when exposed to targeted anticancer drugs
A. Stewart, E. Coker, A. Minchom, P. Thavasu +6 more
20160 citations
Semantic Scholar
Abstract 1828: A genomic-transcriptomic-phosphoproteomic study to interrogate lapatinib resistance in an HER2 over expressing SKBR3 human breast cancer cell line model
P. Thavasu, R. T. Poele, Mark T. Hughes, A. Stewart +2 more
20140 citations
Semantic Scholar
Abstract 2441: Evaluation of combination of an EGFR and AKT inhibitor inEGFRmutant andEGFRwild type non-small cell lung cancer cells lines.
M. Puglisi, P. Thavasu, A. Stewart, J. Bhosle +3 more
20130 citations
Semantic Scholar
L11.06HUMAN CANCER CELLS ISOLATED FROM ASCITES AS MODELS TO OPTIMIZE THE USE OF TARGETED ANTICANCER AGENTS IN OVARIAN CANCER
U. Banerji, A. Stewart, P. Thavasu, Susana Banerjee +1 more
20130 citations Open access
Semantic Scholar
Abstract 2341: A study of relationships between signalling output and growth inhibition to personalize combinations of MEK and AKT inhibitors.
A. Stewart, P. Thavasu, J. de Bono, U. Banerji
20130 citations
Semantic Scholar
Molecular Medicine in Practice The Association of PI 3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer
C. Carden, A. Stewart, P. Thavasu, E. Kipps +11 more
20120 citations
Semantic Scholar
Abstract 931: The combination of the dual mTORC1/mTORC2 inhibitor AZD2014 and paclitaxel in human ovarian cancer models
A. Stewart, P. Thavasu, S. Heaton, Susana Banerjee +2 more
20120 citations
Semantic Scholar
Advanced Ovarian Cancer The Association of PI3 Kinase Signaling and Chemoresistance in
C. Carden, A. Stewart, P. Thavasu
20120 citations
Semantic Scholar

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U. Banerji×38
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U. Banerji — researcher profile on SciRah
P. Thavasu×19
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P. Thavasu — researcher profile on SciRah
J. de Bono×16
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J. de Bono — researcher profile on SciRah
A. Minchom×13
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A. Minchom — researcher profile on SciRah

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A. Georgiou — researcher profile on SciRah

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E. Coker — researcher profile on SciRah

B. Al-Lazikani×8

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L. Pickard — researcher profile on SciRah

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J. Bhosle — researcher profile on SciRah

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M. O'Brien — researcher profile on SciRah

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S. Popat — researcher profile on SciRah

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T. Yap — researcher profile on SciRah