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D. Wiederschain · SciRah

Researcher profile · Semantic Scholar

D. Wiederschain

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D. Wiederschain — researcher profile on SciRah

h-index: 37
Works: 92
Citations: 6,860

Most-cited papers

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
William E. Dowdle, B. Nyfeler, Jane Nagel, R. Elling +43 more
2014Nature Cell Biology731 citations
Semantic Scholar
PTEN-deficient cancers depend on PIK3CB
S. Wee, D. Wiederschain, S. Maira, Alice T. Loo +5 more
2008Proceedings of the National Academy of Sciences of the United States of America562 citations Open access
Semantic Scholar
Single-vector inducible lentiviral RNAi system for oncology target validation
D. Wiederschain, W. Susan, Lin Chen, Alice T. Loo +8 more
2009Cell Cycle450 citations Open access
Semantic Scholar
Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model.
Jian-Min Fang, Yuen W. Shing, D. Wiederschain, Li Yan +5 more
2000Proceedings of the National Academy of Sciences of the United States of America415 citations Open access
Semantic Scholar
Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion
K. Tateishi, H. Wakimoto, A. Iafrate, Shota Tanaka +25 more
2015Cancer Cell395 citations Open access
Semantic Scholar
The generation of endostatin is mediated by elastase.
Wei Wen, M. Moses, D. Wiederschain, J. Arbiser +1 more
1999Cancer Research308 citations
Semantic Scholar
Regulation of Angiostatin Production by Matrix Metalloproteinase-2 in a Model of Concomitant Resistance*
M. O'Reilly, D. Wiederschain, W. Stetler-Stevenson, J. Folkman +1 more
1999Journal of Biological Chemistry286 citations Open access
Semantic Scholar
Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53*
Ji-Jie Gu, Hidehiko Kawai, L. Nie, H. Kitao +5 more
2002Journal of Biological Chemistry280 citations Open access
Semantic Scholar
Increased incidence of matrix metalloproteinases in urine of cancer patients.
M. Moses, D. Wiederschain, K. Loughlin, D. Zurakowski +2 more
1998Cancer Research275 citations
Semantic Scholar
Troponin I is present in human cartilage and inhibits angiogenesis.
M. Moses, D. Wiederschain, I. Wu, C. Fernández +6 more
1999Proceedings of the National Academy of Sciences of the United States of America221 citations Open access
Semantic Scholar
Local delivery of mRNA-encoding cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models
Christian Hotz, T. Wagenaar, F. Gieseke, D. Bangari +33 more
2021Science Translational Medicine196 citations
Semantic Scholar
DNA Damage-induced MDMX Degradation Is Mediated by MDM2*
Hidehiko Kawai, D. Wiederschain, H. Kitao, Jeremy R Stuart +2 more
2003Journal of Biological Chemistry174 citations Open access
Semantic Scholar
RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity.
Hidehiko Kawai, V. Lopez-Pajares, Mihee M. Kim, D. Wiederschain +1 more
2007Cancer Research158 citations Open access
Semantic Scholar
Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition
Michael Lampa, H. Arlt, T. He, B. Ospina +14 more
2017PLoS ONE157 citations Open access
Semantic Scholar
Tumor-Specific Urinary MMP Fingerprinting: Identification of High Molecular Weight Urinary MMP Species
R. Roy, Gwendolyn Louis, K. Loughlin, D. Wiederschain +4 more
2008Clinical Cancer Research151 citations Open access
Semantic Scholar
A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells
E. Seung, Z. Xing, Lan Wu, E. Rao +24 more
2022Nature148 citations
Semantic Scholar
Critical Contribution of the MDM2 Acidic Domain to p53 Ubiquitination
Hidehiko Kawai, D. Wiederschain, Zhi-Min Yuan
2003Molecular and Cellular Biology136 citations Open access
Semantic Scholar
Therapeutic Opportunities with Pharmacological Inhibition of CD38 with Isatuximab
T. Martin, K. Corzo, M. Chiron, H. Van de Velde +9 more
2019Cells135 citations Open access
Semantic Scholar
Contribution of Polycomb Homologues Bmi-1 and Mel-18 to Medulloblastoma Pathogenesis
D. Wiederschain, Lin Chen, B. Johnson, Kimberly Bettano +10 more
2007Molecular and Cellular Biology125 citations Open access
Semantic Scholar
Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule
Gejing Deng, Junqing Shen, M. Yin, Jessica Mcmanus +23 more
2014Journal of Biological Chemistry118 citations Open access
Semantic Scholar
Isatuximab Acts Through Fc-Dependent, Independent, and Direct Pathways to Kill Multiple Myeloma Cells
Chen Zhu, Zhi-Li Song, Anlai Wang, Srimathi Srinivasan +14 more
2020Frontiers in Immunology112 citations Open access
Semantic Scholar
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents
G. Griebel, P. Pichat, S. Beeské, T. Leroy +27 more
2015Scientific Reports101 citations Open access
Semantic Scholar
Identification of p53 Sequence Elements That Are Required for MDM2-Mediated Nuclear Export
Ji-Jie Gu, L. Nie, D. Wiederschain, Zhi-Min Yuan
2001Molecular and Cellular Biology99 citations Open access
Semantic Scholar
Anti–miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation
T. Wagenaar, S. Zabludoff, S. Ahn, C. Allerson +24 more
2015Molecular Cancer Research79 citations Open access
Semantic Scholar
The role of matrix metalloproteinase activity in the maturation of human capillary endothelial cells in vitro.
B. Kräling, D. Wiederschain, Thomas Boehm, M. Rehn +2 more
1999Journal of Cell Science78 citations
Semantic Scholar
Dysregulated proteolytic balance as the basis of excess extracellular matrix in fibrotic disease.
C. Peters, Michael R. Freeman, C. Fernández, J. Shepard +2 more
1997American Journal of Physiology76 citations
Semantic Scholar
The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells.
Zainab Jagani, D. Wiederschain, Alice T. Loo, D. He +9 more
2010Cancer Research75 citations Open access
Semantic Scholar
Multiple Mixed Lineage Leukemia (MLL) Fusion Proteins Suppress p53-mediated Response to DNA Damage*
D. Wiederschain, Hidehiko Kawai, A. Shilatifard, Zhi-Min Yuan
2005Journal of Biological Chemistry65 citations Open access
Semantic Scholar
Dynamics of extracellular matrix production and turnover in tissue engineered cardiovascular structures
U. Stock, D. Wiederschain, Susan M. Kilroy, D. Shum-Tim +4 more
2001Journal of Cellular Biochemistry61 citations
Semantic Scholar
Molecular Basis of p53 Functional Inactivation by the Leukemic Protein MLL-ELL
D. Wiederschain, Hidehiko Kawai, Ji-Jie Gu, A. Shilatifard +1 more
2003Molecular and Cellular Biology51 citations Open access
Semantic Scholar
Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade
R. Greco, Hong-Jin Qu, H. Qu, J. Theilhaber +15 more
2020Oncoimmunology48 citations Open access
Semantic Scholar
BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression
I. Mandel, Dana Haves Ziv, I. Goldshtein, T. Peretz +13 more
2022Journal for ImmunoTherapy of Cancer45 citations Open access
Semantic Scholar
Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells
T. Wagenaar, T. Tolstykh, Chao-Mei Shi, Lan Jiang +21 more
2014Nucleic Acids Research43 citations Open access
Semantic Scholar
PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene.
Zhuyan Guo, Anlai Wang, Weidong Zhang, M. Levit +19 more
2014Blood43 citations
Semantic Scholar
Dual Role of p300 in the Regulation of p53 Stability*
Hidehiko Kawai, L. Nie, D. Wiederschain, Zhi-Min Yuan
2001Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody
Jessica D. Weaver, E. Stack, Joshua A. Buggé, Changyun Hu +25 more
2022Oncoimmunology39 citations Open access
Semantic Scholar
Matrix metalloproteinases and their inhibitors in aqueous humor.
Sherleen H. Huang, A. Adamis, D. Wiederschain, David T. Shima +2 more
1996Experimental Eye Research38 citations
Semantic Scholar
Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T Cell Activation in Tumors.
B. Umiker, Yasmin Hashambhoy-Ramsay, Jeff Smith, Tanzila Rahman +22 more
2023Molecular Cancer Therapeutics35 citations Open access
Semantic Scholar
Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches
Q. Gao, I. Mechin, Nayantara H. Kothari, Zhuyan Guo +21 more
2013Journal of Biological Chemistry32 citations Open access
Semantic Scholar
An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy
M. Bernardo, T. Tolstykh, Yu-An Zhang, D. Bangari +16 more
2021Oncoimmunology28 citations Open access
Semantic Scholar
Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms
Shih-Min A. Huang, Anlai Wang, R. Greco, Zhifang Li +15 more
2014OncoTarget27 citations Open access
Semantic Scholar
Mutual Dependence of MDM 2 and MDMX in Their Functional Inactivation of p 53 *
Ji-Jie Gu, Hidehiko Kawai, L. Nie, H. Kitao +5 more
200226 citations
Semantic Scholar
Mechanism of functional inactivation of a Li-Fraumeni syndrome p53 that has a mutation outside of the DNA-binding domain.
Ji-Jie Gu, Hidehiko Kawai, D. Wiederschain, Zhi-Min Yuan
2001Cancer Research24 citations
Semantic Scholar
Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation
Z. Ding, Chao-Mei Shi, Lan Jiang, T. Tolstykh +20 more
2017OncoTarget23 citations Open access
Semantic Scholar
Class IA phosphoinositide 3-kinase isoforms and human tumorigenesis: implications for cancer drug discovery and development
S. Wee, C. Lengauer, D. Wiederschain
2008Current Opinion in Oncology22 citations
Semantic Scholar
SAR442085, a novel anti-CD38 antibody with enhanced antitumor activity against multiple myeloma.
S. Kassem, Béré K Diallo, N. El-Murr, N. Carrié +15 more
2021Blood20 citations Open access
Semantic Scholar
Evidence for a Distinct Inhibitory Factor in the Regulation of p53 Functional Activity*
D. Wiederschain, Ji-Jie Gu, Zhi-Min Yuan
2001Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Utility of the RIG-I Agonist Triphosphate RNA for Melanoma Therapy
Mike W. Helms, K. Jahn-Hofmann, Felix A Gnerlich, C. Metz-Weidmann +14 more
2019Molecular Cancer Therapeutics15 citations Open access
Semantic Scholar
Pre-clinical development of a novel CD3-CD123 bispecific T-cell engager using cross-over dual-variable domain (CODV) format for acute myeloid leukemia (AML) treatment
Hélène Bonnevaux, S. Guérif, J. Albrecht, E. Jouannot +22 more
2021Oncoimmunology14 citations Open access
Semantic Scholar
An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells
M. J. Kobylarz, Jonathan M. Goodwin, Z. Kang, J. W. Annand +18 more
2020PLoS ONE12 citations Open access
Semantic Scholar

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