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H. Qu · SciRah

Researcher profile · Semantic Scholar

H. Qu

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H. Qu — researcher profile on SciRah

h-index: 21
Works: 53
Citations: 1,782

Most-cited papers

Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.
Xiong Cai, H. Zhai, J. Wang, J. Forrester +5 more
2010Journal of Medicinal Chemistry257 citations Open access
Semantic Scholar
Cancer Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3-Kinase Signaling
C. Qian, C. Lai, R. Bao, Da-Gong Wang +13 more
2012Clinical Cancer Research218 citations Open access
Semantic Scholar
Local delivery of mRNA-encoding cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models
Christian Hotz, T. Wagenaar, F. Gieseke, D. Bangari +33 more
2021Science Translational Medicine196 citations
Semantic Scholar
CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity.
C. Lai, R. Bao, X. Tao, J. Wang +15 more
2010Cancer Research192 citations Open access
Semantic Scholar
CUDC-305, a Novel Synthetic HSP90 Inhibitor with Unique Pharmacologic Properties for Cancer Therapy
R. Bao, C. Lai, H. Qu, Da-Gong Wang +12 more
2009Clinical Cancer Research107 citations Open access
Semantic Scholar
Long non-coding RNA HOTAIR promotes HLA-G expression via inhibiting miR-152 in gastric cancer cells.
Bingtan Song, Zhongzheng Guan, Feng-Jun Liu, Dong-Sheng Sun +2 more
2015Biochemical and Biophysical Research Communications - BBRC75 citations
Semantic Scholar
The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children.
Yuling Zhang, Xi Wang, Ye Liu, H. Qu +3 more
2012Swiss medical weekly70 citations Open access
Semantic Scholar
Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non–small cell lung cancer
R. Bao, C. Lai, Da-Gong Wang, H. Qu +13 more
2009Molecular Cancer Therapeutics62 citations
Semantic Scholar
TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis
Wen-ji Yang, Fanghui Han, Yi-pei Gu, H. Qu +3 more
2023Acta Pharmacologica Sinica51 citations Open access
Semantic Scholar
Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade
R. Greco, Hong-Jin Qu, H. Qu, J. Theilhaber +15 more
2020Oncoimmunology48 citations Open access
Semantic Scholar
Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells
T. Wagenaar, T. Tolstykh, Chao-Mei Shi, Lan Jiang +21 more
2014Nucleic Acids Research43 citations Open access
Semantic Scholar
TGF-β induces HLA-G expression through inhibiting miR-152 in gastric cancer cells
Zhongzheng Guan, Bingtan Song, Feng-Jun Liu, Dong-Sheng Sun +2 more
2015Journal of Biomedical Sciences40 citations Open access
Semantic Scholar
Downregulation of histone demethylase JMJD1C inhibits colorectal cancer metastasis through targeting ATF2.
Cheng Chen, Maimaiti Aihemaiti, Xin Zhang, H. Qu +3 more
2018American Journal of Cancer Research37 citations
Semantic Scholar
Discovery of Highly Potent and Selective Thyroid Hormone Receptor β Agonists for the Treatment of Nonalcoholic Steatohepatitis.
Liuyu Hu, Yi-pei Gu, Junzhi Liang, Meng-Meng Ning +6 more
2023Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-β signaling pathway in cancer cells.
Dandan Tong, H. Qu, Xiang-Ning Meng, Yang Jiang +6 more
2014Oncology Report31 citations Open access
Semantic Scholar
Pegylated phosphotidylethanolamine inhibiting P-glycoprotein expression and enhancing retention of doxorubicin in MCF7/ADR cells.
Jing Wang, H. Qu, Ling-Tao Jin, Wenfeng Zeng +6 more
2011Journal of Pharmacy and Science30 citations
Semantic Scholar
An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy
M. Bernardo, T. Tolstykh, Yu-An Zhang, D. Bangari +16 more
2021Oncoimmunology28 citations Open access
Semantic Scholar
FKBP10 functioned as a cancer‐promoting factor mediates cell proliferation, invasion, and migration via regulating PI3K signaling pathway in stomach adenocarcinoma
Ruogu Wang, Dan Zhang, Chun-Hong Zhao, Qi-long Wang +2 more
2019Kaohsiung Journal of Medical Sciences27 citations Open access
Semantic Scholar
Integrated Analysis of the ETS Family in Melanoma Reveals a Regulatory Role of ETV7 in the Immune Microenvironment
H. Qu, Hui Zhao, Xi Zhang, Yang Liu +3 more
2020Frontiers in Immunology26 citations Open access
Semantic Scholar
Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation
Z. Ding, Chao-Mei Shi, Lan Jiang, T. Tolstykh +20 more
2017OncoTarget23 citations Open access
Semantic Scholar
MicroRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells by targeting the fatty acid synthase/Wnt signaling pathway
Zhichao Xu, Chunli Li, H. Qu, Hui-Ling Li +2 more
2017Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine22 citations Open access
Semantic Scholar
Knockdown of RAI14 suppresses the progression of gastric cancer
Cheng Chen, A. Maimaiti, Xin Zhang, H. Qu +3 more
2018OncoTargets and Therapy20 citations Open access
Semantic Scholar
Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition.
H. Qu, Hong Yin, Su Yan, M. Tao +2 more
2016Oncology Report14 citations
Semantic Scholar
NTRK2 is an oncogene and associated with microRNA-22 regulation in human gastric cancer cell lines
Jin-Hua Hu, Yong Huang, Yuanhua Wu, Feng-Jun Liu +3 more
2016Tumor Biology14 citations
Semantic Scholar
Core immune cell infiltration signatures identify molecular subtypes and promote precise checkpoint immunotherapy in cutaneous melanoma
Zheng Zhu, Guo-Yin Li, Zhenning Li, Ying-Hua Wu +6 more
2022Frontiers in Immunology13 citations Open access
Semantic Scholar
Evaluation of the effect of glutathione on cisplatin antitumor activity and kidney injury at different administration times.
Yan-Yan Xu, Na Jiang, Tongtong Liu, H. Qu +1 more
2012Molecular Medicine Reports13 citations Open access
Semantic Scholar
Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice
Su-Ling Huang, Wei Xie, Yang-liang Ye, Jia Liu +7 more
2022Acta Pharmacologica Sinica12 citations Open access
Semantic Scholar
Trends in the Research Into Immune Checkpoint Blockade by Anti-PD1/PDL1 Antibodies in Cancer Immunotherapy: A Bibliometric Study
Yi-Ting Sun, Li-Qing Jiang, T. Wen, Xiao-Yu Guo +7 more
2021Frontiers in Pharmacology12 citations Open access
Semantic Scholar
FOXD4 induces tumor progression in colorectal cancer by regulation of the SNAI3/CDH1 axis
Cheng Chen, Maimaiti Aihemaiti, Xin Zhang, H. Qu +3 more
2018Cancer Biology & Therapy12 citations Open access
Semantic Scholar
Acute and chronic administration of SHR117887, a novel and specific dipeptidyl peptidase-4 inhibitor, improves metabolic control in diabetic rodent models
Xiao Liu, Li-Na Zhang, Ying Feng, Lei Zhang +3 more
2012Acta Pharmacologica Sinica11 citations Open access
Semantic Scholar
SHR3824, a novel selective inhibitor of renal sodium glucose cotransporter 2, exhibits antidiabetic efficacy in rodent models
Pang-ke Yan, Li-Na Zhang, Ying Feng, H. Qu +3 more
2014Acta Pharmacologica Sinica10 citations Open access
Semantic Scholar
The synergistic antitumor activity of arsenic trioxide and vitamin K2 in HL-60 cells involves increased ROS generation and regulation of the ROS-dependent MAPK signaling pathway.
H. Qu, D. Tong, Yan-Qing Zhang, Kai Kang +3 more
2013Pharmazie8 citations Open access
Semantic Scholar
Abstract 3744: Antitumor activity of CUDC-907, a dual PI3K and HDAC inhibitor, in hematological cancer models
R. Bao, Da-Gong Wang, H. Qu, L. Yin +13 more
20128 citations
Semantic Scholar
Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis.
Fanghui Han, Meng-Meng Ning, Kai Wang, Yi-pei Gu +3 more
2022European journal of medicinal chemistry7 citations Open access
Semantic Scholar
Identification of Oxidative Stress-Associated Molecular Subtypes and Signature for Predicting Survival Outcome of Cervical Squamous Cell Carcinoma
L. Wang, H. Qu, Xiao-Lin Ma, Xiao-Mei Liu
2022Oxidative Medicine and Cellular Longevity5 citations Open access
Semantic Scholar
Abstract LB-130: Combinatorial treatment with intratumoral cytokine mRNAs results in high frequency of tumor rejection and development of anti-tumor immunity across a range of preclinical cancer models
T. Wagenaar, Christian Hotz, F. Gieseke, Hui Cao +28 more
2018Immunology5 citations
Semantic Scholar
Combination therapy with 5-amino-4-imidazolecarboxamide riboside and arsenic trioxide in acute myeloid leukemia cells involving AMPK/TSC2/mTOR pathway.
Lan Chen, Fengtong Han, H. Qu, Hong-Ji Yan +2 more
2013Pharmazie3 citations Open access
Semantic Scholar
Cancer Therapy : Preclinical CUDC-305 , a Novel Synthetic HSP 90 Inhibitor with Unique Pharmacologic Properties for Cancer Therapy
R. Bao, C. Lai, H. Qu, Da-Gong Wang +12 more
20092 citations
Semantic Scholar
Abstract 2615: Antitumor activity of a dual PI3K and HDAC inhibitor in hematologic cancer models
R. Bao, Da-Gong Wang, H. Qu, L. Yin +12 more
20111 citations
Semantic Scholar
Abstract 3249: Design and synthesis of imidazopyridine derivatives as novel HSP90 inhibitors for the treatment of cancer
Xiong Cai, H. Zhai, J. Wang, M. Samson +14 more
20111 citations
Semantic Scholar
Characterization of a Hedgehog pathway antagonist in a mouse medulloblastoma allograft model.
H. Tian, D. Marshall, C. Ahn, Z. Modrusan +11 more
20061 citations
Semantic Scholar
Abstract 1590: An experimental tumor model resistant to anti-PD-1 is sensitive to local mRNA immunotherapy
M. Bernardo, T. Tolstykh, Yu-An Zhang, D. Bangari +9 more
2021Immunology0 citations
Semantic Scholar
Abstract 1711: Induction of anti-tumor immunity by intratumoral delivery of mRNA encoding cytokines and TNFRSF agonists
J. Gavigan, Chao-Mei Shi, Michael Lampa, N. Malkova +6 more
2021Immunology0 citations
Semantic Scholar
Research in the correlation between PPS and the gene mutation of IRF6
Yi-Dan Sun, H. Qu, Lihong Ren, Haiyan Wang
20190 citations
Semantic Scholar
Abstract 2489: Sensitivity of liver cancer cell lines to B-catenin knock-down correlates with pathway activation
Z. Ding, Chao-Mei Shi, Lan Jiang, T. Tolstykh +20 more
2018Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
Osthenol inhibits the viability of HCT 116 cells through suppressing PI 3 K / AKT signaling pathway
Biao Zhuang, Zhijun Min, Tan Wang, Peng Zhang +3 more
20170 citations
Semantic Scholar
The role and mechanism of low-dose aspirin with IFN-α in inhibiting growth and metastasis of hepatocellular carcinoma
Tao Li, Xu-Ting Zhi, Zhao-Ru Dong, H. Qu
20120 citations
Semantic Scholar
Abstract C70: Antitumor activity of CUDC-907, a single small molecule inhibitor that targets both PI3K and HDAC, in hematologic cancer models.
R. Bao, Da-Gong Wang, H. Qu, J. Wang +13 more
20110 citations
Semantic Scholar
Abstract 2619: Potential advantages of CUDC-101, a multi-targeted HDAC, EGFR and HER2 inhibitor, on preventing drug resistance and tumor metastasis
J. Wang, K. Selmi, M. Samson, J. Forrester +13 more
20110 citations
Semantic Scholar
Abstract 4469: Antitumor activity of a single small molecule agent targeting Pi3K/mTor and HDAC
R. Bao, C. Lai, Da-Gong Wang, H. Qu +13 more
20100 citations
Semantic Scholar

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