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J. Yano · SciRah

Researcher profile · Semantic Scholar

J. Yano

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J. Yano — researcher profile on SciRah

h-index: 24
Works: 64
Citations: 4,402

Most-cited papers

The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution*
J. Yano, M. R. Wester, G. Schoch, K. J. Griffin +2 more
2004Journal of Biological Chemistry683 citations Open access
Semantic Scholar
Adaptations for the Oxidation of Polycyclic Aromatic Hydrocarbons Exhibited by the Structure of Human P450 1A2*♦
S. Sansen, J. Yano, R. L. Reynald, G. Schoch +3 more
2007Journal of Biological Chemistry449 citations Open access
Semantic Scholar
The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-Å Resolution*
M. R. Wester, J. Yano, G. Schoch, Christine Yang +3 more
2004Journal of Biological Chemistry417 citations Open access
Semantic Scholar
Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein
K. Aertgeerts, R. Skene, J. Yano, Bi-Ching Sang +11 more
2011Journal of Biological Chemistry376 citations Open access
Semantic Scholar
Structure of Human Microsomal Cytochrome P450 2C8
G. Schoch, J. Yano, M. R. Wester, K. J. Griffin +2 more
2004Journal of Biological Chemistry361 citations Open access
Semantic Scholar
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875
A. Srivastava, J. Yano, Yoshihiko Hirozane, G. Kefala +8 more
2014Nature346 citations
Semantic Scholar
Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen
J. Yano, M. Hsu, K. J. Griffin, C. Stout +1 more
2005Nature Structural &Molecular Biology299 citations
Semantic Scholar
Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold.
T. Ishikawa, M. Seto, H. Banno, Y. Kawakita +13 more
2011Journal of Medicinal Chemistry222 citations Open access
Semantic Scholar
Crystal Structure of a Thermophilic Cytochrome P450 from the Archaeon Sulfolobus solfataricus *
J. Yano, L. S. Koo, D. Schuller, Hui-Ying Li +2 more
2000Journal of Biological Chemistry173 citations Open access
Semantic Scholar
Determinants of Cytochrome P450 2C8 Substrate Binding
G. Schoch, J. Yano, S. Sansen, P. Dansette +2 more
2008Journal of Biological Chemistry158 citations Open access
Semantic Scholar
Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.
J. Yano, Travis T. Denton, M. Cerny, Xiao-Dong Zhang +2 more
2006Journal of Medicinal Chemistry109 citations Open access
Semantic Scholar
Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.
Masanori Okaniwa, M. Hirose, T. Arita, M. Yabuki +13 more
2013Journal of Medicinal Chemistry103 citations Open access
Semantic Scholar
New understandings of thermostable and peizostable enzymes.
J. Yano, T. Poulos
2003Current Opinion in Biotechnology97 citations
Semantic Scholar
Preliminary Characterization and Crystal Structure of a Thermostable Cytochrome P450 from Thermus thermophilus *
J. Yano, F. Blasco, Hui-Ying Li, R. Schmid +2 more
2003Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice
Toshiya Nishi, Shinichi Kondo, M. Miyamoto, Sayuri T. Watanabe +14 more
2020Scientific Reports73 citations Open access
Semantic Scholar
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds.
Masanori Okaniwa, M. Hirose, T. Imada, T. Ohashi +18 more
2012Journal of Medicinal Chemistry65 citations
Semantic Scholar
Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Betty Lam, Yasuyoshi Arikawa, Joshua Cramlett, Q. Dong +18 more
2016Bioorganic & Medicinal Chemistry Letters59 citations Open access
Semantic Scholar
Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor.
Yasufumi Miyamoto, Yoshihiro Banno, Tohru Yamashita, Tatsuhiko Fujimoto +18 more
2011Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H).
Tatsuki Koike, M. Yoshikawa, H. Ando, William Farnaby +7 more
2021Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554.
Yoshihiro Banno, Yasufumi Miyamoto, M. Sasaki, Satoru Oi +14 more
2011Bioorganic & Medicinal Chemistry36 citations Open access
Semantic Scholar
Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors.
A. Gould, Ruth Adams, S. Adhikari, K. Aertgeerts +44 more
2011Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate.
Katsuji Aikawa, Moriteru Asano, K. Ono, N. Habuka +10 more
2017Bioorganic & Medicinal Chemistry33 citations Open access
Semantic Scholar
Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.
Hironobu Maezaki, Yoshihiro Banno, Yasufumi Miyamoto, Yuusuke Moritou +15 more
2011Bioorganic & Medicinal Chemistry28 citations Open access
Semantic Scholar
Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125.
Yasufumi Miyamoto, Yoshihiro Banno, Tohru Yamashita, Tatsuhiko Fujimoto +16 more
2011Bioorganic & Medicinal Chemistry24 citations Open access
Semantic Scholar
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.
Moriteru Asano, T. Hitaka, T. Imada, Masami Yamada +12 more
2017Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.
M. Hirose, Masanori Okaniwa, T. Miyazaki, T. Imada +13 more
2012Bioorganic & Medicinal Chemistry16 citations Open access
Semantic Scholar
STRUCTURAL ANALYSIS OF THE MECHANISM OF INHIBITION AND ALLOSTERIC ACTIVATION OF THE KINASE DOMAIN OF HER 2
K. Aertgeerts, R. Skene, J. Yano, Bi-Ching Sang +11 more
201111 citations
Semantic Scholar
Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.
Y. Kajita, Shuhei Ikeda, M. Yoshikawa, H. Fukuda +7 more
2022Journal of Medicinal Chemistry9 citations Open access
Semantic Scholar
Crystal Structure of Human Microsomal P450 3A4
J. Yano, M. R. Wester, G. Schoch, K. J. Griffin +2 more
20048 citations
Semantic Scholar
Genomic Discovery and Structure–Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors
Jack R. Davison, M. Hadjithomas, S. P. Romeril, Y. Choi +37 more
2024Journal of Medicinal Chemistry7 citations Open access
Semantic Scholar
Molecular replacement in P450 crystal structure determinations.
Hui-Ying Li, J. Yano, T. Poulos
2002Methods in Enzymology3 citations
Semantic Scholar
Corrigendum to “Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554” [Bioorg. Med. Chem. 19 (2011) 4482–4498]
Hironobu Maezaki, Yoshihiro Banno, Yasufumi Miyamoto, Yusuke Moritoh +15 more
20112 citations Open access
Semantic Scholar
Crystal structure of Human GPR40 bound to allosteric agonist TAK-875
A. Srivastava, J. Yano, Yoshihiko Hirozane, G. Kefala +8 more
20141 citations
Semantic Scholar
Abstract C255: Discovery of TAK-632: A selective kinase inhibitor of pan-RAF with potent antitumor activity against BRAF and NRAS mutant melanomas.
Masanori Okaniwa, M. Hirose, T. Arita, M. Yabuki +13 more
20131 citations
Semantic Scholar
Crystal Structure of the Kinase domain of Human B-raf with a [1,3]thiazolo[5,4-b]pyridine derivative
J. Yano, K. Aertgeerts
20121 citations
Semantic Scholar
Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone
S. Sansen, J. Yano, R. L. Reynald, G. Schöch +2 more
20071 citations
Semantic Scholar
Analysis of Burkholderia pseudomallei IspF in complex with sulfapyridine, sulfamonomethoxine, ethoxzolamide and acetazolamide.
Dakota L Grote, Christopher Stewart, Drashti G. Daraji, Parisa Enayati +14 more
2025Acta Crystallographica Section F Structural Biology Communications0 citations Open access
Semantic Scholar
Co-complex CYP46A1 with 9129 (1b)
W. Lane, J. Yano
20210 citations
Semantic Scholar
Co-complex CYP46A1 with 8114 (3f)
W. Lane, J. Yano
20210 citations
Semantic Scholar
Co-complex CYP46A1 with 7742 (Soticlestat/TAK-935))
W. Lane, J. Yano
20210 citations
Semantic Scholar
Crystal structure of IspD from Mycobacterium paratuberculosis
P. G. Pierce, M. Bolejack, J. Yano, D. Lorimer +2 more
20200 citations
Semantic Scholar
Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor
J. Yano, K. Aertgeerts
20140 citations
Semantic Scholar
Crystal Structure of Human B-raf bound to a DFG-out Inhibitor TAK-632
J. Yano, O. Masanori
20130 citations
Semantic Scholar
Crystal Structure of Human B-raf bound to a DFG-out Inhibitor 5B
J. Yano, O. Masanori
20130 citations
Semantic Scholar
Crystal Structure of Human DPP4 Bound to TAK-294
J. Yano, K. Aertgeerts
20110 citations
Semantic Scholar
Crystal Structure of Human DPP4 Bound to TAK-986
J. Yano, K. Aertgeerts
20110 citations
Semantic Scholar
Crystal Structure of Human DPP4 Bound to TAK-100
J. Yano, K. Aertgeerts
20110 citations
Semantic Scholar
B-Raf kinase domain in complex with a tetrahydronaphthalene inhibitor
M. Sintchak, K. Aertgeerts, J. Yano
20110 citations
Semantic Scholar
CYP2C8DH COMPLEXED WITH TROGLITAZONE
G. Schoch, J. Yano, S. Sansen, C. Stout +1 more
20080 citations
Semantic Scholar
CYP2C8dH complexed with 2 molecules of 9-cis retinoic acid
G. Schoch, J. Yano, C. Stout, E. Johnson
20070 citations
Semantic Scholar

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