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K. J. Griffin · SciRah

Researcher profile · Semantic Scholar

K. J. Griffin

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K. J. Griffin — researcher profile on SciRah

h-index: 33
Works: 56
Citations: 6,037

Most-cited papers

The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution*
J. Yano, M. R. Wester, G. Schoch, K. J. Griffin +2 more
2004Journal of Biological Chemistry683 citations Open access
Semantic Scholar
Peroxisome proliferator activated receptor-alpha expression in human liver.
C. N. Palmer, M. Hsu, K. J. Griffin, J. Raucy +1 more
1998Molecular Pharmacology485 citations
Semantic Scholar
Adaptations for the Oxidation of Polycyclic Aromatic Hydrocarbons Exhibited by the Structure of Human P450 1A2*♦
S. Sansen, J. Yano, R. L. Reynald, G. Schoch +3 more
2007Journal of Biological Chemistry449 citations Open access
Semantic Scholar
LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase.
M. Manns, K. J. Griffin, K. Sullivan, E. F. Johnson
1991Journal of Clinical Investigation433 citations Open access
Semantic Scholar
The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-Å Resolution*
M. R. Wester, J. Yano, G. Schoch, Christine Yang +3 more
2004Journal of Biological Chemistry417 citations Open access
Semantic Scholar
Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.
M. Manns, E. F. Johnson, K. J. Griffin, E. M. Tan +1 more
1989Journal of Clinical Investigation365 citations Open access
Semantic Scholar
Structure of Human Microsomal Cytochrome P450 2C8
G. Schoch, J. Yano, M. R. Wester, K. J. Griffin +2 more
2004Journal of Biological Chemistry361 citations Open access
Semantic Scholar
The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.
A. Muerhoff, K. J. Griffin, Eric F. Johnson
1992Journal of Biological Chemistry304 citations Open access
Semantic Scholar
Novel Sequence Determinants in Peroxisome Proliferator Signaling (*)
C. N. Palmer, M. Hsu, K. J. Griffin, E. Johnson
1995Journal of Biological Chemistry300 citations Open access
Semantic Scholar
Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen
J. Yano, M. Hsu, K. J. Griffin, C. Stout +1 more
2005Nature Structural &Molecular Biology299 citations
Semantic Scholar
Role of the peroxisome proliferator‐activated receptor in cytochrome P450 4A gene regulation
Eric F. Johnson, C. N. A. Palmer, K. J. Griffin, M. Hsu
1996The FASEB Journal186 citations
Semantic Scholar
Identification of Peroxisome Proliferator-responsive Human Genes by Elevated Expression of the Peroxisome Proliferator-activated Receptor α in HepG2 Cells*
M. Hsu, U. Savas, K. J. Griffin, E. F. Johnson
2001Journal of Biological Chemistry185 citations Open access
Semantic Scholar
A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli.
Toby H. Richardson, Frank Jung, K. J. Griffin, M. R. Wester +6 more
1995Archives of Biochemistry and Biophysics150 citations
Semantic Scholar
Human Cytochrome P450 Family 4 Enzymes: Function, Genetic Variation and Regulation
M. Hsu, U. Savas, K. J. Griffin, E. Johnson
2007Drug metabolism reviews (Softcover ed.)120 citations
Semantic Scholar
Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors.
U. Savas, K. J. Griffin, E. F. Johnson
1999Molecular Pharmacology110 citations
Semantic Scholar
A Carboxyl-terminal Extension of the Zinc Finger Domain Contributes to the Specificity and Polarity of Peroxisome Proliferator-activated Receptor DNA Binding*
M. Hsu, C. N. Palmer, Wu Song, K. J. Griffin +1 more
1998Journal of Biological Chemistry110 citations Open access
Semantic Scholar
Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter.
C. N. A. Palmer, M. Hsu, A. Muerhoff, K. J. Griffin +1 more
1994Journal of Biological Chemistry90 citations
Semantic Scholar
Regulation of P450 4A expression by peroxisome proliferator activated receptors.
E. Johnson, M. Hsu, U. Savas, K. J. Griffin
2002Toxicology78 citations
Semantic Scholar
Expression of rabbit cytochromes P4504A which catalyze the omega-hydroxylation of arachidonic acid, fatty acids, and prostaglandins.
L. Roman, C. N. Palmer, J. Clark, A. Muerhoff +3 more
1993Archives of Biochemistry and Biophysics75 citations
Semantic Scholar
Multiple gene-like sequences related to the rabbit hepatic progesterone 21-hydroxylase cytochrome P-450 1.
R. Tukey, S. Okino, H. Barnes, K. J. Griffin +1 more
1985Journal of Biological Chemistry69 citations Open access
Semantic Scholar
Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli.
C. N. Palmer, Toby H. Richardson, K. J. Griffin, M. Hsu +3 more
1993Biochimica et Biophysica Acta68 citations
Semantic Scholar
Identification of cytochrome P450IA2 as a human autoantigen.
M. Manns, K. J. Griffin, L. Quattrochi, Michael Sacher +3 more
1990Archives of Biochemistry and Biophysics63 citations
Semantic Scholar
Cloning and expression of three rabbit kidney cDNAs encoding lauric acid omega-hydroxylases.
Eric F. Johnson, Diana L. Walker, K. J. Griffin, J. E. Clark +3 more
1990Biochemistry61 citations
Semantic Scholar
Regulation of Human Cytochrome P450 4F2 Expression by Sterol Regulatory Element-binding Protein and Lovastatin*
M. Hsu, U. Savas, K. J. Griffin, E. Johnson
2007Journal of Biological Chemistry53 citations Open access
Semantic Scholar
A single amino acid change in the mouse peroxisome proliferator-activated receptor alpha alters transcriptional responses to peroxisome proliferators.
M. Hsu, C. N. A. Palmer, K. J. Griffin, Eric F. Johnson
1995Molecular Pharmacology51 citations
Semantic Scholar
RABBIT PREGNANE X RECEPTOR IS ACTIVATED BY RIFAMPICIN 1
U. Savas, M. R. Wester, K. J. Griffin, Eric F. Johnson
200047 citations
Semantic Scholar
Identification of amino acid substitutions that confer a high affinity for sulfaphenazole binding and a high catalytic efficiency for warfarin metabolism to P450 2C19.
Frank Jung, K. J. Griffin, Wu Song, Toby H. Richardson +2 more
1998Biochemistry46 citations
Semantic Scholar
Regulation of the rabbit cytochrome P-450 3c gene. Age-dependent expression and transcriptional activation by rifampicin.
C. Potenza, U. Pendurthi, D. Strom, R. Tukey +3 more
1989Journal of Biological Chemistry46 citations Open access
Semantic Scholar
A single amino acid substitution confers progesterone 6 beta-hydroxylase activity to rabbit cytochrome P450 2C3.
M. Hsu, K. J. Griffin, Yan Wang, B. Kemper +1 more
1993Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6.
S. Okino, L. Quattrochi, H. Barnes, S. Osanto +3 more
1985Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
Conditional regulation of the human CYP4X1 and CYP4Z1 genes.
U. Savas, M. Hsu, K. J. Griffin, D. Bell +1 more
2005Archives of Biochemistry and Biophysics42 citations
Semantic Scholar
Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51.
Toby H. Richardson, K. J. Griffin, Frank Jung, Judy L. Raucy +1 more
1997Archives of Biochemistry and Biophysics35 citations
Semantic Scholar
Three monoclonal antibodies to rabbit microsomal cytochrome P-450 1 recognize distinct epitopes that are shared to different degrees among other electrophoretic types of cytochrome P-450.
I. Reubi, K. J. Griffin, Judy L. Raucy, Eric F. Johnson
1984Journal of Biological Chemistry34 citations
Semantic Scholar
Characterization of a rabbit gene encoding a clofibrate-inducible fatty acid omega-hydroxylase: CYP4A6.
A. Muerhoff, K. J. Griffin, Eric F. Johnson
1992Archives of Biochemistry and Biophysics24 citations
Semantic Scholar
Variations in hepatic progesterone 21-hydroxylase activity reflect differences in the microsomal concentration of rabbit cytochrome P-450 1.
Eric F. Johnson, K. J. Griffin
1985Archives of Biochemistry and Biophysics21 citations
Semantic Scholar
Rabbit Prostaglandin ω-Hydroxylase (CYP4A4): Gene Structure and Expression
C. N. A. Palmer, K. J. Griffin, E. Johnson
199318 citations
Semantic Scholar
Characterization of a second gene product related to rabbit cytochrome P-450 1.
Eric F. Johnson, H. Barnes, K. J. Griffin, S. Okino +1 more
1987Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Use of a monoclonal antibody specific for rabbit microsomal cytochrome P-450 3b to characterize the participation of this cytochrome in the microsomal 6 beta- and 16 alpha-hydroxylation of progesterone.
Ingrid Reubi, K. J. Griffin, Judy L. Raucy, Eric F. Johnson
1984Biochemistry16 citations
Semantic Scholar
Simple regression and outlier detection using the median method
M. Moen, K. J. Griffin, A. H. Kalantar
19939 citations
Semantic Scholar
Intraspecies individuality for the metabolism of steroids.
Eric F. Johnson, M. Finlayson, Judy L. Raucy, H. Barnes +3 more
1987Xenobiotica; the fate of foreign compounds in biological systems9 citations
Semantic Scholar
Crystal Structure of Human Microsomal P450 3A4
J. Yano, M. R. Wester, G. Schoch, K. J. Griffin +2 more
20048 citations
Semantic Scholar
Rabbit pregnane X receptor is activated by rifampicin.
U. Savas, M. R. Wester, K. J. Griffin, Eric F. Johnson
2000Drug Metabolism And Disposition8 citations
Semantic Scholar
Human recombinant LKM (P150 DB1) antigen is a sensitive and specific diagnostic reagent for differential diagnosis of chronic hepatitis
M. Manns, E. F. Johnson, K. J. Griffin, K. Z. Zum Buschenfelde +2 more
19893 citations
Semantic Scholar
The role of the peroxisome proliferator activated receptor in the induction of the rabbit CYP4A6 gene
A. Muerhoff, K. J. Griffin, E. F. Johnson
19922 citations
Semantic Scholar
Studies on species cross-reactivity of hemopexin by use of monoclonal and polyclonal antibodies.
Sylvia A. Metcalfe, M. De Falco, K. J. Griffin, Heng H. Liem +1 more
1987Biochemical and Biophysical Research Communications - BBRC2 citations
Semantic Scholar
The Role of Nuclear Receptors in the Regulation of P450s and Other Genes by Peroxisome Proliferators
E. Johnson, C. N. Palmer, M. Hsu, K. J. Griffin
19951 citations
Semantic Scholar
Rabbit prostaglandin omega-hydroxylase (CYP4A4): gene structure and expression.
C. N. Palmer, K. J. Griffin, E. F. Johnson
1993Archives of Biochemistry and Biophysics1 citations
Semantic Scholar
Multiple Forms of Rabbit Cytochrome P450: Comparison of Chemical Physical, Immunological and Biocatalytic Properties
Eric F. Johnson, T. Kronbach, A. Muerhoff, K. J. Griffin +2 more
19911 citations
Semantic Scholar
Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound
J. Yano, M. Hsu, K. J. Griffin, C. Stout +1 more
20050 citations
Semantic Scholar
The Crystal Structure of Human, Nicotine Metabolizing Cytochrome P450 2A6
J. Yano, K. J. Griffin, C. Stout, E. Johnson
20050 citations
Semantic Scholar

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J. Yano — researcher profile on SciRah

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A. Muerhoff — researcher profile on SciRah

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R. Tukey — researcher profile on SciRah

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